CA2958146C - Cultivation of hair inductive cells - Google Patents
Cultivation of hair inductive cells Download PDFInfo
- Publication number
- CA2958146C CA2958146C CA2958146A CA2958146A CA2958146C CA 2958146 C CA2958146 C CA 2958146C CA 2958146 A CA2958146 A CA 2958146A CA 2958146 A CA2958146 A CA 2958146A CA 2958146 C CA2958146 C CA 2958146C
- Authority
- CA
- Canada
- Prior art keywords
- cells
- hair
- medium
- cell
- culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 94
- 230000001939 inductive effect Effects 0.000 title claims abstract description 70
- 238000000034 method Methods 0.000 claims abstract description 54
- 239000002609 medium Substances 0.000 claims abstract description 25
- 239000001963 growth medium Substances 0.000 claims abstract description 23
- 230000001143 conditioned effect Effects 0.000 claims abstract description 16
- 238000012258 culturing Methods 0.000 claims abstract description 12
- 210000004027 cell Anatomy 0.000 claims description 210
- 230000002500 effect on skin Effects 0.000 claims description 39
- 210000003317 double-positive, alpha-beta immature T lymphocyte Anatomy 0.000 claims description 34
- 210000002950 fibroblast Anatomy 0.000 claims description 19
- 238000002054 transplantation Methods 0.000 claims description 11
- 230000000735 allogeneic effect Effects 0.000 claims description 5
- 239000006143 cell culture medium Substances 0.000 claims description 3
- 230000002062 proliferating effect Effects 0.000 claims description 3
- 238000000108 ultra-filtration Methods 0.000 claims description 3
- 239000013603 viral vector Substances 0.000 claims description 3
- 238000003306 harvesting Methods 0.000 claims description 2
- 239000012679 serum free medium Substances 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 230000003750 conditioning effect Effects 0.000 abstract description 14
- 230000006698 induction Effects 0.000 abstract description 12
- 239000003636 conditioned culture medium Substances 0.000 description 58
- 210000001519 tissue Anatomy 0.000 description 25
- 210000002510 keratinocyte Anatomy 0.000 description 21
- 210000003491 skin Anatomy 0.000 description 11
- 238000003556 assay Methods 0.000 description 10
- 238000012360 testing method Methods 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 8
- 210000003780 hair follicle Anatomy 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 7
- 210000000064 prostate epithelial cell Anatomy 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 210000003981 ectoderm Anatomy 0.000 description 6
- 210000001339 epidermal cell Anatomy 0.000 description 6
- 102000013814 Wnt Human genes 0.000 description 5
- 108050003627 Wnt Proteins 0.000 description 5
- 238000003501 co-culture Methods 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 238000001574 biopsy Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000002919 epithelial cell Anatomy 0.000 description 4
- 210000000981 epithelium Anatomy 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 210000003716 mesoderm Anatomy 0.000 description 4
- 210000003098 myoblast Anatomy 0.000 description 4
- 210000002307 prostate Anatomy 0.000 description 4
- 210000002027 skeletal muscle Anatomy 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 201000004384 Alopecia Diseases 0.000 description 3
- 102000009389 Prostaglandin D receptors Human genes 0.000 description 3
- 108050000258 Prostaglandin D receptors Proteins 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000036621 balding Effects 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000003779 hair growth Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 239000012678 infectious agent Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 210000002752 melanocyte Anatomy 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 238000007747 plating Methods 0.000 description 3
