CA3040584A1 - Crystalline hydrate of the compound (2s,3r)-isopropyl 2-(((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2h-pyran-4-yl)methyl)-1h-benzo[d]imidazol-5-yl)methyl)amino)-3-hydroxybutanoate edisylate - Google Patents
Crystalline hydrate of the compound (2s,3r)-isopropyl 2-(((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2h-pyran-4-yl)methyl)-1h-benzo[d]imidazol-5-yl)methyl)amino)-3-hydroxybutanoate edisylate Download PDFInfo
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- CA3040584A1 CA3040584A1 CA3040584A CA3040584A CA3040584A1 CA 3040584 A1 CA3040584 A1 CA 3040584A1 CA 3040584 A CA3040584 A CA 3040584A CA 3040584 A CA3040584 A CA 3040584A CA 3040584 A1 CA3040584 A1 CA 3040584A1
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- crystalline hydrate
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1614939.5A GB201614939D0 (en) | 2016-09-02 | 2016-09-02 | Crystalline hydrate |
| GB1614939.5 | 2016-09-02 | ||
| PCT/EP2017/071867 WO2018041946A1 (en) | 2016-09-02 | 2017-08-31 | Crystalline hydrate of the compound (2s,3r)-isopropyl 2-(((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2h-pyran-4-yl)methyl)-1h-benzo[d]imidazol-5-yl)methyl)amino)-3-hydroxybutanoate edisylate |
Publications (1)
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|---|---|
| CA3040584A1 true CA3040584A1 (en) | 2018-03-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3040584A Pending CA3040584A1 (en) | 2016-09-02 | 2017-08-31 | Crystalline hydrate of the compound (2s,3r)-isopropyl 2-(((2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1-((tetrahydro-2h-pyran-4-yl)methyl)-1h-benzo[d]imidazol-5-yl)methyl)amino)-3-hydroxybutanoate edisylate |
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|---|---|
| US (1) | US10676466B2 (zh) |
| EP (1) | EP3507286A1 (zh) |
| JP (1) | JP6983873B2 (zh) |
| KR (1) | KR20190044655A (zh) |
| CN (1) | CN110012667B (zh) |
| AU (1) | AU2017317723A1 (zh) |
| BR (1) | BR112019004168A2 (zh) |
| CA (1) | CA3040584A1 (zh) |
| GB (1) | GB201614939D0 (zh) |
| RU (1) | RU2019105794A (zh) |
| WO (1) | WO2018041946A1 (zh) |
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| GB201504689D0 (en) * | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| PT3833964T (pt) * | 2018-08-07 | 2023-08-17 | Norton Waterford Ltd | Aplicação de espetroscopia de raman para o fabrico de pós de inalação |
| CN111658654A (zh) * | 2020-07-16 | 2020-09-15 | 中国农业科学院兰州兽医研究所 | 化合物jq-1用于预防或治疗非洲猪瘟的新用途 |
| CN111686107B (zh) * | 2020-07-16 | 2021-06-08 | 中国农业科学院兰州兽医研究所 | 化合物plx51107用于制备预防或治疗非洲猪瘟药物的新用途 |
| CN111686114B (zh) * | 2020-07-16 | 2021-06-08 | 中国农业科学院兰州兽医研究所 | 化合物i-bet-762用于制备预防或治疗非洲猪瘟药物的新用途 |
| CN111588721B (zh) * | 2020-07-16 | 2021-06-08 | 中国农业科学院兰州兽医研究所 | 化合物zl0580用于制备预防或治疗非洲猪瘟药物的新用途 |
| CN111588725B (zh) * | 2020-07-16 | 2021-06-08 | 中国农业科学院兰州兽医研究所 | 化合物arv-825用于制备预防或治疗非洲猪瘟药物的新用途 |
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| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
| GB0515584D0 (en) | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
| AR058289A1 (es) | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | Colector para ser usado en dispensador de medicamento |
| EP2493310A4 (en) * | 2009-10-27 | 2014-03-12 | Glaxosmithkline Llc | BENZIMIDAZOLES AS INHIBITORS OF ACID GRAS SYNTHASE |
| GB0919434D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| TWI527811B (zh) * | 2013-05-09 | 2016-04-01 | 吉李德科學股份有限公司 | 作爲溴結構域抑制劑的苯並咪唑衍生物 |
| US20150051208A1 (en) * | 2013-08-14 | 2015-02-19 | Boehringer Ingelheim International Gmbh | Pyridinones |
| US9428515B2 (en) * | 2014-05-09 | 2016-08-30 | Boehringer Ingelheim International Gmbh | Benzimidazole derivatives |
| GB201504689D0 (en) * | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
-
2016
- 2016-09-02 GB GBGB1614939.5A patent/GB201614939D0/en not_active Ceased
-
2017
- 2017-08-31 AU AU2017317723A patent/AU2017317723A1/en not_active Abandoned
- 2017-08-31 US US16/326,970 patent/US10676466B2/en active Active
- 2017-08-31 WO PCT/EP2017/071867 patent/WO2018041946A1/en unknown
- 2017-08-31 KR KR1020197009050A patent/KR20190044655A/ko unknown
- 2017-08-31 CN CN201780065438.XA patent/CN110012667B/zh active Active
- 2017-08-31 EP EP17758877.9A patent/EP3507286A1/en active Pending
- 2017-08-31 CA CA3040584A patent/CA3040584A1/en active Pending
- 2017-08-31 RU RU2019105794A patent/RU2019105794A/ru not_active Application Discontinuation
- 2017-08-31 JP JP2019511884A patent/JP6983873B2/ja active Active
- 2017-08-31 BR BR112019004168A patent/BR112019004168A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN110012667B (zh) | 2022-12-13 |
| US10676466B2 (en) | 2020-06-09 |
| CN110012667A (zh) | 2019-07-12 |
| BR112019004168A2 (pt) | 2019-05-28 |
| KR20190044655A (ko) | 2019-04-30 |
| WO2018041946A1 (en) | 2018-03-08 |
| JP6983873B2 (ja) | 2021-12-17 |
| US20190177307A1 (en) | 2019-06-13 |
| JP2019526574A (ja) | 2019-09-19 |
| GB201614939D0 (en) | 2016-10-19 |
| EP3507286A1 (en) | 2019-07-10 |
| RU2019105794A (ru) | 2020-10-02 |
| AU2017317723A1 (en) | 2019-03-21 |
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