CA2989814A1 - Nasolacrimal implants and related methods for tear stimulation - Google Patents
Nasolacrimal implants and related methods for tear stimulation Download PDFInfo
- Publication number
- CA2989814A1 CA2989814A1 CA2989814A CA2989814A CA2989814A1 CA 2989814 A1 CA2989814 A1 CA 2989814A1 CA 2989814 A CA2989814 A CA 2989814A CA 2989814 A CA2989814 A CA 2989814A CA 2989814 A1 CA2989814 A1 CA 2989814A1
- Authority
- CA
- Canada
- Prior art keywords
- stimulator
- stimulation
- stimulus
- proximal end
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
- A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37205—Microstimulators, e.g. implantable through a cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
- A61N1/37223—Circuits for electromagnetic coupling
- A61N1/37229—Shape or location of the implanted or external antenna
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/378—Electrical supply
- A61N1/3787—Electrical supply from an external energy source
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Acoustics & Sound (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Surgery (AREA)
- Thermal Sciences (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rehabilitation Therapy (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Prostheses (AREA)
- Electrotherapy Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562180265P | 2015-06-16 | 2015-06-16 | |
| US62/180,265 | 2015-06-16 | ||
| US201662321961P | 2016-04-13 | 2016-04-13 | |
| US62/321,961 | 2016-04-13 | ||
| PCT/US2016/037167 WO2016205107A1 (en) | 2015-06-16 | 2016-06-13 | Nasolacrimal implants and related methods for tear stimulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2989814A1 true CA2989814A1 (en) | 2016-12-22 |
Family
ID=56360477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2989814A Abandoned CA2989814A1 (en) | 2015-06-16 | 2016-06-13 | Nasolacrimal implants and related methods for tear stimulation |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US10004634B2 (https=) |
| EP (1) | EP3310433A1 (https=) |
| JP (1) | JP2018517517A (https=) |
| CN (1) | CN107835706A (https=) |
| AU (1) | AU2016277825B2 (https=) |
| CA (1) | CA2989814A1 (https=) |
| WO (1) | WO2016205107A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
| EP2967817B1 (en) | 2013-03-12 | 2021-03-10 | Oculeve, Inc. | Implant delivery devices and systems |
| EP2986339A4 (en) | 2013-04-19 | 2016-12-21 | Oculeve Inc | Nasal stimulation devices and methods |
| US9770583B2 (en) | 2014-02-25 | 2017-09-26 | Oculeve, Inc. | Polymer formulations for nasolacrimal stimulation |
| WO2015196164A2 (en) | 2014-06-21 | 2015-12-23 | Accelemed, Llc | Method and apparatus for neuromodulation treatments of pain and other conditions |
| US9687652B2 (en) | 2014-07-25 | 2017-06-27 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
| EP3209371A4 (en) | 2014-10-22 | 2018-10-24 | Oculeve, Inc. | Implantable nasal stimulator systems and methods |
| EP3721938A1 (en) | 2014-10-22 | 2020-10-14 | Oculeve, Inc. | Stimulation devices and methods for treating dry eye |
| AU2015335772B2 (en) | 2014-10-22 | 2020-07-09 | Oculeve, Inc. | Contact lens for increasing tear production |
| WO2017044904A1 (en) | 2015-09-11 | 2017-03-16 | Nalu Medical, Inc. | Apparatus for peripheral or spinal stimulation |
| US10426958B2 (en) * | 2015-12-04 | 2019-10-01 | Oculeve, Inc. | Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
| IL243686B (en) | 2016-01-19 | 2022-05-01 | Epitech Mag Ltd | Device for increasing the integrity of the eye epithelium using magnetic pulses |
| AU2017221321B2 (en) | 2016-02-19 | 2021-04-15 | Nalu Medical, Inc. | Apparatus with enhanced stimulation waveforms |
| US10252048B2 (en) | 2016-02-19 | 2019-04-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
| WO2017165410A1 (en) | 2016-03-21 | 2017-09-28 | Nalu Medical, Inc. | Devices and methods for positioning external devices in relation to implanted devices |
| US10695219B2 (en) * | 2016-04-08 | 2020-06-30 | ThermiGen, LLC | Apparatus and method for treatment of dry eye using radio frequency heating |
| AU2017260237A1 (en) | 2016-05-02 | 2018-11-22 | Oculeve, Inc. | Intranasal stimulation for treatment of meibomian gland disease and blepharitis |
| EP3484577B1 (en) | 2016-07-18 | 2025-06-18 | Nalu Medical, Inc. | Systems for treating pelvic disorders and pain conditions |
| JP7044795B2 (ja) | 2016-10-14 | 2022-03-30 | オリンピック オフサルミック, インコーポレイテッド | 眼の疾患のための治療用超音波 |
| US12233017B2 (en) | 2016-10-14 | 2025-02-25 | Olympic Ophthalmics, Inc. | Quiet handheld devices and methods for treatment of disorders |
| EP3547898A4 (en) | 2016-12-02 | 2020-07-08 | Oculeve, Inc. | APPARATUS AND METHOD FOR PREDICTING EYE DROUGHT AND TREATMENT RECOMMENDATION |
