CA2972433A1 - Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results - Google Patents
Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results Download PDFInfo
- Publication number
- CA2972433A1 CA2972433A1 CA2972433A CA2972433A CA2972433A1 CA 2972433 A1 CA2972433 A1 CA 2972433A1 CA 2972433 A CA2972433 A CA 2972433A CA 2972433 A CA2972433 A CA 2972433A CA 2972433 A1 CA2972433 A1 CA 2972433A1
- Authority
- CA
- Canada
- Prior art keywords
- tumor
- cancer
- subject
- genetic
- polynucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 263
- 230000001747 exhibiting effect Effects 0.000 title claims abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 156
- 201000010099 disease Diseases 0.000 title claims description 152
- 238000012360 testing method Methods 0.000 title claims description 130
- 238000011282 treatment Methods 0.000 title claims description 93
- 238000001514 detection method Methods 0.000 title description 31
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 445
- 201000011510 cancer Diseases 0.000 claims abstract description 193
- 102000040430 polynucleotide Human genes 0.000 claims abstract description 150
- 108091033319 polynucleotide Proteins 0.000 claims abstract description 150
- 239000002157 polynucleotide Substances 0.000 claims abstract description 150
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 111
- 238000012163 sequencing technique Methods 0.000 claims abstract description 80
- 206010069754 Acquired gene mutation Diseases 0.000 claims abstract description 64
- 230000037439 somatic mutation Effects 0.000 claims abstract description 64
- 210000004027 cell Anatomy 0.000 claims description 240
- 230000002068 genetic effect Effects 0.000 claims description 177
- 229940079593 drug Drugs 0.000 claims description 118
- 239000003814 drug Substances 0.000 claims description 114
- 239000000523 sample Substances 0.000 claims description 113
- 230000004075 alteration Effects 0.000 claims description 99
- 108090000623 proteins and genes Proteins 0.000 claims description 94
- 108700028369 Alleles Proteins 0.000 claims description 39
- 238000004458 analytical method Methods 0.000 claims description 38
- 238000002560 therapeutic procedure Methods 0.000 claims description 34
- 230000010076 replication Effects 0.000 claims description 28
- 230000004044 response Effects 0.000 claims description 24
- 238000013507 mapping Methods 0.000 claims description 23
- 230000015654 memory Effects 0.000 claims description 22
- 238000009877 rendering Methods 0.000 claims description 21
- 229920002521 macromolecule Polymers 0.000 claims description 18
- 150000007523 nucleic acids Chemical class 0.000 claims description 18
- 230000000007 visual effect Effects 0.000 claims description 18
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 230000002829 reductive effect Effects 0.000 claims description 15
- 230000000392 somatic effect Effects 0.000 claims description 15
- 230000032823 cell division Effects 0.000 claims description 14
- 238000012544 monitoring process Methods 0.000 claims description 14
- 239000012472 biological sample Substances 0.000 claims description 13
- 230000004077 genetic alteration Effects 0.000 claims description 12
- 230000006870 function Effects 0.000 claims description 11
- 238000005192 partition Methods 0.000 claims description 11
- 210000001082 somatic cell Anatomy 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 9
- 231100000118 genetic alteration Toxicity 0.000 claims description 8
- 239000013068 control sample Substances 0.000 claims description 7
- 230000035945 sensitivity Effects 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- 230000009467 reduction Effects 0.000 claims description 4
- 238000000638 solvent extraction Methods 0.000 claims description 4
- 230000008261 resistance mechanism Effects 0.000 claims description 3
- 108020004414 DNA Proteins 0.000 description 158
- 102000053602 DNA Human genes 0.000 description 153
- 230000035772 mutation Effects 0.000 description 55
- 239000002773 nucleotide Substances 0.000 description 43
- 210000004369 blood Anatomy 0.000 description 41
- 239000008280 blood Substances 0.000 description 41
- 125000003729 nucleotide group Chemical group 0.000 description 41
- 230000008569 process Effects 0.000 description 38
- 239000012634 fragment Substances 0.000 description 37
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 30
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 30
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 28
- 210000004881 tumor cell Anatomy 0.000 description 25
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 24
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 24
- 206010009944 Colon cancer Diseases 0.000 description 21
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 20
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 20
- 206010006187 Breast cancer Diseases 0.000 description 17
- 208000026310 Breast neoplasm Diseases 0.000 description 17
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 17
- 230000003321 amplification Effects 0.000 description 16
- 238000003199 nucleic acid amplification method Methods 0.000 description 16
- 210000004602 germ cell Anatomy 0.000 description 15
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 description 13
- 101000779641 Homo sapiens ALK tyrosine kinase receptor Proteins 0.000 description 13
- 102100039788 GTPase NRas Human genes 0.000 description 12
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 description 12
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 12
- 102100030708 GTPase KRas Human genes 0.000 description 11
- 230000002159 abnormal effect Effects 0.000 description 11
- 210000001124 body fluid Anatomy 0.000 description 11
- 230000003247 decreasing effect Effects 0.000 description 11
- 230000004927 fusion Effects 0.000 description 11
- 238000003860 storage Methods 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 11
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 10
- 108091035707 Consensus sequence Proteins 0.000 description 10
- 238000002512 chemotherapy Methods 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 10
- 102100034540 Adenomatous polyposis coli protein Human genes 0.000 description 9
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 9
- 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 description 9
- 206010068052 Mosaicism Diseases 0.000 description 9
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 9
- 102000001759 Notch1 Receptor Human genes 0.000 description 9
- 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 description 9
- 210000000349 chromosome Anatomy 0.000 description 9
- 238000004891 communication Methods 0.000 description 9
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 description 9
- 238000003745 diagnosis Methods 0.000 description 9
- 102200055464 rs113488022 Human genes 0.000 description 9
- 210000002700 urine Anatomy 0.000 description 9
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 8
- 102100028286 Proto-oncogene tyrosine-protein kinase receptor Ret Human genes 0.000 description 8
- 208000006265 Renal cell carcinoma Diseases 0.000 description 8
- 108020005091 Replication Origin Proteins 0.000 description 8
- 229960002465 dabrafenib Drugs 0.000 description 8
- 238000012217 deletion Methods 0.000 description 8
- 230000037430 deletion Effects 0.000 description 8
- 201000001441 melanoma Diseases 0.000 description 8
- 230000004544 DNA amplification Effects 0.000 description 7
