CA2968522A1 - Methods and formulations for treating vascular eye diseases - Google Patents
Methods and formulations for treating vascular eye diseases Download PDFInfo
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- CA2968522A1 CA2968522A1 CA2968522A CA2968522A CA2968522A1 CA 2968522 A1 CA2968522 A1 CA 2968522A1 CA 2968522 A CA2968522 A CA 2968522A CA 2968522 A CA2968522 A CA 2968522A CA 2968522 A1 CA2968522 A1 CA 2968522A1
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
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| US201562147232P | 2015-04-14 | 2015-04-14 | |
| US62/147,232 | 2015-04-14 | ||
| US14/943,490 | 2015-11-17 | ||
| US14/943,490 US20160144025A1 (en) | 2014-11-25 | 2015-11-17 | Methods and formulations for treating vascular eye diseases |
| PCT/US2015/061543 WO2016085750A1 (en) | 2014-11-25 | 2015-11-19 | Methods and formulations for treating vascular eye diseases |
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| CA2968522A1 true CA2968522A1 (en) | 2016-06-02 |
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| HUE018715T2 (hu) | 2006-06-16 | 2024-10-28 | Regeneron Pharma | Intravitreális beadásra alkalmas VEGF antagonista készítmények |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| AU2010271105C1 (en) | 2009-01-12 | 2014-08-21 | Aerpio Therapeutics, Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| JO3182B1 (ar) * | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| CN104039351A (zh) | 2011-10-13 | 2014-09-10 | 阿尔皮奥治疗学股份有限公司 | 用于治疗血管渗漏综合征和癌症的方法 |
| AU2014221144B2 (en) | 2013-02-21 | 2018-03-22 | Rsem, Limited Partnership | Inhibition of Sema3A in the prevention and treatment of ocular hyperpermeability |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| US11104730B2 (en) | 2013-11-20 | 2021-08-31 | Regeneren Pharmaceuticals, Inc. | Methods of treating eye disorders with APLNR antagonists and VEGF inhibitors |
| CN106456614A (zh) | 2014-03-14 | 2017-02-22 | 爱尔皮奥治疗有限公司 | HPTP‑β抑制剂 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
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| EP3977994B1 (en) | 2015-09-23 | 2024-04-24 | EyePoint Pharmaceuticals, Inc. | Activators of tie-2 for use in treating intraocular pressure |
| NZ783685A (en) | 2015-12-30 | 2025-09-26 | Kodiak Sciences Inc | Antibodies and conjugates thereof |
| WO2018017714A1 (en) | 2016-07-20 | 2018-01-25 | Aerpio Therapeutics, Inc. | HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß) |
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| IL270267B2 (en) * | 2017-05-06 | 2024-06-01 | Regeneron Pharma | Methods of treating eye disorders with aplnr antagonists and vegf inhibitors |
| IL312394B2 (en) * | 2017-08-18 | 2025-07-01 | Regeneron Pharma | Capillary Isoelectric Focusing Image for Analysis of Protein Variants in a Sample Matrix |
| SG11202004268PA (en) * | 2017-11-30 | 2020-06-29 | Regeneron Pharma | Use of a vegf antagonist to treat angiogenic eye disorders |
| KR20250002808A (ko) * | 2017-12-22 | 2025-01-07 | 삼성바이오에피스 주식회사 | Vegf 길항제를 포함하는 액상 조성물 |
| WO2019147944A1 (en) | 2018-01-26 | 2019-08-01 | The Regents Of The University Of California | Methods and compositions for treatment of angiogenic disordres using anti-vegf agents |
| EP3749359A1 (en) * | 2018-02-06 | 2020-12-16 | F. Hoffmann-La Roche AG | Treatment of ophthalmologic diseases |
| SG11202008242XA (en) | 2018-03-02 | 2020-09-29 | Kodiak Sciences Inc | Il-6 antibodies and fusion constructs and conjugates thereof |
| EP3761953A1 (en) | 2018-03-08 | 2021-01-13 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
| US11426446B2 (en) | 2018-03-08 | 2022-08-30 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
| CN108671229B (zh) * | 2018-05-08 | 2022-03-25 | 华博生物医药技术（上海）有限公司 | 一种重组人血管内皮生长因子受体-抗体融合蛋白的药物组合制剂 |
| CN118948760A (zh) | 2018-05-10 | 2024-11-15 | 瑞泽恩制药公司 | 含有高浓度vegf受体融合蛋白的制剂 |
| CN112912104A (zh) * | 2018-08-17 | 2021-06-04 | 三钰生物科技股份有限公司 | 抗血管新生融合蛋白及其用途 |
| MA54052A (fr) | 2018-10-29 | 2022-02-09 | Hoffmann La Roche | Formulation d'anticorps |
| CN109598628B (zh) * | 2018-11-30 | 2022-09-20 | 平安医疗健康管理股份有限公司 | 医保欺诈行为的识别方法、装置、设备及可读存储介质 |
| CA3119241A1 (en) | 2018-12-18 | 2020-06-25 | Novartis Ag | Protein solution formulation containing high concentration of an anti-vegf antibody |
| US11634485B2 (en) | 2019-02-18 | 2023-04-25 | Eli Lilly And Company | Therapeutic antibody formulation |
| EP3962482A4 (en) | 2019-04-29 | 2023-01-11 | EyePoint Pharmaceuticals, Inc. | TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL |
