CA2959117C - Methods and compositions for producing hepatocyte-like cells - Google Patents

Methods and compositions for producing hepatocyte-like cells Download PDF

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Publication number
CA2959117C
CA2959117C CA2959117A CA2959117A CA2959117C CA 2959117 C CA2959117 C CA 2959117C CA 2959117 A CA2959117 A CA 2959117A CA 2959117 A CA2959117 A CA 2959117A CA 2959117 C CA2959117 C CA 2959117C
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cells
hepatocyte
days
population
culture
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CA2959117A1 (en
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Gary Peltz
Dan Xu
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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CA2959117A 2013-09-19 2014-09-17 Methods and compositions for producing hepatocyte-like cells Active CA2959117C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361880056P 2013-09-19 2013-09-19
US61/880,056 2013-09-19
PCT/US2014/056049 WO2015042125A2 (en) 2013-09-19 2014-09-17 Methods and compositions for producing hepatocyte-like cells

Publications (2)

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CA2959117A1 CA2959117A1 (en) 2015-03-26
CA2959117C true CA2959117C (en) 2023-08-22

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CA2959117A Active CA2959117C (en) 2013-09-19 2014-09-17 Methods and compositions for producing hepatocyte-like cells

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US (3) US10004767B2 (OSRAM)
EP (2) EP3685884A1 (OSRAM)
JP (3) JP6683615B2 (OSRAM)
CA (1) CA2959117C (OSRAM)
DK (1) DK3046628T3 (OSRAM)
ES (1) ES2767062T3 (OSRAM)
SG (3) SG10201802231RA (OSRAM)
WO (1) WO2015042125A2 (OSRAM)

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JP2016529920A (ja) 2016-09-29
US11291691B2 (en) 2022-04-05
SG11201707615YA (en) 2017-10-30
WO2015042125A3 (en) 2015-11-05
SG10201802231RA (en) 2018-05-30
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