CA3024114C - Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods - Google Patents
Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods Download PDFInfo
- Publication number
- CA3024114C CA3024114C CA3024114A CA3024114A CA3024114C CA 3024114 C CA3024114 C CA 3024114C CA 3024114 A CA3024114 A CA 3024114A CA 3024114 A CA3024114 A CA 3024114A CA 3024114 C CA3024114 C CA 3024114C
- Authority
- CA
- Canada
- Prior art keywords
- clostridium
- strain
- naturally occurring
- bacterium
- autoethanogenum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/065—Ethanol, i.e. non-beverage with microorganisms other than yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/16—Butanols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0101—Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/07—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with an iron-sulfur protein as acceptor (1.2.7)
- C12Y102/07005—Aldehyde ferredoxin oxidoreductase (1.2.7.5)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Oil, Petroleum & Natural Gas (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662336639P | 2016-05-14 | 2016-05-14 | |
| US62/336,639 | 2016-05-14 | ||
| PCT/US2017/032564 WO2017200884A1 (en) | 2016-05-14 | 2017-05-12 | Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3024114A1 CA3024114A1 (en) | 2017-11-23 |
| CA3024114C true CA3024114C (en) | 2020-02-04 |
Family
ID=60295016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3024114A Active CA3024114C (en) | 2016-05-14 | 2017-05-12 | Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10294498B2 (https=) |
| EP (1) | EP3464559A4 (https=) |
| JP (2) | JP7502029B2 (https=) |
| KR (2) | KR102514023B1 (https=) |
| CN (1) | CN109477063A (https=) |
| CA (1) | CA3024114C (https=) |
| EA (1) | EA201892627A1 (https=) |
| SG (1) | SG11201810031RA (https=) |
| WO (1) | WO2017200884A1 (https=) |
| ZA (1) | ZA201807617B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017200884A1 (en) * | 2016-05-14 | 2017-11-23 | Lanzatech, Inc. | Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods |
| KR102073308B1 (ko) * | 2017-08-29 | 2020-02-05 | 광주과학기술원 | 에탄올 비생산성 아세토젠 균주를 에탄올 생성균주로 전환하는 방법 및 상기 에탄올 생성균주로부터 일산화탄소를 이용한 에탄올의 제조방법 |
| CN109929862B (zh) * | 2019-03-14 | 2022-09-16 | 云南农业大学 | 一种从反刍动物瘤胃宏转录组数据筛选纤维素酶基因进行克隆的方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593886A (en) | 1992-10-30 | 1997-01-14 | Gaddy; James L. | Clostridium stain which produces acetic acid from waste gases |
| UA72220C2 (uk) | 1998-09-08 | 2005-02-15 | Байоенджініерінг Рісорсиз, Інк. | Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання |
| NZ546496A (en) | 2006-04-07 | 2008-09-26 | Lanzatech New Zealand Ltd | Gas treatment process |
| US7704723B2 (en) | 2006-08-31 | 2010-04-27 | The Board Of Regents For Oklahoma State University | Isolation and characterization of novel clostridial species |
| NZ553984A (en) | 2007-03-19 | 2009-07-31 | Lanzatech New Zealand Ltd | Alcohol production process |
| JP5600296B2 (ja) | 2007-11-13 | 2014-10-01 | ランザテク・ニュージーランド・リミテッド | 新規細菌及びその使用法 |
| CN102317463B (zh) | 2008-06-09 | 2014-12-03 | 蓝瑟科技纽西兰有限公司 | 厌氧微生物发酵生产丁二醇 |
| US8039239B2 (en) * | 2008-12-16 | 2011-10-18 | Coskata, Inc. | Recombinant microorganisms having modified production of alcohols and acids |
| WO2011112103A1 (en) | 2010-03-10 | 2011-09-15 | Lanzatech New Zealand Limited | Acid production by fermentation |
| US20110262954A1 (en) * | 2010-03-18 | 2011-10-27 | Universitat Regensburg | Shuttle vector based transformation system for pyrococcus furiosus |
| US20120045807A1 (en) | 2010-08-19 | 2012-02-23 | Lanzatech New Zealand Limited | Process for producing chemicals using microbial fermentation of substrates comprising carbon monoxide |
| WO2012026833A1 (en) | 2010-08-26 | 2012-03-01 | Lanzatech New Zealand Limited | Process for producing ethanol and ethylene via fermentation |
| US20110236941A1 (en) | 2010-10-22 | 2011-09-29 | Lanzatech New Zealand Limited | Recombinant microorganism and methods of production thereof |
| BR112013021524A2 (pt) | 2011-02-25 | 2017-06-13 | Lanzatech New Zealand Ltd | micro-organismos recombinantes e usos dos mesmos |
| CN103582703A (zh) * | 2011-03-31 | 2014-02-12 | 新西兰郎泽科技公司 | 一种用于控制丁二醇生产的发酵方法 |
| EP2753700B1 (en) | 2011-09-08 | 2020-02-19 | Lanzatech New Zealand Limited | A fermentation process |
