CA3004794A1 - Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment - Google Patents

Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment Download PDF

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Publication number
CA3004794A1
CA3004794A1 CA3004794A CA3004794A CA3004794A1 CA 3004794 A1 CA3004794 A1 CA 3004794A1 CA 3004794 A CA3004794 A CA 3004794A CA 3004794 A CA3004794 A CA 3004794A CA 3004794 A1 CA3004794 A1 CA 3004794A1
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CA
Canada
Prior art keywords
cancer
fgfr2
antibody
cells
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3004794A
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English (en)
French (fr)
Inventor
Kristen Pierce
Janine Powers
Servando Palencia
Robert Sikorski
Majid GHODDUSI
Kartik KRISHNAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Five Prime Therapeutics Inc
Original Assignee
Five Prime Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Five Prime Therapeutics Inc filed Critical Five Prime Therapeutics Inc
Publication of CA3004794A1 publication Critical patent/CA3004794A1/en
Pending legal-status Critical Current

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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Food Science & Technology (AREA)
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  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
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CA3004794A 2015-11-23 2016-11-22 Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment Pending CA3004794A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562258731P 2015-11-23 2015-11-23
US62/258,731 2015-11-23
US201662314174P 2016-03-28 2016-03-28
US62/314,174 2016-03-28
US201662379094P 2016-08-24 2016-08-24
US62/379,094 2016-08-24
PCT/US2016/063332 WO2017091577A1 (en) 2015-11-23 2016-11-22 Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment

Publications (1)

Publication Number Publication Date
CA3004794A1 true CA3004794A1 (en) 2017-06-01

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ID=57589165

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3004794A Pending CA3004794A1 (en) 2015-11-23 2016-11-22 Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment

Country Status (14)

Country Link
US (4) US20170145103A1 (https=)
EP (1) EP3380523A1 (https=)
JP (3) JP7349787B2 (https=)
KR (2) KR20250034528A (https=)
CN (2) CN116327924A (https=)
AU (2) AU2016359609B2 (https=)
BR (1) BR112018010410A8 (https=)
CA (1) CA3004794A1 (https=)
IL (2) IL291926B2 (https=)
MX (2) MX2018006181A (https=)
RU (1) RU2745707C2 (https=)
SG (2) SG11201804134YA (https=)
TW (2) TWI881245B (https=)
WO (2) WO2017091580A1 (https=)

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PH12021552742A1 (en) 2013-08-01 2022-05-23 Five Prime Therapeutics Inc Afucosylated anti-fgfr2iiib antibodies
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
US20170145103A1 (en) * 2015-11-23 2017-05-25 Five Prime Therapeutics, Inc. Predicting response to cancer treatment with fgfr2 inhibitors
US12414945B2 (en) 2015-12-17 2025-09-16 Eisai R&D Management Co., Ltd. Therapeutic agent for breast cancer
SG10202112636SA (en) 2017-05-16 2021-12-30 Five Prime Therapeutics Inc Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
CN111821434A (zh) * 2019-04-17 2020-10-27 上海君实生物医药科技股份有限公司 抗pd-1抗体在制备治疗实体瘤的药物中的用途
CN108440673B (zh) * 2018-04-08 2021-08-17 海南医学院 Fc融合蛋白PD1/FGFR1及其应用
EP3813868A4 (en) * 2018-05-15 2022-03-02 Merck Patent GmbH Dosing regimens for targeted tgf-b inhibition for use in treating cancer in treatment naive subjects
SG11202100642UA (en) * 2018-08-29 2021-03-30 Five Prime Therapeutics Inc Cd80 extracellular domain fc fusion protein dosing regimens
AU2019328305A1 (en) * 2018-08-29 2021-03-04 Shattuck Labs, Inc. Combination therapies comprising tim-3-based chimeric proteins
WO2020056132A1 (en) 2018-09-13 2020-03-19 University Of Southern California Novel fgfr inhibitors and uses thereof
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US20170145103A1 (en) 2017-05-25
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