- 238000003908 quality control method Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 2
- 201000008275 breast carcinoma Diseases 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000012136 culture method Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000002889 endothelial cell Anatomy 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000003676 hair loss Effects 0.000 description 2
- 208000024963 hair loss Diseases 0.000 description 2
- 210000003494 hepatocyte Anatomy 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 201000009051 Embryonal Carcinoma Diseases 0.000 description 1
- 241000132179 Eurotium medium Species 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 206010068168 androgenetic alopecia Diseases 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 239000007640 basal medium Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 210000001900 endoderm Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000013411 master cell bank Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000008384 membrane barrier Effects 0.000 description 1
- 238000001531 micro-dissection Methods 0.000 description 1
- 230000000394 mitotic effect Effects 0.000 description 1
- 238000004264 monolayer culture Methods 0.000 description 1
- RLZZZVKAURTHCP-UHFFFAOYSA-N phenanthrene-3,4-diol Chemical compound C1=CC=C2C3=C(O)C(O)=CC=C3C=CC2=C1 RLZZZVKAURTHCP-UHFFFAOYSA-N 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 238000001814 protein method Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 238000000275 quality assurance Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000011076 safety test Methods 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000002107 sheath cell Anatomy 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000007390 skin biopsy Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 210000001057 smooth muscle myoblast Anatomy 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/24—Genital tract cells, non-germinal cells from gonads
- C12N2502/246—Cells of the male genital tract, non-germinal testis cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42611102P | 2002-11-14 | 2002-11-14 | |
| US60/426,111 | 2002-11-14 | ||
| CA2505409A CA2505409C (en) | 2002-11-14 | 2003-11-14 | Cultivation of hair inductive cells |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2505409A Division CA2505409C (en) | 2002-11-14 | 2003-11-14 | Cultivation of hair inductive cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2958146A1 CA2958146A1 (en) | 2004-05-27 |
| CA2958146C true CA2958146C (en) | 2019-08-20 |
Family
ID=32313110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2958146A Expired - Lifetime CA2958146C (en) | 2002-11-14 | 2003-11-14 | Cultivation of hair inductive cells |
| CA2505409A Expired - Lifetime CA2505409C (en) | 2002-11-14 | 2003-11-14 | Cultivation of hair inductive cells |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2505409A Expired - Lifetime CA2505409C (en) | 2002-11-14 | 2003-11-14 | Cultivation of hair inductive cells |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7785876B2 (enExample) |
| EP (1) | EP1563061B1 (enExample) |
| JP (1) | JP4550582B2 (enExample) |
| AU (1) | AU2003282244B2 (enExample) |
| CA (2) | CA2958146C (enExample) |
| DK (1) | DK1563061T3 (enExample) |
| ES (1) | ES2387617T3 (enExample) |
| WO (1) | WO2004044188A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7920901A (en) | 2000-08-08 | 2002-03-04 | Bioamide Inc | Scaffolds for tissue engineered hair |