- 239000005517 L01XE01 - Imatinib Substances 0.000 description 7
- 206010035226 Plasma cell myeloma Diseases 0.000 description 7
- 238000001574 biopsy Methods 0.000 description 7
- 230000004545 gene duplication Effects 0.000 description 7
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 206010061289 metastatic neoplasm Diseases 0.000 description 7
- 230000011987 methylation Effects 0.000 description 7
- 238000007069 methylation reaction Methods 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 6
- 108700024394 Exon Proteins 0.000 description 6
- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 description 6
- 239000005551 L01XE03 - Erlotinib Substances 0.000 description 6
- 239000002144 L01XE18 - Ruxolitinib Substances 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 description 6
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 6
- 208000036878 aneuploidy Diseases 0.000 description 6
- 231100001075 aneuploidy Toxicity 0.000 description 6
- 238000004422 calculation algorithm Methods 0.000 description 6
- 108091092240 circulating cell-free DNA Proteins 0.000 description 6
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 description 6
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 229960002411 imatinib Drugs 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 210000000056 organ Anatomy 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000000284 resting effect Effects 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 description 6
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 5
- 208000003174 Brain Neoplasms Diseases 0.000 description 5
- 229940124602 FDA-approved drug Drugs 0.000 description 5
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 description 5
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 description 5
- 239000002146 L01XE16 - Crizotinib Substances 0.000 description 5
- 108700020796 Oncogene Proteins 0.000 description 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 5
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 description 5
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 description 5
- 208000020584 Polyploidy Diseases 0.000 description 5
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 5
- 206010039491 Sarcoma Diseases 0.000 description 5
- 208000005718 Stomach Neoplasms Diseases 0.000 description 5
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- 238000004590 computer program Methods 0.000 description 5
- 230000000875 corresponding effect Effects 0.000 description 5
- KTEIFNKAUNYNJU-GFCCVEGCSA-N crizotinib Chemical compound O([C@H](C)C=1C(=C(F)C=CC=1Cl)Cl)C(C(=NC=1)N)=CC=1C(=C1)C=NN1C1CCNCC1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 0.000 description 5
- 229940000406 drug candidate Drugs 0.000 description 5
- 230000001973 epigenetic effect Effects 0.000 description 5
- 229960001433 erlotinib Drugs 0.000 description 5
- 239000003777 experimental drug Substances 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 230000037442 genomic alteration Effects 0.000 description 5
- 208000032839 leukemia Diseases 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229960001972 panitumumab Drugs 0.000 description 5
- 210000004214 philadelphia chromosome Anatomy 0.000 description 5
- 210000002381 plasma Anatomy 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- 229960000215 ruxolitinib Drugs 0.000 description 5
- HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical compound C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 description 5
- 210000003296 saliva Anatomy 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 229960004066 trametinib Drugs 0.000 description 5
- 229960000575 trastuzumab Drugs 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 4
- 206010005003 Bladder cancer Diseases 0.000 description 4
- 201000009030 Carcinoma Diseases 0.000 description 4
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 4
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 description 4
- 238000001712 DNA sequencing Methods 0.000 description 4
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 4
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 description 4
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 206010025323 Lymphomas Diseases 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 208000034578 Multiple myelomas Diseases 0.000 description 4
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 4
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 4
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 4
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 4
- 206010060862 Prostate cancer Diseases 0.000 description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 4
- 108091008611 Protein Kinase B Proteins 0.000 description 4
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 description 4
- 102100033479 RAF proto-oncogene serine/threonine-protein kinase Human genes 0.000 description 4
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 description 4
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 description 4
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 4
- 102100033254 Tumor suppressor ARF Human genes 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000008236 biological pathway Effects 0.000 description 4
- 229960005395 cetuximab Drugs 0.000 description 4
- 238000007385 chemical modification Methods 0.000 description 4
- 230000002759 chromosomal effect Effects 0.000 description 4
- 229960005061 crizotinib Drugs 0.000 description 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 4
- 210000001840 diploid cell Anatomy 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 201000004101 esophageal cancer Diseases 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 206010017758 gastric cancer Diseases 0.000 description 4
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
- 201000010536 head and neck cancer Diseases 0.000 description 4
- 208000014829 head and neck neoplasm Diseases 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 4
- 238000007481 next generation sequencing Methods 0.000 description 4
- 201000002528 pancreatic cancer Diseases 0.000 description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 230000004043 responsiveness Effects 0.000 description 4
- 239000004065 semiconductor Substances 0.000 description 4
- 201000011549 stomach cancer Diseases 0.000 description 4
- 238000012706 support-vector machine Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 4
- 230000005945 translocation Effects 0.000 description 4
- 238000002604 ultrasonography Methods 0.000 description 4
- 201000005112 urinary bladder cancer Diseases 0.000 description 4
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 description 4
- 108010004586 Ataxia Telangiectasia Mutated Proteins Proteins 0.000 description 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 3
- 206010061818 Disease progression Diseases 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 description 3
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 description 3
- 102100029974 GTPase HRas Human genes 0.000 description 3
- 230000010558 Gene Alterations Effects 0.000 description 3
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 description 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 3
- 208000003445 Mouth Neoplasms Diseases 0.000 description 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 3
- 102000043276 Oncogene Human genes 0.000 description 3
- 208000000453 Skin Neoplasms Diseases 0.000 description 3
