CA2968309A1 - 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators - Google Patents
6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators Download PDFInfo
- Publication number
- CA2968309A1 CA2968309A1 CA2968309A CA2968309A CA2968309A1 CA 2968309 A1 CA2968309 A1 CA 2968309A1 CA 2968309 A CA2968309 A CA 2968309A CA 2968309 A CA2968309 A CA 2968309A CA 2968309 A1 CA2968309 A1 CA 2968309A1
- Authority
- CA
- Canada
- Prior art keywords
- general formula
- compound
- alkyl
- halo
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1420593.4A GB201420593D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
GB1420594.2 | 2014-11-19 | ||
GB1420593.4 | 2014-11-19 | ||
GBGB1420594.2A GB201420594D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
GB1505670.8 | 2015-04-01 | ||
GBGB1505670.8A GB201505670D0 (en) | 2015-04-01 | 2015-04-01 | Compounds |
PCT/GB2015/053516 WO2016079517A1 (en) | 2014-11-19 | 2015-11-19 | 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2968309A1 true CA2968309A1 (en) | 2016-05-26 |
Family
ID=54704019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2968309A Abandoned CA2968309A1 (en) | 2014-11-19 | 2015-11-19 | 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators |
Country Status (16)
Country | Link |
---|---|
US (1) | US10301350B2 (de) |
EP (1) | EP3221331B1 (de) |
JP (1) | JP6700274B2 (de) |
KR (1) | KR102526631B1 (de) |
CN (1) | CN107207559B (de) |
BR (1) | BR112017010319B1 (de) |
CA (1) | CA2968309A1 (de) |
DK (1) | DK3221331T3 (de) |
EA (1) | EA033427B1 (de) |
ES (1) | ES2759725T3 (de) |
HK (1) | HK1246801A1 (de) |
MX (1) | MX2017006563A (de) |
PL (1) | PL3221331T3 (de) |
PT (1) | PT3221331T (de) |
TW (1) | TWI690536B (de) |
WO (1) | WO2016079517A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI686401B (zh) | 2014-11-19 | 2020-03-01 | 英商Nzp英國有限公司 | 化合物(三) |
DK3221332T3 (da) | 2014-11-19 | 2019-07-29 | Nzp Uk Ltd | Fremstilling af steroide fxr-modulatorer |
MX2017006567A (es) | 2014-11-19 | 2018-01-26 | Nzp Uk Ltd | Esteroides 6.alfa.-alquil-6,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr). |
CZ2015504A3 (cs) * | 2015-07-16 | 2017-01-25 | Zentiva, K.S. | Krystalické formy obeticholové kyseliny |
CN108495858A (zh) * | 2015-12-22 | 2018-09-04 | 英特塞普特医药品公司 | 奥贝胆酸的多晶结晶形式 |
GB201608776D0 (en) * | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
GB201608779D0 (en) * | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
AU2017368069B2 (en) * | 2016-11-29 | 2021-07-08 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
EP3431486A1 (de) * | 2017-07-18 | 2019-01-23 | Bionice, S.L.U. | Verfahren und zwischenprodukte zur synthese von obeticholsäure und derivaten davon |
CN111138509B (zh) * | 2018-11-02 | 2022-12-06 | 东莞东阳光药物研发有限公司 | 奥贝胆酸的制备方法 |
CN112521438B (zh) * | 2020-12-08 | 2021-11-23 | 苏利制药科技江阴有限公司 | 一种β-谷甾醇的合成工艺 |
WO2023288123A1 (en) * | 2021-07-16 | 2023-01-19 | Interecept Pharmaceuticals, Inc. | Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid |
CN113912661B (zh) * | 2021-11-11 | 2023-04-21 | 湖南科瑞生物制药股份有限公司 | 一种7-羟基甾体化合物的合成方法 |
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US2624748A (en) | 1950-09-09 | 1953-01-06 | Upjohn Co | Bisnorchola-4, 6-dien-3-one-22-al |
