CA3022203A1 - Pharmaceutical combination composition comprising complex formulations of ivacaftor and lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them - Google Patents
Pharmaceutical combination composition comprising complex formulations of ivacaftor and lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them Download PDFInfo
- Publication number
- CA3022203A1 CA3022203A1 CA3022203A CA3022203A CA3022203A1 CA 3022203 A1 CA3022203 A1 CA 3022203A1 CA 3022203 A CA3022203 A CA 3022203A CA 3022203 A CA3022203 A CA 3022203A CA 3022203 A1 CA3022203 A1 CA 3022203A1
- Authority
- CA
- Canada
- Prior art keywords
- complex
- ivacaftor
- lumacaftor
- pharmaceutical combination
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000000203 mixture Substances 0.000 title claims abstract description 361
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 73
- 238000000034 method Methods 0.000 title claims abstract description 66
- 229940052950 ivacaftor and lumacaftor Drugs 0.000 title claims abstract description 33
- 150000003839 salts Chemical class 0.000 title claims abstract description 13
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- 229960004508 ivacaftor Drugs 0.000 claims description 223
- UFSKUSARDNFIRC-UHFFFAOYSA-N lumacaftor Chemical compound N1=C(C=2C=C(C=CC=2)C(O)=O)C(C)=CC=C1NC(=O)C1(C=2C=C3OC(F)(F)OC3=CC=2)CC1 UFSKUSARDNFIRC-UHFFFAOYSA-N 0.000 claims description 200
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 49
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1600271A HUP1600271A2 (hu) | 2016-04-25 | 2016-04-25 | Ivacaftor és Lumacaftor sóinak és származékainak komplexei, eljárás azok elõállítására és azok gyógyszerészetileg elfogadható készítményei |
HUP1600271 | 2016-04-25 | ||
PCT/IB2017/052374 WO2017187340A1 (en) | 2016-04-25 | 2017-04-25 | Pharmaceutical combination composition comprising complex formulations of ivacaftor and lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3022203A1 true CA3022203A1 (en) | 2017-11-02 |
Family
ID=89992149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3022203A Abandoned CA3022203A1 (en) | 2016-04-25 | 2017-04-25 | Pharmaceutical combination composition comprising complex formulations of ivacaftor and lumacaftor and their salts and derivatives, process for their preparation thereof and pharmaceutical compositions containing them |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP3448384A1 (ja) |
JP (1) | JP2019514898A (ja) |
CN (1) | CN109475546A (ja) |
AU (1) | AU2017256184A1 (ja) |
CA (1) | CA3022203A1 (ja) |
HU (1) | HUP1600271A2 (ja) |
IL (1) | IL262494A (ja) |
WO (1) | WO2017187340A1 (ja) |
Families Citing this family (2)
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US10898484B2 (en) * | 2018-05-31 | 2021-01-26 | Celltaxis, Llc | Method of reducing pulmonary exacerbations in respiratory disease patients |
WO2023044365A1 (en) * | 2021-09-17 | 2023-03-23 | Doublerainbow Biosciences Inc. | Use of cyclodextrin to enhance solubility of substrates and increase enzymatic glycosylation reaction efficiency |
Family Cites Families (29)
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PL1773816T3 (pl) | 2004-06-24 | 2015-06-30 | Vertex Pharma | Modulatory transporterów posiadających kasetę wiążącą ATP |
US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
EP3208272B1 (en) | 2005-11-08 | 2020-01-08 | Vertex Pharmaceuticals Incorporated | Heterocyclic modulators of atp-binding cassette transporters |
HUE049976T2 (hu) | 2005-12-28 | 2020-11-30 | Vertex Pharma | N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói |
RS55559B1 (sr) | 2007-12-07 | 2017-05-31 | Vertex Pharma | Čvrste forme 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il) benzoeve kiseline |
AU2008335439A1 (en) | 2007-12-07 | 2009-06-18 | Vertex Pharmaceuticals Incorporated | Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
