CA2960649A1 - Motorized suprachoroidal injection of therapeutic agent - Google Patents
Motorized suprachoroidal injection of therapeutic agent Download PDFInfo
- Publication number
- CA2960649A1 CA2960649A1 CA2960649A CA2960649A CA2960649A1 CA 2960649 A1 CA2960649 A1 CA 2960649A1 CA 2960649 A CA2960649 A CA 2960649A CA 2960649 A CA2960649 A CA 2960649A CA 2960649 A1 CA2960649 A1 CA 2960649A1
- Authority
- CA
- Canada
- Prior art keywords
- cannula
- needle
- eye
- relative
- approximately
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003814 drug Substances 0.000 title claims abstract description 51
- 229940124597 therapeutic agent Drugs 0.000 title claims abstract description 49
- 238000002347 injection Methods 0.000 title description 3
- 239000007924 injection Substances 0.000 title description 3
- 210000003161 choroid Anatomy 0.000 claims abstract description 46
- 210000003786 sclera Anatomy 0.000 claims abstract description 29
- 239000012530 fluid Substances 0.000 claims description 14
- 230000004913 activation Effects 0.000 claims description 12
- 230000033001 locomotion Effects 0.000 claims description 7
- 238000013519 translation Methods 0.000 claims description 5
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 210000001525 retina Anatomy 0.000 abstract description 18
- 206010064930 age-related macular degeneration Diseases 0.000 abstract description 7
- 208000008069 Geographic Atrophy Diseases 0.000 abstract description 5
- 210000003583 retinal pigment epithelium Anatomy 0.000 abstract description 3
- 210000001508 eye Anatomy 0.000 description 113
- 238000000034 method Methods 0.000 description 44
- 239000000463 material Substances 0.000 description 31
- 208000002352 blister Diseases 0.000 description 12
- 208000002780 macular degeneration Diseases 0.000 description 12
- 238000013459 approach Methods 0.000 description 11
- 239000000049 pigment Substances 0.000 description 9
- 206010025421 Macule Diseases 0.000 description 8
- 239000013307 optical fiber Substances 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 238000012800 visualization Methods 0.000 description 7
- 230000014509 gene expression Effects 0.000 description 6
- 238000005286 illumination Methods 0.000 description 5
- 230000035515 penetration Effects 0.000 description 5
- 238000003825 pressing Methods 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 230000000007 visual effect Effects 0.000 description 5
- 239000003855 balanced salt solution Substances 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- 210000000795 conjunctiva Anatomy 0.000 description 4
- 238000002224 dissection Methods 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 210000001747 pupil Anatomy 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- 229920002614 Polyether block amide Polymers 0.000 description 3
- 208000007014 Retinitis pigmentosa Diseases 0.000 description 3
- 210000003484 anatomy Anatomy 0.000 description 3
- 210000005252 bulbus oculi Anatomy 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 3
- 229910001000 nickel titanium Inorganic materials 0.000 description 3
- 230000000149 penetrating effect Effects 0.000 description 3
- 230000005043 peripheral vision Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 208000024304 Choroidal Effusions Diseases 0.000 description 2
- 208000002367 Retinal Perforations Diseases 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 150000002605 large molecules Chemical class 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000002207 retinal effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 210000003954 umbilical cord Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 208000032400 Retinal pigmentation Diseases 0.000 description 1
