CA2967877A1 - Lanthanide complex formulations - Google Patents
Lanthanide complex formulations Download PDFInfo
- Publication number
- CA2967877A1 CA2967877A1 CA2967877A CA2967877A CA2967877A1 CA 2967877 A1 CA2967877 A1 CA 2967877A1 CA 2967877 A CA2967877 A CA 2967877A CA 2967877 A CA2967877 A CA 2967877A CA 2967877 A1 CA2967877 A1 CA 2967877A1
- Authority
- CA
- Canada
- Prior art keywords
- lanthanide
- chelator
- resin
- solution
- dota
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052747 lanthanoid Inorganic materials 0.000 title claims abstract description 91
- 150000002602 lanthanoids Chemical class 0.000 title claims abstract description 76
- 239000000203 mixture Substances 0.000 title claims description 35
- 238000009472 formulation Methods 0.000 title claims description 18
- 239000002738 chelating agent Substances 0.000 claims abstract description 103
- 238000000034 method Methods 0.000 claims abstract description 97
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 64
- 229910052751 metal Inorganic materials 0.000 claims abstract description 49
- 239000002184 metal Substances 0.000 claims abstract description 49
- 239000011575 calcium Substances 0.000 claims abstract description 42
- 229920002536 Scavenger resin Polymers 0.000 claims abstract description 40
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 38
- -1 lanthanide metal complex Chemical class 0.000 claims abstract description 35
- 238000002360 preparation method Methods 0.000 claims abstract description 24
- 239000012535 impurity Substances 0.000 claims abstract description 20
- 229910021644 lanthanide ion Inorganic materials 0.000 claims abstract description 15
- 239000002616 MRI contrast agent Substances 0.000 claims abstract description 14
- 229920005989 resin Polymers 0.000 claims description 62
- 239000011347 resin Substances 0.000 claims description 62
- 229910052688 Gadolinium Inorganic materials 0.000 claims description 51
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims description 45
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims description 36
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical class CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 33
- 239000008194 pharmaceutical composition Substances 0.000 claims description 32
- 229960003194 meglumine Drugs 0.000 claims description 30
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- 230000008569 process Effects 0.000 claims description 19
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- 238000004519 manufacturing process Methods 0.000 claims description 18
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- 239000002872 contrast media Substances 0.000 claims description 12
- 239000007790 solid phase Substances 0.000 claims description 11
- 238000004659 sterilization and disinfection Methods 0.000 claims description 11
- 125000002091 cationic group Chemical group 0.000 claims description 9
- 150000004696 coordination complex Chemical class 0.000 claims description 8
- NBZBKCUXIYYUSX-UHFFFAOYSA-N iminodiacetic acid Chemical compound OC(=O)CNCC(O)=O NBZBKCUXIYYUSX-UHFFFAOYSA-N 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 239000011701 zinc Substances 0.000 claims description 6
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- 229910052725 zinc Inorganic materials 0.000 claims description 5
- HHLZCENAOIROSL-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OC(=O)CN1CCNCCN(CC(O)=O)CCN(CC(O)=O)CC1 HHLZCENAOIROSL-UHFFFAOYSA-N 0.000 claims description 4
- JHALWMSZGCVVEM-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1 JHALWMSZGCVVEM-UHFFFAOYSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- 239000003729 cation exchange resin Substances 0.000 claims description 4
- 125000000524 functional group Chemical group 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- VIFBVOSDYUIKIK-UHFFFAOYSA-J sodium;gadolinium(3+);2-[4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate Chemical compound [Na+].[Gd+3].[O-]C(=O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 VIFBVOSDYUIKIK-UHFFFAOYSA-J 0.000 claims description 4
- 125000000129 anionic group Chemical group 0.000 claims description 2
- 238000007865 diluting Methods 0.000 claims description 2
- FDSYTWVNUJTPMA-UHFFFAOYSA-N 2-[3,9-bis(carboxymethyl)-3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl]acetic acid Chemical compound C1N(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC2=CC=CC1=N2 FDSYTWVNUJTPMA-UHFFFAOYSA-N 0.000 claims 1
