CA3021833A1 - Pathway recognition algorithm using data integration on genomic models (paradigm) - Google Patents

Pathway recognition algorithm using data integration on genomic models (paradigm) Download PDF

Info

Publication number
CA3021833A1
CA3021833A1 CA3021833A CA3021833A CA3021833A1 CA 3021833 A1 CA3021833 A1 CA 3021833A1 CA 3021833 A CA3021833 A CA 3021833A CA 3021833 A CA3021833 A CA 3021833A CA 3021833 A1 CA3021833 A1 CA 3021833A1
Authority
CA
Canada
Prior art keywords
pathway
network
gene
pathways
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA3021833A
Other languages
English (en)
French (fr)
Inventor
Charles J. Vaske
Stephen C. Benz
Joshua M. Stuart
David Haussler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of CA3021833A1 publication Critical patent/CA3021833A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F16/00—Information retrieval; Database structures therefor; File system structures therefor
    • G06F16/20—Information retrieval; Database structures therefor; File system structures therefor of structured data, e.g. relational data
    • G06F16/22—Indexing; Data structures therefor; Storage structures
    • G06F16/2219—Large Object storage; Management thereof
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/30—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/60—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Data Mining & Analysis (AREA)
  • Public Health (AREA)
  • Databases & Information Systems (AREA)
  • Probability & Statistics with Applications (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Software Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA3021833A 2011-10-26 2011-10-31 Pathway recognition algorithm using data integration on genomic models (paradigm) Abandoned CA3021833A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/317,769 US10192641B2 (en) 2010-04-29 2011-10-26 Method of generating a dynamic pathway map
US13/317,769 2011-10-26
CA2853702A CA2853702A1 (en) 2011-10-26 2011-10-31 Pathway recognition algorithm using data integration on genomic models (paradigm)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2853702A Division CA2853702A1 (en) 2011-10-26 2011-10-31 Pathway recognition algorithm using data integration on genomic models (paradigm)

Publications (1)

Publication Number Publication Date
CA3021833A1 true CA3021833A1 (en) 2013-05-02

Family

ID=48168183

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3021833A Abandoned CA3021833A1 (en) 2011-10-26 2011-10-31 Pathway recognition algorithm using data integration on genomic models (paradigm)
CA2853702A Abandoned CA2853702A1 (en) 2011-10-26 2011-10-31 Pathway recognition algorithm using data integration on genomic models (paradigm)

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2853702A Abandoned CA2853702A1 (en) 2011-10-26 2011-10-31 Pathway recognition algorithm using data integration on genomic models (paradigm)

Country Status (9)