| CN110423281B (zh) * | 2019-07-31 | 2021-04-30 | 成都金唯科生物科技有限公司 | 用于治疗老年性黄斑变性的融合蛋白、病毒载体和药物 |
| AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CA3168512A1 (en) | 2019-11-25 | 2021-06-03 | Napoleone Ferrara | Long-acting vegf inhibitors for intraocular neovascularization |
| CN113493519B (zh) * | 2020-03-19 | 2022-12-27 | 浙江道尔生物科技有限公司 | 一种半衰期显著延长的治疗眼部血管新生疾病的融合蛋白 |
| US20230157533A1 (en) * | 2020-04-29 | 2023-05-25 | Novartis Ag | A computer-implemented system and method for assessing a level of activity of a disease or condition in a patient's eye |
| CN115803009A (zh) | 2020-05-08 | 2023-03-14 | 瑞泽恩制药公司 | 用于治疗眼病和癌症的vegf阱和微阱及方法 |
| CN115734971A (zh) * | 2020-06-22 | 2023-03-03 | 信达生物制药(苏州)有限公司 | 抗ang-2抗体及其用途 |
| US20230270670A1 (en) * | 2020-07-24 | 2023-08-31 | Pangen Biotech Inc. | Ophthalmic liquid composition |
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| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| WO2005072772A1 (en) * | 2004-01-30 | 2005-08-11 | Suomen Punainen Risti Veripalvelu | Pharmaceutical compositions |
| AR059066A1 (es) * | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| HUE018715T2 (hu) | 2006-06-16 | 2024-10-28 | Regeneron Pharma | Intravitreális beadásra alkalmas VEGF antagonista készítmények |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| CA2665956A1 (en) * | 2009-05-07 | 2010-11-07 | Samir Patel | Combination treatment for ocular diseases |
| US20120076787A1 (en) | 2009-05-28 | 2012-03-29 | Peter Adamson | Combination of a tnf-alpha antagonist and a vegf antagonist for use in the treatment or prevention of diseases of the eye |
| US8980268B2 (en) * | 2009-07-29 | 2015-03-17 | Regeneron Pharamceuticals, Inc. | Methods for treating cancer by administering an anti-Ang-2 antibody |
| US20120189635A1 (en) * | 2009-07-29 | 2012-07-26 | Regeneron Pharmaceuticals, Inc. | Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2) |
| JO3182B1 (ar) * | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
| AR080794A1 (es) * | 2010-03-26 | 2012-05-09 | Hoffmann La Roche | Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2 |
| EP2663325A1 (en) | 2011-01-13 | 2013-11-20 | Regeneron Pharmaceuticals, Inc. | Use of a vegf antagonist to treat angiogenic eye disorders |
| CN104169299B (zh) * | 2012-01-23 | 2018-06-05 | 瑞泽恩制药公司 | 含抗Ang-2 抗体的稳定化制剂 |
| DK3495387T3 (da) * | 2012-07-13 | 2021-11-08 | Roche Glycart Ag | Bispecifikke anti-VEGF-/anti-ANG-2-antistoffer og deres anvendelse ved behandling af okulære vaskulære sygdomme |
| EP3851454A1 (en) * | 2012-12-05 | 2021-07-21 | Novartis AG | Compositions and methods for antibodies targeting epo |
| JO3405B1 (ar) * | 2013-01-09 | 2019-10-20 | Regeneron Pharma | الأجسام المضادة لمضاد مستقبل عامل النمو المشتق من الصفائح الدموية - بيتا واستخداماتها |
| BR112016000282A2 (pt) * | 2013-07-11 | 2017-12-12 | Novartis Ag | uso de antagonista de vegf em tratamento de retinopatia da prematuridade |
| DE112014005747T5 (de) * | 2013-12-17 | 2016-10-06 | Kymab Limited | Antikörper zur Verwendung bei der Behandlung von Zuständen, die mit spezifischen PCSK9 Varianten in spezifischen Patientenpopulationen in Beziehung stehen |
| US9914769B2 (en) * | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
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- 2015-11-19 AU AU2015353838A patent/AU2015353838A1/en not_active Abandoned
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- 2015-11-19 PE PE2017000901A patent/PE20170900A1/es unknown
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2016
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| IL252159A0 (en) | 2017-07-31 |
| EP3224278A1 (en) | 2017-10-04 |
| CO2017004715A2 (es) | 2017-09-20 |
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| WO2016085750A1 (en) | 2016-06-02 |
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| US20190117767A1 (en) | 2019-04-25 |
| BR112017009807A2 (pt) | 2018-02-27 |
| MX2017006129A (es) | 2018-04-10 |
| CN107001457A (zh) | 2017-08-01 |
| PE20170900A1 (es) | 2017-07-12 |
| PH12017500834A1 (en) | 2017-10-30 |
| JP2017536414A (ja) | 2017-12-07 |
| CL2017001188A1 (es) | 2017-11-24 |
| MA40306A1 (fr) | 2019-03-29 |
| MA41028A (fr) | 2017-10-03 |
| IL252159B (en) | 2021-03-25 |
| AU2015353838A1 (en) | 2017-06-08 |
| US20170080086A1 (en) | 2017-03-23 |
| SG11201703609UA (en) | 2017-06-29 |
| KR20170087950A (ko) | 2017-07-31 |
| EP3224278A4 (en) | 2018-07-11 |
| US20160144025A1 (en) | 2016-05-26 |
| JP2021046431A (ja) | 2021-03-25 |
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