AU2016277825B2 - Nasolacrimal implants and related methods for tear stimulation - Google Patents

Nasolacrimal implants and related methods for tear stimulation Download PDF

Info

Publication number
AU2016277825B2
AU2016277825B2 AU2016277825A AU2016277825A AU2016277825B2 AU 2016277825 B2 AU2016277825 B2 AU 2016277825B2 AU 2016277825 A AU2016277825 A AU 2016277825A AU 2016277825 A AU2016277825 A AU 2016277825A AU 2016277825 B2 AU2016277825 B2 AU 2016277825B2
Authority
AU
Australia
Prior art keywords
stimulator
stimulus
stimulation
subject
lacrimal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016277825A
Other languages
English (en)
Other versions
AU2016277825A1 (en
Inventor
Malik Y. Kahook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Colorado Colorado Springs
Original Assignee
University of Colorado System
University of Colorado Colorado Springs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Colorado System, University of Colorado Colorado Springs filed Critical University of Colorado System
Publication of AU2016277825A1 publication Critical patent/AU2016277825A1/en
Application granted granted Critical
Publication of AU2016277825B2 publication Critical patent/AU2016277825B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026Ophthalmic product dispenser attachments to facilitate positioning near the eye
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00772Apparatus for restoration of tear ducts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/02Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36046Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37205Microstimulators, e.g. implantable through a cannula
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators
    • A61N1/37217Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A61N1/37223Circuits for electromagnetic coupling
    • A61N1/37229Shape or location of the implanted or external antenna
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/378Electrical supply
    • A61N1/3787Electrical supply from an external energy source
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/004Magnetotherapy specially adapted for a specific therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • A61N5/0603Apparatus for use inside the body for treatment of body cavities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36057Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N2007/0004Applications of ultrasound therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Acoustics & Sound (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Surgery (AREA)
  • Thermal Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Prostheses (AREA)
  • Electrotherapy Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
AU2016277825A 2015-06-16 2016-06-13 Nasolacrimal implants and related methods for tear stimulation Ceased AU2016277825B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562180265P 2015-06-16 2015-06-16
US62/180,265 2015-06-16
US201662321961P 2016-04-13 2016-04-13
US62/321,961 2016-04-13
PCT/US2016/037167 WO2016205107A1 (en) 2015-06-16 2016-06-13 Nasolacrimal implants and related methods for tear stimulation

Publications (2)

Publication Number Publication Date
AU2016277825A1 AU2016277825A1 (en) 2018-01-18
AU2016277825B2 true AU2016277825B2 (en) 2019-04-18

Family

ID=56360477

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016277825A Ceased AU2016277825B2 (en) 2015-06-16 2016-06-13 Nasolacrimal implants and related methods for tear stimulation

Country Status (7)

