CA2993806A1 - Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor - Google Patents

Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor Download PDF

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Publication number
CA2993806A1
CA2993806A1 CA2993806A CA2993806A CA2993806A1 CA 2993806 A1 CA2993806 A1 CA 2993806A1 CA 2993806 A CA2993806 A CA 2993806A CA 2993806 A CA2993806 A CA 2993806A CA 2993806 A1 CA2993806 A1 CA 2993806A1
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Prior art keywords
mdscs
mdsc
inflammasome
gvhd
subject
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Pending
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CA2993806A
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English (en)
French (fr)
Inventor
Peter J. Murray
Jenny P. Y. TING
Robert ZEISER
Bruce R. Blazar
Brent H. KOEHN
Jeff S. MILLER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albert Ludwigs Universitaet Freiburg
University of North Carolina at Chapel Hill
St Jude Childrens Research Hospital
University of Minnesota System
Original Assignee
Albert Ludwigs Universitaet Freiburg
University of North Carolina at Chapel Hill
St Jude Childrens Research Hospital
University of Minnesota System
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Application filed by Albert Ludwigs Universitaet Freiburg, University of North Carolina at Chapel Hill, St Jude Childrens Research Hospital, University of Minnesota System filed Critical Albert Ludwigs Universitaet Freiburg
Publication of CA2993806A1 publication Critical patent/CA2993806A1/en
Pending legal-status Critical Current

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CA2993806A 2015-08-06 2016-08-05 Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor Pending CA2993806A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562201990P 2015-08-06 2015-08-06
US62/201,990 2015-08-06
PCT/US2016/045739 WO2017024213A1 (en) 2015-08-06 2016-08-05 Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor

Publications (1)

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CA2993806A1 true CA2993806A1 (en) 2017-02-09

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CA2993806A Pending CA2993806A1 (en) 2015-08-06 2016-08-05 Modulating inflammasome activation of myeloid-derived supperssor cells for treating gvhd or tumor

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US (2) US10894061B2 (enExample)
EP (3) EP3682889B1 (enExample)
JP (3) JP6927499B2 (enExample)
CN (2) CN108883131B (enExample)
AU (2) AU2016303622B2 (enExample)
CA (1) CA2993806A1 (enExample)
ES (2) ES2789574T3 (enExample)
PT (1) PT3682889T (enExample)
WO (1) WO2017024213A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3682889B1 (en) * 2015-08-06 2023-02-01 Regents of the University of Minnesota Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd
FR3100715B1 (fr) * 2019-09-12 2023-09-29 Francais Du Sang Ets Utilisation de HDL dans la prophylaxie de la maladie du greffon contre l’hôte
WO2022216615A1 (en) * 2021-04-05 2022-10-13 Rhode Island Hospital Compositions and methods for the prevention or treatment of rheumatoid arthritis
CN113707223A (zh) * 2021-04-21 2021-11-26 吴安华 一种预测肿瘤炎性小体活性状态及治疗敏感性的基因集系统及方法

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
US20040136973A1 (en) 2002-11-07 2004-07-15 Eliezer Huberman Human stem cell materials and methods
EP2300000A1 (en) 2008-07-03 2011-03-30 University of Massachusetts Methods and compositions for reducing inflammation and treating inflammatory disorders
US8334101B2 (en) 2008-09-26 2012-12-18 University Of Massachusetts Intracellular DNA receptor
US20120082688A1 (en) * 2008-11-26 2012-04-05 Mount Sinai School Of Medicine In Vitro Generation of Myeloid Derived Suppressor Cells
US8951529B2 (en) 2009-12-22 2015-02-10 Icahn School Of Medicine At Mount Sinai Methods of using small compounds to enhance myeloid derived suppressor cell function for treating autoimmune diseases
US20140377278A1 (en) 2012-01-10 2014-12-25 Yale University Compositions and Methods for Assessing and Treating Inflammatory Diseases and Disorders
AR095882A1 (es) * 2013-04-22 2015-11-18 Hoffmann La Roche Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
JP6359013B2 (ja) 2013-07-29 2018-07-18 国立大学法人 鹿児島大学 １，５−ｄ−アンヒドロフルクトースを含むアポトーシス関連スペック様カード蛋白質の機能阻害薬
LT3240801T (lt) * 2014-12-31 2021-02-25 Checkmate Pharmaceuticals, Inc. Kombinuota navikų imunoterapija
JP6959865B2 (ja) * 2015-01-21 2021-11-05 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ガイドとして自身のカルレティキュリンを使用して癌細胞を食べるマクロファージ
EP3682889B1 (en) * 2015-08-06 2023-02-01 Regents of the University of Minnesota Modulating inflammasome activation of myeloid-derived suppressor cells for treating gvhd
KR102599839B1 (ko) 2015-11-13 2023-11-09 큐에프 테크놀로지스 에이에스 물을 모으기 위한 장치 및 방법
GB201721185D0 (en) * 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
CN112646777B (zh) * 2020-12-31 2022-11-04 广州医科大学 一种扩增髓系来源的抑制性细胞的方法

Also Published As

Publication number Publication date
EP3331538B1 (en) 2020-03-11
EP4218776A3 (en) 2024-02-28
EP4218776A2 (en) 2023-08-02
WO2017024213A1 (en) 2017-02-09
AU2016303622B2 (en) 2022-07-07
PT3682889T (pt) 2023-03-09
US12234480B2 (en) 2025-02-25
CN108883131A (zh) 2018-11-23
ES2939534T3 (es) 2023-04-24
ES2789574T3 (es) 2020-10-26
CN114790447A (zh) 2022-07-26
AU2016303622A8 (en) 2018-05-31
JP2018536620A (ja) 2018-12-13
HK1256917A1 (en) 2019-10-04
US20180214483A1 (en) 2018-08-02
EP3682889B1 (en) 2023-02-01
JP7235259B2 (ja) 2023-03-08
US20210128612A1 (en) 2021-05-06
JP2023053338A (ja) 2023-04-12
CN108883131B (zh) 2022-04-29
EP3682889A1 (en) 2020-07-22
EP3331538A1 (en) 2018-06-13
JP6927499B2 (ja) 2021-09-01
AU2016303622A1 (en) 2018-02-22
AU2022228188A1 (en) 2022-09-29
JP2021167345A (ja) 2021-10-21
US10894061B2 (en) 2021-01-19

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