Country Link
US (2) US10192641B2 (ko)
EP (1) EP2771830A4 (ko)
JP (4) JP6061941B2 (ko)
KR (2) KR101554530B1 (ko)
CN (2) CN108664762A (ko)
AU (1) AU2011380013B2 (ko)
CA (2) CA3021833A1 (ko)
IL (2) IL232243A (ko)
WO (1) WO2013062505A1 (ko)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3699915A1 (en) 2010-04-29 2020-08-26 The Regents of The University of California Pathway recognition algorithm using data integration on genomic models (paradigm)
DE102011079034A1 (de) 2011-07-12 2013-01-17 Siemens Aktiengesellschaft Ansteuerung eines technischen Systems
EP2870581B1 (en) 2012-07-06 2023-11-29 Nant Holdings IP, LLC Healthcare analysis stream management
WO2014055125A1 (en) * 2012-10-05 2014-04-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. Pathways for treating patients
KR101626487B1 (ko) 2012-10-09 2016-06-01 파이브3 제노믹스, 엘엘씨 생물학적 경로 내의 조절 상호작용의 학습 및 확인을 위한 시스템 및 방법
JP6449779B2 (ja) * 2012-12-26 2019-01-09 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 目的遺伝子発現の線形結合を用いた細胞信号伝達経路活性の評価
AU2014274224B2 (en) * 2013-05-28 2016-06-09 Five3 Genomics, Llc Paradigm drug response networks
JP6054555B2 (ja) 2013-06-28 2016-12-27 ナントミクス，エルエルシー 診断テストを特定するための経路分析
US10114925B2 (en) 2013-07-26 2018-10-30 Nant Holdings Ip, Llc Discovery routing systems and engines
KR102004335B1 (ko) 2013-09-26 2019-07-26 파이브3 제노믹스, 엘엘씨 바이러스-연관 종양을 위한 시스템, 방법, 및 조성물
CN106852176A (zh) 2014-03-25 2017-06-13 凡弗3基因组有限公司 用于功能证实癌症突变的rna分析的系统和方法
EP3149641A4 (en) * 2014-05-30 2018-01-24 Nantomics, LLC Systems and methods for comprehensive analysis of molecular profiles across multiple tumor and germline exomes
CA2974199A1 (en) 2015-01-20 2016-07-28 Nantomics, Llc Systems and methods for response prediction to chemotherapy in high grade bladder cancer
AU2016280074B2 (en) * 2015-06-15 2020-03-19 Nantomics, Llc Systems and methods for patient-specific prediction of drug responses from cell line genomics
KR20240010089A (ko) 2015-10-12 2024-01-23 난토믹스, 엘엘씨 네오에피토프의 반복적 발견 및 이에 대한 적응성 면역치료 및 방법
KR102375973B1 (ko) * 2015-11-05 2022-03-17 김훈 사례기반 추론엔진을 이용한 보안 서버 및 보안 기능의 설치를 위한 저장 매체
CN105447337B (zh) * 2015-11-13 2018-01-26 大连理工大学 一种基于动态网络图分析的时间序列数据处理方法
AU2017219901B2 (en) 2016-02-19 2022-07-14 Nant Holdings Ip, Llc Methods of immunogenic modulation
EP3475434A4 (en) 2016-03-24 2020-07-29 Nantcell, Inc. SEQUENCE ARRANGEMENTS AND SEQUENCES FOR NEOEPITOP REPRESENTATION
AU2017261353A1 (en) * 2016-05-05 2018-11-08 Nantomics, Llc Checkpoint failure and methods therefor
US20170329914A1 (en) * 2016-05-11 2017-11-16 International Business Machines Corporation Predicting Personalized Cancer Metastasis Routes, Biological Mediators of Metastasis and Metastasis Blocking Therapies
AU2017290840A1 (en) 2016-06-30 2019-01-24 Nantomics, Llc Synthetic WGS bioinformatics validation
WO2018005973A1 (en) 2016-06-30 2018-01-04 Nant Holdings Ip, Llc Nant cancer vaccine
US20180039732A1 (en) * 2016-08-03 2018-02-08 Nantomics, Llc Dasatinib response prediction models and methods therefor
WO2018039567A1 (en) 2016-08-25 2018-03-01 Nantomics, Llc Immunotherapy markers and uses therefor
EP3535422A2 (en) * 2016-11-07 2019-09-11 Grail, Inc. Methods of identifying somatic mutational signatures for early cancer detection
CN110168646B (zh) * 2016-11-17 2023-12-19 南特生物科学公司 预测抗癌途径的验证
WO2018094204A1 (en) * 2016-11-17 2018-05-24 Arivale, Inc. Determining relationships between risks for biological conditions and dynamic analytes
CA3044424C (en) 2016-11-21 2023-05-23 Nant Holdings Ip, Llc Fractal combination therapy
US10629292B2 (en) 2016-12-19 2020-04-21 Seven Bridges Genomics, Inc. Generation and use of simulated genomic data
EP3579885A4 (en) 2017-02-07 2020-12-16 Nantcell, Inc. MAXIMIZING T CELL MEMORY, COMPOSITIONS AND RELATED METHODS
US20180251849A1 (en) * 2017-03-03 2018-09-06 General Electric Company Method for identifying expression distinguishers in biological samples
AU2018244307A1 (en) * 2017-03-28 2019-10-24 Nant Holdings Ip, Llc Modeling miRNA induced silencing in breast cancer with paradigm
KR102306403B1 (ko) 2017-04-24 2021-09-28 난트셀, 인크. 표적화된 네오에피토프 벡터 및 그에 관한 방법 (targeted neoepitope vectors and methods therefor)
US10686669B2 (en) * 2017-06-16 2020-06-16 Cisco Technology, Inc. Collecting network models and node information from a network
US11773187B2 (en) 2018-01-17 2023-10-03 Nantbio, Inc. Enhanced immunogenicity for GPI-anchored antigens
RU2741703C1 (ru) * 2018-03-01 2021-01-28 Общество с ограниченной ответственностью «Онкобокс» Платформа анализа генетической информации oncobox
WO2019178546A1 (en) 2018-03-16 2019-09-19 Scipher Medicine Corporation Methods and systems for predicting response to anti-tnf therapies
US11823773B2 (en) 2018-04-13 2023-11-21 Nant Holdings Ip, Llc Nant cancer vaccine strategies
TWI816603B (zh) 2018-04-23 2023-09-21 美商南特細胞公司 新抗原表位疫苗及免疫刺激組合物及方法
US11564980B2 (en) 2018-04-23 2023-01-31 Nantcell, Inc. Tumor treatment method with an individualized peptide vaccine
CN108795934B (zh) * 2018-05-23 2022-06-21 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) 日本血吸虫SjELAV-like 2基因的siRNA及其应用
US11189361B2 (en) * 2018-06-28 2021-11-30 International Business Machines Corporation Functional analysis of time-series phylogenetic tumor evolution tree
US11211148B2 (en) 2018-06-28 2021-12-28 International Business Machines Corporation Time-series phylogenetic tumor evolution trees
JP7404648B2 (ja) 2019-04-25 2023-12-26 富士通株式会社 治療薬提示方法、治療薬提示装置、及び治療薬提示プログラム
AU2020308906A1 (en) 2019-06-27 2022-02-03 Scipher Medicine Corporation Developing classifiers for stratifying patients
CN112816275B (zh) * 2019-11-18 2022-04-05 中国科学院深圳先进技术研究院 脑部修块装置
CN111161796B (zh) * 2019-12-30 2024-04-16 中南大学 一种预测PD潜在gene和miRNA的方法及系统
RU2756883C1 (ru) * 2020-06-09 2021-10-06 ФГАУ "Военный инновационный технополис "ЭРА" Устройство для вероятностного моделирования процесса функционирования телекоммуникационной сети
CN111883203B (zh) * 2020-07-03 2023-12-29 上海厦维医学检验实验室有限公司 用于预测pd-1疗效的模型的构建方法
US11481235B2 (en) * 2021-01-11 2022-10-25 Evicore Healthcare MSI, LLC Database framework model transformation for pathway identification
US11439159B2 (en) 2021-03-22 2022-09-13 Shiru, Inc. System for identifying and developing individual naturally-occurring proteins as food ingredients by machine learning and database mining combined with empirical testing for a target food function
CN113434693B (zh) * 2021-06-23 2023-02-21 重庆邮电大学工业互联网研究院 一种基于智慧数据平台的数据集成方法
CN113436729A (zh) * 2021-07-08 2021-09-24 湖南大学 一种基于异构图卷积神经网络的合成致死相互作用预测方法
CN115203172B (zh) * 2022-06-30 2023-11-07 北京亚控科技发展有限公司 模型构建及模型数据订阅方法、装置、电子设备和介质