- IQUHNCOJRJBMSU-UHFFFAOYSA-N H3HP-DO3A Chemical compound CC(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 IQUHNCOJRJBMSU-UHFFFAOYSA-N 0.000 claims 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 1
- 239000000243 solution Substances 0.000 description 70
- 229960005069 calcium Drugs 0.000 description 36
- 239000013522 chelant Substances 0.000 description 20
- GFSTXYOTEVLASN-UHFFFAOYSA-K gadoteric acid Chemical compound [Gd+3].OC(=O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 GFSTXYOTEVLASN-UHFFFAOYSA-K 0.000 description 19
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 17
- 239000011734 sodium Substances 0.000 description 17
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- 150000002500 ions Chemical class 0.000 description 11
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- 230000002000 scavenging effect Effects 0.000 description 10
- RYHQMKVRYNEBNJ-BMWGJIJESA-K gadoterate meglumine Chemical compound [Gd+3].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 RYHQMKVRYNEBNJ-BMWGJIJESA-K 0.000 description 9
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- CMIHHWBVHJVIGI-UHFFFAOYSA-N gadolinium(iii) oxide Chemical compound [O-2].[O-2].[O-2].[Gd+3].[Gd+3] CMIHHWBVHJVIGI-UHFFFAOYSA-N 0.000 description 6
- 238000003384 imaging method Methods 0.000 description 6
- 238000002595 magnetic resonance imaging Methods 0.000 description 6
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- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 5
- 125000004429 atom Chemical group 0.000 description 5
- 229910001424 calcium ion Inorganic materials 0.000 description 5
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- 238000004458 analytical method Methods 0.000 description 4
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- ORZHVTYKPFFVMG-UHFFFAOYSA-N xylenol orange Chemical compound OC(=O)CN(CC(O)=O)CC1=C(O)C(C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C=C(CN(CC(O)=O)CC(O)=O)C(O)=C(C)C=2)=C1 ORZHVTYKPFFVMG-UHFFFAOYSA-N 0.000 description 4
- QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical compound C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 description 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
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- MEANOSLIBWSCIT-UHFFFAOYSA-K gadolinium trichloride Chemical compound Cl[Gd](Cl)Cl MEANOSLIBWSCIT-UHFFFAOYSA-K 0.000 description 3
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- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- 101150067539 AMBP gene Proteins 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
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- 238000013353 HPLC-CAD method Methods 0.000 description 2
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- 229940068917 polyethylene glycols Drugs 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1421162.7 | 2014-11-28 | ||
| GBGB1421162.7A GB201421162D0 (en) | 2014-11-28 | 2014-11-28 | Lanthanide complex formulations |
| PCT/EP2015/077970 WO2016083605A1 (en) | 2014-11-28 | 2015-11-27 | Lanthanide complex formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2967877A1 true CA2967877A1 (en) | 2016-06-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2967877A Pending CA2967877A1 (en) | 2014-11-28 | 2015-11-27 | Lanthanide complex formulations |
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| Country | Link |
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| US (3) | US10576169B2 (zh) |
| EP (1) | EP3224250A1 (zh) |
| JP (1) | JP6846347B2 (zh) |
| KR (2) | KR20170092546A (zh) |
| CN (1) | CN107001293B (zh) |
| AU (1) | AU2015352426B2 (zh) |
| BR (1) | BR112017010889B1 (zh) |
| CA (1) | CA2967877A1 (zh) |
| GB (1) | GB201421162D0 (zh) |
| MX (1) | MX2017006800A (zh) |
| RU (1) | RU2707070C2 (zh) |
| WO (1) | WO2016083605A1 (zh) |
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| GB201421162D0 (en) | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Lanthanide complex formulations |
| EP3562517A1 (en) * | 2016-12-29 | 2019-11-06 | Inventure, LLC | Solvent-free gadolinium contrast agents |
| US20190269805A1 (en) | 2016-12-29 | 2019-09-05 | Inventure, LLC | Solvent-free gadolinium contrast agents |
| US11654424B1 (en) * | 2019-06-10 | 2023-05-23 | Triad National Security, Llc | Method embodiments for making lanthanide metal complexes from lanthanide metal oxides and separating the same from heavy lanthanide metal oxides, actinide oxides, and non-lanthanide rare earth element oxides |
| GB201919073D0 (en) * | 2019-12-20 | 2020-02-05 | Ge Healthcare As | Novel manufacturing process |
| CN113527222B (zh) * | 2020-04-21 | 2023-06-13 | 威智医药股份有限公司 | 一种钆特酸葡甲胺的制备方法 |