| IN2014DN10168A (https=) | 2012-05-30 | 2015-08-21 | Lanzatech New Zealand Ltd | |
| US20130323820A1 (en) | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| CN113186144A (zh) | 2012-06-08 | 2021-07-30 | 朗泽科技新西兰有限公司 | 重组微生物和其用途 |
| US9347076B2 (en) | 2012-06-21 | 2016-05-24 | Lanzatech New Zealand Limited | Recombinant microorganisms that make biodiesel |
| IN2015DN01365A (https=) | 2012-08-28 | 2015-07-03 | Lanzatech New Zealand Ltd | |
| MY194094A (en) * | 2013-03-15 | 2022-11-11 | Lanzatech New Zealand Ltd | A System and Method for Controlling Metabolite Production in a Microbial Fermentation |
| BR112015030208A2 (pt) * | 2013-06-05 | 2017-08-22 | Lanzatech New Zealand Ltd | Métodos para produzir um produto de fermentação e um micro-organismo, e, micro-organismo recombinante |
| US20150275238A1 (en) * | 2014-03-28 | 2015-10-01 | University Of Georgia Research Foundation, Inc. | Genetically engineered microbes and methods for converting organic acids to alcohols |
| FI3209786T3 (fi) | 2014-10-22 | 2023-06-13 | Lanzatech Nz Inc | Monivaiheisia bioreaktoriprosesseja |
| US10174303B2 (en) | 2015-05-27 | 2019-01-08 | Lanzatech New Zealand Limited | Genetically engineered microorganisms for the production of chorismate-derived products |
| CA3151149C (en) | 2015-10-13 | 2024-03-26 | Lanzatech Nz, Inc. | Genetically engineered bacterium comprising energy-generating fermentation pathway |
| WO2017200884A1 (en) * | 2016-05-14 | 2017-11-23 | Lanzatech, Inc. | Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods |
-
2017
- 2017-05-12 WO PCT/US2017/032564 patent/WO2017200884A1/en not_active Ceased
- 2017-05-12 KR KR1020187035923A patent/KR102514023B1/ko active Active
- 2017-05-12 CN CN201780029930.1A patent/CN109477063A/zh active Pending
- 2017-05-12 EA EA201892627A patent/EA201892627A1/ru unknown
- 2017-05-12 US US15/594,252 patent/US10294498B2/en active Active
- 2017-05-12 KR KR1020237009707A patent/KR20230044031A/ko not_active Ceased
- 2017-05-12 JP JP2019512182A patent/JP7502029B2/ja active Active
- 2017-05-12 CA CA3024114A patent/CA3024114C/en active Active
- 2017-05-12 EP EP17799922.4A patent/EP3464559A4/en active Pending
- 2017-05-12 SG SG11201810031RA patent/SG11201810031RA/en unknown
-
2018
- 2018-11-13 ZA ZA2018/07617A patent/ZA201807617B/en unknown
-
2022
- 2022-07-19 JP JP2022115092A patent/JP2022163046A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7502029B2 (ja) | 2024-06-18 |
| JP2022163046A (ja) | 2022-10-25 |
| KR20230044031A (ko) | 2023-03-31 |
| JP2019514441A (ja) | 2019-06-06 |
| WO2017200884A1 (en) | 2017-11-23 |
| CA3024114A1 (en) | 2017-11-23 |
| EP3464559A1 (en) | 2019-04-10 |
| US20170327849A1 (en) | 2017-11-16 |
| US10294498B2 (en) | 2019-05-21 |
| SG11201810031RA (en) | 2018-12-28 |
| KR102514023B1 (ko) | 2023-03-23 |
| KR20190017790A (ko) | 2019-02-20 |
| CN109477063A (zh) | 2019-03-15 |
| EA201892627A1 (ru) | 2019-04-30 |
| ZA201807617B (en) | 2021-04-28 |
| EP3464559A4 (en) | 2020-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Liew et al. | Metabolic engineering of Clostridium autoethanogenum for selective alcohol production | |
| US9834795B2 (en) | Recombinant microorganisms and uses therefor | |
| AU2012221176B2 (en) | Recombinant microorganisms and uses therefor | |
| AU2017222688B2 (en) | CRISPR/Cas systems for C-1 fixing bacteria | |
| US9365868B2 (en) | Fermentation process for producing isopropanol using a recombinant microorganism | |
| US20130224839A1 (en) | Recombinant Microorganism and Methods of Production Thereof | |
| JP2022163046A (ja) | 修飾されたアルデヒド：フェレドキシンオキシドレダクターゼ活性を有する微生物および関連方法 | |
| AU2021284451B2 (en) | Microorganism with knock-in at acetolactate decarboxylase gene locus | |
| CA2956204C (en) | Genetically engineered bacterium with altered carbon monoxide dehydrogenase (codh) activity | |
| EA041749B1 (ru) | Микроорганизм с модифицированной активностью альдегид:ферредоксин оксидоредуктазы и связанные способы | |
| NZ614459B2 (en) | Recombinant microorganisms and uses therefor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20181113 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 8TH ANNIV.) - STANDARD Year of fee payment: 8 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250429 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250429 |