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 description 3
- 108091008605 VEGF receptors Proteins 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000013528 artificial neural network Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 201000007455 central nervous system cancer Diseases 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 238000013500 data storage Methods 0.000 description 3
- 230000005750 disease progression Effects 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- -1 for example Chemical class 0.000 description 3
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 3
- 230000007614 genetic variation Effects 0.000 description 3
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 description 3
- 238000012165 high-throughput sequencing Methods 0.000 description 3
- 238000009396 hybridization Methods 0.000 description 3
- 210000002865 immune cell Anatomy 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000009533 lab test Methods 0.000 description 3
- 206010024627 liposarcoma Diseases 0.000 description 3
- 208000020816 lung neoplasm Diseases 0.000 description 3
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 description 3
- 201000000050 myeloid neoplasm Diseases 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 229960002087 pertuzumab Drugs 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 230000008707 rearrangement Effects 0.000 description 3
- FNHKPVJBJVTLMP-UHFFFAOYSA-N regorafenib Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 FNHKPVJBJVTLMP-UHFFFAOYSA-N 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 238000002626 targeted therapy Methods 0.000 description 3
- 230000001131 transforming effect Effects 0.000 description 3
- 229960001612 trastuzumab emtansine Drugs 0.000 description 3
- 229960003862 vemurafenib Drugs 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 description 2
- 229930024421 Adenine Natural products 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
- 108091093088 Amplicon Proteins 0.000 description 2
- 206010005949 Bone cancer Diseases 0.000 description 2
- 208000018084 Bone neoplasm Diseases 0.000 description 2
- 102100028914 Catenin beta-1 Human genes 0.000 description 2
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 description 2
- 108091007854 Cdh1/Fizzy-related Proteins 0.000 description 2
- 102000038594 Cdh1/Fizzy-related Human genes 0.000 description 2
- 208000037051 Chromosomal Instability Diseases 0.000 description 2
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 2
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 description 2
- 101150029707 ERBB2 gene Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102100038595 Estrogen receptor Human genes 0.000 description 2
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 description 2
- 102100028138 F-box/WD repeat-containing protein 7 Human genes 0.000 description 2
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 description 2
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 description 2
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 description 2
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 description 2
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 description 2
- 102100025334 Guanine nucleotide-binding protein G(q) subunit alpha Human genes 0.000 description 2
- 102100032610 Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Human genes 0.000 description 2
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 description 2
- 101000916173 Homo sapiens Catenin beta-1 Proteins 0.000 description 2
- 101001060231 Homo sapiens F-box/WD repeat-containing protein 7 Proteins 0.000 description 2
- 101000738568 Homo sapiens G1/S-specific cyclin-E1 Proteins 0.000 description 2
- 101000857888 Homo sapiens Guanine nucleotide-binding protein G(q) subunit alpha Proteins 0.000 description 2
- 101001014590 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Proteins 0.000 description 2
- 101001014594 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Proteins 0.000 description 2
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 2
- 101000599886 Homo sapiens Isocitrate dehydrogenase [NADP], mitochondrial Proteins 0.000 description 2
- 101001014610 Homo sapiens Neuroendocrine secretory protein 55 Proteins 0.000 description 2
- 101001109719 Homo sapiens Nucleophosmin Proteins 0.000 description 2
- 101000797903 Homo sapiens Protein ALEX Proteins 0.000 description 2
- 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 description 2
- 101000628562 Homo sapiens Serine/threonine-protein kinase STK11 Proteins 0.000 description 2
- 101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 description 2
- 101001087416 Homo sapiens Tyrosine-protein phosphatase non-receptor type 11 Proteins 0.000 description 2
- 102100037845 Isocitrate dehydrogenase [NADP], mitochondrial Human genes 0.000 description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 description 2
- 101150105104 Kras gene Proteins 0.000 description 2
- 239000005411 L01XE02 - Gefitinib Substances 0.000 description 2
- 239000002147 L01XE04 - Sunitinib Substances 0.000 description 2
- 239000002067 L01XE06 - Dasatinib Substances 0.000 description 2
- 239000002136 L01XE07 - Lapatinib Substances 0.000 description 2
- 239000005536 L01XE08 - Nilotinib Substances 0.000 description 2
- 239000003798 L01XE11 - Pazopanib Substances 0.000 description 2
- 239000002118 L01XE12 - Vandetanib Substances 0.000 description 2
- 239000002145 L01XE14 - Bosutinib Substances 0.000 description 2
- 239000002138 L01XE21 - Regorafenib Substances 0.000 description 2
- 239000002176 L01XE26 - Cabozantinib Substances 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 208000009018 Medullary thyroid cancer Diseases 0.000 description 2
- 208000000172 Medulloblastoma Diseases 0.000 description 2
- 206010027476 Metastases Diseases 0.000 description 2
- 102100025725 Mothers against decapentaplegic homolog 4 Human genes 0.000 description 2
- 101710143112 Mothers against decapentaplegic homolog 4 Proteins 0.000 description 2
- 208000033383 Neuroendocrine tumor of pancreas Diseases 0.000 description 2
- 102100022678 Nucleophosmin Human genes 0.000 description 2
- 108091007960 PI3Ks Proteins 0.000 description 2
- 206010067517 Pancreatic neuroendocrine tumour Diseases 0.000 description 2
- 238000003559 RNA-seq method Methods 0.000 description 2
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 description 2
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 description 2
- 208000015634 Rectal Neoplasms Diseases 0.000 description 2
- 201000000582 Retinoblastoma Diseases 0.000 description 2
- 108700028341 SMARCB1 Proteins 0.000 description 2
- 101150008214 SMARCB1 gene Proteins 0.000 description 2
- 102100025746 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Human genes 0.000 description 2
- 101710181599 Serine/threonine-protein kinase STK11 Proteins 0.000 description 2
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 208000021712 Soft tissue sarcoma Diseases 0.000 description 2
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 description 2
- 206010043515 Throat cancer Diseases 0.000 description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 description 2
- 208000037280 Trisomy Diseases 0.000 description 2
- 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 description 2
- 102100033019 Tyrosine-protein phosphatase non-receptor type 11 Human genes 0.000 description 2
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 229960000643 adenine Drugs 0.000 description 2