| CN113801071B (zh) * | 2021-09-14 | 2023-04-07 | 安徽普利药业有限公司 | 一种钆特酸葡甲胺的精制方法 |
Family Cites Families (16)
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| US4028234A (en) * | 1974-06-06 | 1977-06-07 | Aerojet-General Corporation | Buffering agents |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
| NZ229700A (en) * | 1988-06-24 | 1993-01-27 | Dow Chemical Co | Tetraazacyclododecane derivatives containing a linker/spacer moiety capable of forming antibody conjugates; complexes with radionuclides and conjugates of such compounds and complexes with antibodies or antibody fragments |
| IT1269839B (it) | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
| US5665239A (en) * | 1996-01-16 | 1997-09-09 | Culligan International Company | Processes for deionization and demineralization of fluids |
| IT1292128B1 (it) | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
| FR2772025B1 (fr) | 1997-12-10 | 2000-03-03 | Guerbet Sa | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
| JP2005523235A (ja) | 2001-07-17 | 2005-08-04 | テラファルム ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のキレート化剤およびその接合体、該キレート化剤およびその接合体の診断剤および治療剤としての合成および使用 |
| WO2008144728A1 (en) * | 2007-05-21 | 2008-11-27 | Bracco Imaging S.P.A. | Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications |
| US20090208421A1 (en) | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
| FR2945448B1 (fr) | 2009-05-13 | 2012-08-31 | Guerbet Sa | Procede de preparation d'une formulation pharmaceutique de chelate de lanthanide sous forme de poudre. |
| EP2338874A1 (en) | 2009-12-16 | 2011-06-29 | Bracco Imaging S.p.A | Process for the preparation of chelated compounds |
| BR112015017675A2 (pt) | 2013-01-28 | 2017-07-11 | Agfa Healthcare | processo para a produção de 1, 4, 7, 10 – tetraazaciclododecano-1, 4, 7, 10-ácido tetra acético e complexos do mesmo |
| EP2786768A1 (en) | 2013-04-04 | 2014-10-08 | Agfa Healthcare | Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide |
| GB201421162D0 (en) | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Lanthanide complex formulations |
-
2014
- 2014-11-28 GB GBGB1421162.7A patent/GB201421162D0/en not_active Ceased
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2015
- 2015-11-27 KR KR1020177014038A patent/KR20170092546A/ko not_active IP Right Cessation
- 2015-11-27 CA CA2967877A patent/CA2967877A1/en active Pending
- 2015-11-27 BR BR112017010889-5A patent/BR112017010889B1/pt active IP Right Grant
- 2015-11-27 EP EP15804098.0A patent/EP3224250A1/en active Pending
- 2015-11-27 JP JP2017526514A patent/JP6846347B2/ja active Active
- 2015-11-27 US US15/531,431 patent/US10576169B2/en active Active
- 2015-11-27 AU AU2015352426A patent/AU2015352426B2/en active Active
- 2015-11-27 MX MX2017006800A patent/MX2017006800A/es unknown
- 2015-11-27 KR KR1020237028434A patent/KR102608019B1/ko active IP Right Grant
- 2015-11-27 CN CN201580064643.5A patent/CN107001293B/zh active Active
- 2015-11-27 WO PCT/EP2015/077970 patent/WO2016083605A1/en active Application Filing
- 2015-11-27 RU RU2017116220A patent/RU2707070C2/ru active
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2020
- 2020-01-24 US US16/752,307 patent/US11400172B2/en active Active
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2022
- 2022-06-28 US US17/851,454 patent/US20220354971A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3224250A1 (en) | 2017-10-04 |
| MX2017006800A (es) | 2017-09-08 |
| WO2016083605A1 (en) | 2016-06-02 |
| US10576169B2 (en) | 2020-03-03 |
| JP6846347B2 (ja) | 2021-03-24 |
| CN107001293A (zh) | 2017-08-01 |
| AU2015352426A1 (en) | 2017-05-25 |
| CN107001293B (zh) | 2023-09-19 |
| KR20230125860A (ko) | 2023-08-29 |
| US20170258945A1 (en) | 2017-09-14 |
| US20220354971A1 (en) | 2022-11-10 |
| BR112017010889A2 (pt) | 2018-02-14 |
| RU2017116220A3 (zh) | 2019-02-25 |
| RU2707070C2 (ru) | 2019-11-22 |
| RU2017116220A (ru) | 2018-12-28 |
| US11400172B2 (en) | 2022-08-02 |
| US20200155712A1 (en) | 2020-05-21 |
| JP2017535553A (ja) | 2017-11-30 |
| GB201421162D0 (en) | 2015-01-14 |
| KR20170092546A (ko) | 2017-08-11 |
| AU2015352426B2 (en) | 2020-03-05 |
| KR102608019B1 (ko) | 2023-11-30 |
| BR112017010889B1 (pt) | 2022-02-22 |
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| US20220354971A1 (en) | Lanthanide complex formulations | |
| CA2967873C (en) | Formulation of lanthanide metal complex with macrocyclic chelator | |
| EP3223863B1 (en) | Formulations comprising a meglumine salt of the metal complex gd-dota |
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