CA3011663C - 5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof - Google Patents

5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof Download PDF

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Publication number
CA3011663C
CA3011663C CA3011663A CA3011663A CA3011663C CA 3011663 C CA3011663 C CA 3011663C CA 3011663 A CA3011663 A CA 3011663A CA 3011663 A CA3011663 A CA 3011663A CA 3011663 C CA3011663 C CA 3011663C
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Canada
Prior art keywords
mrna
phosphorothiolate
cap
cap analog
deoxy
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CA3011663A
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English (en)
French (fr)
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CA3011663A1 (en
Inventor
Jacek Jemielity
Kaja Fac-Dabrowska
Blazej Wojtczak
Marek Baranowski
Anna NOWICKA
Joanna Kowalska
Pawel SIKORSKI
Marcin Warminski
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Uniwersytet Warszawski
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Uniwersytet Warszawski
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Publication of CA3011663A1 publication Critical patent/CA3011663A1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C07H1/04—Introducing polyphosphoric acid radicals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3011663A 2016-01-29 2017-01-27 5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof Active CA3011663C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL415967A PL415967A1 (pl) 2016-01-29 2016-01-29 5'-tiofosforanowe analogi końca 5' mRNA (kapu), sposób ich otrzymywania i zastosowanie
PLPL415967 2016-01-29
PCT/IB2017/050447 WO2017130151A1 (en) 2016-01-29 2017-01-27 5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof

Publications (2)

Publication Number Publication Date
CA3011663A1 CA3011663A1 (en) 2017-08-03
CA3011663C true CA3011663C (en) 2023-10-31

Family

ID=58387852

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3011663A Active CA3011663C (en) 2016-01-29 2017-01-27 5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof

Country Status (11)

Country Link
US (1) US11066436B2 (pl)
EP (1) EP3408276B1 (pl)
JP (1) JP7144050B2 (pl)
KR (1) KR102742219B1 (pl)
CN (1) CN109071589A (pl)
AU (1) AU2017211693B2 (pl)
CA (1) CA3011663C (pl)
EA (1) EA038834B1 (pl)
ES (1) ES2879802T3 (pl)
PL (2) PL415967A1 (pl)
WO (1) WO2017130151A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020231697A1 (en) * 2019-05-10 2020-11-19 New England Biolabs, Inc. Chemical capping for template switching
CN110907358B (zh) * 2019-12-09 2022-08-30 福建师范大学 一种光微流微泡腔铅离子传感器的实现装置及方法
PL432884A1 (pl) * 2020-02-12 2021-08-16 Uniwersytet Warszawski Nowe analogi kapu końca 5' mRNA, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA i peptydu
CN113337558A (zh) * 2020-08-20 2021-09-03 深圳市瑞吉生物科技有限公司 一种Cap2结构5`帽子类似物及其制备方法和应用
EP4208549A4 (en) 2020-09-04 2025-04-16 Verve Therapeutics, Inc. Compositions and methods for capping RNAs
WO2023167880A2 (en) * 2022-03-01 2023-09-07 Verve Therapeutics, Inc. Compositions and methods for capping rnas
CN114685588B (zh) * 2022-05-05 2024-03-29 江苏申基生物科技有限公司 一种含开环核苷结构的起始加帽寡核苷酸引物
CN116143855B (zh) * 2022-11-08 2023-11-28 江苏申基生物科技有限公司 一种乙烯基膦酸修饰的mRNA帽类似物及其制备方法和应用
EP4464713A1 (en) 2023-05-18 2024-11-20 Siec Badawcza Lukasiewicz - PORT Polski Osrodek Rozwoju Technologii Circular rna analogs, preparation and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008546424A (ja) 2005-06-28 2008-12-25 アジェンコート パーソナル ジェノミクス コーポレイション 修飾ポリヌクレオチドを作製する方法および配列決定する方法
EP2167523B1 (en) * 2007-06-19 2014-07-23 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap
PL215513B1 (pl) 2008-06-06 2013-12-31 Univ Warszawski Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka
EP2281579A1 (en) * 2009-08-05 2011-02-09 BioNTech AG Vaccine composition comprising 5'-Cap modified RNA
ES2647832T3 (es) * 2013-03-14 2017-12-26 Translate Bio, Inc. Ácidos ribonucleicos con nucleótidos modificados con 4-tio y procedimientos relacionados
RS59991B1 (sr) * 2013-08-08 2020-04-30 Scripps Research Inst Metoda enzimskog in vitro obeležavanja specifičnog za položaj nukleinskih kiselina uvođenjem neprirodnih nukleotida

Also Published As

Publication number Publication date
KR20180100595A (ko) 2018-09-11
ES2879802T3 (es) 2021-11-23
PL3408276T3 (pl) 2021-10-25
PL415967A1 (pl) 2017-07-31
US20190300563A1 (en) 2019-10-03
AU2017211693A1 (en) 2018-08-09
EA201891429A1 (ru) 2019-02-28
EA038834B1 (ru) 2021-10-26
KR102742219B1 (ko) 2024-12-13
CA3011663A1 (en) 2017-08-03
US11066436B2 (en) 2021-07-20
CN109071589A (zh) 2018-12-21
AU2017211693B2 (en) 2021-09-09
JP2019504837A (ja) 2019-02-21
WO2017130151A1 (en) 2017-08-03
EP3408276A1 (en) 2018-12-05
EP3408276B1 (en) 2021-04-07
JP7144050B2 (ja) 2022-09-29

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