CA3046982A1 - Compositions et procedes pour la reprogrammation de cellules somatiques en cellules vasculogeniques induites - Google Patents
Compositions et procedes pour la reprogrammation de cellules somatiques en cellules vasculogeniques induites Download PDFInfo
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- 230000019635 sulfation Effects 0.000 description 1
- 238000005670 sulfation reaction Methods 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
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- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
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- 101150075675 tatC gene Proteins 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 125000005309 thioalkoxy group Chemical group 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
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- 230000000451 tissue damage Effects 0.000 description 1
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- 230000017423 tissue regeneration Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 210000003956 transport vesicle Anatomy 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000000427 trigeminal ganglion Anatomy 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- HDZZVAMISRMYHH-KCGFPETGSA-N tubercidin Chemical compound C1=CC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O HDZZVAMISRMYHH-KCGFPETGSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000006459 vascular development Effects 0.000 description 1
- 230000004862 vasculogenesis Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 229960001134 von willebrand factor Drugs 0.000 description 1
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
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Abstract
L'invention concerne des compositions et des procédés pour la reprogrammation directe de cellules somatiques en cellules vasculogéniques induites in vitro et in vivo Ces compositions et procédés sont utiles à diverses fins, y compris le développement de thérapies pro-angiogéniques.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662438260P | 2016-12-22 | 2016-12-22 | |
US62/438,260 | 2016-12-22 | ||
US201762530132P | 2017-07-08 | 2017-07-08 | |
US62/530,132 | 2017-07-08 | ||
PCT/US2017/067631 WO2018119091A1 (fr) | 2016-12-22 | 2017-12-20 | Compositions et procédés pour la reprogrammation de cellules somatiques en cellules vasculogéniques induites |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3046982A1 true CA3046982A1 (fr) | 2018-06-28 |
Family
ID=62628033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3046982A Pending CA3046982A1 (fr) | 2016-12-22 | 2017-12-20 | Compositions et procedes pour la reprogrammation de cellules somatiques en cellules vasculogeniques induites |
Country Status (9)
Country | Link |
---|---|
US (1) | US11578107B2 (fr) |
EP (1) | EP3558328A4 (fr) |
JP (1) | JP2020511116A (fr) |
KR (1) | KR20190096414A (fr) |
CN (1) | CN110753758A (fr) |
AU (2) | AU2017379880A1 (fr) |
BR (1) | BR112019012997A2 (fr) |
CA (1) | CA3046982A1 (fr) |
WO (1) | WO2018119091A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130123647A1 (en) | 2011-05-03 | 2013-05-16 | The Research Foundation Of State University Of New York | Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections |
WO2019161165A1 (fr) | 2018-02-15 | 2019-08-22 | Ohio State Innovation Foundation | Dispositifs et procédés microfluidiques pour électroporation à haut débit |
JP2021531805A (ja) * | 2018-08-01 | 2021-11-25 | オハイオ・ステイト・イノベーション・ファウンデーション | 皮膚をインスリン産生組織にリプログラミングするための組成物および方法 |
CN114423413A (zh) * | 2019-07-02 | 2022-04-29 | 俄亥俄州国家创新基金会 | 利用皮肤-脑轴的神经退行性疾病疗法 |
CA3154463A1 (fr) * | 2019-09-20 | 2021-03-25 | The Trustees Of Indiana University | Fibroblastes vasculogeniques |
US20230120162A1 (en) * | 2020-02-27 | 2023-04-20 | The Trustees Of Indiana University | Cell-targeted nanoparticles to inhibit rna cargo |
CA3174443A1 (fr) * | 2020-03-04 | 2021-09-10 | The Trustees Of Indiana University | Procedes de re-engagement d'une voie de cicatrisation de plaie ftale pour la reparation de la peau d'un adulte |
WO2021188894A2 (fr) * | 2020-03-20 | 2021-09-23 | University Of Massachusetts | Micro-arn pour la prévention d'une maladie thromboembolique veineuse clinique |