US4289872A (en) | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
WO1993021259A1 (en) | 1992-04-14 | 1993-10-28 | Cornell Research Foundation Inc. | Dendritic based macromolecules and method of production |
AU6392894A (en) | 1993-02-26 | 1994-09-14 | Magainin Pharmaceuticals, Inc. | Chemical synthesis of squalamine |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
ES2248581T3 (es) | 2001-03-12 | 2006-03-16 | Intercept Pharmaceuticals, Inc. | Esteroides como agonistas de fxr. |
US20090062256A1 (en) | 2001-06-01 | 2009-03-05 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION |
WO2003040211A2 (en) | 2001-11-07 | 2003-05-15 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
EP1568706A1 (de) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Neuer Steroid-Agonist für FXR |
ITMI20050912A1 (it) * | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
JP2007210888A (ja) | 2006-01-12 | 2007-08-23 | Mitsubishi Chemicals Corp | ステロイド化合物の製造方法 |
WO2007095174A2 (en) | 2006-02-14 | 2007-08-23 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions |
WO2008002573A2 (en) | 2006-06-27 | 2008-01-03 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
WO2008091540A2 (en) | 2007-01-19 | 2008-07-31 | Intercept Pharmaceuticals, Inc. | 23-substituted bile acids as tgr5 modulators and methods of use thereof |
US8796249B2 (en) | 2008-07-30 | 2014-08-05 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
KR101667436B1 (ko) | 2008-11-19 | 2016-10-18 | 인터셉트 파마슈티컬즈, 인크. | Tgr5 조절제 및 그의 사용 방법 |
ES2774368T3 (es) * | 2008-11-19 | 2020-07-20 | Intercept Pharmaceuticals Inc | Moduladores de TGR5 y métodos de uso de los mismos |
JP2013500986A (ja) | 2009-07-29 | 2013-01-10 | ザ・ユニバーシティ・オブ・シカゴ | 肝臓x受容体アゴニスト |
EA032347B1 (ru) | 2012-06-19 | 2019-05-31 | Интерсепт Фармасьютикалз, Инк. | Получение, применение и твердые формы обетихолевой кислоты |
AU2013334122B2 (en) | 2012-10-26 | 2017-11-02 | Intercept Pharmaceuticals, Inc. | Process for preparing bile acid derivatives |
MY170802A (en) * | 2012-11-28 | 2019-08-28 | Intercept Pharmaceuticals Inc | Treatment of pulmonary disease |
US20140206657A1 (en) * | 2013-01-18 | 2014-07-24 | City Of Hope | Bile acid analog tgr5 agonists |
JP6326131B2 (ja) | 2013-05-14 | 2018-05-16 | インターセプト ファーマシューティカルズ, インコーポレイテッド | ファルネソイドx受容体調節物質としての、胆汁酸の11−ヒドロキシル誘導体およびそのアミノ酸抱合体 |
CN105392780A (zh) | 2013-05-24 | 2016-03-09 | 雀巢产品技术援助有限公司 | 用于预测肠易激综合征诊断的途径特异性测定 |
US10166246B2 (en) | 2014-05-27 | 2019-01-01 | City Of Hope | TGR5 agonist complexes for treating diabetes and cancer |
MX2020004024A (es) | 2014-05-29 | 2021-12-10 | Bar Pharmaceuticals S R L | Derivados del colano para uso en el tratamiento y/o prevencion de enfermedades en las que intervienen el fxr y el tgr5/gpbar1. |
RU2017118569A (ru) | 2014-11-06 | 2018-12-06 | Энанта Фармасьютикалс, Инк. | Аналоги желчных кислот как агонисты fxr/tgr5 и способы их применения |
DK3221332T3 (da) | 2014-11-19 | 2019-07-29 | Nzp Uk Ltd | Fremstilling af steroide fxr-modulatorer |
TWI686401B (zh) | 2014-11-19 | 2020-03-01 | 英商Nzp英國有限公司 | 化合物(三) |