- 239000004775 Tyvek Substances 0.000 description 1
- 229920000690 Tyvek Polymers 0.000 description 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000011325 dry age related macular degeneration Diseases 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000018769 loss of vision Diseases 0.000 description 1
- 231100000864 loss of vision Toxicity 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00736—Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1585—Needle inserters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
- A61M2005/1586—Holding accessories for holding infusion needles on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049118P | 2014-09-11 | 2014-09-11 | |
| US62/049,118 | 2014-09-11 | ||
| US14/840,622 US10064752B2 (en) | 2014-09-11 | 2015-08-31 | Motorized suprachoroidal injection of therapeutic agent |
| US14/840,622 | 2015-08-31 | ||
| PCT/US2015/049430 WO2016040635A1 (en) | 2014-09-11 | 2015-09-10 | Motorized suprachoroidal injection of therapeutic agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2960649A1 true CA2960649A1 (en) | 2016-03-17 |
Family
ID=55453677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2960649A Abandoned CA2960649A1 (en) | 2014-09-11 | 2015-09-10 | Motorized suprachoroidal injection of therapeutic agent |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10064752B2 (enExample) |
| EP (1) | EP3191033B1 (enExample) |
| JP (1) | JP6541162B2 (enExample) |
| KR (1) | KR20170063697A (enExample) |
| CN (1) | CN107249523B (enExample) |
| AU (1) | AU2015315044A1 (enExample) |
| BR (1) | BR112017004828B1 (enExample) |
| CA (1) | CA2960649A1 (enExample) |
| MX (1) | MX2017003260A (enExample) |
| PH (1) | PH12017500443A1 (enExample) |
| RU (1) | RU2017112036A (enExample) |
| SG (1) | SG11201701968QA (enExample) |
| WO (1) | WO2016040635A1 (enExample) |
| ZA (1) | ZA201702514B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4555981A3 (en) | 2014-02-12 | 2025-08-06 | Genentech, Inc. | Method and apparatus for suprachoroidal administration of therapeutic agent |
| US10064752B2 (en) | 2014-09-11 | 2018-09-04 | Orbit Biomedical Limited | Motorized suprachoroidal injection of therapeutic agent |
| US10258502B2 (en) | 2014-09-18 | 2019-04-16 | Orbit Biomedical Limited | Therapeutic agent delivery device |
| EP3193985B1 (en) | 2014-09-19 | 2020-08-12 | Oxular Limited | Ophthalmic delivery device |
| ES2954983T3 (es) | 2015-09-17 | 2023-11-28 | Oxular Ltd | Dispositivo de inyección oftálmica |
| US10478553B2 (en) | 2016-03-09 | 2019-11-19 | Orbit Biomedical Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
| ES2950350T3 (es) | 2016-03-16 | 2023-10-09 | Oxular Ltd | Dispositivo de administración oftálmica |
| US11197937B2 (en) | 2016-04-15 | 2021-12-14 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
| US10806629B2 (en) | 2016-06-17 | 2020-10-20 | Gyroscope Therapeutics Limited | Injection device for subretinal delivery of therapeutic agent |
| US11000410B2 (en) | 2016-06-17 | 2021-05-11 | Gyroscope Therapeutics Limited | Guide apparatus for tangential entry into suprachoroidal space |
| US10646374B2 (en) | 2016-06-17 | 2020-05-12 | Orbit Biomedical Limited | Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent |
| WO2018057871A1 (en) * | 2016-09-23 | 2018-03-29 | The Regents Of The University Of California | Surgical device for ab-externo sub-retinal fluid drainage |