WO2021253007A1 (fr) * | 2020-06-12 | 2021-12-16 | Emory University | Reprogrammation directe in vivo à l'aide d'un gène de facteur de transcription etv2 pour la formation de cellules endothéliales et de vaisseaux |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1648914A4 (fr) | 2003-07-31 | 2009-12-16 | Regulus Therapeutics Inc | Composes oligomeres et compositions utilisables pour moduler des petits arn non-codants |
US20050142581A1 (en) | 2003-09-04 | 2005-06-30 | Griffey Richard H. | Microrna as ligands and target molecules |
WO2006093526A2 (fr) | 2004-07-21 | 2006-09-08 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprenant une nucleobase modifiee ou non naturelle |
US20080213891A1 (en) | 2004-07-21 | 2008-09-04 | Alnylam Pharmaceuticals, Inc. | RNAi Agents Comprising Universal Nucleobases |
EP1913011B1 (fr) | 2004-08-04 | 2016-11-02 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprenant un ligand attache a une nucleobase modifiee ou non naturelle |
US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
EP1919512B1 (fr) | 2005-08-10 | 2014-11-12 | Alnylam Pharmaceuticals Inc. | Oligonucléotides chimiquement modifiés pouvant être employés dans la modulation de micro-arn et applications |
DK1931780T3 (en) | 2005-08-29 | 2016-01-25 | Regulus Therapeutics Inc | Antisense-forbindelser med forøget anti-microrna-aktivitet |
JP5523705B2 (ja) | 2005-08-29 | 2014-06-18 | レグルス・セラピューティクス・インコーポレイテッド | Mir−122aをモジュレートする使用方法 |
EP2388328A1 (fr) | 2006-01-27 | 2011-11-23 | Isis Pharmaceuticals, Inc. | Composés oligomères et compositions pour une utilisation dans la modulation de micro ARN |
CA2649045C (fr) | 2006-04-03 | 2019-06-11 | Santaris Pharma A/S | Composition pharmaceutique renfermant des oligonucleotides antisens anti-mirna |
WO2008046911A2 (fr) | 2006-10-20 | 2008-04-24 | Exiqon A/S | Nouveaux microarn humains associés au cancer |
US20090137504A1 (en) | 2006-12-21 | 2009-05-28 | Soren Morgenthaler Echwald | Microrna target site blocking oligos and uses thereof |
US9816086B2 (en) * | 2010-07-06 | 2017-11-14 | The Ohio State University | Dose and location controlled drug/gene/particle delivery to individual cells by nanoelectroporation |
US8785192B2 (en) * | 2010-07-07 | 2014-07-22 | Cellular Dynamics International, Inc. | Endothelial cell production by programming |
CA2874764C (fr) * | 2012-05-30 | 2022-11-01 | Cornell University | Generation de cellules endotheliales fonctionnelles et durables a partir de cellules derivees du fluide amniotique humain |
JP2015109833A (ja) * | 2013-11-08 | 2015-06-18 | 学校法人慶應義塾 | 線維芽細胞から血管内皮細胞を製造する方法 |
WO2015133792A1 (fr) * | 2014-03-03 | 2015-09-11 | 국립대학법인 울산과학기술대학교 산학협력단 | Composition pour induire la transdifférenciation directe de cellules somatiques en cellules progénitrices vasculaires, et son utilisation |
EP3117839A4 (fr) | 2014-03-03 | 2017-12-20 | UNIST (Ulsan National Institute of Science and Technology) | Composition pour induire la transdifférenciation directe de cellules somatiques en cellules progénitrices vasculaires, et son utilisation |
US10023842B2 (en) | 2014-04-29 | 2018-07-17 | Emory University | Endothelial and endothelial like cells produced from fibroblasts and uses related thereto |
-
2017
- 2017-12-20 CA CA3046982A patent/CA3046982A1/fr active Pending
- 2017-12-20 KR KR1020197021467A patent/KR20190096414A/ko not_active Application Discontinuation
- 2017-12-20 WO PCT/US2017/067631 patent/WO2018119091A1/fr unknown
- 2017-12-20 JP JP2019533223A patent/JP2020511116A/ja active Pending
- 2017-12-20 BR BR112019012997A patent/BR112019012997A2/pt unknown
- 2017-12-20 AU AU2017379880A patent/AU2017379880A1/en not_active Abandoned
- 2017-12-20 EP EP17882356.3A patent/EP3558328A4/fr active Pending
- 2017-12-20 CN CN201780080253.6A patent/CN110753758A/zh active Pending
- 2017-12-20 US US16/471,808 patent/US11578107B2/en active Active
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2024
- 2024-03-08 AU AU2024201552A patent/AU2024201552A1/en active Pending
Also Published As
Publication number | Publication date |
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WO2018119091A1 (fr) | 2018-06-28 |
KR20190096414A (ko) | 2019-08-19 |
JP2020511116A (ja) | 2020-04-16 |
AU2017379880A1 (en) | 2019-07-04 |
EP3558328A1 (fr) | 2019-10-30 |
CN110753758A (zh) | 2020-02-04 |
BR112019012997A2 (pt) | 2019-12-10 |
US11578107B2 (en) | 2023-02-14 |
AU2024201552A1 (en) | 2024-05-02 |
EP3558328A4 (fr) | 2020-08-26 |
US20200115425A1 (en) | 2020-04-16 |
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