CA2993709A1 - Disposable bioprocess system supporting biological activity - Google Patents

Disposable bioprocess system supporting biological activity Download PDF

Info

Publication number
CA2993709A1
CA2993709A1 CA2993709A CA2993709A CA2993709A1 CA 2993709 A1 CA2993709 A1 CA 2993709A1 CA 2993709 A CA2993709 A CA 2993709A CA 2993709 A CA2993709 A CA 2993709A CA 2993709 A1 CA2993709 A1 CA 2993709A1
Authority
CA
Canada
Prior art keywords
liquid
container
broth
disposable bioprocess
valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2993709A
Other languages
English (en)
French (fr)
Inventor
Per Stobbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stobbe GmbH
Original Assignee
Stobbe Pharma Tech GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stobbe Pharma Tech GmbH filed Critical Stobbe Pharma Tech GmbH
Publication of CA2993709A1 publication Critical patent/CA2993709A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/04—Seals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2993709A 2015-08-08 2016-05-17 Disposable bioprocess system supporting biological activity Pending CA2993709A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201500453 2015-08-08
DKPA201500453 2015-08-08
PCT/EP2016/061000 WO2017025210A1 (en) 2015-08-08 2016-05-17 Disposable bioprocess system supporting biological activity

Publications (1)

Publication Number Publication Date
CA2993709A1 true CA2993709A1 (en) 2017-02-16

Family

ID=56068872

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2993709A Pending CA2993709A1 (en) 2015-08-08 2016-05-17 Disposable bioprocess system supporting biological activity

Country Status (7)

Country Link
US (4) US11414642B2 (enExample)
EP (1) EP3331983A1 (enExample)
JP (4) JP2018534940A (enExample)
KR (2) KR102621101B1 (enExample)
CN (1) CN108350405A (enExample)
CA (1) CA2993709A1 (enExample)
WO (1) WO2017025210A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3665261A1 (en) * 2017-12-20 2020-06-17 Sartorius Stedim Biotech GmbH Insertable components for single-use containers
US20210155888A1 (en) * 2018-08-08 2021-05-27 Sartorius Stedim Biotech Gmbh Bioreactor with filter unit and method for treating a cell broth