| US11273072B2 (en) | 2017-01-13 | 2022-03-15 | Gyroscope Therapeutics Limited | Suprachoroidal injection device |
| US11076984B2 (en) | 2017-03-13 | 2021-08-03 | Gyroscope Therapeutics Limited | Method of performing subretinal drainage and agent delivery |
| US11033427B2 (en) | 2017-04-13 | 2021-06-15 | Alcon Inc. | Vitreoretinal instruments for fluid aspiration |
| EP3621685B1 (en) | 2017-05-08 | 2025-11-26 | Medtronic MiniMed, Inc. | Flexible tubing, cannula and insertion needle |
| US11564834B2 (en) * | 2017-09-15 | 2023-01-31 | Oxular Limited | Sterile lyophilized drug compositions and methods for treating ocular diseases or conditions |
| WO2019067540A1 (en) * | 2017-09-27 | 2019-04-04 | Regenxbio Inc. | TREATMENT OF OCULAR DISEASES WITH A TOTALLY HUMAN POST-TRANSLATIONAL MODIFICATION ANTI-VEGF FAB |
| CN109224190B (zh) * | 2018-07-20 | 2020-11-03 | 陈红雨 | 一种用于患儿头部注射的固定器 |
| CN109200384A (zh) * | 2018-10-31 | 2019-01-15 | 中国人民解放军陆军特色医学中心 | 一种留置针 |
| US11759355B1 (en) | 2019-02-26 | 2023-09-19 | Gyroscope Therapeutics Limited | Method of delivering leading blebs and agent to subretinal space |
| SG11202110789VA (en) * | 2019-04-03 | 2021-10-28 | Regenxbio Inc | Gene therapy for eye pathologies |
| US11690974B2 (en) | 2019-04-25 | 2023-07-04 | Warsaw Orthopedic, Inc. | Methods and devices for delivering therapeutic materials to the intervertebral disc |
| WO2021034493A1 (en) * | 2019-08-22 | 2021-02-25 | Boston Scientific Scimed, Inc. | Systems and methods for controlling needle penetration |
| US20220280608A1 (en) | 2019-08-26 | 2022-09-08 | Regenxbio Inc. | Treatment of diabetic retinopathy with fully-human post-translationally modified anti-vegf fab |
| CN114728049A (zh) | 2019-10-07 | 2022-07-08 | 再生生物股份有限公司 | 腺相关病毒载体药物组合物和方法 |
| EP4041147A1 (en) | 2019-10-11 | 2022-08-17 | Gyroscope Therapeutics Limited | Dose clip assembly for syringe |
| AU2021358781A1 (en) | 2020-10-07 | 2023-05-18 | Tern Therapeutics, Llc | Gene therapy for ocular manifestations of cln2 disease |
| WO2022171771A1 (en) | 2021-02-12 | 2022-08-18 | Boehringer Ingelheim International Gmbh | Complement c3 antigen binding proteins |
| EP4453028A1 (en) | 2021-12-22 | 2024-10-30 | CDR-Life AG | Anti-c3 antibodies and antigen-binding fragments thereof and their uses for treating eye or ocular diseases |
| EP4507741A1 (en) | 2022-04-14 | 2025-02-19 | RegenxBio Inc. | Gene therapy for treating an ocular disease |
| WO2024052733A1 (en) | 2022-09-06 | 2024-03-14 | Gyroscope Therapeutics Limited | Apparatus for subretinal administration of therapeutic agent via dual-curved needle |
| WO2024059794A1 (en) * | 2022-09-16 | 2024-03-21 | Cvrx, Inc. | System, devices, and methods for guidewire delivery |
| EP4593955A1 (en) | 2022-09-30 | 2025-08-06 | RegenxBio Inc. | Treatment of ocular diseases with recombinant viral vectors encoding anti-vegf fab |
| KR20250138741A (ko) | 2023-01-13 | 2025-09-22 | 제넨테크, 인크. | 주사기용 용량 도킹 장치 |
| TW202529711A (zh) | 2023-09-29 | 2025-08-01 | 美商建南德克公司 | 眼插管導引器、施用器及標記器械 |
| WO2025160409A1 (en) | 2024-01-26 | 2025-07-31 | Flagship Pioneering Innovations V, Inc. | Viral vectors for modulating vegf function |
| WO2025207699A1 (en) | 2024-03-27 | 2025-10-02 | Genentech, Inc. | Torque ring for subretinal injection device |
| WO2025217214A2 (en) | 2024-04-08 | 2025-10-16 | Regenxbio Inc. | Recombinant adeno-associated viruses and uses thereof |
