CA2959198A1 - Proteines de fusion recombinantes pour la prevention ou le traitement des adherences des tissus ou des organes - Google Patents
Proteines de fusion recombinantes pour la prevention ou le traitement des adherences des tissus ou des organes Download PDFInfo
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- CA2959198A1 CA2959198A1 CA2959198A CA2959198A CA2959198A1 CA 2959198 A1 CA2959198 A1 CA 2959198A1 CA 2959198 A CA2959198 A CA 2959198A CA 2959198 A CA2959198 A CA 2959198A CA 2959198 A1 CA2959198 A1 CA 2959198A1
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- fusion protein
- recombinant fusion
- adhesions
- protein according
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6418—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals from snakes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21074—Venombin A (3.4.21.74)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
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- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Surgery (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne des protéines de fusion recombinantes, contenant une enzyme fibrinogénolytique avec une séquence d'acides aminés qui est liée en C-terminal et/ou N-terminal à la séquence d'acides aminés d'au moins un domaine stabilisateur inerte de haut poids moléculaire ayant un poids moléculaire > 50 kDa, pour la prévention ou le traitement des adhérences des tissus ou des organes, en particulier des adhérences péritonéales après les interventions chirurgicales.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102014112212.7 | 2014-08-26 | ||
| DE102014112212.7A DE102014112212A1 (de) | 2014-08-26 | 2014-08-26 | Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen |
| PCT/EP2015/069176 WO2016030278A1 (fr) | 2014-08-26 | 2015-08-20 | Protéines de fusion recombinantes pour la prévention ou le traitement des adhérences des tissus ou des organes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2959198A1 true CA2959198A1 (fr) | 2016-03-03 |
Family
ID=53969360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2959198A Pending CA2959198A1 (fr) | 2014-08-26 | 2015-08-20 | Proteines de fusion recombinantes pour la prevention ou le traitement des adherences des tissus ou des organes |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10837007B2 (fr) |
| EP (1) | EP3185891B1 (fr) |
| JP (1) | JP7025928B2 (fr) |
| CN (1) | CN107109387A (fr) |
| CA (1) | CA2959198A1 (fr) |
| DE (1) | DE102014112212A1 (fr) |
| ES (1) | ES2799829T3 (fr) |
| PL (1) | PL3185891T3 (fr) |
| WO (1) | WO2016030278A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102014112212A1 (de) * | 2014-08-26 | 2016-03-03 | Akesion Gmbh | Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3682754D1 (de) | 1985-12-16 | 1992-01-16 | Ethicon Inc | Hemmung von post-chirurgischer adhaesionsbildung durch topische verabreichung von gewebeplasminogenaktivator. |
| AU621305B2 (en) | 1987-07-01 | 1992-03-12 | Genentech Inc. | Method and therapeutic compositions for the prevention of fibrin deposition or adhesions |
| DE3741149A1 (de) | 1987-12-04 | 1989-06-15 | Thomae Gmbh Dr K | Zubereitungsformen zur verhinderung von adhaesionen von organen und organteilen |
| US5156969A (en) | 1988-09-02 | 1992-10-20 | Genentech Inc. | Tissue plasminogen activator variant with deletion of amino acids 466-470 having fibrin specific properties |
| CA2015127A1 (fr) * | 1989-04-26 | 1990-10-26 | John G. Gray, Jr. | Sequences d'adn encodant des polypeptides du genre ancrod et composes contenant le produit d'expression |
| CA1335361C (fr) | 1989-05-24 | 1995-04-25 | Andrei Z. Budzynski | Complexes diriges contre les thrombus et formes d'activateurs du plasminogene et de fragments de fibrine |
| US5468505A (en) | 1992-02-28 | 1995-11-21 | Board Of Regents, The University Of Texas System | Local delivery of fibrinolysis enhancing agents |
