CA3013623A1 - Methods of differentiating stem cell-derived ectodermal lineage precursors - Google Patents

Methods of differentiating stem cell-derived ectodermal lineage precursors Download PDF

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Publication number
CA3013623A1
CA3013623A1 CA3013623A CA3013623A CA3013623A1 CA 3013623 A1 CA3013623 A1 CA 3013623A1 CA 3013623 A CA3013623 A CA 3013623A CA 3013623 A CA3013623 A CA 3013623A CA 3013623 A1 CA3013623 A1 CA 3013623A1
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cells
signaling
activator
stem cells
population
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English (en)
French (fr)
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Lorenz Studer
Bastian Zimmer
Jason Tchieu
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Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Cancer Center
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    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
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CA3013623A 2016-02-05 2017-02-06 Methods of differentiating stem cell-derived ectodermal lineage precursors Pending CA3013623A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662292014P 2016-02-05 2016-02-05
US62/292,014 2016-02-05
US201662299361P 2016-02-24 2016-02-24
US62/299,361 2016-02-24
US62/350,032 2016-06-14
US201662350032P 2016-06-15 2016-06-15
PCT/US2017/016723 WO2017136834A1 (en) 2016-02-05 2017-02-06 Methods of differentiating stem cell-derived ectodermal lineage precursors

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CA3013623A1 true CA3013623A1 (en) 2017-08-10

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CA3013623A Pending CA3013623A1 (en) 2016-02-05 2017-02-06 Methods of differentiating stem cell-derived ectodermal lineage precursors

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US (3) US11326148B2 (https=)
EP (1) EP3411048A4 (https=)
JP (2) JP7523885B2 (https=)
KR (1) KR20180105236A (https=)
AU (1) AU2017214749B2 (https=)
CA (1) CA3013623A1 (https=)
IL (1) IL260979B2 (https=)
WO (1) WO2017136834A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180105236A (ko) 2016-02-05 2018-09-27 메모리얼 슬로안-케터링 캔서 센터 줄기 세포-유래 외배엽 계통 전구체의 분화 방법
WO2018024186A1 (zh) * 2016-08-02 2018-02-08 江苏恒瑞医药股份有限公司 一种人胰岛素或其类似物的酰化衍生物
CA3075036A1 (en) * 2017-09-07 2019-03-14 Memorial Sloan-Kettering Cancer Center Methods of differentiating stem cell-derived ectodermal lineage precursors
WO2019094873A1 (en) * 2017-11-10 2019-05-16 Memorial Sloan-Kettering Cancer Center Derivation of somatotrophs from stem cells and uses thereof
IT201800009133A1 (it) * 2018-10-03 2020-04-03 Università Cattolica del Sacro Cuore Identificazione di biomarcatori molecolari predittivi di risposta al trattamento radiochemoterapico nel carcinoma della cervice
KR102451074B1 (ko) * 2019-01-11 2022-10-05 차의과학대학교 산학협력단 Ｔｇｆ-베타 ⅰ 수용체의 저해제 및 ｂｍｐ 저해제를 포함하는 줄기 세포의 신경능선세포로의 분화용 조성물, 키트, 및 이를 이용한 방법
KR20200087541A (ko) * 2019-01-11 2020-07-21 차의과학대학교 산학협력단 Ｔｇｆ-베타 ⅰ 수용체의 저해제 및 ｂｍｐ 저해제를 포함하는 줄기 세포의 신경능선세포로의 분화용 조성물, 키트, 및 이를 이용한 방법
WO2025085899A1 (en) * 2023-10-19 2025-04-24 The Research Foundation For The State University Of New York Production of salivary gland epithelial progenitors and salivary gland cell organoids for regenerative medicine and drug testing purposes