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968770A (en) 1995-02-10 1999-10-19 Millennium Pharmaceuticals, Inc. Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd523 as a target
US7709454B2 (en) 1997-06-20 2010-05-04 New York University Methods and compositions for inhibiting tumorigenesis
US6980958B1 (en) * 2000-01-11 2005-12-27 Zycare, Inc. Apparatus and methods for monitoring and modifying anticoagulation therapy of remotely located patients
WO2001055951A2 (en) 2000-01-25 2001-08-02 Cellomics, Inc. Method and system for automated inference of physico-chemical interaction knowl edge
AU2002355996A1 (en) 2001-08-16 2003-03-03 Biotech Research Venture Pte Limited Method for modelling biochemical pathways
US20040167763A1 (en) 2002-05-31 2004-08-26 Liebman Michael N Information processing method for evaluating biochemical pathway models using clinical data
US8005620B2 (en) 2003-08-01 2011-08-23 Dna Twopointo Inc. Systems and methods for biopolymer engineering
WO2005096207A1 (ja) 2004-03-30 2005-10-13 Shigeo Ihara 文献情報処理システム
JP2006185412A (ja) 2004-12-03 2006-07-13 Kazusa Dna Kenkyusho 情報処理装置、情報処理方法及びそのプログラム
US7848890B2 (en) 2004-12-08 2010-12-07 Electronics And Telecommunications Research Institute Method and system for predicting gene pathway using gene expression pattern data and protein interaction data
US20060293859A1 (en) 2005-04-13 2006-12-28 Venture Gain L.L.C. Analysis of transcriptomic data using similarity based modeling
CA2608359A1 (en) 2005-05-13 2006-11-23 Duke University Gene expression signatures for oncogenic pathway deregulation
EP1891444A2 (en) * 2005-05-17 2008-02-27 GenPat77 Pharmacogenetics AG Tirc7 as marker for detecting early immune activation
JP2007011996A (ja) 2005-07-04 2007-01-18 Fujitsu Ltd 発現情報の解析方法及びそのシステム
JP2007052766A (ja) * 2005-07-22 2007-03-01 Mathematical Systems Inc パスウェイ表示方法、情報処理装置及びパスウェイ表示プログラム
CN101790731B (zh) * 2007-03-16 2013-11-06 纳特拉公司 用于清除遗传数据干扰并确定染色体拷贝数的系统和方法
EP2366162A1 (en) 2008-11-18 2011-09-21 Collabrx, Inc. Individualized cancer treatment
JP5429567B2 (ja) 2009-06-29 2014-02-26 株式会社ジェイテクト アンギュラ玉軸受用樹脂保持器
GB2474694B (en) * 2009-10-23 2011-11-02 Innovia Films Ltd Biodegradable composites
JP5670911B2 (ja) * 2009-11-09 2015-02-18 大日本住友製薬株式会社 支援装置、支援方法、及びコンピュータプログラム
EP3699915A1 (en) 2010-04-29 2020-08-26 The Regents of The University of California Pathway recognition algorithm using data integration on genomic models (paradigm)

