CA2981518A1 - Methods of stratifying patients for treatment with retinoic acid receptor-.alpha. agonists - Google Patents
Methods of stratifying patients for treatment with retinoic acid receptor-.alpha. agonists Download PDFInfo
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- CA2981518A1 CA2981518A1 CA2981518A CA2981518A CA2981518A1 CA 2981518 A1 CA2981518 A1 CA 2981518A1 CA 2981518 A CA2981518 A CA 2981518A CA 2981518 A CA2981518 A CA 2981518A CA 2981518 A1 CA2981518 A1 CA 2981518A1
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- Engineering & Computer Science (AREA)
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- Gynecology & Obstetrics (AREA)
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| US201562268203P | 2015-12-16 | 2015-12-16 | |
| US62/268,203 | 2015-12-16 | ||
| PCT/US2016/025256 WO2016161107A1 (en) | 2015-03-31 | 2016-03-31 | METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-α AGONISTS |
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| CA2981518C CA2981518C (en) | 2024-06-25 |
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| EP (2) | EP3967305A1 (pl) |
| JP (4) | JP6952604B2 (pl) |
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| CN (2) | CN107613969B (pl) |
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| US20160000674A1 (en) | 2013-03-15 | 2016-01-07 | Avisenna Cosmetics, Llc | Topical compositions for reducing the effects of aging |
| EP3967305A1 (en) | 2015-03-31 | 2022-03-16 | Syros Pharmaceuticals, Inc. | Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists |
| US9868994B2 (en) | 2016-04-08 | 2018-01-16 | Syros Pharmaceuticals, Inc. | Methods of stratifying patients for treatment with retinoic acid receptor-α agonists |
| WO2017177167A1 (en) * | 2016-04-08 | 2017-10-12 | Syros Pharmaceuticals, Inc. | Rara agonists for the treatment of aml and mds |
| TW201823471A (zh) * | 2016-10-06 | 2018-07-01 | 美商錫羅斯製藥公司 | 以視黃酸受體-α促效劑及抗CD38抗體治療病患之方法 |
| WO2018136961A1 (en) * | 2017-01-23 | 2018-07-26 | Syros Pharmaceuticals Inc. | METHODS OF TREATING PATIENTS WITH A RETINOIC ACID RECEPTOR-α AGONIST AND AN ANTI-CD38 ANTIBODY |
| JP2019043865A (ja) * | 2017-08-31 | 2019-03-22 | ひまわり製薬株式会社 | ざ瘡様疾患を治療又は予防するための皮膚外用組成物 |
| WO2020069187A1 (en) * | 2018-09-28 | 2020-04-02 | The Children's Medical Center Corporation | Combination therapy for acute myeloid leukemia |
| CN116209452A (zh) * | 2020-08-06 | 2023-06-02 | 赛罗斯制药有限公司 | 用于治疗aml的疗法和rara激动剂、低甲基化剂和bcl-2抑制剂的用途 |
| CN112390731B (zh) * | 2020-11-16 | 2022-11-25 | 成都大学 | 一种具有多靶点的维甲酸类衍生物及其制备方法与应用 |
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| DE3580134D1 (de) | 1984-07-07 | 1990-11-22 | Shudo Koichi Prof Dr Chem | Benzoesaeurederivate. |
| US5089509A (en) | 1988-09-15 | 1992-02-18 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
| JP2752630B2 (ja) | 1988-03-29 | 1998-05-18 | 大鵬薬品工業株式会社 | 新規安息香酸誘導体及びその製造方法 |
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| US5759785A (en) | 1992-05-14 | 1998-06-02 | Baylor College Of Medicine | Method of identifying hormone antagonists and agonists |
| US5455265A (en) | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
| US5824685A (en) | 1995-02-01 | 1998-10-20 | The Johns Hopkins University School Of Medicine | Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists |
| FR2739777B1 (fr) | 1995-10-11 | 1997-11-14 | Cird Galderma | Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose |
| US5675024A (en) | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
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| HUP9902645A3 (en) | 1996-03-18 | 1999-12-28 | Eisai Co Ltd | Fused-ring carboxylic acid derivatives |
| WO1997035589A1 (en) | 1996-03-26 | 1997-10-02 | Kopreski Michael S | Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer |
| US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
| US6355669B1 (en) | 1997-10-22 | 2002-03-12 | Eisai Co., Ltd. | Retinoic acid agonists as preventive and therapeutic agents for nephritis |
| CA2702148C (en) | 1999-01-06 | 2014-03-04 | Genenews Inc. | Method of profiling gene expression in a human subject having an infectious disease |
| TWI281911B (en) | 2000-04-04 | 2007-06-01 | Allergan Inc | Treatment of tumors with RARalpha selective retinoid compounds in combination with other anti-tumor agents |
| AU2002328226A1 (en) * | 2001-09-17 | 2003-04-01 | Angiogene Inc. | Modulation of retinoic acid receptor gene expression and therapeutic uses thereof |
| JP5113038B2 (ja) | 2006-03-23 | 2013-01-09 | テムリック株式会社 | 癌治療用キットおよび癌治療用医薬組成物 |
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| CA2827015A1 (en) * | 2010-02-11 | 2011-08-18 | The Royal Institution For The Advancement Of Learning/Mcgill University | Hybrid molecule having mixed retinoic acid receptor agonism and histone deacetylase inhibitory properties |
| JP6295249B2 (ja) * | 2012-06-07 | 2018-03-14 | チルドレンズ ホスピタル ロサンゼルス | レチノイドアゴニストを用いた好中球減少症の治療方法 |
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| RU2016101109A (ru) | 2013-07-15 | 2017-08-18 | Дзе Боард Оф Трастис Оф Дзе Лилэнд Стэнфорд Джуниор Юниверсити | Медицинское применение агонистов cd38 |
| CA2932120C (en) | 2013-12-06 | 2023-09-19 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
| EP3089743B1 (en) | 2013-12-30 | 2018-07-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination of an arsenic compound and at least one retinoid for treating acute myeloid leukemia |
| JP2018512396A (ja) | 2015-03-09 | 2018-05-17 | キングス・カレッジ・ロンドン | Ｔｈ１応答を増強するためのｒａｒアルファアゴニストを用いた併用療法 |
| EP3967305A1 (en) | 2015-03-31 | 2022-03-16 | Syros Pharmaceuticals, Inc. | Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists |
| EP3957304A1 (en) | 2015-11-25 | 2022-02-23 | IO Therapeutics, Inc. | Use of cyp26-resistant rar alpha selective agonists in the treatment of cancer |
| US9868994B2 (en) | 2016-04-08 | 2018-01-16 | Syros Pharmaceuticals, Inc. | Methods of stratifying patients for treatment with retinoic acid receptor-α agonists |
| WO2017177167A1 (en) | 2016-04-08 | 2017-10-12 | Syros Pharmaceuticals, Inc. | Rara agonists for the treatment of aml and mds |
| TW201823471A (zh) | 2016-10-06 | 2018-07-01 | 美商錫羅斯製藥公司 | 以視黃酸受體-α促效劑及抗CD38抗體治療病患之方法 |
| WO2018136961A1 (en) | 2017-01-23 | 2018-07-26 | Syros Pharmaceuticals Inc. | METHODS OF TREATING PATIENTS WITH A RETINOIC ACID RECEPTOR-α AGONIST AND AN ANTI-CD38 ANTIBODY |
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