MX2011003249A (es) | 2008-09-29 | 2011-05-19 | Vertex Pharma | Unidades de dosificacion del acido 3-(6-(1-(2,2-difluorobenzo[d][1 ,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoi co. |
CN109081804B (zh) | 2010-03-25 | 2021-12-10 | 弗特克斯药品有限公司 | 环丙烷甲酰胺的固体形式 |
NZ602838A (en) | 2010-04-07 | 2015-06-26 | Vertex Pharma | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof |
CN102933206A (zh) | 2010-04-07 | 2013-02-13 | 弗特克斯药品有限公司 | 3-(6-(1-(2,2-二氟苯并[d][1,3]二氧杂环戊烯-5-基)环丙烷甲酰胺基)-3-甲基吡啶-2-基)苯甲酸的固体形式 |
NZ607494A (en) | 2010-08-27 | 2015-04-24 | Vertex Pharma | Pharmaceutical composition and administrations thereof |
UA114619C2 (uk) | 2012-01-25 | 2017-07-10 | Вертекс Фармасьютікалз Інкорпорейтед | СКЛАД 3-(6-(1-(2,2-ДИФТОРОБЕНЗО[d][1,3]ДІОКСОЛ-5-ІЛ)ЦИКЛОПРОПАНКАРБОКСАМІДО)-3-МЕТИЛПІРИДИН-2-ІЛ)БЕНЗОЙНОЇ КИСЛОТИ |
BR112014021090B1 (pt) | 2012-02-27 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma |
AU2013290444B2 (en) | 2012-07-16 | 2018-04-26 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof |
NZ745659A (en) * | 2012-11-02 | 2020-04-24 | Vertex Pharma | Pharmaceutical compositions for the treatment of cftr mediated diseases |
JP6146990B2 (ja) | 2012-11-16 | 2017-06-14 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたcftr増強物質 |
US20140221424A1 (en) | 2013-01-30 | 2014-08-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for use in the treatment of cystic fibrosis |
US9550735B2 (en) | 2013-01-31 | 2017-01-24 | Glenmark Pharmaceuticals Limited | Process for the preparation of ivacaftor and solvates thereof |
WO2014125506A2 (en) | 2013-02-15 | 2014-08-21 | Laurus Labs Private Limited | A process for the preparation of ivacaftor and its intermediates |
CN104030981A (zh) | 2013-03-06 | 2014-09-10 | 上海特化医药科技有限公司 | Ivacaftor的制备方法及其中间体 |
HUP1300647A2 (hu) * | 2013-11-12 | 2015-05-28 | Druggability Technologies Ip Holdco Jersey Ltd | Ciklosporin A és származékainak komplexei, elõállításuk és gyógyszerészeti kompozícióik |
JP6963896B2 (ja) | 2013-11-12 | 2021-11-10 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Cftr媒介性疾患の処置のための医薬組成物を調製する方法 |
WO2015071841A1 (en) * | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
HUP1300646A2 (en) * | 2013-11-12 | 2015-05-28 | Druggability Technologies Ip Holdco Jersey Ltd | Complexes of fulvestrant and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
CA2927661A1 (en) | 2013-11-13 | 2015-05-21 | Apotex Inc. | Solid forms of ivacaftor and processes for the preparation thereof |
HUP1400075A2 (hu) * | 2014-02-14 | 2015-08-28 | Druggability Technologies Ip Holdco Jersey Ltd | Sirolimus és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói |
PT3925607T (pt) | 2014-04-15 | 2023-09-26 | Vertex Pharma | Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística |
EP3142748B1 (en) | 2014-05-15 | 2019-09-11 | Celgene Corporation | Use of pde4 inhibitors and combinations thereof for the treatment of cystic fibrosis |
CN104725314A (zh) | 2015-03-23 | 2015-06-24 | 上海皓元化学科技有限公司 | 一种Ivacaftor的新晶型及其制备方法 |
-
2016
- 2016-04-25 HU HU1600271A patent/HUP1600271A2/hu unknown
-
2017
- 2017-04-25 WO PCT/IB2017/052374 patent/WO2017187340A1/en active Application Filing
- 2017-04-25 JP JP2018555738A patent/JP2019514898A/ja not_active Withdrawn
- 2017-04-25 CA CA3022203A patent/CA3022203A1/en not_active Abandoned
- 2017-04-25 CN CN201780039649.6A patent/CN109475546A/zh active Pending
- 2017-04-25 EP EP17726698.8A patent/EP3448384A1/en not_active Withdrawn
- 2017-04-25 AU AU2017256184A patent/AU2017256184A1/en not_active Abandoned
-
2018
- 2018-10-21 IL IL262494A patent/IL262494A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2017187340A1 (en) | 2017-11-02 |
JP2019514898A (ja) | 2019-06-06 |
CN109475546A (zh) | 2019-03-15 |
WO2017187340A4 (en) | 2017-12-28 |
IL262494A (en) | 2018-12-31 |
EP3448384A1 (en) | 2019-03-06 |
AU2017256184A1 (en) | 2018-12-13 |
HUP1600271A2 (hu) | 2017-10-30 |
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