CA3040795A1 - Polymyxin-alginate oligomer conjugates - Google Patents
Polymyxin-alginate oligomer conjugates Download PDFInfo
- Publication number
- CA3040795A1 CA3040795A1 CA3040795A CA3040795A CA3040795A1 CA 3040795 A1 CA3040795 A1 CA 3040795A1 CA 3040795 A CA3040795 A CA 3040795A CA 3040795 A CA3040795 A CA 3040795A CA 3040795 A1 CA3040795 A1 CA 3040795A1
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- CA
- Canada
- Prior art keywords
- polymyxin
- alginate oligomer
- alginate
- conjugate
- colistin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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| GB1617860.0 | 2016-10-21 | ||
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| GBGB1714710.9A GB201714710D0 (en) | 2017-09-13 | 2017-09-13 | Polymyxin-alginate oligomer conjugates |
| GB1714710.9 | 2017-09-13 | ||
| PCT/EP2017/076927 WO2018073449A1 (en) | 2016-10-21 | 2017-10-20 | Polymyxin-alginate oligomer conjugates |
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| CN115003311B (zh) * | 2019-12-14 | 2024-04-19 | 乔杜里·马努 | 降低多器官毒性的多元药物制剂 |
| US20230141981A1 (en) * | 2020-01-21 | 2023-05-11 | Shanghai Micurx Pharmaceuticals Co., Ltd | Novel compounds and composition for targeted therapy of kidney-associated cancers |
| US12037631B2 (en) * | 2020-10-06 | 2024-07-16 | City University Of Hong Kong | System and method for detecting a target enzyme |
| CN113081956A (zh) * | 2021-04-12 | 2021-07-09 | 青岛大学附属医院 | 一种氧化海藻酸钠改性的那他霉素滴眼液及其制备方法 |
| CN113069556B (zh) * | 2021-04-12 | 2022-04-08 | 青岛大学附属医院 | 一种枝接那他霉素的氧化海藻酸纤维膜及其制备方法 |
| US20240376155A1 (en) * | 2021-07-21 | 2024-11-14 | Shanghai Micurx Pharmaceutical Co., Ltd. | Novel compounds and compositions for targeted therapy of renal cancers |
| EP4373836A4 (en) * | 2021-07-21 | 2025-10-22 | Shanghai Micurx Pharmaceutical Co Ltd | COMPOUNDS AND COMPOSITIONS FOR TARGETED THERAPY OF KIDNEY DISEASES |
| CN114009731B (zh) * | 2021-11-05 | 2024-01-02 | 恒枫食品科技有限公司 | 一种茶风味基料及其制备方法、应用 |
| CN114752535A (zh) * | 2022-05-16 | 2022-07-15 | 北京昊峰节能环保科技有限公司 | 一种总石油烃污染地下水生物修复剂及其制备方法与应用 |
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| GB976301A (en) * | 1960-10-27 | 1964-11-25 | Calmic Ltd | Preparation and use of alginates |
| US5177059A (en) * | 1989-11-15 | 1993-01-05 | Sandoz Ltd. | Polymyxin B conjugates |
| IL96326A (en) * | 1989-11-15 | 1995-07-31 | Sandoz Ag | Polymyxin conjugates, their preparation and pharmaceutical preparations containing them |
| GB2270920B (en) * | 1992-09-25 | 1997-04-02 | Univ Keele | Alginate-bioactive agent conjugates |
| US6011008A (en) * | 1997-01-08 | 2000-01-04 | Yissum Research Developement Company Of The Hebrew University Of Jerusalem | Conjugates of biologically active substances |
| PT2268142T (pt) * | 2007-11-27 | 2017-06-02 | Algipharma As | Utilização de oligómeros alginados no combate aos biofilmes |
| RU2586253C2 (ru) * | 2009-06-03 | 2016-06-10 | АльгиФарма АС | Обработка акинетобактерий альгинатными олигомерами и антибиотиками |
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- 2017-10-20 DK DK17791037.9T patent/DK3528830T3/da active
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| RU2019109719A (ru) | 2020-11-24 |
| WO2018073449A1 (en) | 2018-04-26 |
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| EP3528830B1 (en) | 2022-10-05 |
| EP3528830A1 (en) | 2019-08-28 |
| RU2019109719A3 (enExample) | 2021-02-20 |
| US20190328833A1 (en) | 2019-10-31 |
| BR112019007927A2 (pt) | 2019-07-02 |
| CN109843315A (zh) | 2019-06-04 |
| DK3528830T3 (da) | 2022-12-19 |
| JP2020503253A (ja) | 2020-01-30 |
| AU2017345295A1 (en) | 2019-05-02 |
| ES2933983T3 (es) | 2023-02-15 |
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