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5649786B2 (ja) 2006-03-07 2015-01-07 ギータ シュロフ ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法
WO2008008266A2 (en) 2006-07-07 2008-01-17 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Biohybrid elastomeric scaffolds and methods of use thereof
WO2010096496A2 (en) 2009-02-17 2010-08-26 Memorial Sloan-Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
WO2011019092A1 (en) 2009-08-12 2011-02-17 Kyoto University Method for inducing differentiation of pluripotent stem cells into neural precursor cells
DK3578988T3 (da) 2010-05-25 2025-02-24 Memorial Sloan Kettering Cancer Center Fremgangsmåde til nociceptordifferentiering af humane embryonale stamceller og anvendelse heraf
US20110296542A1 (en) 2010-05-28 2011-12-01 Kevin Ka-Wang Wang Exogenous matrix-supported topical application of stem cells to organ surface
WO2012091978A2 (en) 2010-12-31 2012-07-05 University Of Georgia Research Foundation, Inc. Differentiation of human pluripotent stem cells to multipotent neural crest cells
EP2667881A4 (en) * 2011-01-24 2015-04-22 Univ Leland Stanford Junior METHOD FOR IN VITRO GENERATION OF INTERNAL CELLS
EP3693455A1 (en) * 2011-11-04 2020-08-12 Memorial Sloan-Kettering Cancer Center Midbrain dopamine (da) neurons for engraftment
WO2013166488A1 (en) * 2012-05-04 2013-11-07 Indiana University Research & Technology Corporation Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells
WO2013188744A1 (en) 2012-06-15 2013-12-19 Baylor College Of Medicine Perineurium derived adult stem cells and methods of use
US10160950B2 (en) * 2013-03-01 2018-12-25 Wisconsin Alumni Research Foundation Methods of maintaining, expanding and differentiating neuronal subtype specific progenitors
EP3498824A1 (en) 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
AU2014352773B2 (en) 2013-11-21 2021-04-29 Memorial Sloan-Kettering Cancer Center Specification of functional cranial placode derivatives from human pluripotent stem cells
JP6304818B2 (ja) 2014-04-21 2018-04-04 花王株式会社 皮膚由来多能性前駆細胞の作製方法
JP6598185B2 (ja) 2014-11-07 2019-10-30 国立大学法人京都大学 軟骨過形成疾患の予防および治療剤ならびにそのスクリーニング方法
WO2016104574A1 (ja) 2014-12-24 2016-06-30 国立大学法人京都大学 異所性骨化の予防・治療剤及びそのスクリーニング方法
AU2016270793B2 (en) * 2015-06-01 2022-06-09 Memorial Sloan-Kettering Cancer Center Methods of in vitro differentiation of midbrain dopamine (MDA) neurons
US11186821B2 (en) 2015-06-02 2021-11-30 National Institute Of Advanced Industrial Science And Technology Method for inducing differentiation of neural crest cells into neurons of the autonomic nervous system
SG11201803061UA (en) * 2015-10-21 2018-05-30 Univ Indiana Res & Tech Corp Methods of generating human inner ear sensory epithelia and sensory neurons
EP3414322A4 (en) * 2015-12-23 2020-03-04 Memorial Sloan-Kettering Cancer Center CELL THERAPY AND DRUG DISCOVERY BASED ON CELL LINES DERIVED FROM HUMAN ENTERAL NEURAL CREST DERIVED FROM PLURIPOTENT STEM CELLS
EP3448985A4 (en) * 2016-01-27 2019-08-21 Memorial Sloan-Kettering Cancer Center DIFFERENTIATION OF CORTIC NEURONS FROM HUMAN PLURIPOTENTIAL STEM CELLS
KR20180105236A (ko) 2016-02-05 2018-09-27 메모리얼 슬로안-케터링 캔서 센터 줄기 세포-유래 외배엽 계통 전구체의 분화 방법

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EP3411048A4 (en) 2019-07-31
US11326148B2 (en) 2022-05-10
JP2019503703A (ja) 2019-02-14
US20240327796A1 (en) 2024-10-03
KR20180105236A (ko) 2018-09-27
AU2017214749A8 (en) 2018-09-13
IL260979B2 (en) 2023-08-01
AU2017214749B2 (en) 2024-03-28
WO2017136834A1 (en) 2017-08-10
JP2022088676A (ja) 2022-06-14
US11959104B2 (en) 2024-04-16
WO2017136834A8 (en) 2018-08-23
AU2017214749A1 (en) 2018-09-06
EP3411048A1 (en) 2018-12-12
US20220228123A1 (en) 2022-07-21
IL260979A (https=) 2018-09-20
IL260979B1 (en) 2023-04-01
JP7523885B2 (ja) 2024-07-29
US20190071643A1 (en) 2019-03-07

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