TW201642860A - 布羅莫結構域抑制劑 - Google Patents
布羅莫結構域抑制劑 Download PDFInfo
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- TW201642860A TW201642860A TW105112168A TW105112168A TW201642860A TW 201642860 A TW201642860 A TW 201642860A TW 105112168 A TW105112168 A TW 105112168A TW 105112168 A TW105112168 A TW 105112168A TW 201642860 A TW201642860 A TW 201642860A
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- Taiwan
- Prior art keywords
- pharmaceutical composition
- compound
- methylsulfonylphenyl
- cyclopropylmethoxy
- methylisoquinolin
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Bioinformatics & Cheminformatics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US201562151205P | 2015-04-22 | 2015-04-22 |
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| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| US10702517B2 (en) | 2015-04-22 | 2020-07-07 | Celgene Quanticel Research, Inc. | Bromodomain inhibitor |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| CN110099685A (zh) * | 2016-10-20 | 2019-08-06 | 赛尔基因光迪斯研究公司 | 溴结构域抑制剂 |
| AU2017347853B2 (en) | 2016-10-27 | 2022-02-17 | Celgene Quanticel Research, Inc. | Bromodomain and extra-terminal protein inhibitor combination therapy |
| JP7434274B2 (ja) * | 2018-07-23 | 2024-02-20 | セルジーン・クオンティセル・リサーチ・インコーポレイテッド | ブロモドメイン阻害剤の合成方法 |
| CN117136057A (zh) * | 2021-02-22 | 2023-11-28 | 赛尔基因昆蒂赛尔研究公司 | 用于治疗前列腺癌的溴结构域(bet)抑制剂 |
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| GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| GB0919434D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| WO2013097052A1 (en) * | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| PE20161065A1 (es) * | 2013-10-18 | 2016-11-19 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| CN110099685A (zh) * | 2016-10-20 | 2019-08-06 | 赛尔基因光迪斯研究公司 | 溴结构域抑制剂 |
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| HK1243948A1 (zh) | 2018-07-27 |
| AR104340A1 (es) | 2017-07-12 |
| EP3285770A4 (en) | 2018-10-31 |
| AU2016252992A1 (en) | 2017-11-09 |
| ECSP17071545A (es) | 2017-12-01 |
| MX2017013501A (es) | 2018-02-09 |
| CA2983446C (en) | 2024-04-09 |
| CA2983446A1 (en) | 2016-10-27 |
| MX377159B (es) | 2025-03-07 |
| PH12017501933A1 (en) | 2018-03-19 |
| CL2017002679A1 (es) | 2018-05-25 |
| SG11201708627TA (en) | 2017-11-29 |
| IL255120B (en) | 2021-03-25 |
| PE20180036A1 (es) | 2018-01-09 |
| EP3285770A1 (en) | 2018-02-28 |
| JP2018513863A (ja) | 2018-05-31 |
| BR112017022691A2 (pt) | 2018-07-17 |
| NZ736630A (en) | 2024-03-22 |
| CO2017011482A2 (es) | 2018-01-31 |
| MX390077B (es) | 2025-03-20 |
| US20160310423A1 (en) | 2016-10-27 |
| EA201792317A1 (ru) | 2018-03-30 |
| KR20170139119A (ko) | 2017-12-18 |
| WO2016172618A1 (en) | 2016-10-27 |
| ZA201707186B (en) | 2019-01-30 |
| MX2020010899A (es) | 2022-02-15 |
| IL255120A0 (en) | 2017-12-31 |
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