CA2990192A1 - Compositions and methods for inhibiting arginase activity - Google Patents
Compositions and methods for inhibiting arginase activity Download PDFInfo
- Publication number
- CA2990192A1 CA2990192A1 CA2990192A CA2990192A CA2990192A1 CA 2990192 A1 CA2990192 A1 CA 2990192A1 CA 2990192 A CA2990192 A CA 2990192A CA 2990192 A CA2990192 A CA 2990192A CA 2990192 A1 CA2990192 A1 CA 2990192A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- aryl
- cancer
- alkylene
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 154
- 230000000694 effects Effects 0.000 title claims description 19
- 239000000203 mixture Substances 0.000 title description 54
- 102000004452 Arginase Human genes 0.000 title description 19
- 108700024123 Arginases Proteins 0.000 title description 19
- 230000002401 inhibitory effect Effects 0.000 title description 3
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 172
- 239000004475 Arginine Substances 0.000 claims abstract description 164
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 164
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- 125000003118 aryl group Chemical group 0.000 claims description 160
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| US201562183524P | 2015-06-23 | 2015-06-23 | |
| US62/183,524 | 2015-06-23 | ||
| PCT/US2016/038983 WO2016210106A1 (en) | 2015-06-23 | 2016-06-23 | Compositions and methods for inhibiting arginase activity |
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| EP (1) | EP3313410A4 (OSRAM) |
| JP (2) | JP2018520352A (OSRAM) |
| KR (1) | KR20180021117A (OSRAM) |
| CN (1) | CN107921051A (OSRAM) |
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| WO (1) | WO2016210106A1 (OSRAM) |
| ZA (1) | ZA201800328B (OSRAM) |
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| RU2586219C2 (ru) | 2010-04-22 | 2016-06-10 | Марс, Инкорпорейтед | Ингибиторы аргиназы и их терапевтические применения |
| AU2011320732B2 (en) | 2010-10-26 | 2018-07-05 | Mars Incorporated | Boronates as arginase inhibitors |
| KR20180021117A (ko) | 2015-06-23 | 2018-02-28 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 아르기나제 활성 억제를 위한 조성물 및 방법 |
| MA43131B1 (fr) * | 2015-10-30 | 2020-07-29 | Calithera Biosciences Inc | Compositions et procédés d'inhibition de l'activité de l'arginase |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| MA46793A (fr) | 2016-11-08 | 2019-09-18 | Calithera Biosciences Inc | Polythérapies faisant appel à un inhibiteur d'arginase |
| SG10201911243WA (en) | 2016-12-22 | 2020-02-27 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity |
| CN108794517B (zh) * | 2017-04-27 | 2021-03-30 | 南京谷睿生物科技有限公司 | 一种精氨酸酶抑制剂及其制备方法与用途 |
| EA201992695A1 (ru) * | 2017-05-12 | 2020-05-15 | Калитера Байосайнсиз, Инк. | Способ получения (3r,4s)-3-ацетамидо-4-аллил-n-(трет-бутил)пирролидин-3-карбоксамида |
| WO2019000163A1 (zh) * | 2017-06-26 | 2019-01-03 | 余祖江 | 精氨酸在制备抗肿瘤药物中的用途 |
| WO2019120296A1 (en) * | 2017-12-22 | 2019-06-27 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heterocyclic compounds as arginase inhibitors |
| DK3752251T3 (da) | 2018-02-17 | 2025-12-15 | Astrazeneca Ab | Arginasehæmmere og fremgangsmåder til anvendelse deraf |
| SG11202008113RA (en) * | 2018-03-05 | 2020-09-29 | Arcus Biosciences Inc | Arginase inhibitors |
| US10851099B2 (en) | 2018-03-29 | 2020-12-01 | Oncoarendi Therapeutics S.A. | Dipeptide piperidine derivatives |
| CN111770756B (zh) * | 2018-04-27 | 2023-03-31 | 四川科伦博泰生物医药股份有限公司 | 非天然氨基酸类衍生物、包含其的药物组合物及其制备方法和用途 |
| RS65608B1 (sr) * | 2018-08-22 | 2024-07-31 | Astrazeneca Ab | Inhibitori arginaze i postupci za njihovo korišćenje |
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| JP2021185146A (ja) | 2021-12-09 |
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| US20190343852A1 (en) | 2019-11-14 |
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| MY192605A (en) | 2022-08-29 |
| SG10202110144TA (en) | 2021-10-28 |
| ZA201800328B (en) | 2018-12-19 |
| US20180360860A1 (en) | 2018-12-20 |
| EP3313410A1 (en) | 2018-05-02 |
| IL256352A (en) | 2018-02-28 |
| CN107921051A (zh) | 2018-04-17 |
| MA42269A (fr) | 2018-05-02 |
| AU2016281620B2 (en) | 2021-07-22 |
| US20210077510A1 (en) | 2021-03-18 |
| EP3313410A4 (en) | 2019-01-02 |
| JP2018520352A (ja) | 2018-07-26 |
| PH12017502391A1 (en) | 2018-06-25 |
| MX385315B (es) | 2025-03-14 |
| EA201890113A1 (ru) | 2018-07-31 |
| WO2016210106A1 (en) | 2016-12-29 |
| US10143699B2 (en) | 2018-12-04 |
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