CA3042249A1 - Anti-pd1 and anti-ctla4 antibodies - Google Patents
Anti-pd1 and anti-ctla4 antibodies Download PDFInfo
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- CA3042249A1 CA3042249A1 CA3042249A CA3042249A CA3042249A1 CA 3042249 A1 CA3042249 A1 CA 3042249A1 CA 3042249 A CA3042249 A CA 3042249A CA 3042249 A CA3042249 A CA 3042249A CA 3042249 A1 CA3042249 A1 CA 3042249A1
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
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| EP3538137A2 (en) | 2016-11-08 | 2019-09-18 | Qilu Puget Sound Biotherapeutics Corporation | Anti-pd1 and anti-ctla4 antibodies |
| MX2021007860A (es) * | 2018-12-28 | 2021-10-26 | Transgene | Poxvirux deficiente en m2. |
| US20220235144A1 (en) * | 2019-03-04 | 2022-07-28 | Qilu Puget Sound Biotherapeutics Corporation | Anti-sirp-alpha antibodies |
| CN114650867A (zh) | 2019-08-30 | 2022-06-21 | 齐鲁普吉湾生物治疗公司 | 抗cd20抗体、抗cd37抗体及它们的混合物 |
| US12473349B2 (en) * | 2020-05-06 | 2025-11-18 | Korea University Research And Business Foundation | PD-1 variants having increased PD-L1 affinity |
| CN111875697B (zh) * | 2020-08-03 | 2021-10-01 | 杭州皓阳生物技术有限公司 | 一种包含肽标签的融合蛋白 |
| WO2022178319A1 (en) * | 2021-02-18 | 2022-08-25 | Qilu Puget Sound Biotherapeutics Corporation | Combinations of anti-pd1 and anti-ctla4 antibodies |
| WO2023160517A1 (zh) * | 2022-02-22 | 2023-08-31 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
| CN119255817A (zh) * | 2022-03-28 | 2025-01-03 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
| CN118946366A (zh) * | 2022-04-13 | 2024-11-12 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
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| WO1993016719A2 (en) | 1992-02-26 | 1993-09-02 | Allergan, Inc. | Use of platelet derived growth factor in ophthalmic wound healing |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| ES2706547T3 (es) * | 1998-12-23 | 2019-03-29 | Pfizer | Anticuerpos monoclonales humanos para CTLA-4 |
| EE05627B1 (et) * | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| WO2001014424A2 (en) * | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| EP1896582A4 (en) | 2005-05-09 | 2009-04-08 | Ono Pharmaceutical Co | HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS |
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| CA2647282A1 (en) * | 2006-04-05 | 2007-10-11 | Pfizer Products Inc. | Ctla4 antibody combination therapy |
| JP2009541275A (ja) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー／エス | 二重特異性抗体の生産 |
| WO2008156712A1 (en) * | 2007-06-18 | 2008-12-24 | N. V. Organon | Antibodies to human programmed death receptor pd-1 |
| PT2235064E (pt) | 2008-01-07 | 2016-03-01 | Amgen Inc | Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática |
| US8263073B2 (en) * | 2008-02-04 | 2012-09-11 | Medarex, Inc. | Anti-CTLA-4 antibodies with reduced blocking of binding of CTLA-4 to B7 and uses thereof |
| MX2010012579A (es) * | 2008-05-29 | 2010-12-20 | Squibb Bristol Myers Co | Metodos para predecir respuesta de pacientes a modulacion de la via co-estimuladora. |
| JO3246B1 (ar) | 2009-09-09 | 2018-03-08 | Regeneron Pharma | اجسام مضادة بشرية ذات ألفة تفاعل عالية مع مستقبل 2 المفعل بالبروتين البشري |
| EP2949671A1 (en) * | 2009-10-12 | 2015-12-02 | Pfizer Inc | Cancer treatment |
| JP5995851B2 (ja) | 2010-10-18 | 2016-09-21 | メディアファーマ エス． アール． エル．Ｍｅｄｉａｐｈａｒｍａ Ｓ． Ｒ． Ｌ． | ＥｒｂＢ３結合抗体 |
| EP2686348B1 (en) | 2011-03-17 | 2015-12-30 | Ramot at Tel-Aviv University Ltd. | Bi- and monospecific, asymmetric antibodies and methods of generating the same |
| CN202105787U (zh) | 2011-06-03 | 2012-01-11 | 杨自强 | 糠粞分离机 |
| TWI835048B (zh) | 2011-08-01 | 2024-03-11 | 美商建南德克公司 | 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法 |
| CN102851338A (zh) | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| UY35148A (es) | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| CA3085446C (en) | 2013-03-13 | 2022-08-09 | Ibentrus, Inc. | Protein in which electrostatic interaction is introduced within hydrophobic interaction site and preparation method thereof |
| HUE046249T2 (hu) * | 2013-12-12 | 2020-02-28 | Shanghai hengrui pharmaceutical co ltd | PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| MA44082A (fr) * | 2015-12-14 | 2018-10-24 | Macrogenics Inc | Molécules bispécifiques présentant une immunoréactivité par rapport à pd-1 et à ctla-4 et leurs procédés d'utilisation |
| EP3538137A2 (en) | 2016-11-08 | 2019-09-18 | Qilu Puget Sound Biotherapeutics Corporation | Anti-pd1 and anti-ctla4 antibodies |
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| JP7455897B2 (ja) | 2024-03-26 |
| CN118480125A (zh) | 2024-08-13 |
| US12037397B2 (en) | 2024-07-16 |
| CN110312523A (zh) | 2019-10-08 |
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