Country Link
US (5) US10004634B2 (https=)
EP (1) EP3310433A1 (https=)
JP (1) JP2018517517A (https=)
CN (1) CN107835706A (https=)
AU (1) AU2016277825B2 (https=)
CA (1) CA2989814A1 (https=)
WO (1) WO2016205107A1 (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9821159B2 (en) 2010-11-16 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
EP2967817B1 (en) 2013-03-12 2021-03-10 Oculeve, Inc. Implant delivery devices and systems
EP2986339A4 (en) 2013-04-19 2016-12-21 Oculeve Inc Nasal stimulation devices and methods
US9770583B2 (en) 2014-02-25 2017-09-26 Oculeve, Inc. Polymer formulations for nasolacrimal stimulation
WO2015196164A2 (en) 2014-06-21 2015-12-23 Accelemed, Llc Method and apparatus for neuromodulation treatments of pain and other conditions
US9687652B2 (en) 2014-07-25 2017-06-27 Oculeve, Inc. Stimulation patterns for treating dry eye
EP3209371A4 (en) 2014-10-22 2018-10-24 Oculeve, Inc. Implantable nasal stimulator systems and methods
EP3721938A1 (en) 2014-10-22 2020-10-14 Oculeve, Inc. Stimulation devices and methods for treating dry eye
AU2015335772B2 (en) 2014-10-22 2020-07-09 Oculeve, Inc. Contact lens for increasing tear production
WO2017044904A1 (en) 2015-09-11 2017-03-16 Nalu Medical, Inc. Apparatus for peripheral or spinal stimulation
US10426958B2 (en) * 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
IL243686B (en) 2016-01-19 2022-05-01 Epitech Mag Ltd Device for increasing the integrity of the eye epithelium using magnetic pulses
AU2017221321B2 (en) 2016-02-19 2021-04-15 Nalu Medical, Inc. Apparatus with enhanced stimulation waveforms
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
WO2017165410A1 (en) 2016-03-21 2017-09-28 Nalu Medical, Inc. Devices and methods for positioning external devices in relation to implanted devices
US10695219B2 (en) * 2016-04-08 2020-06-30 ThermiGen, LLC Apparatus and method for treatment of dry eye using radio frequency heating
AU2017260237A1 (en) 2016-05-02 2018-11-22 Oculeve, Inc. Intranasal stimulation for treatment of meibomian gland disease and blepharitis
EP3484577B1 (en) 2016-07-18 2025-06-18 Nalu Medical, Inc. Systems for treating pelvic disorders and pain conditions
JP7044795B2 (ja) 2016-10-14 2022-03-30 オリンピック オフサルミック, インコーポレイテッド 眼の疾患のための治療用超音波
US12233017B2 (en) 2016-10-14 2025-02-25 Olympic Ophthalmics, Inc. Quiet handheld devices and methods for treatment of disorders
EP3547898A4 (en) 2016-12-02 2020-07-08 Oculeve, Inc. APPARATUS AND METHOD FOR PREDICTING EYE DROUGHT AND TREATMENT RECOMMENDATION
WO2018126062A1 (en) 2016-12-30 2018-07-05 Nalu Medical, Inc. Stimulation apparatus
EP3585475B1 (en) 2017-02-24 2024-04-03 Nalu Medical, Inc. Apparatus with sequentially implanted stimulators
WO2018208992A1 (en) 2017-05-09 2018-11-15 Nalu Medical, Inc. Stimulation apparatus
IL253677B2 (en) 2017-07-26 2023-06-01 Epitech Mag Ltd A magnetic device for the treatment of living tissues
US11554104B2 (en) * 2017-08-18 2023-01-17 The Schepens Eye Research Institute, Inc. Compositions for the treatment of dry eye and methods of use thereof
US11147737B2 (en) 2018-02-26 2021-10-19 Olympic Ophthalmics, Inc. Handheld device with motorized member for treatment of disorders
KR102521685B1 (ko) 2018-10-02 2023-04-14 주식회사 티엠디랩 형상기억 고분자를 포함하는 비루관 튜브
PE20211169A1 (es) * 2018-10-15 2021-06-30 Burgos Alejandro Gamboa Aplicador de soluciones oftalmicas en envases de monodosis y un kit que contiene el mismo
WO2020130176A1 (ko) * 2018-12-19 2020-06-25 부산대학교 산학협력단 안구 건조증 치료용 장치
US11730358B2 (en) * 2019-02-15 2023-08-22 California Institute Of Technology Tear flow measurement device
US11446495B2 (en) 2019-05-14 2022-09-20 Twenty Twenty Therapeutics Llc Therapeutic devices for placement underneath the eyelid and associated systems, devices, and methods for dry eye treatment
IL267166B (en) * 2019-06-06 2022-06-01 Novoxel Ltd System and method for treating eyelid inflammation by creating lesions in skin tissue
EP3993866A4 (en) 2019-07-02 2023-07-12 Nalu Medical, Inc. Stimulation apparatus
US20210338481A1 (en) * 2020-04-20 2021-11-04 Bruce B. Becker Lacrimal gland implant for drug delivery and method
US20220313999A1 (en) * 2021-03-31 2022-10-06 Twenty Twenty Therapeutics Llc Multidirectional periocular nerve stimulation and associated systems, devices, and methods
US11813468B2 (en) * 2021-07-16 2023-11-14 Medtronic, Inc. Connector conditioning/bore plug
CN114306925B (zh) * 2022-01-05 2023-03-17 苏州好博医疗器械股份有限公司 一种手持式电极
US12472376B2 (en) 2022-02-06 2025-11-18 Demaod Ltd Devices and methods for stimulating tear secretion

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012139063A2 (en) * 2011-04-07 2012-10-11 Oculeve, Inc. Stimulation devices and methods