| WO2025217230A1 (en) | 2024-04-08 | 2025-10-16 | Regenxbio Inc. | Vectorized anti-complement antibodies and complement agents and administration thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2045634U (zh) * | 1989-01-11 | 1989-10-11 | 晁三万 | 多功能微调眼科手术刀 |
| US6309374B1 (en) * | 1998-08-03 | 2001-10-30 | Insite Vision Incorporated | Injection apparatus and method of using same |
| CN2409937Y (zh) * | 2000-02-03 | 2000-12-13 | 李根林 | 视网膜移植器 |
| US20020087128A1 (en) | 2000-08-31 | 2002-07-04 | Mpnb Ltd. | Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same |
| US20040199130A1 (en) | 2003-04-03 | 2004-10-07 | Chornenky Victor I. | Apparatus and method for treatment of macular degeneration |
| CA2530422C (en) | 2003-06-27 | 2016-01-05 | Ian Ross Harris | Postpartum-derived cells for use in treatment of disease of the heart and circulatory system |
| JP2010504151A (ja) * | 2006-09-19 | 2010-02-12 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 中空の解剖学的に懸吊された器官の手術のためのシステム、装置、及び方法 |
| EP3878495B1 (en) * | 2011-03-16 | 2024-06-12 | Becton, Dickinson and Company | Multiple use disposable injection pen |
| US9539384B2 (en) * | 2012-09-28 | 2017-01-10 | Animas Corporation | Telescoping piston drive for medical infusion device |
| EP4555981A3 (en) * | 2014-02-12 | 2025-08-06 | Genentech, Inc. | Method and apparatus for suprachoroidal administration of therapeutic agent |
| US10064752B2 (en) | 2014-09-11 | 2018-09-04 | Orbit Biomedical Limited | Motorized suprachoroidal injection of therapeutic agent |
-
2015
- 2015-08-31 US US14/840,622 patent/US10064752B2/en active Active
- 2015-09-10 CA CA2960649A patent/CA2960649A1/en not_active Abandoned
- 2015-09-10 SG SG11201701968QA patent/SG11201701968QA/en unknown
- 2015-09-10 EP EP15775026.6A patent/EP3191033B1/en active Active
- 2015-09-10 MX MX2017003260A patent/MX2017003260A/es unknown
- 2015-09-10 KR KR1020177009663A patent/KR20170063697A/ko not_active Withdrawn
- 2015-09-10 CN CN201580061178.XA patent/CN107249523B/zh active Active
- 2015-09-10 JP JP2017513696A patent/JP6541162B2/ja active Active
- 2015-09-10 AU AU2015315044A patent/AU2015315044A1/en not_active Abandoned
- 2015-09-10 RU RU2017112036A patent/RU2017112036A/ru unknown
- 2015-09-10 BR BR112017004828-0A patent/BR112017004828B1/pt active IP Right Grant
- 2015-09-10 WO PCT/US2015/049430 patent/WO2016040635A1/en not_active Ceased
-
2017
- 2017-03-09 PH PH12017500443A patent/PH12017500443A1/en unknown
- 2017-04-10 ZA ZA2017/02514A patent/ZA201702514B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017526478A (ja) | 2017-09-14 |
| SG11201701968QA (en) | 2017-04-27 |
| AU2015315044A1 (en) | 2017-03-30 |
| EP3191033A1 (en) | 2017-07-19 |
| US20160074217A1 (en) | 2016-03-17 |
| BR112017004828B1 (pt) | 2021-12-14 |
| KR20170063697A (ko) | 2017-06-08 |
| BR112017004828A2 (pt) | 2017-12-12 |
| RU2017112036A (ru) | 2018-10-11 |
| WO2016040635A1 (en) | 2016-03-17 |
| JP6541162B2 (ja) | 2019-07-10 |
| EP3191033B1 (en) | 2019-11-06 |
| CN107249523B (zh) | 2020-09-22 |
| MX2017003260A (es) | 2018-02-12 |
| ZA201702514B (en) | 2019-07-31 |
| US10064752B2 (en) | 2018-09-04 |
| PH12017500443A1 (en) | 2017-07-31 |
| CN107249523A (zh) | 2017-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10064752B2 (en) | Motorized suprachoroidal injection of therapeutic agent | |
| US20230355432A1 (en) | Sub-retinal tangential needle catheter guide and introducer | |
| US20250318953A1 (en) | Therapeutic agent delivery device with convergent lumen | |
| US10219936B2 (en) | Therapeutic agent delivery device with advanceable cannula and needle |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20190910 |