CA3045703C - Piperidine-2,6-dione derivatives and ulcerative colitis treating - Google Patents
Piperidine-2,6-dione derivatives and ulcerative colitis treating Download PDFInfo
- Publication number
- CA3045703C CA3045703C CA3045703A CA3045703A CA3045703C CA 3045703 C CA3045703 C CA 3045703C CA 3045703 A CA3045703 A CA 3045703A CA 3045703 A CA3045703 A CA 3045703A CA 3045703 C CA3045703 C CA 3045703C
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- CA
- Canada
- Prior art keywords
- dione
- pharmaceutically acceptable
- acceptable salts
- dioxopiperidin
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 201000006704 Ulcerative Colitis Diseases 0.000 title claims abstract description 79
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- WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611041317 | 2016-11-24 | ||
| CN201611041317.5 | 2016-11-24 | ||
| PCT/CN2017/112668 WO2018095377A1 (zh) | 2016-11-24 | 2017-11-23 | 哌啶-2,6-二酮衍生物以及溃疡性结肠炎的治疗 |
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| CA3045703A1 CA3045703A1 (en) | 2018-05-31 |
| CA3045703C true CA3045703C (en) | 2021-11-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA3045703A Active CA3045703C (en) | 2016-11-24 | 2017-11-23 | Piperidine-2,6-dione derivatives and ulcerative colitis treating |
| CA3049161A Active CA3049161C (en) | 2016-11-24 | 2017-11-23 | Piperidine-2,6-dione derivatives and crohn's disease treating |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3049161A Active CA3049161C (en) | 2016-11-24 | 2017-11-23 | Piperidine-2,6-dione derivatives and crohn's disease treating |
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| Country | Link |
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| US (4) | US11485724B2 (enExample) |
| EP (2) | EP3546450A4 (enExample) |
| JP (2) | JP7143296B2 (enExample) |
| CN (2) | CN108101886A (enExample) |
| AU (2) | AU2017366515B2 (enExample) |
| CA (2) | CA3045703C (enExample) |
| WO (2) | WO2018095377A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108101886A (zh) | 2016-11-24 | 2018-06-01 | 天津和美生物技术有限公司 | 哌啶-2,6-二酮衍生物及其在治疗溃疡性结肠炎中的用途 |
| CN108727319A (zh) * | 2018-09-05 | 2018-11-02 | 常州大学 | 一种3-硝基邻苯二甲酸酐的制备方法 |
| CN109293631B (zh) * | 2018-11-30 | 2020-05-08 | 常州制药厂有限公司 | 3-氨基-n-(2，6-二氧代-3-哌啶基)-邻苯二甲酰亚胺化合物的制备方法 |
| GB202002926D0 (en) * | 2020-02-28 | 2020-04-15 | Benevolentai Tech Limited | Compositions and uses thereof |
| CN111320604B (zh) * | 2020-04-22 | 2021-02-09 | 牡丹江医学院 | 一种治疗小儿口腔黏膜疾病的化合物、制备方法及其用途 |
| CN118370746A (zh) * | 2024-04-25 | 2024-07-23 | 江苏省中医院 | 马尿酸在制备溃疡性结肠炎治疗药物中的应用 |
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| ES2172474B1 (es) * | 2001-03-01 | 2004-01-16 | Fundacion Universitaria San Pa | Derivados de glutarimida como agentes terapeuticos. |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| CN100488959C (zh) | 2003-03-27 | 2009-05-20 | 天津和美生物技术有限公司 | 水溶性的酞胺哌啶酮衍生物 |
| CA2538864C (en) * | 2003-09-17 | 2013-05-07 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Thalidomide analogs as tnf-alpha modulators |
| MX2007008903A (es) | 2005-01-25 | 2007-09-07 | Celgene Corp | Metodos y composiciones que usan 4-amino-2-(3-metil-2,6- dioxopiperidin-3-il)-isoindol-1,3-diona. |
| CN100383139C (zh) | 2005-04-07 | 2008-04-23 | 天津和美生物技术有限公司 | 可抑制细胞释放肿瘤坏死因子的哌啶-2，6-二酮衍生物 |
| CN1961876A (zh) * | 2005-11-08 | 2007-05-16 | 北京恩华医药研究院 | 邻苯二甲酰亚胺衍生物在制备抗新血管生成的药物中的用途 |
| ES2664872T3 (es) * | 2010-06-18 | 2018-04-23 | Taiho Pharmaceutical Co., Ltd | Moduladores PRPK-TPRKB y sus usos |
| SG11201507759WA (en) | 2013-04-02 | 2015-10-29 | Celgene Corp | Methods and compositions using 4-amino-2-(2,6-dioxo-piperidine-3-yl)-isoindoline-1,3-dione for treatment and management of central nervous system cancers |
| CN108101886A (zh) | 2016-11-24 | 2018-06-01 | 天津和美生物技术有限公司 | 哌啶-2,6-二酮衍生物及其在治疗溃疡性结肠炎中的用途 |
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2017
- 2017-11-23 CN CN201711184758.5A patent/CN108101886A/zh active Pending
- 2017-11-23 CN CN201711185728.6A patent/CN108101887A/zh active Pending
- 2017-11-23 US US16/464,224 patent/US11485724B2/en active Active
- 2017-11-23 WO PCT/CN2017/112668 patent/WO2018095377A1/zh not_active Ceased
- 2017-11-23 US US16/464,228 patent/US20220372013A2/en active Pending
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- 2017-11-23 EP EP17873820.9A patent/EP3546449A4/en active Pending
- 2017-11-23 AU AU2017366515A patent/AU2017366515B2/en active Active
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- 2017-11-23 JP JP2019528110A patent/JP7143295B2/ja active Active
- 2017-11-23 AU AU2017366514A patent/AU2017366514B2/en active Active
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2022
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2023
- 2023-12-08 US US18/533,755 patent/US12331030B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020500205A (ja) | 2020-01-09 |
| JP2020500204A (ja) | 2020-01-09 |
| WO2018095377A1 (zh) | 2018-05-31 |
| US12331030B2 (en) | 2025-06-17 |
| JP7143296B2 (ja) | 2022-09-28 |
| JP7143295B2 (ja) | 2022-09-28 |
| EP3546450A4 (en) | 2020-06-10 |
| CA3045703A1 (en) | 2018-05-31 |
| US20220372013A2 (en) | 2022-11-24 |
| AU2017366514B2 (en) | 2021-01-21 |
| US11873287B2 (en) | 2024-01-16 |
| US20190352277A1 (en) | 2019-11-21 |
| EP3546449A4 (en) | 2020-06-10 |
| US20220306600A1 (en) | 2022-09-29 |
| WO2018095378A1 (zh) | 2018-05-31 |
| US11485724B2 (en) | 2022-11-01 |
| CN108101887A (zh) | 2018-06-01 |
| EP3546450A1 (en) | 2019-10-02 |
| AU2017366514A1 (en) | 2019-06-13 |
| CN108101886A (zh) | 2018-06-01 |
| AU2017366515A1 (en) | 2019-06-13 |
| US20240132466A1 (en) | 2024-04-25 |
| CA3049161A1 (en) | 2018-05-31 |
| CA3049161C (en) | 2023-03-07 |
| AU2017366515B2 (en) | 2021-01-21 |
| EP3546449A1 (en) | 2019-10-02 |
| US20190389835A1 (en) | 2019-12-26 |
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