CA3007996A1 - Compositions and methods for treatment of her2 positive metastatic breast cancer - Google Patents
Compositions and methods for treatment of her2 positive metastatic breast cancer Download PDFInfo
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- CA3007996A1 CA3007996A1 CA3007996A CA3007996A CA3007996A1 CA 3007996 A1 CA3007996 A1 CA 3007996A1 CA 3007996 A CA3007996 A CA 3007996A CA 3007996 A CA3007996 A CA 3007996A CA 3007996 A1 CA3007996 A1 CA 3007996A1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4203—Receptors for growth factors
- A61K40/4205—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/49—Breast
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Landscapes
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| US201562265382P | 2015-12-09 | 2015-12-09 | |
| US62/265,382 | 2015-12-09 | ||
| PCT/US2016/066018 WO2017100709A1 (en) | 2015-12-09 | 2016-12-09 | Compositions and methods for treatment of her2 positive metastatic breast cancer |
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| CA3007996A1 true CA3007996A1 (en) | 2017-06-15 |
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| JP (1) | JP2018537536A (enExample) |
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| AU (1) | AU2016366677A1 (enExample) |
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| WO (1) | WO2017100709A1 (enExample) |
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| JP7373991B2 (ja) | 2016-07-15 | 2023-11-06 | ビラクタ セラピューティクス，インク． | 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤 |
| AU2018289572A1 (en) * | 2017-06-22 | 2020-01-23 | University Of Southern California | Combination cancer therapy using chimeric antigen receptor engineered natural killer cells as chemotherapeutic drug carriers |
| JP7062754B2 (ja) * | 2017-08-15 | 2022-05-06 | ナントセル，インコーポレイテッド | ｈａＮＫセツキシマブ併用及び方法 |
| CN110484507B (zh) * | 2018-01-31 | 2023-10-13 | 温州医科大学 | 一种靶向肿瘤Her2的新型嵌合抗原受体T细胞的制备技术 |
| IL321548A (en) | 2018-05-22 | 2025-08-01 | Immunitybio Inc | Recombinant NK cells expressing a chimeric antigen receptor (CAR) for epsilon-FC and uses thereof |
| CA3108754A1 (en) * | 2018-08-06 | 2020-02-13 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and tubulin inhibitor |
| EP3746547A4 (en) * | 2018-10-31 | 2021-12-01 | Nantkwest, Inc. | ELIMINATION OF POSITIVE MALIGNITIES FOR PD-L1 BY NK CELLS EXPRESSING A PD-L1 CHEMERIC ANTIGEN RECEPTOR |
| JP7555392B2 (ja) * | 2019-07-26 | 2024-09-24 | ナントクウェスト，インコーポレーテッド | 腫瘍溶解のための有効な治療用製剤としての、抗体を予め負荷したｃｄ１６＋ｎｋ－９２細胞 |
| TW202216776A (zh) | 2020-07-07 | 2022-05-01 | 美商康愈有限責任公司 | Mic抗體及結合劑以及其使用方法 |
| CN112675313A (zh) * | 2020-12-28 | 2021-04-20 | 烟台大学 | 连接曲妥珠单抗片段的美登素纳米粒组合物 |
| CN114807237A (zh) * | 2022-05-12 | 2022-07-29 | 广东普罗凯融生物医药科技有限公司 | 一种过表达CD16a的NK细胞的制备方法及其应用 |
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| PL215263B1 (pl) * | 2002-02-25 | 2013-11-29 | Elan Pharm Inc | Kompozycja do przewleklego leczenia patologicznego zapalenia i zastosowanie natalizumabu lub jego immunologicznie aktywnego fragmentu do wytwarzania leku |
| PL1836225T3 (pl) * | 2005-01-06 | 2012-05-31 | Novo Nordisk As | Czynniki wiążące kir i sposoby ich stosowania |
| AU2006236439B2 (en) * | 2005-04-15 | 2012-05-03 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| EP2161339A1 (en) * | 2008-08-29 | 2010-03-10 | F. Hoffmann-La Roche Ag | ADCC with modified NK92 cells |
| ES2935906T3 (es) * | 2013-11-01 | 2023-03-13 | Immunitybio Inc | Composiciones y métodos tumoricidas y antimicrobianos |
| CN113699159A (zh) * | 2014-03-28 | 2021-11-26 | 明尼苏达大学评议会 | 涉及经工程改造的cd16的多肽、细胞和方法 |
| CN107613993A (zh) * | 2015-03-27 | 2018-01-19 | 南克维斯特公司 | 与癌症药物的联合治疗中的nk‑92细胞 |
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- 2016-12-09 EP EP16874010.8A patent/EP3386522A4/en not_active Withdrawn
- 2016-12-09 AU AU2016366677A patent/AU2016366677A1/en not_active Abandoned
- 2016-12-09 WO PCT/US2016/066018 patent/WO2017100709A1/en not_active Ceased
- 2016-12-09 CN CN201680080518.8A patent/CN109475576A/zh active Pending
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- 2016-12-09 US US15/781,428 patent/US20180360881A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20180360881A1 (en) | 2018-12-20 |
| AU2016366677A1 (en) | 2018-07-26 |
| EP3386522A4 (en) | 2019-06-19 |
| CN109475576A (zh) | 2019-03-15 |
| KR20180123214A (ko) | 2018-11-15 |
| EP3386522A1 (en) | 2018-10-17 |
| JP2018537536A (ja) | 2018-12-20 |
| WO2017100709A1 (en) | 2017-06-15 |
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