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 description 2
- 238000007622 bioinformatic analysis Methods 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- UBPYILGKFZZVDX-UHFFFAOYSA-N bosutinib Chemical compound C1=C(Cl)C(OC)=CC(NC=2C3=CC(OC)=C(OCCCN4CCN(C)CC4)C=C3N=CC=2C#N)=C1Cl UBPYILGKFZZVDX-UHFFFAOYSA-N 0.000 description 2
- JJWKPURADFRFRB-UHFFFAOYSA-N carbonyl sulfide Chemical compound O=C=S JJWKPURADFRFRB-UHFFFAOYSA-N 0.000 description 2
- 108091092259 cell-free RNA Proteins 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 229940104302 cytosine Drugs 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 239000003596 drug target Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000007672 fourth generation sequencing Methods 0.000 description 2
- 229960002584 gefitinib Drugs 0.000 description 2
- 102000054767 gene variant Human genes 0.000 description 2
- 238000011331 genomic analysis Methods 0.000 description 2
- 208000005017 glioblastoma Diseases 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 description 2
- 238000012417 linear regression Methods 0.000 description 2
- 201000005202 lung cancer Diseases 0.000 description 2
- 229940124302 mTOR inhibitor Drugs 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 201000005962 mycosis fungoides Diseases 0.000 description 2
- JTSLALYXYSRPGW-UHFFFAOYSA-N n-[5-(4-cyanophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC(C1=C2)=CNC1=NC=C2C1=CC=C(C#N)C=C1 JTSLALYXYSRPGW-UHFFFAOYSA-N 0.000 description 2
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 description 2
- 229960003347 obinutuzumab Drugs 0.000 description 2
- 201000008968 osteosarcoma Diseases 0.000 description 2
- 208000021010 pancreatic neuroendocrine tumor Diseases 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 238000000513 principal component analysis Methods 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 239000003197 protein kinase B inhibitor Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000012175 pyrosequencing Methods 0.000 description 2
- 229960004836 regorafenib Drugs 0.000 description 2
- 102200108201 rs1042522 Human genes 0.000 description 2
- 102200048955 rs121434569 Human genes 0.000 description 2
- 102200124923 rs121913254 Human genes 0.000 description 2
- 102200003067 rs1670283 Human genes 0.000 description 2
- 102200003068 rs1881420 Human genes 0.000 description 2
- 102200003069 rs1881421 Human genes 0.000 description 2
- 102200015965 rs459552 Human genes 0.000 description 2
- 102200087780 rs77375493 Human genes 0.000 description 2
- 238000007480 sanger sequencing Methods 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 238000007841 sequencing by ligation Methods 0.000 description 2
- 208000000649 small cell carcinoma Diseases 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 229940113082 thymine Drugs 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 description 2
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 description 1
- 101150023956 ALK gene Proteins 0.000 description 1
- 102100034580 AT-rich interactive domain-containing protein 1A Human genes 0.000 description 1
- 102000000872 ATM Human genes 0.000 description 1
- ULXXDDBFHOBEHA-ONEGZZNKSA-N Afatinib Chemical compound N1=CN=C2C=C(OC3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-ONEGZZNKSA-N 0.000 description 1
- 108010029445 Agammaglobulinaemia Tyrosine Kinase Proteins 0.000 description 1
- 206010061424 Anal cancer Diseases 0.000 description 1
- 208000007860 Anus Neoplasms Diseases 0.000 description 1
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 102000036365 BRCA1 Human genes 0.000 description 1
- 108700020463 BRCA1 Proteins 0.000 description 1
- 101150072950 BRCA1 gene Proteins 0.000 description 1
- 102000052609 BRCA2 Human genes 0.000 description 1
- 108700020462 BRCA2 Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 206010004593 Bile duct cancer Diseases 0.000 description 1
- 101001042041 Bos taurus Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Proteins 0.000 description 1
- 206010006143 Brain stem glioma Diseases 0.000 description 1
- 101150008921 Brca2 gene Proteins 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- 101710098191 C-4 methylsterol oxidase ERG25 Proteins 0.000 description 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 description 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 1
- 229940045513 CTLA4 antagonist Drugs 0.000 description 1
- 206010065305 Cancer in remission Diseases 0.000 description 1
- 206010007275 Carcinoid tumour Diseases 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 201000009047 Chordoma Diseases 0.000 description 1
- 206010065163 Clonal evolution Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000009798 Craniopharyngioma Diseases 0.000 description 1
- 108010058546 Cyclin D1 Proteins 0.000 description 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 1
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 description 1
- 102000009512 Cyclin-Dependent Kinase Inhibitor p15 Human genes 0.000 description 1
- 108010009356 Cyclin-Dependent Kinase Inhibitor p15 Proteins 0.000 description 1
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 description 1
- 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 description 1
- 102100032218 Cytokine-inducible SH2-containing protein Human genes 0.000 description 1
- 208000008334 Dermatofibrosarcoma Diseases 0.000 description 1
- 206010057070 Dermatofibrosarcoma protuberans Diseases 0.000 description 1
- 101100310856 Drosophila melanogaster spri gene Proteins 0.000 description 1
- 102100031480 Dual specificity mitogen-activated protein kinase kinase 1 Human genes 0.000 description 1
- 102100023266 Dual specificity mitogen-activated protein kinase kinase 2 Human genes 0.000 description 1
- 101150039808 Egfr gene Proteins 0.000 description 1
- 101001003194 Eleusine coracana Alpha-amylase/trypsin inhibitor Proteins 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- 201000008228 Ependymoblastoma Diseases 0.000 description 1
- 206010014967 Ependymoma Diseases 0.000 description 1
- 206010014968 Ependymoma malignant Diseases 0.000 description 1
- 208000006168 Ewing Sarcoma Diseases 0.000 description 1
- 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 description 1
- 102100024185 G1/S-specific cyclin-D2 Human genes 0.000 description 1
- 102100037858 G1/S-specific cyclin-E1 Human genes 0.000 description 1
- 102100027541 GTP-binding protein Rheb Human genes 0.000 description 1
- 102100025477 GTP-binding protein Rit1 Human genes 0.000 description 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 description 1
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 description 1
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 description 1
- 208000032612 Glial tumor Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 101000924266 Homo sapiens AT-rich interactive domain-containing protein 1A Proteins 0.000 description 1
- 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 description 1
- 101000943420 Homo sapiens Cytokine-inducible SH2-containing protein Proteins 0.000 description 1
- 101000967216 Homo sapiens Eosinophil cationic protein Proteins 0.000 description 1
- 101000882584 Homo sapiens Estrogen receptor Proteins 0.000 description 1
- 101000980741 Homo sapiens G1/S-specific cyclin-D2 Proteins 0.000 description 1
- 101000574654 Homo sapiens GTP-binding protein Rit1 Proteins 0.000 description 1