Also Published As

Publication number Publication date
KR20150048909A (ko) 2015-05-07
JP2014532859A (ja) 2014-12-08
IL248380A0 (en) 2016-11-30
JP2019008812A (ja) 2019-01-17
JP6061941B2 (ja) 2017-01-18
WO2013062505A1 (en) 2013-05-02
CN104011726A (zh) 2014-08-27
IL232243A (en) 2016-11-30
US20150142465A1 (en) 2015-05-21
EP2771830A1 (en) 2014-09-03
CA2853702A1 (en) 2013-05-02
AU2011380013B2 (en) 2014-06-05
IL248380B (en) 2019-07-31
KR101554530B1 (ko) 2015-09-21
CN108664762A (zh) 2018-10-16
JP6129998B2 (ja) 2017-05-17
KR20140078766A (ko) 2014-06-25
JP6854792B2 (ja) 2021-04-07
EP2771830A4 (en) 2015-03-25
JP2016122451A (ja) 2016-07-07
US10192641B2 (en) 2019-01-29
JP2017182813A (ja) 2017-10-05
IL232243A0 (en) 2014-06-30
JP6396532B2 (ja) 2018-09-26
US20120158391A1 (en) 2012-06-21
AU2011380013A1 (en) 2014-05-08

Similar Documents

Publication Publication Date Title
US11043282B2 (en) Pathway analysis computing system and method
JP6854792B2 (ja) ゲノムモデルに関するデータ統合を用いたパスウェイ認識アルゴリズム（ｐａｒａｄｉｇｍ）
AU2014221248B2 (en) Pathway recognition algorithm using data integration on genomic models (paradigm)

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190415

FZDE Discontinued

Effective date: 20211026