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US4745100A (en) 1985-05-14 1988-05-17 Eye Research Institute Of Retina Foundation Stimulation of tear secretion
US4951683A (en) 1989-01-19 1990-08-28 Davis Jeffrey P Device for detecting keratoconjunctivitis sicca
US5713833A (en) 1994-01-26 1998-02-03 Milligan; Lee John Septum nerve stimulator
US5961987A (en) 1996-10-31 1999-10-05 University Of Iowa Research Foundation Ocular protein stimulants
WO2000067676A1 (de) * 1999-05-07 2000-11-16 Eberhard-Karls-Universität Tübingen Universitätsklinikum Retina-implantat und verfahren zur herstellung eines solchen
US7146209B2 (en) 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
US20020035358A1 (en) 2000-05-09 2002-03-21 Ming Wang Pulsed electromagnetic field therapy for treatment of corneal disorders and injuries
US7204995B2 (en) 2002-01-31 2007-04-17 El-Sherif Dalia M Treatment and control of dry eye by use of biodegradable polymer capsules
JP2004208898A (ja) 2002-12-27 2004-07-29 Japan Science & Technology Agency 緑内障治療用房水排出インプラント
US20090240276A1 (en) 2003-11-04 2009-09-24 Parviz Robert Ainpour Gel Plug For Blockage Of The Canaliculus
US20050197614A1 (en) 2004-03-04 2005-09-08 Wilson Pritchard Occlusive biomedical devices, punctum plugs, and methods of use thereof
DK1765454T3 (en) 2004-07-02 2016-05-02 Mati Therapeutics Inc Device for submission of treatment medium to eye
US7117870B2 (en) 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
WO2006031658A2 (en) 2004-09-10 2006-03-23 Allergan, Inc. Therapeutic lacrimal canalicular inserts and related methods
SE0403020D0 (sv) * 2004-12-13 2004-12-13 Rickard Braanemark Implantat
US8401665B2 (en) * 2005-04-01 2013-03-19 Boston Scientific Neuromodulation Corporation Apparatus and methods for detecting position and migration of neurostimulation leads
US8950405B2 (en) 2006-05-15 2015-02-10 Tearscience, Inc. Treatment of obstructive disorders of the eye or eyelid
US7981095B2 (en) 2005-07-18 2011-07-19 Tearscience, Inc. Methods for treating meibomian gland dysfunction employing fluid jet
WO2013003594A2 (en) 2011-06-28 2013-01-03 Tearscience, Inc. Methods and systems for treating meibomian gland dysfunction using radio-frequency energy
US20080114423A1 (en) 2006-05-15 2008-05-15 Grenon Stephen M Apparatus for inner eyelid treatment of meibomian gland dysfunction
US8083787B2 (en) 2005-07-18 2011-12-27 Tearscience, Inc. Method and apparatus for treating meibomian gland dysfunction
US20090043365A1 (en) 2005-07-18 2009-02-12 Kolis Scientific, Inc. Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma
US7981145B2 (en) 2005-07-18 2011-07-19 Tearscience Inc. Treatment of meibomian glands
US7247623B2 (en) 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
EP2004172B1 (en) 2006-03-31 2019-03-13 Mati Therapeutics Inc. Drug delivery structures and compositions for nasolacrimal system
US8128674B2 (en) 2006-05-15 2012-03-06 Tearscience, Inc. System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8128673B2 (en) 2006-05-15 2012-03-06 Tearscience, Inc. System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction
US8137390B2 (en) 2006-05-15 2012-03-20 Tearscience, Inc. System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction
US8007524B2 (en) 2006-05-15 2011-08-30 Tearscience, Inc. Heat treatment and heat loss reduction for treating meibomian gland dysfunction
JP4854393B2 (ja) 2006-06-21 2012-01-18 三星電子株式会社 電圧発生回路
US20080086101A1 (en) 2006-08-25 2008-04-10 David Freilich Ophthalmic insert
US8090426B2 (en) 2006-10-27 2012-01-03 Felder Robin A Microelectronic biosensor plug
NZ583858A (en) * 2007-09-07 2012-08-31 Quadra Logic Tech Inc Lacrimal implant detection with detection device
CN102670352A (zh) 2007-09-07 2012-09-19 Qlt股份有限公司 用于泪腺植入物的插入和抽出工具
CA2698508C (en) 2007-09-07 2017-06-06 Alan R. Rapacki Lacrimal implants and related methods
US7981195B2 (en) 2007-11-09 2011-07-19 Praxair Technology, Inc. System for preventing contaminants from reaching a gas purifier
WO2009079559A1 (en) 2007-12-17 2009-06-25 University Of Florida Research Foundation, Inc. Dry eye treatment by puncta plugs
WO2009134371A2 (en) 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Composite lacrimal insert and related methods
WO2009145755A1 (en) 2008-05-30 2009-12-03 Qlt Plug Delivery, Inc Surface treated implantable articles and related methods
CA2730101A1 (en) 2008-07-08 2010-01-14 Qlt Plug Delivery, Inc. Lacrimal implant body including comforting agent
US8201562B2 (en) 2008-12-02 2012-06-19 Odrich Steven Multi-piece punctal plug
KR20110132369A (ko) 2009-02-23 2011-12-07 큐엘티 인코포레이티드 눈물 임플란트 및 관련 방법
RU2013127313A (ru) 2010-11-16 2014-12-27 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Системы и способы лечения сухого глаза
US9821159B2 (en) * 2010-11-16 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
US8983615B2 (en) 2011-02-21 2015-03-17 Boston Scientific Neuromodulation Corporation System for communication with implantable medical devices using a bridge device
US9199080B2 (en) 2011-09-12 2015-12-01 Okuvision Gmbh Method for treating an eye
US9724230B2 (en) 2012-01-04 2017-08-08 Sight Sciences, Inc. Dry eye treatment apparatus and methods
GB201202387D0 (en) 2012-02-13 2012-03-28 Nachum Zvi Device for in-vivo determination of eye moisture
CN102688080B (zh) * 2012-06-05 2015-03-18 杭州柳茶医药科技有限公司 一种自动调节泪量的鼻泪管栓塞体及与其配套的安放工具
EP2945686B1 (en) 2013-01-15 2024-11-20 The Regents of The University of Colorado, A Body Corporate Lacrimal system drug delivery device
WO2014138709A1 (en) 2013-03-08 2014-09-12 Oculeve, Inc. Devices and methods for treating dry eye in animals
EP2967817B1 (en) 2013-03-12 2021-03-10 Oculeve, Inc. Implant delivery devices and systems
EP2986339A4 (en) 2013-04-19 2016-12-21 Oculeve Inc Nasal stimulation devices and methods
US9770583B2 (en) 2014-02-25 2017-09-26 Oculeve, Inc. Polymer formulations for nasolacrimal stimulation
US9687652B2 (en) 2014-07-25 2017-06-27 Oculeve, Inc. Stimulation patterns for treating dry eye

