CA2997671A1 - Combination therapies for treating cancer - Google Patents
Combination therapies for treating cancer Download PDFInfo
- Publication number
- CA2997671A1 CA2997671A1 CA2997671A CA2997671A CA2997671A1 CA 2997671 A1 CA2997671 A1 CA 2997671A1 CA 2997671 A CA2997671 A CA 2997671A CA 2997671 A CA2997671 A CA 2997671A CA 2997671 A1 CA2997671 A1 CA 2997671A1
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- agents
- tumor
- chloro
- adamantane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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Landscapes
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- Animal Behavior & Ethology (AREA)
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- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| EP4134076A1 (en) | 2014-10-24 | 2023-02-15 | Redhill Biopharma Ltd. | Therapy for inhibition of single-stranded rna virus replication |
| WO2018195434A1 (en) | 2017-04-21 | 2018-10-25 | Lisanti Michael P | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| CA3060509A1 (en) | 2017-04-21 | 2018-10-25 | Federica Sotgia | Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy |
| KR20200010343A (ko) | 2017-05-19 | 2020-01-30 | 루넬라 바이오테크 인코포레이티드 | 안티미토신: 암 줄기 세포를 근절하기 위한 미토콘드리아 생물발생의 표적화 억제제 |
| WO2018213764A1 (en) | 2017-05-19 | 2018-11-22 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| EP3644988B1 (en) | 2017-06-26 | 2023-02-22 | Lunella Biotech, Inc. | Mitoketoscins: mitochondrial-based therapeutics targeting ketone metabolism in cancer cells |
| JP2020534285A (ja) | 2017-09-15 | 2020-11-26 | アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | 投与および処置の方法 |
| EP3681494A4 (en) * | 2017-09-15 | 2021-08-04 | Ampersand Biopharmaceuticals, Inc. | INHIBITION OF SPONTANEOUS METASTASIS BY PROTEIN INHIBITORS OF CYSTEIN PROTEASES |
| BR112021013952A2 (pt) * | 2019-01-16 | 2021-11-16 | Apogee Biotechnology Corp | Métodos de indução de uma resposta imunológica anticâncer |
| WO2020154716A1 (en) * | 2019-01-26 | 2020-07-30 | University Of Rochester | Compositions and methods for treating prostate cancer |
| CA3174438A1 (en) * | 2020-03-10 | 2021-09-16 | Redhill Biopharma Ltd. | Treatment of coronavirus infection |
| US11471448B2 (en) | 2020-12-15 | 2022-10-18 | Redhill Biopharma Ltd. | Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia |
| CN119700770A (zh) * | 2025-01-09 | 2025-03-28 | 首都医科大学附属北京佑安医院 | 氯法齐明在制备修复肠黏膜或改善肠道菌群药物中的应用 |
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| CA2189001A1 (en) * | 1994-04-26 | 1995-11-02 | Nobuhiro Narita | Medicinal composition as a remedy for nonsmall cell lung cancer |
| AUPP437698A0 (en) * | 1998-06-30 | 1998-07-23 | Baumgart, Karl | Methods for treatment of coronary, carotid and other vascular disease |
| DE59909210D1 (de) * | 1998-07-20 | 2004-05-19 | Wilex Ag | Urokinase-Inhibitoren |
| AUPR644301A0 (en) * | 2001-07-17 | 2001-08-09 | Unisearch Limited | Method and composition for treatment of cancer |
| US6864264B1 (en) * | 2002-08-20 | 2005-03-08 | Gloria L. Anderson | 1-adamantyl chalcones for the treatment of proliferative disorders |
| DE10323898A1 (de) * | 2003-05-26 | 2004-12-23 | Wilex Ag | Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe |
| DE102004057195A1 (de) * | 2004-11-26 | 2006-06-01 | Wilex Ag | Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon |
| US20060142304A1 (en) * | 2004-12-27 | 2006-06-29 | Michael Southall | Method for treating or preventing pruritic and neurogenic skin disorders |
| US20060270631A1 (en) * | 2005-05-26 | 2006-11-30 | Smith Charles D | Methods for the treatment and prevention of angiogenic diseases |
| ES2528451T3 (es) * | 2005-06-17 | 2015-02-10 | Apogee Biothechnology Corporation | Inhibidores de esfingosina cinasa |
| TWI405756B (zh) * | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
| US20080226624A1 (en) * | 2007-03-07 | 2008-09-18 | Wolfgang Schmalix | Combined treatment of cancer by urokinase inhibition and a cytostatic anti-cancer agent for enhancing the anti-metastatic effect |
| HRP20190045T1 (hr) * | 2008-02-08 | 2019-03-08 | Red Hill Biopharma Ltd. | Metode i sastavi za liječenje upalne bolesti crijeva |
| TWI573590B (zh) * | 2011-09-20 | 2017-03-11 | 雷希爾生藥有限公司 | 治療自體免疫疾病之組成物及方法 |
| EP3560497A1 (en) * | 2012-08-30 | 2019-10-30 | The Texas A&M University System | Compositions and methods for drug-sensitization or inhibition of a cancer cell |
| EP4134076A1 (en) * | 2014-10-24 | 2023-02-15 | Redhill Biopharma Ltd. | Therapy for inhibition of single-stranded rna virus replication |
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| US20170095460A1 (en) | 2017-04-06 |
| CN108136207A (zh) | 2018-06-08 |
| MX382754B (es) | 2025-03-13 |
| US11633385B2 (en) | 2023-04-25 |
| WO2017060771A3 (en) | 2017-07-06 |
| RU2018109902A3 (enExample) | 2020-03-05 |
| JP6963545B2 (ja) | 2021-11-10 |
| KR20180058716A (ko) | 2018-06-01 |
| US20210128538A1 (en) | 2021-05-06 |
| HK1259342A1 (zh) | 2019-11-29 |
| MX2018004309A (es) | 2018-05-22 |
| US10463654B2 (en) | 2019-11-05 |
| EP3359255A2 (en) | 2018-08-15 |
| AU2016336133A1 (en) | 2018-03-15 |
| BR112018003232A2 (pt) | 2018-09-25 |
| AU2016336133B2 (en) | 2021-02-25 |
| US10946000B2 (en) | 2021-03-16 |
| WO2017060771A2 (en) | 2017-04-13 |
| JP2018533560A (ja) | 2018-11-15 |
| US20200113881A1 (en) | 2020-04-16 |
| RU2727474C2 (ru) | 2020-07-21 |
| RU2018109902A (ru) | 2019-11-07 |
| EP3359255A4 (en) | 2019-06-12 |
| US9844540B2 (en) | 2017-12-19 |
| US20180125831A1 (en) | 2018-05-10 |
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| EEER | Examination request |
Effective date: 20211006 |
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| FZDE | Discontinued |
Effective date: 20240308 |