| US6461640B1 (en) | 1995-12-08 | 2002-10-08 | Board Of Regents, The University Of Texas System | Local delivery of fibrinolysis enhancing agents |
| SE9600216D0 (sv) | 1996-01-18 | 1996-01-18 | Hans Arne Hansson | Styrning av läkningsprocesser |
| AU753458B2 (en) * | 1997-12-09 | 2002-10-17 | Bristol-Myers Squibb Company | Fibrinogen-converting enzyme hybrids |
| US6214594B1 (en) * | 1998-05-08 | 2001-04-10 | University Of California | Size enhanced fibrinolytic enzymes: limitations of plasma inactivation |
| GB9810127D0 (en) * | 1998-05-13 | 1998-07-08 | Ml Lab Plc | Prevention of surgical adhesions |
| US6818018B1 (en) * | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| JP2005538932A (ja) | 2002-02-07 | 2005-12-22 | アベンティス、ベーリング、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング | アルブミン融合クニッツドメインペプチド |
| US20050074865A1 (en) * | 2002-08-27 | 2005-04-07 | Compound Therapeutics, Inc. | Adzymes and uses thereof |
| US20040224006A1 (en) | 2003-04-21 | 2004-11-11 | Samn Raffaniello | Ancrod irradiated, impregnated or coated sutures and other first aid or wound management bandaging materials for minimizing scarring and/or preventing excessive scar formation |
| KR100785378B1 (ko) | 2005-09-05 | 2007-12-14 | 주식회사 바이오레인 | 다층구조의 유착방지제 |
| CN101321863A (zh) * | 2005-10-03 | 2008-12-10 | 阿斯利康(瑞典)有限公司 | 具有受调控的血浆半衰期的融合蛋白 |
| EP1816201A1 (fr) * | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée |
| NZ593837A (en) * | 2007-11-29 | 2013-01-25 | Grifols Therapeutics Inc | Recombinantly modified plasmin |
| US8629314B2 (en) | 2007-12-18 | 2014-01-14 | Ethicon, Inc. | Surgical barriers having adhesion inhibiting properties |
| WO2010144508A1 (fr) * | 2009-06-08 | 2010-12-16 | Amunix Operating Inc. | Polypeptides de régulation du glucose et leurs procédés de production et d'utilisation |
| AU2010284977A1 (en) * | 2009-08-20 | 2012-03-29 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
| US8557961B2 (en) | 2010-04-02 | 2013-10-15 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
| US9133270B2 (en) * | 2011-03-08 | 2015-09-15 | The Trustees Of The University Of Pennsylvania | Antibody-like proteins for therapeutic and diagnostic use |
| CA2849409A1 (fr) * | 2011-09-23 | 2013-03-28 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Agents du facteur de necrose tumorale alpha et utilisations de ceux-ci |
| CN103623396B (zh) * | 2013-04-07 | 2016-03-02 | 安源生物科技(上海)有限公司 | 包含重组组织型纤溶酶原激活剂的药物组合物 |
| DE102014112212A1 (de) * | 2014-08-26 | 2016-03-03 | Akesion Gmbh | Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen |
-
2014
- 2014-08-26 DE DE102014112212.7A patent/DE102014112212A1/de not_active Withdrawn
-
2015
- 2015-08-20 WO PCT/EP2015/069176 patent/WO2016030278A1/fr active Application Filing
- 2015-08-20 EP EP15753942.0A patent/EP3185891B1/fr active Active
- 2015-08-20 CN CN201580058048.0A patent/CN107109387A/zh active Pending
- 2015-08-20 CA CA2959198A patent/CA2959198A1/fr active Pending
- 2015-08-20 US US15/506,558 patent/US10837007B2/en active Active
- 2015-08-20 JP JP2017530418A patent/JP7025928B2/ja active Active
- 2015-08-20 ES ES15753942T patent/ES2799829T3/es active Active
- 2015-08-20 PL PL15753942T patent/PL3185891T3/pl unknown
-
2020
- 2020-11-13 US US17/098,098 patent/US20210189368A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20170253864A1 (en) | 2017-09-07 |
| EP3185891A1 (fr) | 2017-07-05 |
| JP2017526746A (ja) | 2017-09-14 |
| JP7025928B2 (ja) | 2022-02-25 |
| US20210189368A1 (en) | 2021-06-24 |
| ES2799829T3 (es) | 2020-12-21 |
| CN107109387A (zh) | 2017-08-29 |
| US10837007B2 (en) | 2020-11-17 |
| EP3185891B1 (fr) | 2020-04-08 |
| DE102014112212A1 (de) | 2016-03-03 |
| WO2016030278A1 (fr) | 2016-03-03 |
| PL3185891T3 (pl) | 2020-09-07 |
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