CA3047286A1 - Oxazine derivatives as beta-secretase inhibitors and methods of use - Google Patents

Oxazine derivatives as beta-secretase inhibitors and methods of use Download PDF

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Publication number
CA3047286A1
CA3047286A1 CA3047286A CA3047286A CA3047286A1 CA 3047286 A1 CA3047286 A1 CA 3047286A1 CA 3047286 A CA3047286 A CA 3047286A CA 3047286 A CA3047286 A CA 3047286A CA 3047286 A1 CA3047286 A1 CA 3047286A1
Authority
CA
Canada
Prior art keywords
tautomer
compound
pharmaceutically acceptable
acceptable salt
oxazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3047286A
Other languages
English (en)
French (fr)
Inventor
Jennifer R. Allen
Matthew P. Bourbeau
Ning Chen
Michael J. Frohn
Paul E. Harrington
Qingyian Liu
Corey REEVES
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA3047286A1 publication Critical patent/CA3047286A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3047286A 2016-12-15 2017-12-13 Oxazine derivatives as beta-secretase inhibitors and methods of use Pending CA3047286A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662434711P 2016-12-15 2016-12-15
US62/434,711 2016-12-15
US201762570425P 2017-10-10 2017-10-10
US62/570,425 2017-10-10
PCT/US2017/066177 WO2018112081A1 (en) 2016-12-15 2017-12-13 Oxazine derivatives as beta-secretase inhibitors and methods of use

Publications (1)

Publication Number Publication Date
CA3047286A1 true CA3047286A1 (en) 2018-06-21

Family

ID=60888744

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3047286A Pending CA3047286A1 (en) 2016-12-15 2017-12-13 Oxazine derivatives as beta-secretase inhibitors and methods of use

Country Status (8)

Country Link
US (1) US10947223B2 (enExample)
EP (1) EP3555080B1 (enExample)
JP (1) JP7177773B2 (enExample)
AU (1) AU2017376441B2 (enExample)
CA (1) CA3047286A1 (enExample)
MA (1) MA52722A (enExample)
MX (1) MX388696B (enExample)
WO (1) WO2018112081A1 (enExample)

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MA52722A (fr) 2016-12-15 2021-04-14 Amgen Inc Dérivés d'oxazine en tant qu'inhibiteurs de bêta-sécrétase et procédés d'utilisation
MA54101A (fr) 2016-12-15 2021-10-27 Amgen Inc Dérivés de thiazine et d'oxazine bicycliques en tant qu'inhibiteurs de bêta-sécrétase et procédés d'utilisation
EP3555086B1 (en) 2016-12-15 2021-09-01 Amgen Inc. 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
MX386618B (es) 2016-12-15 2025-03-19 Amgen Inc Derivados de tiazina condensados con ciclopropilo como inhibidores de beta-secretasa y métodos de uso.
MX388697B (es) 2016-12-15 2025-03-20 Amgen Inc Derivados de tiazina como inhibidores de beta-secretasa y metodos de uso.
CA3098430A1 (en) 2018-04-27 2019-10-31 Shionogi & Co., Ltd. Tetrahydropyranooxazine derivatives having selective bace1 inhibitory activity

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Also Published As

Publication number Publication date
JP2020503293A (ja) 2020-01-30
EP3555080B1 (en) 2023-09-20
AU2017376441B2 (en) 2021-10-14
WO2018112081A1 (en) 2018-06-21
MA52722A (fr) 2021-04-14
MX2019007101A (es) 2019-12-16
US20200207747A1 (en) 2020-07-02
AU2017376441A1 (en) 2019-07-04
JP7177773B2 (ja) 2022-11-24
US10947223B2 (en) 2021-03-16
MX388696B (es) 2025-03-20
EP3555080A1 (en) 2019-10-23

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