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012139063A2 (en) * 2011-04-07 2012-10-11 Oculeve, Inc. Stimulation devices and methods

Also Published As

Publication number Publication date
EP3310433A1 (en) 2018-04-25
US20160367806A1 (en) 2016-12-22
JP2018517517A (ja) 2018-07-05
US20180036169A1 (en) 2018-02-08
US20180116872A1 (en) 2018-05-03
AU2016277825A1 (en) 2018-01-18
CN107835706A (zh) 2018-03-23
US10004634B2 (en) 2018-06-26
US20180021171A1 (en) 2018-01-25
US10004635B2 (en) 2018-06-26
CA2989814A1 (en) 2016-12-22
WO2016205107A1 (en) 2016-12-22
US20170049619A1 (en) 2017-02-23

Similar Documents

Publication Publication Date Title
AU2016277825B2 (en) Nasolacrimal implants and related methods for tear stimulation
US12274879B2 (en) Optical pressure treatment through electrical stimulation
US20240359004A1 (en) Nasal stimulation devices and methods
US12420097B2 (en) System and methods for controlled electrical modulation for vision therapy
US9199080B2 (en) Method for treating an eye
CN115068202B (zh) 干眼治疗系统
JP2020096842A (ja) ドライアイを治療するための刺激パターン
US11291847B2 (en) Systems and methods for preventing, diagnosing, and/or treating one or more medical conditions via neuromodulation
US20180193193A1 (en) Lacrimal drainage system diagnostic implant
WO2019103754A1 (en) Systems and methods for preventing, diagnosing, and/or treating one or more medical conditions via neuromodulation

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired