CA3059731A1 - Il4/il13 receptor molecule for veterinary use - Google Patents
Il4/il13 receptor molecule for veterinary use Download PDFInfo
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- CA3059731A1 CA3059731A1 CA3059731A CA3059731A CA3059731A1 CA 3059731 A1 CA3059731 A1 CA 3059731A1 CA 3059731 A CA3059731 A CA 3059731A CA 3059731 A CA3059731 A CA 3059731A CA 3059731 A1 CA3059731 A1 CA 3059731A1
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- polypeptide
- il13r
- il4r
- contiguous polypeptide
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5406—IL-4
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5437—IL-13
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
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- Zoology (AREA)
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- Veterinary Medicine (AREA)
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- Pathology (AREA)
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- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US201762488509P | 2017-04-21 | 2017-04-21 | |
| US62/488,509 | 2017-04-21 | ||
| PCT/US2018/028507 WO2018195388A1 (en) | 2017-04-21 | 2018-04-20 | Il4/il13 receptor molecule for veterinary use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3059731A1 true CA3059731A1 (en) | 2018-10-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3059731A Pending CA3059731A1 (en) | 2017-04-21 | 2018-04-20 | Il4/il13 receptor molecule for veterinary use |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11970526B2 (es) |
| EP (1) | EP3612555A4 (es) |
| JP (2) | JP2020517262A (es) |
| KR (1) | KR20200006528A (es) |
| CN (1) | CN110770250A (es) |
| AU (2) | AU2018254542B2 (es) |
| BR (1) | BR112019021812A2 (es) |
| CA (1) | CA3059731A1 (es) |
| MX (1) | MX2019012570A (es) |
| WO (1) | WO2018195388A1 (es) |
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| US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
| WO2018195388A1 (en) | 2017-04-21 | 2018-10-25 | Kindred Biosciences, Inc. | Il4/il13 receptor molecule for veterinary use |
| CA3071337A1 (en) * | 2017-08-15 | 2019-02-21 | Kindred Biosciences, Inc. | Igg fc variants for veterinary use |
| US20210395340A1 (en) * | 2018-10-25 | 2021-12-23 | Kindred Biosciences, Inc. | IL4/IL13 Receptor Molecule for Veterinary Use |
| JP2023522676A (ja) * | 2020-04-22 | 2023-05-31 | キンドレッド バイオサイエンシズ インコーポレイテッド | 動物用のｉｌ４／ｉｌ１３受容体分子 |
| EP4165066A1 (en) * | 2020-06-12 | 2023-04-19 | Beijing Vdjbio Co., Ltd. | Fusion polypeptide |
| AU2022331810A1 (en) | 2021-08-20 | 2024-02-29 | Intervet International B.V. | Fusion proteins for treating atopic dermatitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| US7253264B1 (en) | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
| US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5705154A (en) | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
| US6428788B1 (en) | 1995-03-15 | 2002-08-06 | Penn State University | Compositions and methods for specifically targeting tumors |
| US7078494B1 (en) | 1996-03-01 | 2006-07-18 | Genetics Institute, Llc | Antibodies to human IL-13bc and methods of their use in inhibiting IL-13 binding |
| WO1998023289A1 (en) | 1996-11-27 | 1998-06-04 | The General Hospital Corporation | MODULATION OF IgG BINDING TO FcRn |
| US6743604B1 (en) | 1996-12-13 | 2004-06-01 | Smithkline Beecham Corporation | Substances and their uses |
| US7083949B2 (en) | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| AU780031B2 (en) | 1998-12-14 | 2005-02-24 | Genetics Institute, Llc | Cytokine receptor chain |
| US6846486B1 (en) | 2000-02-24 | 2005-01-25 | Advanced Biotherapy Concepts, Inc. | Method of treating allergy by administering an anti-histamine antibody |
| WO2001077332A2 (en) | 2000-04-07 | 2001-10-18 | Heska Corporation | Compositions and methods related to canine igg and canine il-13 receptors |
| ES2614260T3 (es) | 2000-05-26 | 2017-05-30 | Immunex Corporation | Uso de anticuerpos contra el receptor de interleuquina-4 y composiciones de los mismos |
| KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| WO2005032399A2 (en) | 2003-05-30 | 2005-04-14 | The Regents Of The University Of California | Il4 receptor antagonists for horse, dog and cat |
| SG10201900535UA (en) | 2003-12-23 | 2019-02-27 | Genentech Inc | Novel anti-il 13 antibodies and uses thereof |
| JP2008504806A (ja) * | 2004-02-27 | 2008-02-21 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｉｌ−４／ｉｌ−１３特異的ポリペプチドおよびその治療上の使用 |
| CN1922204A (zh) | 2004-02-27 | 2007-02-28 | 瑞泽恩制药公司 | Il－4/il－13特异性的多肽和其治疗应用 |
| US8354109B2 (en) | 2005-12-13 | 2013-01-15 | Suppremol Gmbh | Multimeric Fc receptor polypeptides |
| EP2674440B1 (en) * | 2005-12-16 | 2019-07-03 | IBC Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
| RU2009120202A (ru) | 2006-12-11 | 2011-01-20 | Вайет (Us) | Способы и композиции для лечения и мониторинга лечения связанных с il-13 расстройств |
| WO2009061911A1 (en) | 2007-11-06 | 2009-05-14 | Wyeth | Assays and methods for evaluating multimeric complexes |
| AU2008321074A1 (en) | 2007-11-13 | 2009-05-22 | Sapphire Energy, Inc. | Production of Fc-fusion polypeptides in eukaryotic algae |
| AU2012249359A1 (en) | 2011-04-29 | 2013-11-14 | Janssen Biotech, Inc. | IL4/IL13 binding repeat proteins and uses |
| DK3453400T3 (da) | 2011-12-13 | 2021-04-06 | Pieris Pharmaceuticals Gmbh | Fremgangsmåder til forebyggelse eller behandling af visse forstyrrelser ved inhibering af binding af il-4 og/eller il-13 til deres respektive receptorer |
| EP2850093B1 (en) | 2012-01-27 | 2019-01-09 | The Board of Trustees of the Leland Stanford Junior University | Therapeutic il-13 polypeptides |
| CN110624107A (zh) | 2012-08-21 | 2019-12-31 | 赛诺菲生物技术公司 | 通过施用il-4r拮抗剂治疗或预防哮喘的方法 |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| JP6938383B2 (ja) * | 2015-04-02 | 2021-09-22 | インターベット インターナショナル ベー． フェー． | イヌインターロイキン４受容体アルファに対する抗体 |
| JP2018522026A (ja) | 2015-07-29 | 2018-08-09 | ナノティックス，エルエルシー | 可溶性生体分子を捕捉するためのモジュラー組成物及びそれと関連する方法 |
| US10906957B2 (en) | 2016-09-27 | 2021-02-02 | Epicentrx, Inc. | Immunomodulatory fusion proteins |
| WO2018195388A1 (en) | 2017-04-21 | 2018-10-25 | Kindred Biosciences, Inc. | Il4/il13 receptor molecule for veterinary use |
| US20210395340A1 (en) | 2018-10-25 | 2021-12-23 | Kindred Biosciences, Inc. | IL4/IL13 Receptor Molecule for Veterinary Use |
| JP2023522676A (ja) | 2020-04-22 | 2023-05-31 | キンドレッド バイオサイエンシズ インコーポレイテッド | 動物用のｉｌ４／ｉｌ１３受容体分子 |
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2018
- 2018-04-20 WO PCT/US2018/028507 patent/WO2018195388A1/en active Application Filing
- 2018-04-20 EP EP18788175.0A patent/EP3612555A4/en active Pending
- 2018-04-20 AU AU2018254542A patent/AU2018254542B2/en active Active
- 2018-04-20 JP JP2019556941A patent/JP2020517262A/ja active Pending
- 2018-04-20 BR BR112019021812-2A patent/BR112019021812A2/pt unknown
- 2018-04-20 CA CA3059731A patent/CA3059731A1/en active Pending
- 2018-04-20 KR KR1020197032241A patent/KR20200006528A/ko not_active Application Discontinuation
- 2018-04-20 MX MX2019012570A patent/MX2019012570A/es unknown
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- 2018-04-20 CN CN201880041160.7A patent/CN110770250A/zh active Pending
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2023
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| JP2023078158A (ja) | 2023-06-06 |
| WO2018195388A1 (en) | 2018-10-25 |
| US20200048325A1 (en) | 2020-02-13 |
| RU2019137211A (ru) | 2021-05-21 |
| EP3612555A1 (en) | 2020-02-26 |
| KR20200006528A (ko) | 2020-01-20 |
| AU2018254542B2 (en) | 2022-12-22 |
| BR112019021812A2 (pt) | 2020-05-26 |
| EP3612555A4 (en) | 2020-12-30 |
| AU2018254542A1 (en) | 2019-11-21 |
| RU2019137211A3 (es) | 2021-09-09 |
| AU2023201726A1 (en) | 2023-04-27 |
| US11970526B2 (en) | 2024-04-30 |
| JP2020517262A (ja) | 2020-06-18 |
| CN110770250A (zh) | 2020-02-07 |
| MX2019012570A (es) | 2019-12-02 |
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