CA2983446C - Bromodomain inhibitor - Google Patents

Info

Publication number

CA2983446C

CA2983446C CA2983446A CA2983446A CA2983446C CA 2983446 C CA2983446 C CA 2983446C CA 2983446 A CA2983446 A CA 2983446A CA 2983446 A CA2983446 A CA 2983446A CA 2983446 C CA2983446 C CA 2983446C

Authority

CA

Canada

Prior art keywords

pharmaceutical composition

methylisoquinolin

cyclopropylmethoxy

compound

polymer

Prior art date

2015-04-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 239000007787 solid Substances 0.000 claims abstract description 65
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• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 49
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• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 24
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 22
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• SPTSIOTYTJZTOG-UHFFFAOYSA-N acetic acid;octadecanoic acid Chemical compound CC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O SPTSIOTYTJZTOG-UHFFFAOYSA-N 0.000 claims description 10
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• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 5
• YJRMHIKEMDTYDR-UHFFFAOYSA-N 2-methylisoquinolin-1-one Chemical compound C1=CC=C2C(=O)N(C)C=CC2=C1 YJRMHIKEMDTYDR-UHFFFAOYSA-N 0.000 claims 2
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• UWZAJPITKGWMFJ-UHFFFAOYSA-N 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one Chemical compound Cn1cc(-c2cc(ccc2OCC2CC2)S(C)(=O)=O)c2ccccc2c1=O UWZAJPITKGWMFJ-UHFFFAOYSA-N 0.000 abstract description 6
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