CA2978438A1 - Fluides de silicone oligomere/polymere destines a etre utilises dans des systemes d'administration transdermique de medicaments - Google Patents

Fluides de silicone oligomere/polymere destines a etre utilises dans des systemes d'administration transdermique de medicaments Download PDF

Info

Publication number
CA2978438A1
CA2978438A1 CA2978438A CA2978438A CA2978438A1 CA 2978438 A1 CA2978438 A1 CA 2978438A1 CA 2978438 A CA2978438 A CA 2978438A CA 2978438 A CA2978438 A CA 2978438A CA 2978438 A1 CA2978438 A1 CA 2978438A1
Authority
CA
Canada
Prior art keywords
drug
oligomeric
composition
polymer matrix
polymeric silicone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2978438A
Other languages
English (en)
Inventor
Puchun Liu
Steven Dinh
Jun Liao
Tsuyoshi Endo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noven Pharmaceuticals Inc
Original Assignee
Noven Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noven Pharmaceuticals Inc filed Critical Noven Pharmaceuticals Inc
Publication of CA2978438A1 publication Critical patent/CA2978438A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des fluides de silicone oligomère/polymère utiles dans des systèmes d'administration transdermique de médicaments. L'invention concerne également des compositions destinées à l'administration transdermique d'un médicament, comprenant une matrice polymère contenant un médicament ; un polymère substrat et un fluide de silicone oligomère/polymère ayant des unités -Si(CH3)2-O- récurrentes. L'invention concerne également des procédés et des utilisations.
CA2978438A 2015-03-04 2016-02-26 Fluides de silicone oligomere/polymere destines a etre utilises dans des systemes d'administration transdermique de medicaments Abandoned CA2978438A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562128197P 2015-03-04 2015-03-04
US62/128,197 2015-03-04
PCT/US2016/019717 WO2016140874A1 (fr) 2015-03-04 2016-02-26 Fluides de silicone oligomère/polymère destinés à être utilisés dans des systèmes d'administration transdermique de médicaments

Publications (1)

Publication Number Publication Date
CA2978438A1 true CA2978438A1 (fr) 2016-09-09

Family

ID=55861124

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2978438A Abandoned CA2978438A1 (fr) 2015-03-04 2016-02-26 Fluides de silicone oligomere/polymere destines a etre utilises dans des systemes d'administration transdermique de medicaments

Country Status (10)

Country Link
US (1) US20160256406A1 (fr)
EP (1) EP3265129A1 (fr)
JP (1) JP6873909B2 (fr)
KR (1) KR20170125939A (fr)
CN (1) CN107872974A (fr)
AU (1) AU2016226458A1 (fr)
CA (1) CA2978438A1 (fr)
MX (1) MX2017011349A (fr)
PH (1) PH12017501563A1 (fr)
WO (1) WO2016140874A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3203041A1 (fr) 2021-01-07 2022-07-14 Atsushi Sonobe Compositions transdermiques d'amphetamine a faibles taux de carbamate
US11572339B2 (en) 2021-01-07 2023-02-07 Noven Pharmaceuticals, Inc. Amphetamine carbamate compounds and methods

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5843368B2 (ja) 1980-10-30 1983-09-27 日東電工株式会社 消炎鎮痛貼付剤
JPS58128324A (ja) * 1982-01-28 1983-07-30 Nitto Electric Ind Co Ltd 基剤組成物および外用医薬組成物
US4994267A (en) 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5026556A (en) * 1988-11-10 1991-06-25 Norwich Eaton Pharmaceuticals, Inc. Compositions for the transdermal delivery of pharmaceutical actives
JP2512805B2 (ja) * 1989-07-14 1996-07-03 積水化学工業株式会社 ケトチフェン経皮吸収製剤
CN1151780C (zh) * 1993-01-02 2004-06-02 诺纹制药股份有限公司 基于溶度参数的药物释放系统和改变药物饱和浓度的方法
JPH0733665A (ja) * 1993-05-18 1995-02-03 Kanebo Ltd エメダスチンを含有する粘着性貼付剤
US6180133B1 (en) * 1997-11-25 2001-01-30 Watson Pharmaceuticals, Inc. Antioxidant composition for topical/transdermal prevention and treatment of wrinkles
JP2000063267A (ja) * 1998-08-21 2000-02-29 Senju Pharmaceut Co Ltd 経皮吸収貼付剤
US20040247623A1 (en) * 2003-03-24 2004-12-09 Roger Cady Method and article for treatment of sensory neuron related disorders through transdermal application of botulinum toxin
TW200616589A (en) * 2004-10-08 2006-06-01 Noven Pharma Transdermal delivery of drugs based on crystal size
JP4704764B2 (ja) * 2005-02-03 2011-06-22 日東電工株式会社 爪貼付用粘着組成物および爪用貼付剤
CA2896055C (fr) * 2012-12-28 2021-02-16 Noven Pharmaceuticals, Inc. Compositions et procedes pour l'administration transdermique d'amphetamine et de clonidine
AR095259A1 (es) * 2013-03-15 2015-09-30 Noven Pharma Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria

Also Published As

Publication number Publication date
PH12017501563A1 (en) 2018-02-05
KR20170125939A (ko) 2017-11-15
JP2018507231A (ja) 2018-03-15
MX2017011349A (es) 2018-06-27
AU2016226458A1 (en) 2017-09-21
CN107872974A (zh) 2018-04-03
JP6873909B2 (ja) 2021-05-19
US20160256406A1 (en) 2016-09-08
EP3265129A1 (fr) 2018-01-10
WO2016140874A1 (fr) 2016-09-09

Similar Documents

Publication Publication Date Title
US11427666B2 (en) Silicone-containing acrylic polymers for transdermal drug delivery compositions
US10987316B2 (en) Compositions and methods for transdermal delivery of tertiary amine drugs
US9320742B2 (en) Transdermal testosterone device and delivery
US9833419B2 (en) Transdermal estrogen device and delivery
CA2896055C (fr) Compositions et procedes pour l'administration transdermique d'amphetamine et de clonidine
US11337936B2 (en) Amphetamine transdermal compositions with acrylic block copolymer
US20170112781A1 (en) Transdermal drug delivery systems with polyisobutylene face adhesive
WO2014159573A1 (fr) Compositions transdermiques comprenant du méthylphénidate avec des adhésifs à base de caoutchouc
US20160184246A1 (en) Transdermal drug delivery systems for agomelatine
US20160256406A1 (en) Oligomeric/polymeric silicone fluids for use in transdermal drug delivery systems
US20180036319A1 (en) Transdermal drug delivery systems for norethindrone acetate

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210223

EEER Examination request

Effective date: 20210223

FZDE Discontinued

Effective date: 20230829