CA3044355A1 - Methods of enhancing immune response with everolimus, dactolisib or both - Google Patents

Methods of enhancing immune response with everolimus, dactolisib or both Download PDF

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Publication number
CA3044355A1
CA3044355A1 CA3044355A CA3044355A CA3044355A1 CA 3044355 A1 CA3044355 A1 CA 3044355A1 CA 3044355 A CA3044355 A CA 3044355A CA 3044355 A CA3044355 A CA 3044355A CA 3044355 A1 CA3044355 A1 CA 3044355A1
Authority
CA
Canada
Prior art keywords
pharmaceutically acceptable
acceptable salt
bez235
rad001
combination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3044355A
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English (en)
French (fr)
Inventor
Joan Mannick
Melody MORRIS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA3044355A1 publication Critical patent/CA3044355A1/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3044355A 2016-11-23 2017-11-22 Methods of enhancing immune response with everolimus, dactolisib or both Abandoned CA3044355A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662425766P 2016-11-23 2016-11-23
US62/425,766 2016-11-23
US201762476160P 2017-03-24 2017-03-24
US62/476,160 2017-03-24
US201762576511P 2017-10-24 2017-10-24
US62/576,511 2017-10-24
PCT/IB2017/001579 WO2018096402A1 (en) 2016-11-23 2017-11-22 Methods of enhancing immune response with everolimus, dactolisib or both

Publications (1)

Publication Number Publication Date
CA3044355A1 true CA3044355A1 (en) 2018-05-31

Family

ID=60957348

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3044355A Abandoned CA3044355A1 (en) 2016-11-23 2017-11-22 Methods of enhancing immune response with everolimus, dactolisib or both

Country Status (12)

Country Link
US (3) US10441584B2 (OSRAM)
EP (1) EP3544608A1 (OSRAM)
JP (1) JP2020500930A (OSRAM)
KR (1) KR20190089005A (OSRAM)
CN (1) CN110114070A (OSRAM)
AU (1) AU2017363970A1 (OSRAM)
BR (1) BR112019010470A2 (OSRAM)
CA (1) CA3044355A1 (OSRAM)
IL (1) IL266750A (OSRAM)
MX (1) MX2019006090A (OSRAM)
TW (1) TW201825090A (OSRAM)
WO (1) WO2018096402A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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AU2017363970A1 (en) 2016-11-23 2019-06-20 Novartis Ag Methods of enhancing immune response with everolimus, dactolisib or both
WO2019157516A1 (en) 2018-02-12 2019-08-15 resTORbio, Inc. Combination therapies
WO2020223154A1 (en) * 2019-05-01 2020-11-05 resTORbio, Inc. Methods of enhancing immune response

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Also Published As

Publication number Publication date
MX2019006090A (es) 2019-08-21
US20200054624A1 (en) 2020-02-20
IL266750A (en) 2019-07-31
US20200061051A1 (en) 2020-02-27
EP3544608A1 (en) 2019-10-02
US20180161319A1 (en) 2018-06-14
US10993940B2 (en) 2021-05-04
AU2017363970A1 (en) 2019-06-20
US11045463B2 (en) 2021-06-29
CN110114070A (zh) 2019-08-09
US10441584B2 (en) 2019-10-15
JP2020500930A (ja) 2020-01-16
TW201825090A (zh) 2018-07-16
BR112019010470A2 (pt) 2019-09-10
KR20190089005A (ko) 2019-07-29
WO2018096402A1 (en) 2018-05-31

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FZDE Discontinued

Effective date: 20230524