CA3024747A1 - Methods for subtyping of lung adenocarcinoma - Google Patents

Methods for subtyping of lung adenocarcinoma Download PDF

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Publication number
CA3024747A1
CA3024747A1 CA3024747A CA3024747A CA3024747A1 CA 3024747 A1 CA3024747 A1 CA 3024747A1 CA 3024747 A CA3024747 A CA 3024747A CA 3024747 A CA3024747 A CA 3024747A CA 3024747 A1 CA3024747 A1 CA 3024747A1
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Canada
Prior art keywords
sample
biomarker
expression
nucleic acids
classifier
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Pending
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CA3024747A
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English (en)
French (fr)
Inventor
Hawazin FARUKI
Myla LAI-GOLDMAN
Greg MAYHEW
Jonathan Serody
Charles Perou
David Neil Hayes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Genecentric Therapeutics Inc
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University of North Carolina at Chapel Hill
Genecentric Therapeutics Inc
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Application filed by University of North Carolina at Chapel Hill, Genecentric Therapeutics Inc filed Critical University of North Carolina at Chapel Hill
Publication of CA3024747A1 publication Critical patent/CA3024747A1/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3024747A 2016-05-17 2017-05-17 Methods for subtyping of lung adenocarcinoma Pending CA3024747A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201662337591P 2016-05-17 2016-05-17
US201662337645P 2016-05-17 2016-05-17
US62/337,645 2016-05-17
US62/337,591 2016-05-17
US201662396587P 2016-09-19 2016-09-19
US62/396,587 2016-09-19
US201662420836P 2016-11-11 2016-11-11
US62/420,836 2016-11-11
US201662425717P 2016-11-23 2016-11-23
US62/425,717 2016-11-23
PCT/US2017/033110 WO2017201165A1 (en) 2016-05-17 2017-05-17 Methods for subtyping of lung adenocarcinoma

Publications (1)

Publication Number Publication Date
CA3024747A1 true CA3024747A1 (en) 2017-11-23

Family

ID=60326094

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3024747A Pending CA3024747A1 (en) 2016-05-17 2017-05-17 Methods for subtyping of lung adenocarcinoma

Country Status (6)

Country Link
US (2) US10934595B2 (enExample)
EP (1) EP3458612B1 (enExample)
JP (1) JP7241353B2 (enExample)
CN (2) CN116987790A (enExample)
CA (1) CA3024747A1 (enExample)
WO (1) WO2017201165A1 (enExample)

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CA3024744A1 (en) 2016-05-17 2017-11-23 Genecentric Therapeutics, Inc. Methods for subtyping of lung squamous cell carcinoma
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US20240182984A1 (en) * 2021-03-30 2024-06-06 Genecentric Therapeutics, Inc. Methods for assessing proliferation and anti-folate therapeutic response
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CN113981093B (zh) * 2021-11-26 2023-06-16 大连医科大学附属第一医院 Inpp4b基因表达量的检测剂在制备用于预测肺腺癌放疗敏感性的试剂盒的应用
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CN114574589B (zh) * 2022-04-28 2022-08-16 深圳市第二人民医院(深圳市转化医学研究院) 标志物znf207在制备肺腺癌诊断试剂中的应用及诊断试剂盒
US20250327132A1 (en) * 2022-06-13 2025-10-23 The Government of the United States, as represented by the Director of the Defense Health Agency Lung Cancer-Related Biomarkers and Methods of Using the Same
CN115896282A (zh) * 2022-08-02 2023-04-04 上海市同仁医院 一种对甲状腺微小乳头状癌进行分子分型的方法以及分子标志物应用
CN115862876B (zh) * 2023-03-02 2023-05-26 北京师范大学 基于免疫微环境基因群预测肺腺癌患者预后的装置
CN116403648B (zh) * 2023-06-06 2023-08-01 中国医学科学院肿瘤医院 一种基于多维分析建立的小细胞肺癌免疫新分型方法
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CN117635612A (zh) * 2024-01-25 2024-03-01 天津博思特医疗科技有限责任公司 一种肺部ct图像的识别方法
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Also Published As

Publication number Publication date
CN109790583B (zh) 2023-08-25
US20190338365A1 (en) 2019-11-07
EP3458612B1 (en) 2023-11-15
US20210222254A1 (en) 2021-07-22
EP3458612A1 (en) 2019-03-27
JP2019516407A (ja) 2019-06-20
CN116987790A (zh) 2023-11-03
US10934595B2 (en) 2021-03-02
CN109790583A (zh) 2019-05-21
JP7241353B2 (ja) 2023-03-17
WO2017201165A1 (en) 2017-11-23
US12139763B2 (en) 2024-11-12
EP3458612A4 (en) 2020-02-26

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