- 101001045751 Homo sapiens Hepatocyte nuclear factor 1-alpha Proteins 0.000 description 1
- 101000596894 Homo sapiens High affinity nerve growth factor receptor Proteins 0.000 description 1
- 101000960234 Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic Proteins 0.000 description 1
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 1
- 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 description 1
- 101000686031 Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Proteins 0.000 description 1
- 101000579425 Homo sapiens Proto-oncogene tyrosine-protein kinase receptor Ret Proteins 0.000 description 1
- 101000712530 Homo sapiens RAF proto-oncogene serine/threonine-protein kinase Proteins 0.000 description 1
- 101000771237 Homo sapiens Serine/threonine-protein kinase A-Raf Proteins 0.000 description 1
- 101000799466 Homo sapiens Thrombopoietin receptor Proteins 0.000 description 1
- 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 description 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 description 1
- 101001125402 Homo sapiens Vitamin K-dependent protein C Proteins 0.000 description 1
- 206010021042 Hypopharyngeal cancer Diseases 0.000 description 1
- 206010056305 Hypopharyngeal neoplasm Diseases 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 208000037396 Intraductal Noninfiltrating Carcinoma Diseases 0.000 description 1
- 206010073094 Intraductal proliferative breast lesion Diseases 0.000 description 1
- 206010061252 Intraocular melanoma Diseases 0.000 description 1
- 102100039905 Isocitrate dehydrogenase [NADP] cytoplasmic Human genes 0.000 description 1
- 102000042838 JAK family Human genes 0.000 description 1
- 108091082332 JAK family Proteins 0.000 description 1
- 208000007766 Kaposi sarcoma Diseases 0.000 description 1
- 206010023825 Laryngeal cancer Diseases 0.000 description 1
- 206010061523 Lip and/or oral cavity cancer Diseases 0.000 description 1
- 206010062038 Lip neoplasm Diseases 0.000 description 1
- 108010068342 MAP Kinase Kinase 1 Proteins 0.000 description 1
- 108010068353 MAP Kinase Kinase 2 Proteins 0.000 description 1
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 description 1
- 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 description 1
- 208000032271 Malignant tumor of penis Diseases 0.000 description 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 1
- 238000007476 Maximum Likelihood Methods 0.000 description 1
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 description 1
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 description 1
- 102000013609 MutL Protein Homolog 1 Human genes 0.000 description 1
- 108010026664 MutL Protein Homolog 1 Proteins 0.000 description 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 1
- 108010071382 NF-E2-Related Factor 2 Proteins 0.000 description 1
- 206010028729 Nasal cavity cancer Diseases 0.000 description 1
- 206010028767 Nasal sinus cancer Diseases 0.000 description 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 description 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 102000007530 Neurofibromin 1 Human genes 0.000 description 1
- 108010085793 Neurofibromin 1 Proteins 0.000 description 1
- 101100401106 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) met-7 gene Proteins 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- 208000010505 Nose Neoplasms Diseases 0.000 description 1
- 108010029755 Notch1 Receptor Proteins 0.000 description 1
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 206010031096 Oropharyngeal cancer Diseases 0.000 description 1
- 206010057444 Oropharyngeal neoplasm Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 239000012828 PI3K inhibitor Substances 0.000 description 1
- 239000012823 PI3K/mTOR inhibitor Substances 0.000 description 1
- 206010061332 Paraganglion neoplasm Diseases 0.000 description 1
- 208000003937 Paranasal Sinus Neoplasms Diseases 0.000 description 1
- 208000000821 Parathyroid Neoplasms Diseases 0.000 description 1
- 208000002471 Penile Neoplasms Diseases 0.000 description 1
- 206010034299 Penile cancer Diseases 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
- 206010034811 Pharyngeal cancer Diseases 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 208000007641 Pinealoma Diseases 0.000 description 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 102100025803 Progesterone receptor Human genes 0.000 description 1
- 102100023347 Proto-oncogene tyrosine-protein kinase ROS Human genes 0.000 description 1
- 102000014128 RANK Ligand Human genes 0.000 description 1
- 108010025832 RANK Ligand Proteins 0.000 description 1
- 101150020518 RHEB gene Proteins 0.000 description 1
- 101150111584 RHOA gene Proteins 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 230000018199 S phase Effects 0.000 description 1
- 102000001332 SRC Human genes 0.000 description 1
- 108060006706 SRC Proteins 0.000 description 1
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 description 1
- 206010061934 Salivary gland cancer Diseases 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 102100029437 Serine/threonine-protein kinase A-Raf Human genes 0.000 description 1
- 208000009359 Sezary Syndrome Diseases 0.000 description 1
- 208000021388 Sezary disease Diseases 0.000 description 1
- 102000039471 Small Nuclear RNA Human genes 0.000 description 1
- 108020004688 Small Nuclear RNA Proteins 0.000 description 1
- 102000013380 Smoothened Receptor Human genes 0.000 description 1
- 101710090597 Smoothened homolog Proteins 0.000 description 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 description 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 206010057644 Testis cancer Diseases 0.000 description 1
- 102100034196 Thrombopoietin receptor Human genes 0.000 description 1
- 102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 description 1
- 102100022387 Transforming protein RhoA Human genes 0.000 description 1
- 206010066901 Treatment failure Diseases 0.000 description 1
- 208000026911 Tuberous sclerosis complex Diseases 0.000 description 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
- 102100029823 Tyrosine-protein kinase BTK Human genes 0.000 description 1
- 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 description 1
- 206010046431 Urethral cancer Diseases 0.000 description 1
- 206010046458 Urethral neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 201000005969 Uveal melanoma Diseases 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 102100029477 Vitamin K-dependent protein C Human genes 0.000 description 1
- 206010047741 Vulval cancer Diseases 0.000 description 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 description 1
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 description 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 description 1
- 208000008383 Wilms tumor Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000020990 adrenal cortex carcinoma Diseases 0.000 description 1
- 208000007128 adrenocortical carcinoma Diseases 0.000 description 1
- 229960001686 afatinib Drugs 0.000 description 1
- ULXXDDBFHOBEHA-CWDCEQMOSA-N afatinib Chemical compound N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 0.000 description 1
- 229940042992 afinitor Drugs 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000011123 anti-EGFR therapy Methods 0.000 description 1
- 238000011394 anticancer treatment Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 201000011165 anus cancer Diseases 0.000 description 1
- 229940120638 avastin Drugs 0.000 description 1
