CA3056433A1 - Npra agonists, compositions, and uses thereof - Google Patents
Npra agonists, compositions, and uses thereof Download PDFInfo
- Publication number
- CA3056433A1 CA3056433A1 CA3056433A CA3056433A CA3056433A1 CA 3056433 A1 CA3056433 A1 CA 3056433A1 CA 3056433 A CA3056433 A CA 3056433A CA 3056433 A CA3056433 A CA 3056433A CA 3056433 A1 CA3056433 A1 CA 3056433A1
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- Prior art keywords
- gly
- sequence
- peptide
- ser
- natriuretic peptide
- Prior art date
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- C07—ORGANIC CHEMISTRY
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- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
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| PCT/US2018/023491 WO2018175534A1 (en) | 2017-03-22 | 2018-03-21 | Npra agonists, compositions, and uses thereof |
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| US12440496B2 (en) | 2019-05-22 | 2025-10-14 | Merck Sharp & Dohme Llc | Natriuretic peptide receptor a agonists useful for the treatment of cardiometabolic diseases, kidney disease and diabetes |
| EP4164672A4 (en) * | 2020-06-12 | 2024-10-09 | PharmaIN Corporation | C-TYPE NATRIURETIC PEPTIDES AND RELATED METHODS IN THE TREATMENT OF CANCER |
| CA3184145A1 (en) * | 2020-06-12 | 2021-12-16 | Pharmain Corporation | C-type natriuretic peptides and methods thereof in treating acute lung injury |
| CR20250137A (es) | 2022-10-21 | 2025-05-26 | Lilly Co Eli | Péptidos natriuréticos de acción prolongada y usos de estos |
| US12077561B2 (en) | 2022-11-02 | 2024-09-03 | Novo Nordisk A/S | CNP compounds |
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| US3985722A (en) * | 1973-12-12 | 1976-10-12 | Ajinomoto Co., Inc. | Process for preparing N-higher aliphatic acyl derivatives of amino acids, peptides or proteins |
| FR2687156B1 (fr) * | 1992-02-12 | 1994-04-01 | Roussel Uclaf | Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives. |
| CN1062311C (zh) * | 1996-12-27 | 2001-02-21 | 中国医学科学院基础医学研究所 | 人白细胞介素2衍生物与人心钠素衍生物的融合基因、其蛋白产物及应用 |
| US6319503B1 (en) * | 1998-02-19 | 2001-11-20 | Proteinix Company | Heat shock fusion-based vaccine system |
| JP4237375B2 (ja) * | 2000-03-31 | 2009-03-11 | アスビオファーマ株式会社 | 虚血性疾患の処置又は予防に用いる医薬組成物 |
| DE60331584D1 (de) * | 2002-11-26 | 2010-04-15 | Biocon Ltd | Modifizierte natriuretic verbindungen, konjugate und ihre verwendungen |
| EP2162464A1 (en) * | 2007-06-06 | 2010-03-17 | Boehringer Ingelheim International GmbH | Natriuretic fusion proteins |
| US7960336B2 (en) * | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
| WO2009023270A2 (en) * | 2007-08-15 | 2009-02-19 | Amunix, Inc. | Compositions and methods for modifying properties of biologically active polypeptides |
| AR069409A1 (es) * | 2007-11-21 | 2010-01-20 | Biomarin Pharm Inc | Variantes de peptidos natriureticos de tipo c |
| HUE028539T2 (en) * | 2008-05-23 | 2016-12-28 | Daiichi Sankyo Co Ltd | A peptide capable of extending the half-life of an important peptide in plasma |
| TWI471137B (zh) * | 2009-05-20 | 2015-02-01 | Biomarin Pharm Inc | Ｃ型利鈉胜肽變異體 |
| CA2823066A1 (en) * | 2010-12-27 | 2012-07-05 | Alexion Pharma International Sarl | Compositions comprising natriuretic peptides and methods of use thereof |
| EP2678025B1 (en) * | 2011-02-23 | 2017-03-08 | Madeleine Pharmaceuticals Pty Ltd | Vsdl for use in the treatment of acute decompensated congestive heart failure |
| WO2012115771A2 (en) * | 2011-02-25 | 2012-08-30 | Medtronic, Inc. | Systems and methods for therapy of kidney disease and/or heart failure using chimeric natriuretic peptides |
-
2018
- 2018-03-21 MY MYPI2019005393A patent/MY201165A/en unknown
- 2018-03-21 IL IL269388A patent/IL269388B2/en unknown
- 2018-03-21 AU AU2018239352A patent/AU2018239352A1/en not_active Abandoned
- 2018-03-21 WO PCT/US2018/023491 patent/WO2018175534A1/en not_active Ceased
- 2018-03-21 SG SG11201908580X patent/SG11201908580XA/en unknown
- 2018-03-21 CA CA3056433A patent/CA3056433A1/en active Pending
- 2018-03-21 MX MX2019010960A patent/MX2019010960A/es unknown
- 2018-03-21 EA EA201992226A patent/EA201992226A1/ru unknown
- 2018-03-21 EP EP18771099.1A patent/EP3601314A4/en active Pending
- 2018-03-21 KR KR1020197031122A patent/KR102714599B1/ko active Active
- 2018-03-21 CN CN201880028963.9A patent/CN110603260B/zh active Active
- 2018-03-21 BR BR112019019720A patent/BR112019019720A2/pt unknown
- 2018-03-21 JP JP2019551608A patent/JP7126270B2/ja active Active
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2019
- 2019-09-12 PH PH12019550163A patent/PH12019550163A1/en unknown
- 2019-09-20 US US16/577,947 patent/US20200017567A1/en active Pending
-
2022
- 2022-04-22 JP JP2022070710A patent/JP2022090049A/ja not_active Withdrawn
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2025
- 2025-02-21 AU AU2025201270A patent/AU2025201270A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR102714599B1 (ko) | 2024-10-07 |
| KR20190133201A (ko) | 2019-12-02 |
| MY201165A (en) | 2024-02-08 |
| AU2025201270A1 (en) | 2025-03-13 |
| JP2020511494A (ja) | 2020-04-16 |
| BR112019019720A2 (pt) | 2020-04-28 |
| JP7126270B2 (ja) | 2022-08-26 |
| AU2018239352A1 (en) | 2019-10-10 |
| SG11201908580XA (en) | 2019-10-30 |
| US20200017567A1 (en) | 2020-01-16 |
| CN110603260A (zh) | 2019-12-20 |
| EP3601314A1 (en) | 2020-02-05 |
| MX2019010960A (es) | 2020-01-20 |
| CN110603260B (zh) | 2023-11-07 |
| IL269388B1 (en) | 2024-11-01 |
| IL269388A (en) | 2019-11-28 |
| PH12019550163A1 (en) | 2020-06-08 |
| JP2022090049A (ja) | 2022-06-16 |
| IL269388B2 (en) | 2025-03-01 |
| EP3601314A4 (en) | 2021-01-13 |
| WO2018175534A1 (en) | 2018-09-27 |
| EA201992226A1 (ru) | 2020-02-12 |
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