CA3056392A1 - Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer - Google Patents

Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer Download PDF

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Publication number
CA3056392A1
CA3056392A1 CA3056392A CA3056392A CA3056392A1 CA 3056392 A1 CA3056392 A1 CA 3056392A1 CA 3056392 A CA3056392 A CA 3056392A CA 3056392 A CA3056392 A CA 3056392A CA 3056392 A1 CA3056392 A1 CA 3056392A1
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CA
Canada
Prior art keywords
tumor
csf
oncovexmgm
carcinoma
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3056392A
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English (en)
French (fr)
Inventor
Pedro J. Beltran
Courtney BEERS
Keegan Cooke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA3056392A1 publication Critical patent/CA3056392A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/763—Herpes virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3056392A 2017-03-15 2018-03-14 Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer Pending CA3056392A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762471875P 2017-03-15 2017-03-15
US62/471,875 2017-03-15
PCT/US2018/022442 WO2018170133A1 (en) 2017-03-15 2018-03-14 Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer

Publications (1)

Publication Number Publication Date
CA3056392A1 true CA3056392A1 (en) 2018-09-20

Family

ID=61913527

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3056392A Pending CA3056392A1 (en) 2017-03-15 2018-03-14 Use of oncolytic viruses, alone or in combination with a checkpoint inhibitor, for the treatment of cancer

Country Status (9)

Country Link
US (2) US20200009204A1 (cg-RX-API-DMAC10.html)
EP (1) EP3595690A1 (cg-RX-API-DMAC10.html)
JP (3) JP2020510050A (cg-RX-API-DMAC10.html)
CN (1) CN110461346A (cg-RX-API-DMAC10.html)
AU (2) AU2018235944B2 (cg-RX-API-DMAC10.html)
CA (1) CA3056392A1 (cg-RX-API-DMAC10.html)
MA (1) MA51630A (cg-RX-API-DMAC10.html)
MX (3) MX2019010797A (cg-RX-API-DMAC10.html)
WO (1) WO2018170133A1 (cg-RX-API-DMAC10.html)

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CN116802278A (zh) * 2020-09-18 2023-09-22 成都美杰赛尔生物科技有限公司 溶瘤病毒与经改造的免疫细胞联合治疗肿瘤
US20240299540A1 (en) 2021-02-05 2024-09-12 Iovance Biotherapeutics, Inc. Adjuvant therapy for cancer
JP7697147B2 (ja) 2021-06-03 2025-06-23 上▲海▼允英生物医▲薬▼科技有限公司 腫瘍溶解性ウイルスベクターおよびその適用
TW202321458A (zh) * 2021-09-22 2023-06-01 瑞典商生物創新國際公司 新穎抗體組合及其用途
CN117653676A (zh) * 2022-08-22 2024-03-08 上海长征医院 溶瘤病毒vg161与免疫检查点抑制剂在制备治疗骨与软组织肿瘤药物中的应用
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CN116271052B (zh) * 2022-11-11 2025-07-04 上海市普陀区中心医院 溶瘤病毒vg161或与免疫检查点抑制剂联用在治疗胃癌中的应用
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CN120648657A (zh) * 2024-03-08 2025-09-16 上海锦斯生物技术有限公司 一种修饰的溶瘤病毒及其组合物
CN119524123A (zh) * 2024-11-08 2025-02-28 北京肿瘤医院(北京大学肿瘤医院) 溶瘤病毒联合pd-1单抗在制备黑色素瘤治疗药物中的应用
CN119792537B (zh) * 2025-01-22 2025-10-21 常州大学 利巴韦林与pd-1抑制剂联合用药物组合物及其应用

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Also Published As

Publication number Publication date
JP2023089171A (ja) 2023-06-27
WO2018170133A1 (en) 2018-09-20
MX2024006614A (es) 2024-06-19
JP7654708B2 (ja) 2025-04-01
MX2019010797A (es) 2019-10-24
EP3595690A1 (en) 2020-01-22
AU2024202086A1 (en) 2024-04-18
MX2025001102A (es) 2025-03-07
MA51630A (fr) 2020-01-22
US20260102446A1 (en) 2026-04-16
AU2018235944B2 (en) 2024-01-04
JP2020510050A (ja) 2020-04-02
US20200009204A1 (en) 2020-01-09
AU2018235944A1 (en) 2019-09-26
JP7869895B2 (ja) 2026-06-03
JP2025094078A (ja) 2025-06-24
CN110461346A (zh) 2019-11-15

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