- 229960003005 axitinib Drugs 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 230000037429 base substitution Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000397 bevacizumab Drugs 0.000 description 1
- 208000026900 bile duct neoplasm Diseases 0.000 description 1
- 238000003766 bioinformatics method Methods 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 201000011143 bone giant cell tumor Diseases 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 238000007469 bone scintigraphy Methods 0.000 description 1
- 229940083476 bosulif Drugs 0.000 description 1
- 229960003736 bosutinib Drugs 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229960001292 cabozantinib Drugs 0.000 description 1
- ONIQOQHATWINJY-UHFFFAOYSA-N cabozantinib Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 ONIQOQHATWINJY-UHFFFAOYSA-N 0.000 description 1
- HFCFMRYTXDINDK-WNQIDUERSA-N cabozantinib malate Chemical compound OC(=O)[C@@H](O)CC(O)=O.C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 HFCFMRYTXDINDK-WNQIDUERSA-N 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229940056434 caprelsa Drugs 0.000 description 1
- 208000002458 carcinoid tumor Diseases 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000006990 cholangiocarcinoma Diseases 0.000 description 1
- 238000007635 classification algorithm Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 238000011281 clinical therapy Methods 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 229940034568 cometriq Drugs 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 description 1
- 238000002574 cystoscopy Methods 0.000 description 1
- 229960002448 dasatinib Drugs 0.000 description 1
- 238000003066 decision tree Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 229960001251 denosumab Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 239000005546 dideoxynucleotide Substances 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000022602 disease susceptibility Diseases 0.000 description 1
- 208000028715 ductal breast carcinoma in situ Diseases 0.000 description 1
- 201000007273 ductal carcinoma in situ Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 108700021358 erbB-1 Genes Proteins 0.000 description 1
- 229940082789 erbitux Drugs 0.000 description 1
- 108010038795 estrogen receptors Proteins 0.000 description 1
- 229960005167 everolimus Drugs 0.000 description 1
- 229960000255 exemestane Drugs 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 208000024519 eye neoplasm Diseases 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 201000010175 gallbladder cancer Diseases 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 210000002980 germ line cell Anatomy 0.000 description 1
- 229940087158 gilotrif Drugs 0.000 description 1
- 229940080856 gleevec Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 201000009277 hairy cell leukemia Diseases 0.000 description 1
- 201000010235 heart cancer Diseases 0.000 description 1
- 208000024348 heart neoplasm Diseases 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 229940022353 herceptin Drugs 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 201000006866 hypopharynx cancer Diseases 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000012296 in situ hybridization assay Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 229940005319 inlyta Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960005386 ipilimumab Drugs 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229940045773 jakafi Drugs 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 229960004891 lapatinib Drugs 0.000 description 1
- 206010023841 laryngeal neoplasm Diseases 0.000 description 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
- 201000006721 lip cancer Diseases 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 238000002624 low-dose chemotherapy Methods 0.000 description 1
- 238000009593 lumbar puncture Methods 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229940083118 mekinist Drugs 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003990 molecular pathway Effects 0.000 description 1
- 231100000150 mutagenicity / genotoxicity testing Toxicity 0.000 description 1
- 206010028537 myelofibrosis Diseases 0.000 description 1
- LBWFXVZLPYTWQI-IPOVEDGCSA-N n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C LBWFXVZLPYTWQI-IPOVEDGCSA-N 0.000 description 1
- 201000008026 nephroblastoma Diseases 0.000 description 1
- 229960001346 nilotinib Drugs 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 201000008106 ocular cancer Diseases 0.000 description 1
- 201000002575 ocular melanoma Diseases 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 201000005443 oral cavity cancer Diseases 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 201000006958 oropharynx cancer Diseases 0.000 description 1
- 208000003154 papilloma Diseases 0.000 description 1
- 208000029211 papillomatosis Diseases 0.000 description 1
- 208000007312 paraganglioma Diseases 0.000 description 1
- 201000007052 paranasal sinus cancer Diseases 0.000 description 1
- 238000010238 partial least squares regression Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229960000639 pazopanib Drugs 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 208000020943 pineal parenchymal cell neoplasm Diseases 0.000 description 1
- 208000010916 pituitary tumor Diseases 0.000 description 1
- 208000010626 plasma cell neoplasm Diseases 0.000 description 1
- 238000012123 point-of-care testing Methods 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 108090000468 progesterone receptors Proteins 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000004908 prostatic fluid Anatomy 0.000 description 1
- 238000000575 proteomic method Methods 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 102220014458 rs1050171 Human genes 0.000 description 1
- 102220203488 rs10521 Human genes 0.000 description 1
- 102220123145 rs11145767 Human genes 0.000 description 1
- 102220004841 rs1136201 Human genes 0.000 description 1
- 102220014476 rs1140475 Human genes 0.000 description 1
- 102220010980 rs12628 Human genes 0.000 description 1
- 102220007194 rs1800861 Human genes 0.000 description 1
- 102220007218 rs1800863 Human genes 0.000 description 1
- 102220109126 rs1873778 Human genes 0.000 description 1
- 102220110099 rs2072454 Human genes 0.000 description 1
- 102220110101 rs2227984 Human genes 0.000 description 1
- 102220109128 rs2228230 Human genes 0.000 description 1
- 102220123111 rs2229974 Human genes 0.000 description 1
- 102220011957 rs2229992 Human genes 0.000 description 1
- 102220099466 rs2246745 Human genes 0.000 description 1
- 102220108577 rs2256740 Human genes 0.000 description 1
- 102220108578 rs2293564 Human genes 0.000 description 1
- 102220205453 rs3125006 Human genes 0.000 description 1
- 102220011958 rs351771 Human genes 0.000 description 1
- 102220139478 rs3795850 Human genes 0.000 description 1
- 102220011961 rs41115 Human genes 0.000 description 1
- 102220011962 rs42427 Human genes 0.000 description 1
- 102220108581 rs4358080 Human genes 0.000 description 1
- 102220015498 rs4362222 Human genes 0.000 description 1
- 102220123112 rs4489420 Human genes 0.000 description 1
- 102220011965 rs465899 Human genes 0.000 description 1
- 102220202616 rs7688609 Human genes 0.000 description 1
- 102220110100 rs7801956 Human genes 0.000 description 1
- 102220011964 rs866006 Human genes 0.000 description 1
- 102220203944 rs9411208 Human genes 0.000 description 1