| US20030161815A1 (en) * | 2002-02-12 | 2003-08-28 | Intercytex Limited | Cell delivery system |
| CA2958146C (en) | 2002-11-14 | 2019-08-20 | Aderans Research Institute, Inc. | Cultivation of hair inductive cells |
| US20050233450A1 (en) * | 2004-01-12 | 2005-10-20 | Goetinck Paul F | Methods of inducing hair growth |
| US7597885B2 (en) | 2004-03-26 | 2009-10-06 | Aderans Research Institute, Inc. | Tissue engineered biomimetic hair follicle graft |
| US20060115460A1 (en) * | 2004-08-30 | 2006-06-01 | Naughton Gail K | Compositions and methods comprising WNT proteins to promote repair of damaged tissue |
| KR100616752B1 (ko) * | 2004-11-29 | 2006-08-31 | 박정극 | 모낭 유도 능력이 있는 모유두 조직의 제조방법 |
| US20070087437A1 (en) * | 2005-10-14 | 2007-04-19 | Jifan Hu | Methods for rejuvenating cells in vitro and in vivo |
| TW200731982A (en) * | 2005-10-17 | 2007-09-01 | Aderans Res Inst Inc | Method of delivering cells to the skin |
| WO2007062386A2 (en) | 2005-11-22 | 2007-05-31 | Aderans Research Institute, Inc. | Hair follicle graft from tissue engineered skin |
| JP5386180B2 (ja) | 2006-02-28 | 2014-01-15 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 真皮細胞のコンパクト凝集のための方法 |
| GB0605450D0 (en) * | 2006-03-17 | 2006-04-26 | Intercytex Ltd | Cell co-culture |
| KR100771171B1 (ko) * | 2006-07-05 | 2007-10-29 | 재단법인서울대학교산학협력재단 | 모낭 줄기세포의 분리, 증식 및 분화 방법 및 대머리치료용 조성물 |
| US7922688B2 (en) | 2007-01-08 | 2011-04-12 | Restoration Robotics, Inc. | Automated delivery of a therapeutic or cosmetic substance to cutaneous, subcutaneous and intramuscular tissue regions |
| US7985537B2 (en) | 2007-06-12 | 2011-07-26 | Aderans Research Institute, Inc. | Methods for determining the hair follicle inductive properties of a composition |
| WO2009089380A2 (en) * | 2008-01-08 | 2009-07-16 | The Trustees Of Columbia University In The City Of New York | Methods for p2ry5 mediated regulation of hair growth and mutants thereof |
| GB0916370D0 (en) * | 2009-09-18 | 2009-10-28 | Avecia Biolog Ltd | Compositions |
| HRP20191548T1 (hr) | 2010-11-02 | 2020-02-21 | The Trustees Of Columbia University In The City Of New York | Postupci liječenja poremećaja gubitka kose |
| US9198911B2 (en) | 2010-11-02 | 2015-12-01 | The Trustees Of Columbia University In The City Of New York | Methods for treating hair loss disorders |
| EP3459565A1 (en) | 2012-03-29 | 2019-03-27 | The Trustees of Columbia University in the City of New York | Methods for treating hair loss disorders |
| FR3072972B1 (fr) * | 2017-10-30 | 2023-03-10 | Oreal | Procede de preparation in vitro d’equivalents de papille dermique et de follicule pileux |
| GB201816902D0 (en) * | 2018-10-17 | 2018-11-28 | Hairclone Ltd | Hair Rejuvenation |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8604360D0 (en) | 1986-02-21 | 1986-03-26 | Univ Dundee | Stimulation of hair growth |
| NL8801516A (nl) * | 1988-06-14 | 1990-01-02 | Suiker Unie | Werkwijze voor de fermentatieve bereiding van organische zuren. |
| US5620421A (en) | 1993-12-09 | 1997-04-15 | Schmitz; William L. | Syringe injector system |
| US5571083A (en) | 1994-02-18 | 1996-11-05 | Lemelson; Jerome H. | Method and system for cell transplantation |
| JP3573488B2 (ja) | 1994-04-11 | 2004-10-06 | 独立行政法人 科学技術振興機構 | 毛乳頭細胞の長期継代培養法 |
| US5611811A (en) | 1994-04-29 | 1997-03-18 | Star-Wood, Inc. | Micro and mini hair transplant device |
| US5571811A (en) * | 1994-07-12 | 1996-11-05 | Janssen Pharmaceutica N.V. | Sulfonamide derivatives of azolones |
| US5540657A (en) | 1994-07-15 | 1996-07-30 | Collagen Corporation | Delivery device for injectable materials |
| US5554153A (en) | 1994-08-29 | 1996-09-10 | Cell Robotics, Inc. | Laser skin perforator |
