CA3055777A1 - Deuterated domperidone compositions, methods, and preparation - Google Patents

Deuterated domperidone compositions, methods, and preparation Download PDF

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Publication number
CA3055777A1
CA3055777A1 CA3055777A CA3055777A CA3055777A1 CA 3055777 A1 CA3055777 A1 CA 3055777A1 CA 3055777 A CA3055777 A CA 3055777A CA 3055777 A CA3055777 A CA 3055777A CA 3055777 A1 CA3055777 A1 CA 3055777A1
Authority
CA
Canada
Prior art keywords
domperidone
active
release
deuterated
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3055777A
Other languages
English (en)
French (fr)
Inventor
Catherine Pearce
Piyush Patel
Jon ISAACSOHN
Original Assignee
Cindome Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cindome Pharma Inc filed Critical Cindome Pharma Inc
Publication of CA3055777A1 publication Critical patent/CA3055777A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3055777A 2016-02-04 2018-06-28 Deuterated domperidone compositions, methods, and preparation Pending CA3055777A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662291198P 2016-02-04 2016-02-04
US15/639,431 2017-06-30
US15/639,431 US10266516B2 (en) 2016-02-04 2017-06-30 Deuterated domperidone compositions, methods, and preparation
PCT/US2018/039928 WO2019006078A1 (en) 2016-02-04 2018-06-28 DETERERATED DOMPERIDONE COMPOSITIONS, METHODS AND PREPARATION

Publications (1)

Publication Number Publication Date
CA3055777A1 true CA3055777A1 (en) 2019-01-03

Family

ID=59501077

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3055777A Pending CA3055777A1 (en) 2016-02-04 2018-06-28 Deuterated domperidone compositions, methods, and preparation

Country Status (11)

Country Link
US (2) US10266516B2 (https=)
EP (2) EP3411031B1 (https=)
JP (3) JP7296185B2 (https=)
KR (2) KR102851614B1 (https=)
CN (4) CN108697700B (https=)
AU (2) AU2017213852B2 (https=)
BR (2) BR112018016032B1 (https=)
CA (1) CA3055777A1 (https=)
DK (2) DK3411031T3 (https=)
EA (2) EA035515B1 (https=)
WO (2) WO2017136617A1 (https=)

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WO2016174664A1 (en) 2015-04-29 2016-11-03 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US11364226B2 (en) 2017-06-30 2022-06-21 Cinrx Pharma, Llc Deuterated domperidone compositions, methods, and preparation
WO2017136617A1 (en) * 2016-02-04 2017-08-10 Cinrx Pharma, Llc Deuterated domperidone compositions and methods for therapy of disorders
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
US12478612B2 (en) 2017-06-30 2025-11-25 Cindome Pharma, Inc. Deuterated domperidone compositions, methods, and preparation
AU2019290231A1 (en) * 2018-06-21 2020-12-17 Dermavant Sciences GmbH Topical formulations of DGAT1 inhibitors and their methods of use
ES2869197T3 (es) * 2018-10-25 2021-10-25 Cindome Pharma Inc Formulaciones que contienen domperidona
CA3117682A1 (en) * 2018-10-25 2020-04-30 Cindome Pharma, Inc. Formulations containing deuterated domperidone
WO2022212246A1 (en) * 2021-03-29 2022-10-06 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Multi-enzyme nanoparticle-assisted stable isotope incorporation into small molecules by channeling
EP4525868A1 (en) * 2022-04-20 2025-03-26 CinDome Pharma, Inc. Deuterated domperidone for treating gastroparesis
CN120813355A (zh) * 2023-03-23 2025-10-17 辛多美制药有限公司 用于治疗糖尿病性胃轻瘫的方法

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Also Published As

Publication number Publication date
BR112019028185A2 (pt) 2020-07-07
US10590110B2 (en) 2020-03-17
AU2017213852B2 (en) 2021-04-08
JP2019504068A (ja) 2019-02-14
CN116712432A (zh) 2023-09-08
CN111093653B (zh) 2023-06-23
WO2017136617A8 (en) 2017-10-05
BR112018016032A2 (pt) 2018-12-26
AU2018290905A1 (en) 2020-02-13
JP2023052045A (ja) 2023-04-11
US10266516B2 (en) 2019-04-23
EP3644995A1 (en) 2020-05-06
AU2017213852A1 (en) 2018-07-05
KR102695402B1 (ko) 2024-08-16
BR112018016032B1 (pt) 2024-03-05
WO2019006078A1 (en) 2019-01-03
BR112019028185A8 (pt) 2020-08-11
CA3013123A1 (en) 2017-08-10
CN108697700B (zh) 2021-08-17
EP3411031B1 (en) 2024-07-24
WO2017136617A1 (en) 2017-08-10
EA035515B1 (ru) 2020-06-29
EP3411031A4 (en) 2019-08-07
US20190241543A1 (en) 2019-08-08
EP3644995B1 (en) 2025-05-07
JP7602324B2 (ja) 2024-12-18
EP3411031A1 (en) 2018-12-12
EA201891727A1 (ru) 2018-12-28
DK3644995T3 (da) 2025-08-18
AU2018290905B2 (en) 2022-10-06
KR102851614B1 (ko) 2025-08-29
CN111093653A (zh) 2020-05-01
KR20200044790A (ko) 2020-04-29
KR20180104662A (ko) 2018-09-21
US20170298046A1 (en) 2017-10-19
DK3411031T3 (da) 2024-10-21
JP7296185B2 (ja) 2023-06-22
CN108697700A (zh) 2018-10-23
EA202090183A1 (ru) 2020-04-15
JP2020534246A (ja) 2020-11-26
CN113995755A (zh) 2022-02-01

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