- JFMWPOCYMYGEDM-XFULWGLBSA-N ruxolitinib phosphate Chemical compound OP(O)(O)=O.C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 JFMWPOCYMYGEDM-XFULWGLBSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 201000002314 small intestine cancer Diseases 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- IVDHYUQIDRJSTI-UHFFFAOYSA-N sorafenib tosylate Chemical compound [H+].CC1=CC=C(S([O-])(=O)=O)C=C1.C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 IVDHYUQIDRJSTI-UHFFFAOYSA-N 0.000 description 1
- 229940068117 sprycel Drugs 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 229940090374 stivarga Drugs 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 229960001796 sunitinib Drugs 0.000 description 1
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 description 1
- 238000001847 surface plasmon resonance imaging Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229940034785 sutent Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940081616 tafinlar Drugs 0.000 description 1
- 229940120982 tarceva Drugs 0.000 description 1
- 229940069905 tasigna Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 208000008732 thymoma Diseases 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 208000009999 tuberous sclerosis Diseases 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 229940094060 tykerb Drugs 0.000 description 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 208000037965 uterine sarcoma Diseases 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
- 229960000241 vandetanib Drugs 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 229940069559 votrient Drugs 0.000 description 1
- 201000005102 vulva cancer Diseases 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229940049068 xalkori Drugs 0.000 description 1
- 229940014556 xgeva Drugs 0.000 description 1
- 229940055760 yervoy Drugs 0.000 description 1
- 229940034727 zelboraf Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Treatment And Welfare Office Work (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462098426P | 2014-12-31 | 2014-12-31 | |
| US62/098,426 | 2014-12-31 | ||
| US201562155763P | 2015-05-01 | 2015-05-01 | |
| US62/155,763 | 2015-05-01 | ||
| PCT/US2015/067717 WO2016109452A1 (en) | 2014-12-31 | 2015-12-28 | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2972433A1 true CA2972433A1 (en) | 2016-07-07 |
Family
ID=56284976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2972433A Pending CA2972433A1 (en) | 2014-12-31 | 2015-12-28 | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20170260590A1 (zh) |
| EP (3) | EP3766986B1 (zh) |
| JP (4) | JP6783768B2 (zh) |
| CN (2) | CN107406876B (zh) |
| AU (3) | AU2015374259B2 (zh) |
| CA (1) | CA2972433A1 (zh) |
| ES (2) | ES2828279T3 (zh) |
| GB (1) | GB2552267B (zh) |
| WO (1) | WO2016109452A1 (zh) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2625288T3 (es) | 2011-04-15 | 2017-07-19 | The Johns Hopkins University | Sistema de secuenciación segura |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| ES2886507T3 (es) | 2012-10-29 | 2021-12-20 | Univ Johns Hopkins | Prueba de Papanicolaou para cánceres de ovario y de endometrio |
| SG11201504334WA (en) | 2012-12-10 | 2015-07-30 | Resolution Bioscience Inc | Methods for targeted genomic analysis |
| CN106795562B (zh) | 2014-07-18 | 2022-03-25 | 香港中文大学 | Dna混合物中的组织甲基化模式分析 |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| EP4012715A1 (en) | 2015-02-10 | 2022-06-15 | The Chinese University Of Hong Kong | Detecting mutations for cancer screening and fetal analysis |
| HUE057821T2 (hu) | 2015-07-23 | 2022-06-28 | Univ Hong Kong Chinese | Sejtmentes DNS fragmentációs mintázatának elemzése |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| CN108474040B (zh) | 2015-10-09 | 2023-05-16 | 夸登特健康公司 | 使用无细胞dna的基于群体的治疗推荐 |
| EP3374525B1 (en) | 2015-11-11 | 2021-01-20 | Resolution Bioscience, Inc. | High efficiency construction of dna libraries |
| CN108603228B (zh) | 2015-12-17 | 2023-09-01 | 夸登特健康公司 | 通过分析无细胞dna确定肿瘤基因拷贝数的方法 |
| WO2018039463A1 (en) | 2016-08-25 | 2018-03-01 | Resolution Bioscience, Inc. | Methods for the detection of genomic copy changes in dna samples |
| US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| EP3792922A1 (en) | 2016-09-30 | 2021-03-17 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
| KR20230062684A (ko) | 2016-11-30 | 2023-05-09 | 더 차이니즈 유니버시티 오브 홍콩 | 소변 및 기타 샘플에서의 무세포 dna의 분석 |
| MX2019008458A (es) | 2017-01-17 | 2019-12-02 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos. |
| MY197535A (en) | 2017-01-25 | 2023-06-21 | Univ Hong Kong Chinese | Diagnostic applications using nucleic acid fragments |
| KR102083501B1 (ko) * | 2017-02-09 | 2020-03-02 | 사회복지법인 삼성생명공익재단 | 종양 치료를 위한 표적 유전자 판별 방법 |
| WO2018201072A2 (en) * | 2017-04-28 | 2018-11-01 | 4D Path Inc. | Apparatus, systems, and methods for rapid cancer detection |
| JP7123975B2 (ja) * | 2017-05-16 | 2022-08-23 | ガーダント ヘルス， インコーポレイテッド | 無細胞ｄｎａについての体細胞起源または生殖系列起源の識別 |
| US10636512B2 (en) | 2017-07-14 | 2020-04-28 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
| AU2018342007A1 (en) | 2017-08-07 | 2020-02-27 | Board Of Regents, The University Of Texas Systems | Methods and materials for assessing and treating cancer |
| JP7072825B2 (ja) * | 2017-09-13 | 2022-05-23 | 三菱電機ソフトウエア株式会社 | コピー数計測装置、コピー数計測プログラムおよびコピー数計測方法 |
| AU2018335405A1 (en) * | 2017-09-20 | 2020-04-09 | Guardant Health, Inc. | Methods and systems for differentiating somatic and germline variants |
| EP3704268A4 (en) * | 2017-11-03 | 2021-08-11 | Guardant Health, Inc. | NORMALIZATION OF A TUMOR MUTATION LOAD |
| EP3717662A1 (en) * | 2017-11-28 | 2020-10-07 | Grail, Inc. | Models for targeted sequencing |
| CN110770838B (zh) * | 2017-12-01 | 2023-12-19 | Illumina公司 | 用于确定体细胞突变克隆性的方法和系统 |
| WO2019108807A1 (en) * | 2017-12-01 | 2019-06-06 | Personal Genome Diagnositics Inc. | Process for microsatellite instability detection |
| CN108491689B (zh) * | 2018-02-01 | 2019-07-09 | 杭州纽安津生物科技有限公司 | 基于转录组的肿瘤新抗原鉴定方法 |
| CA3090951C (en) * | 2018-02-12 | 2023-10-17 | F.Hoffmann-La Roche Ag | Method of predicting response to therapy by assessing tumor genetic heterogeneity |
| CA3092352A1 (en) * | 2018-02-27 | 2019-09-06 | Cornell University | Systems and methods for detection of residual disease |
| CN112601826A (zh) * | 2018-02-27 | 2021-04-02 | 康奈尔大学 | 通过全基因组整合进行循环肿瘤dna的超灵敏检测 |
| WO2019195769A1 (en) * | 2018-04-06 | 2019-10-10 | The Brigham And Women's Hospital, Inc. | Methods of diagnosing and treating aggressive cutaneous t-cell lymphomas |
| WO2019204360A1 (en) * | 2018-04-16 | 2019-10-24 | Grail, Inc. | Systems and methods for determining tumor fraction in cell-free nucleic acid |
| EP4353836A3 (en) * | 2018-04-27 | 2024-05-01 | Kao Corporation | Highly accurate sequencing method |
| US20210222251A1 (en) * | 2018-05-08 | 2021-07-22 | Roche Sequencing Solutions, Inc. | Method of cancer prognosis by assessing tumor variant diversity |
| JP7466519B2 (ja) * | 2018-07-23 | 2024-04-12 | ガーダント ヘルス， インコーポレイテッド | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
| CA3111887A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| GB2577548B (en) * | 2018-09-28 | 2022-10-26 | Siemens Healthcare Gmbh | Method for determining a subject's genetic copy number value |
| JP7499239B2 (ja) * | 2018-11-13 | 2024-06-13 | ミリアド・ジェネティックス・インコーポレイテッド | 体細胞変異のための方法およびシステム、ならびにそれらの使用 |
| BR112021009706A2 (pt) * | 2018-11-21 | 2021-08-17 | Karius, Inc. | detecção e predição de doença infecciosa |
| CN109712671B (zh) * | 2018-12-20 | 2020-06-26 | 北京优迅医学检验实验室有限公司 | 基于ctDNA的基因检测装置、存储介质及计算机系统 |
| EP3912007A4 (en) * | 2019-01-10 | 2022-11-02 | Travera LLC | IDENTIFICATION OF CANCER THERAPIES |
| EP3918089A1 (en) | 2019-01-31 | 2021-12-08 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
| CN110428905B (zh) * | 2019-07-02 | 2022-03-29 | 江南大学附属医院 | 一种肿瘤生长趋势预测方法 |
| CN110895963A (zh) * | 2019-10-31 | 2020-03-20 | 深圳兰丁医学检验实验室 | 一种基于人工智能的细胞dna定量检测系统 |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| CA3180386A1 (en) * | 2020-05-29 | 2021-12-02 | Yi-Wen Chen | Genetic diagnostic tool for facioscapulohumeral muscular dystrophy (fshd) |
| CN114267445A (zh) * | 2021-12-23 | 2022-04-01 | 山东众阳健康科技集团有限公司 | 一种诊断一致性检验方法、系统、设备及介质 |
| WO2023183750A1 (en) * | 2022-03-23 | 2023-09-28 | Foundation Medicine, Inc. | Methods and systems for determining tumor heterogeneity |
| CN116403644B (zh) * | 2023-03-03 | 2023-12-05 | 深圳吉因加信息科技有限公司 | 一种用于癌症风险预测的方法及装置 |
| CN117219162A (zh) * | 2023-09-12 | 2023-12-12 | 四川大学 | 针对肿瘤组织str图谱进行身源鉴定的证据强度评估方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7385605B2 (en) * | 2003-12-04 | 2008-06-10 | International Business Machines Corporation | Computer display system for dynamically modifying stacked area line graphs to change the order or presence of a set of stacked areas in the graph respectively representative of the proportions contributed to a total by each of a set of time dependent variables |
| US20060199189A1 (en) * | 2005-03-07 | 2006-09-07 | Bradford Sherry A | Low-dose, sequenced, individualized chemotherapy dosing method |
| CN102473202B (zh) * | 2009-07-08 | 2015-11-25 | 环球创新网络公司 | 用于预测药物在患者中的疗效的方法 |
| JP2013540995A (ja) * | 2010-08-18 | 2013-11-07 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． | 疾患に対する循環バイオマーカー |
| ES2625288T3 (es) | 2011-04-15 | 2017-07-19 | The Johns Hopkins University | Sistema de secuenciación segura |
| AU2011373694A1 (en) * | 2011-07-26 | 2013-05-02 | Verinata Health, Inc. | Method for determining the presence or absence of different aneuploidies in a sample |
| US20130110407A1 (en) * | 2011-09-16 | 2013-05-02 | Complete Genomics, Inc. | Determining variants in genome of a heterogeneous sample |
| SG190466A1 (en) * | 2011-11-18 | 2013-06-28 | Agency Science Tech & Res | Methods for diagnosis and/or prognosis of ovarian cancer |
| DK2828218T3 (da) | 2012-03-20 | 2020-11-02 | Univ Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| US11261494B2 (en) * | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| PT2893040T (pt) * | 2012-09-04 | 2019-04-01 | Guardant Health Inc | Métodos para deteção de mutações raras e de variação do número de cópias |
| EP3795696B1 (en) * | 2013-03-15 | 2023-04-26 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| EP3882362B1 (en) | 2013-03-15 | 2024-05-08 | Guardant Health, Inc. | Methods for sequencing of cell free polynucleotides |
| US10435740B2 (en) * | 2013-04-01 | 2019-10-08 | University Of Florida Research Foundation, Incorporated | Determination of methylation state and chromatin structure of target genetic loci |
| EP3003377A1 (en) * | 2013-05-31 | 2016-04-13 | Novartis AG | Combination therapy containing a pi3k-alpha inhibitor and fgfr kinase inhibitor for treating cancer |
-
2015
- 2015-12-28 AU AU2015374259A patent/AU2015374259B2/en active Active
- 2015-12-28 GB GB1712299.5A patent/GB2552267B/en active Active
- 2015-12-28 EP EP20179648.9A patent/EP3766986B1/en active Active
- 2015-12-28 JP JP2017535008A patent/JP6783768B2/ja active Active
- 2015-12-28 ES ES15876120T patent/ES2828279T3/es active Active
- 2015-12-28 ES ES20179648T patent/ES2923602T3/es active Active
- 2015-12-28 CN CN201580077268.8A patent/CN107406876B/zh active Active
- 2015-12-28 CN CN202111138455.6A patent/CN113930507A/zh active Pending
- 2015-12-28 WO PCT/US2015/067717 patent/WO2016109452A1/en active Application Filing
- 2015-12-28 CA CA2972433A patent/CA2972433A1/en active Pending
- 2015-12-28 EP EP15876120.5A patent/EP3240911B1/en active Active
- 2015-12-28 EP EP22176398.0A patent/EP4123032A1/en active Pending
-
2017
- 2017-02-13 US US15/431,395 patent/US20170260590A1/en active Pending
-
2020
- 2020-04-17 JP JP2020073957A patent/JP7145907B2/ja active Active
- 2020-08-21 US US17/000,010 patent/US20210040565A1/en active Pending
- 2020-11-04 AU AU2020264326A patent/AU2020264326B2/en active Active
-
2021
- 2021-08-31 US US17/462,906 patent/US20210395837A1/en active Pending
- 2021-11-11 JP JP2021184052A patent/JP7458360B2/ja active Active
-
2022
- 2022-03-21 US US17/699,968 patent/US20240141432A9/en active Pending
-
2023
- 2023-07-20 AU AU2023206196A patent/AU2023206196A1/en active Pending
-
2024
- 2024-01-04 JP JP2024000141A patent/JP2024029174A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4123032A1 (en) | 2023-01-25 |
| EP3240911B1 (en) | 2020-08-26 |
| WO2016109452A1 (en) | 2016-07-07 |
| US20210040565A1 (en) | 2021-02-11 |
| ES2923602T3 (es) | 2022-09-28 |
| JP2022024040A (ja) | 2022-02-08 |
| EP3240911A1 (en) | 2017-11-08 |
| CN107406876B (zh) | 2021-09-07 |
| US20170260590A1 (en) | 2017-09-14 |
| JP2024029174A (ja) | 2024-03-05 |
| JP2018507682A (ja) | 2018-03-22 |
| AU2015374259B2 (en) | 2020-08-13 |
| AU2020264326A1 (en) | 2020-11-26 |
| JP6783768B2 (ja) | 2020-11-11 |
| JP7145907B2 (ja) | 2022-10-03 |
| ES2828279T3 (es) | 2021-05-25 |
| CN107406876A (zh) | 2017-11-28 |
| EP3240911A4 (en) | 2018-11-21 |
| JP2020127408A (ja) | 2020-08-27 |
| CN113930507A (zh) | 2022-01-14 |
| GB2552267A (en) | 2018-01-17 |
| EP3766986A1 (en) | 2021-01-20 |
| AU2023206196A1 (en) | 2023-08-10 |
| US20210395837A1 (en) | 2021-12-23 |
| GB2552267B (en) | 2020-06-10 |
| AU2015374259A1 (en) | 2017-08-10 |
| EP3766986B1 (en) | 2022-06-01 |
| GB201712299D0 (en) | 2017-09-13 |
| US20240141432A9 (en) | 2024-05-02 |
| AU2020264326B2 (en) | 2023-05-18 |
| JP7458360B2 (ja) | 2024-03-29 |
| US20220213562A1 (en) | 2022-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2020264326B2 (en) | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results | |
| Pleasance et al. | Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes | |
| JP2022532897A (ja) | マルチラベルがん分類のためのシステムおよび方法 | |
| JP5955557B2 (ja) | 膵臓腫瘍形成の根底にある経路および遺伝性の膵癌遺伝子 | |
| JP2018138031A (ja) | ヘテロ接合性の消失（ｌｏｓｓ ｏｆ ｈｅｔｅｒｏｚｙｇｏｓｉｔｙ）を評価するための方法および材料 | |
| AU2016293025A1 (en) | System and methodology for the analysis of genomic data obtained from a subject | |
| CN113151474A (zh) | 用于癌症检测的血浆dna突变分析 | |
| JP2022533137A (ja) | 腫瘍分率を評価するためのシステムおよび方法 | |
| US20240071628A1 (en) | Database for therapeutic interventions | |
| US20240052419A1 (en) | Methods and systems for detecting genetic variants | |
| KR20200044123A (ko) | 암 환자에서의 향상된 정밀도를 위한 포괄적 게놈 트랜스크립톰 종양-정상 유전자 패널 분석 (comprehensive genomic transcriptomic tumor-normal gene panel analysis for enhanced precision in patients with cancer) | |
| US20230162815A1 (en) | Methods and systems for accurate genotyping of repeat polymorphisms | |
| Bellucca et al. | Molecular Basis and Diagnostic Approach to Isolated and Syndromic Lateralized Overgrowth in Childhood | |
| WO2023183750A1 (en) | Methods and systems for determining tumor heterogeneity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20201218 |
|
| EEER | Examination request |
Effective date: 20201218 |
|
| EEER | Examination request |
Effective date: 20201218 |
|
| EEER | Examination request |
Effective date: 20201218 |
|
| EEER | Examination request |
Effective date: 20201218 |
|
| EEER | Examination request |
Effective date: 20201218 |
|
| EEER | Examination request |
Effective date: 20201218 |