CA2984653C - Identification of tumour-associated cell surface antigens for diagnosis and therapy - Google Patents

Identification of tumour-associated cell surface antigens for diagnosis and therapy Download PDF

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Publication number
CA2984653C
CA2984653C CA2984653A CA2984653A CA2984653C CA 2984653 C CA2984653 C CA 2984653C CA 2984653 A CA2984653 A CA 2984653A CA 2984653 A CA2984653 A CA 2984653A CA 2984653 C CA2984653 C CA 2984653C
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Prior art keywords
tumor
associated antigen
nucleic acid
leu
ser
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Expired - Lifetime
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CA2984653A
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English (en)
French (fr)
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CA2984653A1 (en
Inventor
Ozlem Tureci
Ugur Sahin
Gerd Helftenbein
Volker Schluter
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Biontech SE
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Biontech SE
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Priority to CA3096188A priority Critical patent/CA3096188C/en
Publication of CA2984653A1 publication Critical patent/CA2984653A1/en
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Publication of CA2984653C publication Critical patent/CA2984653C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
CA2984653A 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy Expired - Lifetime CA2984653C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3096188A CA3096188C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10344799A DE10344799A1 (de) 2003-09-26 2003-09-26 Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
DE10344799.7 2003-09-26
CA2539837A CA2539837C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2539837A Division CA2539837C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3096188A Division CA3096188C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy

Publications (2)

Publication Number Publication Date
CA2984653A1 CA2984653A1 (en) 2005-04-07
CA2984653C true CA2984653C (en) 2020-12-15

Family

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Family Applications (4)

Application Number Title Priority Date Filing Date
CA2984653A Expired - Lifetime CA2984653C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
CA2539837A Expired - Lifetime CA2539837C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
CA2814269A Expired - Lifetime CA2814269C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
CA3096188A Expired - Lifetime CA3096188C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA2539837A Expired - Lifetime CA2539837C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
CA2814269A Expired - Lifetime CA2814269C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy
CA3096188A Expired - Lifetime CA3096188C (en) 2003-09-26 2004-09-23 Identification of tumour-associated cell surface antigens for diagnosis and therapy

Country Status (8)

Country Link
US (6) US7875424B2 (cg-RX-API-DMAC7.html)
EP (22) EP2267014A3 (cg-RX-API-DMAC7.html)
JP (5) JP5144933B2 (cg-RX-API-DMAC7.html)
AU (1) AU2004275500B2 (cg-RX-API-DMAC7.html)
CA (4) CA2984653C (cg-RX-API-DMAC7.html)
DE (1) DE10344799A1 (cg-RX-API-DMAC7.html)
ES (1) ES2634705T3 (cg-RX-API-DMAC7.html)
WO (1) WO2005030250A2 (cg-RX-API-DMAC7.html)

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Publication number Publication date
WO2005030250A2 (de) 2005-04-07
EP2332979A3 (de) 2011-09-14
EP2266614A2 (de) 2010-12-29
EP2266617A3 (de) 2012-01-25
CA3096188C (en) 2022-06-07
EP2332983A2 (de) 2011-06-15
EP2295077A2 (de) 2011-03-16
EP2266618A3 (de) 2011-06-22
EP2266617A2 (de) 2010-12-29
EP2267011A3 (de) 2011-05-18
EP2266608B1 (de) 2016-05-25
JP2007506417A (ja) 2007-03-22
US20160053332A1 (en) 2016-02-25
DE10344799A1 (de) 2005-04-14
US20160195539A1 (en) 2016-07-07
CA2984653A1 (en) 2005-04-07
EP2266613A2 (de) 2010-12-29
EP2332980A3 (de) 2012-02-01
JP2014221760A (ja) 2014-11-27
EP2267013A3 (de) 2011-06-08
JP5639989B2 (ja) 2014-12-10
EP2272534A2 (de) 2011-01-12
JP2012110324A (ja) 2012-06-14
EP2266616A2 (de) 2010-12-29
ES2634705T3 (es) 2017-09-28
CA2539837A1 (en) 2005-04-07
CA2814269A1 (en) 2005-04-07
JP5144933B2 (ja) 2013-02-13
EP2267012A3 (de) 2011-05-04
US9733251B2 (en) 2017-08-15
US20080166340A1 (en) 2008-07-10
JP2016199548A (ja) 2016-12-01
EP2332981A3 (de) 2012-02-01
EP2295077A3 (de) 2011-08-10
EP2266611A3 (de) 2011-08-03
EP1664113B1 (de) 2018-01-03
EP2266613A3 (de) 2011-08-03
EP2267014A3 (de) 2012-01-11
JP5969538B2 (ja) 2016-08-17
EP2266615A3 (de) 2011-09-21
US20130280166A1 (en) 2013-10-24
JP2013063975A (ja) 2013-04-11
EP2266608A2 (de) 2010-12-29
JP6196350B2 (ja) 2017-09-13
CA3096188A1 (en) 2005-04-07
EP2266615A2 (de) 2010-12-29
EP2267012B1 (de) 2017-04-26
EP2267012A2 (de) 2010-12-29
EP2267011A2 (de) 2010-12-29
EP2266616A3 (de) 2011-09-14
EP1664113A2 (de) 2006-06-07
EP2332980A2 (de) 2011-06-15
AU2004275500A1 (en) 2005-04-07
US9267177B2 (en) 2016-02-23
EP2332979A2 (de) 2011-06-15
EP2332981A2 (de) 2011-06-15
US9910043B2 (en) 2018-03-06
US20150376718A1 (en) 2015-12-31
JP5804519B2 (ja) 2015-11-04
EP2266609A2 (de) 2010-12-29
EP2266609A3 (de) 2012-02-01
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WO2005030250A3 (de) 2005-08-18
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US7875424B2 (en) 2011-01-25
EP2266611A2 (de) 2010-12-29
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EP2266613B1 (de) 2016-12-14
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EP2266618A2 (de) 2010-12-29
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EP2332983A3 (de) 2012-02-01
EP2267013A2 (de) 2010-12-29
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