CA2962255A1 - Use of annexin v as a method to block tumor induced immunosuppression of the innate immune response - Google Patents

Use of annexin v as a method to block tumor induced immunosuppression of the innate immune response Download PDF

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Publication number
CA2962255A1
CA2962255A1 CA2962255A CA2962255A CA2962255A1 CA 2962255 A1 CA2962255 A1 CA 2962255A1 CA 2962255 A CA2962255 A CA 2962255A CA 2962255 A CA2962255 A CA 2962255A CA 2962255 A1 CA2962255 A1 CA 2962255A1
Authority
CA
Canada
Prior art keywords
cancer
annexin
tumor
cells
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2962255A
Other languages
English (en)
French (fr)
Inventor
Francis Gerard BLANKENBERG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of CA2962255A1 publication Critical patent/CA2962255A1/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CA2962255A 2014-10-03 2015-10-02 Use of annexin v as a method to block tumor induced immunosuppression of the innate immune response Abandoned CA2962255A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462059669P 2014-10-03 2014-10-03
US62/059,669 2014-10-03
PCT/US2015/053828 WO2016054574A1 (en) 2014-10-03 2015-10-02 Use of annexin v as a method to block tumor induced immunosuppression of the innate immune response

Publications (1)

Publication Number Publication Date
CA2962255A1 true CA2962255A1 (en) 2016-04-07

Family

ID=55631651

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2962255A Abandoned CA2962255A1 (en) 2014-10-03 2015-10-02 Use of annexin v as a method to block tumor induced immunosuppression of the innate immune response

Country Status (7)

Country Link
US (1) US11253568B2 (cg-RX-API-DMAC7.html)
EP (1) EP3200811A4 (cg-RX-API-DMAC7.html)
JP (1) JP2017530130A (cg-RX-API-DMAC7.html)
KR (1) KR20170063722A (cg-RX-API-DMAC7.html)
AU (1) AU2015327887A1 (cg-RX-API-DMAC7.html)
CA (1) CA2962255A1 (cg-RX-API-DMAC7.html)
WO (1) WO2016054574A1 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG175993A1 (en) 2009-05-11 2011-12-29 Berg Biosystems Llc Methods for treatment of metabolic disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers
JP6092844B2 (ja) 2011-04-04 2017-03-08 バーグ エルエルシー 中枢神経系腫瘍の治療方法
MX380565B (es) 2013-04-08 2025-03-12 Berg Llc Terapias combinadas de coenzima q10 para el tratamiento de cáncer.
CN105705162A (zh) 2013-09-04 2016-06-22 博格有限责任公司 通过持续输注辅酶q10来治疗癌症的方法
US20170189350A1 (en) 2015-11-16 2017-07-06 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
US20180021270A1 (en) * 2016-07-21 2018-01-25 Berg Llc Methods for the treatment of cancer using coenzyme q10 in combination with immune checkpoint modulators
US10874711B2 (en) 2017-07-05 2020-12-29 The Board Of Trustees Of The Leland Stanford Junior University Use of annexin V to reduce the spread of intracellular pathogens
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CA3180886A1 (en) * 2020-07-09 2022-01-13 Cheng Luo Compositions and methods for inhibiting ythdf1
WO2022212352A1 (en) * 2021-03-29 2022-10-06 The Board Of Trustees Of The Leland Stanford Junior University Reversal of ctl exhaustion with annexin v
US20250049884A1 (en) * 2022-01-03 2025-02-13 The Board Of Trustees Of The Leland Stanford Junior University Blocking and reversing extracellular vesicle driven transcriptomic transformation with annexin v treatment

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7262167B2 (en) * 1995-11-06 2007-08-28 Exibona Ltd. Drug, in particular for modulating the immunological response for the control of viruses, tumors, bacteria and parasites
US6818213B1 (en) * 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
US7635680B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
DE10145254A1 (de) 2001-09-13 2003-04-10 November Ag Molekulare Medizin Verwendung eines Proteins zur Herstellung eines Medikaments zur Stimulierung einer inflammatorischen zellulären Immunantwort
DE10302422A1 (de) * 2003-01-21 2004-07-29 Responsif Gmbh Medikament und Verwendung zur Tumortherapie
US8071545B2 (en) * 2005-03-15 2011-12-06 Lewis S. Coleman, Md, Inc. Therapies and compositions for controlling the stress mechanism and for stabilizing hemostasis in an organism
GB0911042D0 (en) 2009-06-25 2009-08-12 Istituto Superiore Di Sanito Treatment of tumorigenic cells in solid tumours

Also Published As

Publication number Publication date
JP2017530130A (ja) 2017-10-12
EP3200811A1 (en) 2017-08-09
US20220160829A1 (en) 2022-05-26
AU2015327887A1 (en) 2017-04-13
WO2016054574A1 (en) 2016-04-07
US11253568B2 (en) 2022-02-22
US20170202914A1 (en) 2017-07-20
EP3200811A4 (en) 2018-05-02
KR20170063722A (ko) 2017-06-08

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20201002