MX2017006567A (es) | 2014-11-19 | 2018-01-26 | Nzp Uk Ltd | Esteroides 6.alfa.-alquil-6,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr). |
US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
BR112017010893A2 (pt) | 2014-11-26 | 2018-02-06 | Enanta Pharm Inc | análogos de ácidos biliares como agonistas de fxr/tgr5 e métodos de uso dos mesmos |
WO2016086134A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
WO2016086115A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof |
CN106279328A (zh) | 2015-05-20 | 2017-01-04 | 重庆药友制药有限责任公司 | 一种制备6α-烷基鹅去氧胆酸的方法 |
TW201700447A (zh) | 2015-06-19 | 2017-01-01 | 英特賽普醫藥品公司 | Tgr5調控劑及其用法 |
CN106397522A (zh) | 2015-07-31 | 2017-02-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 3,7‑二(叔丁基二甲基硅基氧基)‑6‑烯‑5β‑胆烷‑24‑酸甲酯 |
CN106478759A (zh) | 2015-08-31 | 2017-03-08 | 陕西合成药业股份有限公司 | 奥贝胆酸衍生物及其制备方法和用途 |
CN106478756A (zh) | 2015-09-02 | 2017-03-08 | 中美华世通生物医药科技(武汉)有限公司 | Oca-e单晶及其制备方法和用途 |
CN106518946A (zh) | 2015-09-10 | 2017-03-22 | 上海迪诺医药科技有限公司 | 磺酰脲衍生物、其药物组合物及应用 |
-
2015
- 2015-11-19 CA CA2968309A patent/CA2968309A1/en not_active Abandoned
- 2015-11-19 PL PL15800909T patent/PL3221331T3/pl unknown
- 2015-11-19 EP EP15800909.2A patent/EP3221331B1/de active Active
- 2015-11-19 JP JP2017527817A patent/JP6700274B2/ja active Active
- 2015-11-19 PT PT158009092T patent/PT3221331T/pt unknown
- 2015-11-19 ES ES15800909T patent/ES2759725T3/es active Active
- 2015-11-19 TW TW104138183A patent/TWI690536B/zh active
- 2015-11-19 BR BR112017010319-2A patent/BR112017010319B1/pt active IP Right Grant
- 2015-11-19 EA EA201790884A patent/EA033427B1/ru not_active IP Right Cessation
- 2015-11-19 KR KR1020177016855A patent/KR102526631B1/ko active IP Right Grant
- 2015-11-19 CN CN201580062904.XA patent/CN107207559B/zh active Active
- 2015-11-19 WO PCT/GB2015/053516 patent/WO2016079517A1/en active Application Filing
- 2015-11-19 US US15/528,214 patent/US10301350B2/en active Active
- 2015-11-19 DK DK15800909T patent/DK3221331T3/da active
- 2015-11-19 MX MX2017006563A patent/MX2017006563A/es active IP Right Grant
-
2018
- 2018-03-19 HK HK18103792.4A patent/HK1246801A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TWI690536B (zh) | 2020-04-11 |
EA201790884A1 (ru) | 2017-11-30 |
DK3221331T3 (da) | 2019-12-02 |
PT3221331T (pt) | 2019-12-23 |
KR102526631B1 (ko) | 2023-04-27 |
JP2017534670A (ja) | 2017-11-24 |
NZ731924A (en) | 2020-12-18 |
US10301350B2 (en) | 2019-05-28 |
WO2016079517A1 (en) | 2016-05-26 |
MX2017006563A (es) | 2018-01-26 |
US20170327528A1 (en) | 2017-11-16 |
ES2759725T3 (es) | 2020-05-12 |
EA201790884A8 (ru) | 2019-07-31 |
TW201632537A (zh) | 2016-09-16 |
KR20170086604A (ko) | 2017-07-26 |
EA033427B1 (ru) | 2019-10-31 |
EP3221331B1 (de) | 2019-09-18 |
BR112017010319B1 (pt) | 2023-04-11 |
PL3221331T3 (pl) | 2020-03-31 |
CN107207559B (zh) | 2019-10-25 |
CN107207559A (zh) | 2017-09-26 |
BR112017010319A2 (pt) | 2017-12-26 |
EP3221331A1 (de) | 2017-09-27 |
JP6700274B2 (ja) | 2020-05-27 |
HK1246801A1 (zh) | 2018-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |
Effective date: 20210831 |
|
FZDE | Discontinued |
Effective date: 20210831 |