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230042475A1 (en) * 2015-08-08 2023-02-09 Stobbe Gmbh Disposable bioprocess system supporting biological activity
CN108350405A (zh) * 2015-08-08 2018-07-31 施托贝制药技术股份有限公司 支持生物活性的一次性生物处理系统
CN115225233B (zh) 2017-06-16 2024-08-20 韦勒斯标准与技术协会公司 使用时分双工方案的无线通信系统的用户设备及操作方法
WO2019067966A1 (en) * 2017-09-29 2019-04-04 Lonza Ltd. INFUSION APPARATUS FOR USE IN BIOREACTOR SYSTEMS
GB201717652D0 (en) * 2017-10-26 2017-12-13 Ge Healthcare Bio Sciences Ab Bioprocess System
DE102017127017A1 (de) * 2017-11-16 2019-05-16 Sartorius Stedim Biotech Gmbh Automatisierte Einweg-Filtrationsvorrichtung und Verfahren zur Steuerung einer automatisierten Einweg-Filtrationsvorrichtung
GB201719769D0 (en) * 2017-11-28 2018-01-10 Cronin 3D Ltd Analytical device and methods of use
US10792594B2 (en) * 2017-12-28 2020-10-06 Replegin Corporation Dual pumping arrangement for a hollow fiber filter
CN110241012B (zh) * 2018-03-09 2022-11-01 嘉和生物药业有限公司 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用
JP7144958B2 (ja) 2018-03-30 2022-09-30 株式会社エビデント 観察装置および観察システム
KR101996617B1 (ko) * 2018-10-11 2019-07-04 주식회사 엘지화학 일체형 카트리지
IL263127B (en) * 2018-11-19 2022-07-01 The Interdisciplinary Center Herzliya Cc A liquid-based biological system
DE102019100339B4 (de) * 2019-01-08 2023-07-06 Sartorius Stedim Biotech Gmbh Bioprozesstechnische Anlage
SG11202107432RA (en) * 2019-01-10 2021-08-30 Repligen Corp Hollow fiber filtration systems and methods
US11103827B2 (en) * 2019-02-05 2021-08-31 Generon Igs, Inc. Two-stage gas separation unit contained within a single housing
US11708555B2 (en) * 2019-05-30 2023-07-25 Global Life Sciences Solutions Usa Llc System, method and apparatus for draining a bioreactor vessel
TWI874409B (zh) * 2019-06-13 2025-03-01 美商安進公司 生物製品製造中基於生物量之自動灌注控制
DE102019117446A1 (de) 2019-06-27 2020-12-31 Schott Ag Multi-Sensor-Komponente zur Bioprozesskontrolle
US20210054326A1 (en) * 2019-08-22 2021-02-25 Alliance For Sustainable Energy, Llc Reactor for cell growth
KR20220119689A (ko) * 2019-12-23 2022-08-30 어시스트 메디칼 시스템즈, 인크. 모듈식 유체 전달 시스템
US11535421B2 (en) * 2019-12-30 2022-12-27 Global Life Sciences Solutions Usa Llc System and method for packaging a bioprocessing bag and associated components, and packaging for a bioprocessing bag
KR20220120582A (ko) * 2020-01-02 2022-08-30 에프. 호프만-라 로슈 아게 하나 이상의 인시튜 온라인 센서를 갖는 일회용 세포 배양 용기
EP3854867A1 (de) * 2020-01-23 2021-07-28 FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. Vorkehrung zur kultivierung von prokryotischen und eukaryotischen zellen in einer strukturierten matrix unter physikalischer kräfteeinwirkung
AU2021223603A1 (en) * 2020-02-21 2022-09-01 Braskem S.A. Production of ethanol with one or more co-products in yeast
WO2021187008A1 (ja) * 2020-03-18 2021-09-23 富士フイルム株式会社 細胞培養装置、細胞培養方法及び産生物の製造方法
GB2593223A (en) * 2020-03-20 2021-09-22 Dairy Crest Ltd Reactor
EP4127127A4 (en) * 2020-03-27 2025-07-23 Broadley James Corp SINGLE-USE BIOREACTOR ASSEMBLY WITH INTEGRATED PUMP HEADS
CN115867636A (zh) * 2020-07-06 2023-03-28 默克专利股份公司 用于细胞培养基制备和进行细胞培养的装置和方法
CA3189927A1 (en) * 2020-07-20 2022-01-27 Janssen Biotech, Inc. Fluid filtration system
EP4015614A1 (en) 2020-12-15 2022-06-22 Alfa Laval Corporate AB Method for operating a bioprocessing system and a bioprocessing system
US20240239647A1 (en) * 2021-06-04 2024-07-18 Alphinity Usa, Inc. Vessels with integrated pump having multiple outlets and return lines with agitation or mixing properties
US20230211260A1 (en) * 2021-12-31 2023-07-06 Pall Corporation Fluid filtration system with single use filter and method of using same for automated filter conditioning
US12297825B2 (en) 2022-04-14 2025-05-13 Viking Pump, Inc. Expandable, inner liner pump
GB202210354D0 (en) * 2022-07-14 2022-08-31 Bedford Grant Richard A closure for a bioreactor
CN116640649B (zh) * 2023-06-02 2023-11-28 广州沃道生物科技有限公司 一种好氧农用微生物菌剂生产用高效发酵设备
WO2024256454A2 (en) 2023-06-14 2024-12-19 Stobbe Gmbh Bioprocess system extending a biological process
US12235195B1 (en) * 2024-07-29 2025-02-25 Chinese Research Academy Of Environmental Science Water environmental DNA collection apparatus