| WO1996025889A1 (en) | 1995-02-22 | 1996-08-29 | Jacques Michael Casparian | Dilator/hair implanter device |
| US5685860A (en) | 1995-06-07 | 1997-11-11 | Johnson & Johnson Medical, Inc. | Self-capping needle assembly |
| EP0953040A4 (en) | 1996-04-26 | 2001-12-12 | Univ Case Western Reserve | REGENERATION OF THE SKIN USING MESENCHYMAL STEM CELLS |
| NL1005445C2 (nl) * | 1997-03-05 | 1998-09-21 | Gho St Holding B V | Werkwijze voor het vermenigvuldigen van haar. |
| WO1999001034A1 (en) * | 1997-07-01 | 1999-01-14 | Cooley Jerry E | Method for producing new hair growth |
| GB9817662D0 (en) | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
| JP2000167039A (ja) | 1998-11-30 | 2000-06-20 | Isotis Bv | 人造皮膚 |
| GB9903805D0 (en) | 1999-02-20 | 1999-04-14 | Univ Sheffield | Pluripotential cells-1 |
| US6372494B1 (en) * | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| US20010027293A1 (en) | 1999-06-29 | 2001-10-04 | Ashok V. Joshi | Storage stable fluid injection device and associated process |
| PT1226233E (pt) | 1999-08-05 | 2011-10-04 | Abt Holding Co | Células estaminais adultas multipotentes e métodos para isolamento |
| GB9919218D0 (en) | 1999-08-13 | 1999-10-20 | Imprint Pharm Ltd | Injection means |
| US6224567B1 (en) | 1999-09-08 | 2001-05-01 | Cambridge Biostability Limited | Modified disposable injector device |
| GB9925964D0 (en) | 1999-11-03 | 1999-12-29 | Jahoda Colin A B | Hair transplantation |
| CA2390053A1 (en) | 1999-11-05 | 2001-05-10 | Gerigene Medical Corporation | Augmentation and repair of age-related soft tissue defects |
| DE10005329A1 (de) | 2000-02-08 | 2001-09-20 | Albert Scheller | Humanisiertes, vitalisiertes Haarbewachsen und Haarwiederbewachsen mit subkutanen Kanüleneinstich-Haut-Färbungs-Zeichnungsverfahren |
| CA2403817C (en) * | 2000-03-31 | 2012-05-29 | The General Hospital Corporation | Methods of modulating hair growth |
| BR0206796A (pt) | 2001-01-29 | 2004-02-03 | Aderans Res Inst Inc | Neogênese de folìculo capilar através da injeção de células geradoras de folìculo |
| US6790455B2 (en) | 2001-09-14 | 2004-09-14 | The Research Foundation At State University Of New York | Cell delivery system comprising a fibrous matrix and cells |
| US20050089512A1 (en) | 2001-12-19 | 2005-04-28 | Kordula Schlotmann | Skin/hair equivalent with reconstructed papillae |
| CA2958146C (en) | 2002-11-14 | 2019-08-20 | Aderans Research Institute, Inc. | Cultivation of hair inductive cells |
-
2003
- 2003-11-14 CA CA2958146A patent/CA2958146C/en not_active Expired - Lifetime
- 2003-11-14 AU AU2003282244A patent/AU2003282244B2/en not_active Expired
- 2003-11-14 EP EP03773862A patent/EP1563061B1/en not_active Expired - Lifetime
- 2003-11-14 US US10/534,428 patent/US7785876B2/en not_active Expired - Lifetime
- 2003-11-14 CA CA2505409A patent/CA2505409C/en not_active Expired - Lifetime
- 2003-11-14 WO PCT/GB2003/004949 patent/WO2004044188A1/en not_active Ceased
- 2003-11-14 JP JP2004550840A patent/JP4550582B2/ja not_active Expired - Fee Related
- 2003-11-14 DK DK03773862.2T patent/DK1563061T3/da active
- 2003-11-14 ES ES03773862T patent/ES2387617T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1563061B1 (en) | 2012-06-20 |
| EP1563061A1 (en) | 2005-08-17 |
| JP2006506063A (ja) | 2006-02-23 |
| WO2004044188A1 (en) | 2004-05-27 |
| CA2505409C (en) | 2017-04-04 |
| JP4550582B2 (ja) | 2010-09-22 |
| AU2003282244B2 (en) | 2008-11-20 |
| DK1563061T3 (da) | 2012-10-01 |
| US7785876B2 (en) | 2010-08-31 |
| ES2387617T3 (es) | 2012-09-27 |
| US20050272150A1 (en) | 2005-12-08 |
| CA2505409A1 (en) | 2004-05-27 |
| AU2003282244A1 (en) | 2004-06-03 |
| CA2958146A1 (en) | 2004-05-27 |
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