| WO2018126062A1 (en) | 2016-12-30 | 2018-07-05 | Nalu Medical, Inc. | Stimulation apparatus |
| EP3585475B1 (en) | 2017-02-24 | 2024-04-03 | Nalu Medical, Inc. | Apparatus with sequentially implanted stimulators |
| WO2018208992A1 (en) | 2017-05-09 | 2018-11-15 | Nalu Medical, Inc. | Stimulation apparatus |
| IL253677B2 (en) | 2017-07-26 | 2023-06-01 | Epitech Mag Ltd | A magnetic device for the treatment of living tissues |
| US11554104B2 (en) * | 2017-08-18 | 2023-01-17 | The Schepens Eye Research Institute, Inc. | Compositions for the treatment of dry eye and methods of use thereof |
| US11147737B2 (en) | 2018-02-26 | 2021-10-19 | Olympic Ophthalmics, Inc. | Handheld device with motorized member for treatment of disorders |
| KR102521685B1 (ko) | 2018-10-02 | 2023-04-14 | 주식회사 티엠디랩 | 형상기억 고분자를 포함하는 비루관 튜브 |
| PE20211169A1 (es) * | 2018-10-15 | 2021-06-30 | Burgos Alejandro Gamboa | Aplicador de soluciones oftalmicas en envases de monodosis y un kit que contiene el mismo |
| WO2020130176A1 (ko) * | 2018-12-19 | 2020-06-25 | 부산대학교 산학협력단 | 안구 건조증 치료용 장치 |
| US11730358B2 (en) * | 2019-02-15 | 2023-08-22 | California Institute Of Technology | Tear flow measurement device |
| US11446495B2 (en) | 2019-05-14 | 2022-09-20 | Twenty Twenty Therapeutics Llc | Therapeutic devices for placement underneath the eyelid and associated systems, devices, and methods for dry eye treatment |
| IL267166B (en) * | 2019-06-06 | 2022-06-01 | Novoxel Ltd | System and method for treating eyelid inflammation by creating lesions in skin tissue |
| EP3993866A4 (en) | 2019-07-02 | 2023-07-12 | Nalu Medical, Inc. | Stimulation apparatus |
| US20210338481A1 (en) * | 2020-04-20 | 2021-11-04 | Bruce B. Becker | Lacrimal gland implant for drug delivery and method |
| US20220313999A1 (en) * | 2021-03-31 | 2022-10-06 | Twenty Twenty Therapeutics Llc | Multidirectional periocular nerve stimulation and associated systems, devices, and methods |
| US11813468B2 (en) * | 2021-07-16 | 2023-11-14 | Medtronic, Inc. | Connector conditioning/bore plug |
| CN114306925B (zh) * | 2022-01-05 | 2023-03-17 | 苏州好博医疗器械股份有限公司 | 一种手持式电极 |
| US12472376B2 (en) | 2022-02-06 | 2025-11-18 | Demaod Ltd | Devices and methods for stimulating tear secretion |
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| US5713833A (en) | 1994-01-26 | 1998-02-03 | Milligan; Lee John | Septum nerve stimulator |
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| RU2013127313A (ru) | 2010-11-16 | 2014-12-27 | Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити | Системы и способы лечения сухого глаза |
| US9821159B2 (en) * | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
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| EP2945686B1 (en) | 2013-01-15 | 2024-11-20 | The Regents of The University of Colorado, A Body Corporate | Lacrimal system drug delivery device |
| WO2014138709A1 (en) | 2013-03-08 | 2014-09-12 | Oculeve, Inc. | Devices and methods for treating dry eye in animals |
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| US9770583B2 (en) | 2014-02-25 | 2017-09-26 | Oculeve, Inc. | Polymer formulations for nasolacrimal stimulation |
| US9687652B2 (en) | 2014-07-25 | 2017-06-27 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
-
2016
- 2016-06-13 US US15/180,451 patent/US10004634B2/en active Active
- 2016-06-13 AU AU2016277825A patent/AU2016277825B2/en not_active Ceased
- 2016-06-13 CA CA2989814A patent/CA2989814A1/en not_active Abandoned
- 2016-06-13 EP EP16735753.2A patent/EP3310433A1/en not_active Withdrawn
- 2016-06-13 JP JP2017565074A patent/JP2018517517A/ja active Pending
- 2016-06-13 CN CN201680040343.8A patent/CN107835706A/zh active Pending
- 2016-06-13 WO PCT/US2016/037167 patent/WO2016205107A1/en not_active Ceased
- 2016-11-08 US US15/345,765 patent/US10004635B2/en active Active
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2017
- 2017-09-29 US US15/719,986 patent/US20180036169A1/en not_active Abandoned
- 2017-09-29 US US15/719,937 patent/US20180021171A1/en not_active Abandoned
- 2017-12-29 US US15/858,277 patent/US20180116872A1/en not_active Abandoned
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| AU2016277825B2 (en) | 2019-04-18 |
| EP3310433A1 (en) | 2018-04-25 |
| US20160367806A1 (en) | 2016-12-22 |
| JP2018517517A (ja) | 2018-07-05 |
| US20180036169A1 (en) | 2018-02-08 |
| US20180116872A1 (en) | 2018-05-03 |
| AU2016277825A1 (en) | 2018-01-18 |
| CN107835706A (zh) | 2018-03-23 |
| US10004634B2 (en) | 2018-06-26 |
| US20180021171A1 (en) | 2018-01-25 |
| US10004635B2 (en) | 2018-06-26 |
| WO2016205107A1 (en) | 2016-12-22 |
| US20170049619A1 (en) | 2017-02-23 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20171215 |
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| FZDE | Discontinued |
Effective date: 20200831 |