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0345588A1 (de) * 1988-06-03 1989-12-13 Gesellschaft für Biotechnologische Forschung mbH (GBF) Verfahren und Anordnung zur Regelung eines biologischen Wachstumsprozesses
GB9111028D0 (en) * 1991-05-22 1991-07-17 Bio Flo Ltd Fluid treatment system
US5252041A (en) * 1992-04-30 1993-10-12 Dorr-Oliver Incorporated Automatic control system for diaphragm pumps
JP3083275B2 (ja) * 1997-09-18 2000-09-04 株式会社ワイ・テイ・エス ダブルダイヤフラム式ポンプ
EP0995483A1 (en) 1998-10-23 2000-04-26 The Procter & Gamble Company A cross-flow filtration apparatus
US6544424B1 (en) * 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
US6544788B2 (en) * 2001-02-15 2003-04-08 Vijay Singh Disposable perfusion bioreactor for cell culture
US7905710B2 (en) * 2004-03-26 2011-03-15 Hospira, Inc. System and method for improved low flow medical pump delivery
DE102004019234B3 (de) 2004-04-16 2005-11-24 Sartorius Ag Bioreaktor zur Kultivierung von Mikroorganismen
WO2006101883A2 (en) * 2005-03-16 2006-09-28 Single Use Brx, Llc Apparatus and method for mixing with a diaphragm pump
US8057092B2 (en) 2006-11-30 2011-11-15 Corning Incorporated Disposable spinner flask
JP2009203822A (ja) * 2008-02-26 2009-09-10 Star Micronics Co Ltd ダイヤフラムポンプ
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
WO2010038613A1 (ja) * 2008-09-30 2010-04-08 東レ株式会社 化学品の製造方法および連続培養装置
EP2186634A1 (en) * 2008-11-13 2010-05-19 Amcor Flexibles Transpac N.V. Curl-free polyolefin-based packaging film used for the packaging of sterile products
GB0820779D0 (en) 2008-11-13 2008-12-17 Artelis S A Cell culture device and method of culturing cells
US9228579B2 (en) * 2008-12-19 2016-01-05 Stobbe Tech A/S Method and device for industrial biolayer cultivation
CH702437A1 (fr) * 2009-12-23 2011-06-30 Jean-Denis Rochat Pompe volumetrique alternative a membrane pour usage medical.
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof
US20130196375A1 (en) * 2010-06-23 2013-08-01 Strobbe Tech A/S Biopharmaceutical process apparatuses assembled into a column
US9446354B2 (en) * 2010-08-25 2016-09-20 Repligen Corporation Device, system and process for modification or concentration of cell-depleted fluid
US20130280773A1 (en) * 2010-12-22 2013-10-24 Toray Industries, Inc. Method for producing chemical by continuous fermentation
US9469671B2 (en) * 2011-09-03 2016-10-18 Therapeutic Proteins International, LLC Closed bioreactor
JP6073903B2 (ja) * 2011-10-10 2017-02-01 ダスギプ・インフォメーション・アンド・プロセス・テクノロジー・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＤａｓｇｉｐ Ｉｎｆｏｒｍａｔｉｏｎ Ａｎｄ Ｐｒｏｃｅｓｓ Ｔｅｃｈｎｏｌｏｇｙ Ｇｍｂｈ バイオリアクタを有するバイオテクノロジー装置、バイオリアクタのための排気ガス温度制御デバイス、およびバイオテクノロジー装置内を流れる排気ガスを処理する方法
CN102559480B (zh) * 2011-12-27 2013-02-06 浙江大学 外置式甲烷无泡曝气生物膜反硝化型甲烷厌氧氧化菌富集装置及方法
US9416344B2 (en) 2012-03-15 2016-08-16 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
DK2674480T4 (da) 2012-06-15 2023-05-30 Dasgip Information And Process Tech Gmbh Tilslutningsindretning til en steril envejs-fluidledning af en envejsbioreaktor og fremgangsmåde til behandling af en fluidstrøm
DK2674479T4 (da) 2012-06-15 2025-03-31 Eppendorf Se Envejsbioreaktor og topplade samt fremgangsmåde til fremstilling
US9663753B2 (en) * 2012-09-27 2017-05-30 Ge Healthcare Bio-Sciences Ab Tangential flow perfusion system
CN105339075A (zh) * 2013-06-21 2016-02-17 东丽株式会社 过滤器装置、化学品制造装置和过滤器装置的操作方法
CN108350405A (zh) * 2015-08-08 2018-07-31 施托贝制药技术股份有限公司 支持生物活性的一次性生物处理系统

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3665261A1 (en) * 2017-12-20 2020-06-17 Sartorius Stedim Biotech GmbH Insertable components for single-use containers
US20210155888A1 (en) * 2018-08-08 2021-05-27 Sartorius Stedim Biotech Gmbh Bioreactor with filter unit and method for treating a cell broth
US12252680B2 (en) * 2018-08-08 2025-03-18 Sartorius Stedim Biotech Gmbh Bioreactor with filter unit and method for treating a cell broth

Also Published As

Publication number Publication date
CN108350405A (zh) 2018-07-31
US20180155667A1 (en) 2018-06-07
JP2023100943A (ja) 2023-07-19
KR102621101B1 (ko) 2024-01-05
WO2017025210A1 (en) 2017-02-16
KR20230156168A (ko) 2023-11-13
US12157878B2 (en) 2024-12-03
JP2021061853A (ja) 2021-04-22
US11414642B2 (en) 2022-08-16
EP3331983A1 (en) 2018-06-13
JP7298054B2 (ja) 2023-06-27
KR20180040134A (ko) 2018-04-19
US20180237737A1 (en) 2018-08-23
US12110484B2 (en) 2024-10-08
US20230203426A1 (en) 2023-06-29
JP2025148484A (ja) 2025-10-07
JP2018534940A (ja) 2018-11-29
US20220333059A1 (en) 2022-10-20

Similar Documents

Publication Publication Date Title
US12110484B2 (en) Disposable bioprocess system supporting biological activity
AU2016397306B2 (en) A bioreactor system and method thereof
US20110201100A1 (en) Single use cell culture bioreactor manifold system
US20160319234A1 (en) Continuously controlled hollow fiber bioreactor
US5270207A (en) Circulatory culture equipment
US20110236932A1 (en) Biopharmaceutical plant in a column
US20130196375A1 (en) Biopharmaceutical process apparatuses assembled into a column
CN110066730A (zh) 切向流动灌注系统
US20230056468A1 (en) Retention system
US20230042475A1 (en) Disposable bioprocess system supporting biological activity
JPS62130683A (ja) 哺乳動物細胞を培養する方法および装置
US20190169561A1 (en) In-situ cell retention perfusion bioreactors
JP6705725B2 (ja) 細胞分離装置および培養装置
WO2024256454A2 (en) Bioprocess system extending a biological process
CN119499880A (zh) 一种过滤系统及其方法

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225

EEER Examination request

Effective date: 20210225