CA3046977A1 - Layered particles and processes thereof - Google Patents

Layered particles and processes thereof Download PDF

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Publication number
CA3046977A1
CA3046977A1 CA3046977A CA3046977A CA3046977A1 CA 3046977 A1 CA3046977 A1 CA 3046977A1 CA 3046977 A CA3046977 A CA 3046977A CA 3046977 A CA3046977 A CA 3046977A CA 3046977 A1 CA3046977 A1 CA 3046977A1
Authority
CA
Canada
Prior art keywords
liquid stream
liquid
particles
mixture
stream
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3046977A
Other languages
English (en)
French (fr)
Inventor
Thomai Panagiotou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Delphi Scientific LLC
Original Assignee
Delphi Scientific LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delphi Scientific LLC filed Critical Delphi Scientific LLC
Publication of CA3046977A1 publication Critical patent/CA3046977A1/en
Pending legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/04Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/501Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/45Mixing liquids with liquids; Emulsifying using flow mixing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/80After-treatment of the mixture
    • B01F23/808Filtering the mixture
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/006Coating of the granules without description of the process or the device by which the granules are obtained
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B5/00Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts
    • B32B5/16Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by features of a layer formed of particles, e.g. chips, powder or granules
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0097Dye preparations of special physical nature; Tablets, films, extrusion, microcapsules, sheets, pads, bags with dyes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • B01F23/413Homogenising a raw emulsion or making monodisperse or fine emulsions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • B01F23/414Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4146Emulsions including solid particles, e.g. as solution or dispersion, i.e. molten material or material dissolved in a solvent or dispersed in a liquid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00Mixers with rotating receptacles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3046977A 2016-12-16 2017-12-18 Layered particles and processes thereof Pending CA3046977A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662435514P 2016-12-16 2016-12-16
US62/435,514 2016-12-16
PCT/US2017/066985 WO2018112456A1 (en) 2016-12-16 2017-12-18 Layered particles and processes thereof

Publications (1)

Publication Number Publication Date
CA3046977A1 true CA3046977A1 (en) 2018-06-21

Family

ID=62559393

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3046977A Pending CA3046977A1 (en) 2016-12-16 2017-12-18 Layered particles and processes thereof

Country Status (6)

Country Link
US (2) US11938456B2 (cg-RX-API-DMAC7.html)
EP (1) EP3554478B1 (cg-RX-API-DMAC7.html)
JP (2) JP7637962B2 (cg-RX-API-DMAC7.html)
CA (1) CA3046977A1 (cg-RX-API-DMAC7.html)
IL (1) IL267102B2 (cg-RX-API-DMAC7.html)
WO (1) WO2018112456A1 (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3554478B1 (en) * 2016-12-16 2022-01-26 Delphi Scientific, LLC Layered particles and processes thereof

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US5187554A (en) 1987-08-11 1993-02-16 Sony Corporation Bipolar transistor
US5269980A (en) 1991-08-05 1993-12-14 Northeastern University Production of polymer particles in powder form using an atomization technique
US5484720A (en) * 1994-09-08 1996-01-16 Genentech, Inc. Methods for calcium phosphate transfection
IL144084A0 (en) * 1999-02-03 2002-05-23 Biosante Pharmaceuticals Inc Therapeutic calcium phosphate particles and methods of manufacture and use
WO2004076056A2 (en) 2003-02-26 2004-09-10 Lake Shore Cryotronics Inc. Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
US20050016851A1 (en) * 2003-07-24 2005-01-27 Jensen Klavs F. Microchemical method and apparatus for synthesis and coating of colloidal nanoparticles
DE602005021756D1 (de) * 2004-02-13 2010-07-22 Nod Pharmaceuticals Inc Partikel mit kern aus calciumphosphat-nanopartikeln, biomolekül und gallensäure, herstellungsverfahren und therapeutische verwendung
CA2560959A1 (en) 2004-03-23 2005-09-29 Kyowa Hakko Kogyo Co., Ltd. Method of producing coated fine particles
AU2005237360B2 (en) * 2004-04-30 2010-10-21 Astellas Pharma Inc. Time-limited release type granular pharmaceutical composition for oral administration and intraoral rapid disintegration tablet containing the composition
CN101612542A (zh) * 2005-01-28 2009-12-30 协和发酵麒麟株式会社 被覆微粒的制备方法
WO2006096571A2 (en) * 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US20090035381A1 (en) 2007-08-01 2009-02-05 Stankus John J Electrospraying method for fabrication of particles and coatings and treatment methods thereof
US8187554B2 (en) * 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
JP6250262B2 (ja) * 2009-02-09 2017-12-20 セルテック・アクチボラゲットCellutech Ab ポリマーシェル
EP2496700B1 (en) 2009-11-04 2017-03-01 The University Of British Columbia Nucleic acid-containing lipid particles and related methods
CN104959052B (zh) * 2010-04-09 2018-07-13 帕西拉制药有限公司 用于配制大直径合成膜囊泡的方法
JP6207007B2 (ja) * 2012-05-15 2017-10-04 国立大学法人 千葉大学 リポソームおよびその作製方法
AU2013361292A1 (en) 2012-12-19 2015-07-09 Kashiv Pharma, Llc Supersaturated stabilized nanoparticles for poorly soluble drugs
EP3057693A4 (en) 2013-10-16 2017-08-09 The University Of British Columbia Device for formulating particles at small volumes
SG11201607493QA (en) * 2014-03-11 2016-10-28 Toppan Printing Co Ltd Droplet producing device, droplet producing method, liposome producing method, fixture, and droplet producing kit
ES2767501T3 (es) 2014-05-28 2020-06-17 Evonik Operations Gmbh Nanopartícula
WO2016010840A1 (en) * 2014-07-16 2016-01-21 Novartis Ag Method of encapsulating a nucleic acid in a lipid nanoparticle host
JP6404034B2 (ja) * 2014-08-25 2018-10-10 片山化学工業株式会社 核酸を内封してなる中性又はアニオン性リポソーム及びその製造方法。
EP4481401A3 (en) 2015-02-24 2025-04-23 The University of British Columbia Continuous flow microfluidic system and method
EP3554478B1 (en) 2016-12-16 2022-01-26 Delphi Scientific, LLC Layered particles and processes thereof

Also Published As

Publication number Publication date
JP2020508964A (ja) 2020-03-26
US11938456B2 (en) 2024-03-26
EP3554478B1 (en) 2022-01-26
US20200016562A1 (en) 2020-01-16
JP2023036672A (ja) 2023-03-14
EP3554478A4 (en) 2020-08-26
EP3554478A1 (en) 2019-10-23
JP7637962B2 (ja) 2025-03-03
WO2018112456A1 (en) 2018-06-21
IL267102B2 (en) 2023-06-01
IL267102A (en) 2019-08-29
US20240226840A1 (en) 2024-07-11

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