FR3072972B1 - Procede de preparation in vitro d’equivalents de papille dermique et de follicule pileux - Google Patents

Procede de preparation in vitro d’equivalents de papille dermique et de follicule pileux Download PDF

Info

Publication number
FR3072972B1
FR3072972B1 FR1760242A FR1760242A FR3072972B1 FR 3072972 B1 FR3072972 B1 FR 3072972B1 FR 1760242 A FR1760242 A FR 1760242A FR 1760242 A FR1760242 A FR 1760242A FR 3072972 B1 FR3072972 B1 FR 3072972B1
Authority
FR
France
Prior art keywords
hair follicle
dermal papilla
vitro preparation
equivalents
follicle equivalents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1760242A
Other languages
English (en)
Other versions
FR3072972A1 (fr
Inventor
Khalid Bakkar
Theebah Sellathurai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1760242A priority Critical patent/FR3072972B1/fr
Application filed by LOreal SA filed Critical LOreal SA
Priority to BR112020008348-8A priority patent/BR112020008348A2/pt
Priority to US16/760,109 priority patent/US20200255801A1/en
Priority to CN201880077456.4A priority patent/CN111417717A/zh
Priority to JP2020523695A priority patent/JP7005754B2/ja
Priority to EP18803336.9A priority patent/EP3704226A1/fr
Priority to KR1020207015309A priority patent/KR102390235B1/ko
Priority to PCT/EP2018/079758 priority patent/WO2019086485A1/fr
Publication of FR3072972A1 publication Critical patent/FR3072972A1/fr
Application granted granted Critical
Publication of FR3072972B1 publication Critical patent/FR3072972B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • C12N5/0628—Hair stem cells; Hair progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/31—Pituitary sex hormones, e.g. follicle-stimulating hormone [FSH], luteinising hormone [LH]; Chorionic gonadotropins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues
    • C12N2503/06—Screening or testing on artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FR1760242A 2017-10-30 2017-10-30 Procede de preparation in vitro d’equivalents de papille dermique et de follicule pileux Active FR3072972B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR1760242A FR3072972B1 (fr) 2017-10-30 2017-10-30 Procede de preparation in vitro d’equivalents de papille dermique et de follicule pileux
US16/760,109 US20200255801A1 (en) 2017-10-30 2018-10-30 Method for the in vitro preparation of dermal papilla and hair follicle equivalents
CN201880077456.4A CN111417717A (zh) 2017-10-30 2018-10-30 真皮乳头和毛囊等同物的体外制备方法
JP2020523695A JP7005754B2 (ja) 2017-10-30 2018-10-30 毛乳頭及び毛包同等物をインビトロで調製する方法
BR112020008348-8A BR112020008348A2 (pt) 2017-10-30 2018-10-30 processo para a preparação in vitro de um equivalente de papila dérmica, equivalente de papila dérmica in vitro, processo para a preparação in vitro de equivalente de folículo piloso, equivalente de folículo piloso in vitro, uso de equivalente de folículo piloso in vitro e processo para triagem de pelo menos um composto que modula o crescimento de pelo corporal e/ou cabelo
EP18803336.9A EP3704226A1 (fr) 2017-10-30 2018-10-30 Procédé de préparation in vitro d'équivalents de papille dermique et de follicule pileux
KR1020207015309A KR102390235B1 (ko) 2017-10-30 2018-10-30 진피 모유두 및 모낭 등가물의 시험관 내 제조 방법
PCT/EP2018/079758 WO2019086485A1 (fr) 2017-10-30 2018-10-30 Procédé de préparation in vitro d'équivalents de papille dermique et de follicule pileux

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1760242 2017-10-30
FR1760242A FR3072972B1 (fr) 2017-10-30 2017-10-30 Procede de preparation in vitro d’equivalents de papille dermique et de follicule pileux

Publications (2)

Publication Number Publication Date
FR3072972A1 FR3072972A1 (fr) 2019-05-03
FR3072972B1 true FR3072972B1 (fr) 2023-03-10

Family

ID=61521590

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1760242A Active FR3072972B1 (fr) 2017-10-30 2017-10-30 Procede de preparation in vitro d’equivalents de papille dermique et de follicule pileux

Country Status (8)

Country Link
US (1) US20200255801A1 (fr)
EP (1) EP3704226A1 (fr)
JP (1) JP7005754B2 (fr)
KR (1) KR102390235B1 (fr)
CN (1) CN111417717A (fr)
BR (1) BR112020008348A2 (fr)
FR (1) FR3072972B1 (fr)
WO (1) WO2019086485A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115282137B (zh) * 2022-07-04 2023-08-18 爱美客技术发展股份有限公司 一种外用擦剂护理组合物及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7785876B2 (en) * 2002-11-14 2010-08-31 Aderans Research Institute, Inc. Cultivation of hair inductive cells
KR100616752B1 (ko) * 2004-11-29 2006-08-31 박정극 모낭 유도 능력이 있는 모유두 조직의 제조방법
GB0605450D0 (en) * 2006-03-17 2006-04-26 Intercytex Ltd Cell co-culture
JP5349474B2 (ja) 2007-07-20 2013-11-20 ドングク・ユニヴァーシティー・インダストリー−アカデミック・コーオペレーション・ファンデーション 間葉系幹細胞を利用して毛乳頭組職を製造する方法
EP2105499A1 (fr) * 2008-03-28 2009-09-30 Technische Universität Berlin Procédés de production de nouvelles papilles et microfollicules capillaires et leur utilisation dans des tests in vitro et implantations in vivo
JPWO2010021245A1 (ja) * 2008-08-22 2012-01-26 学校法人慶應義塾 毛乳頭細胞の培養方法
US9982238B2 (en) * 2011-02-09 2018-05-29 Organ Technologies, Inc. Method for producing regenerative organ primordium provided with guide for transplantation, composition containing regenerative organ primordium provided with guide for transplantation produced thereby, and method for transplanting regenerative organ primordium provided with guide for transplantation
JP5887333B2 (ja) * 2011-02-24 2016-03-16 株式会社オーガンテクノロジーズ 毛色が制御された移植用再生毛包原基の製造方法、当該移植用再生毛包原基を含む組成物、およびその移植方法
KR20160019654A (ko) * 2014-08-12 2016-02-22 강원대학교산학협력단 섬유아세포 배양용 배지 조성물, 섬유아세포의 배양방법 및 이를 이용한 피부 재생용 조성물
DE102015110880A1 (de) * 2015-07-06 2017-01-12 Linde Material Handling Gmbh Verfahren zur Steuerung des Ladebetriebs eines Druckspeichers einer mobilen Arbeitsmaschine
FR3041656A1 (fr) * 2015-09-29 2017-03-31 Oreal Utilisation des cellules de la matrice pour la preparation d'un microfollicule pileux
DE102015119880B4 (de) * 2015-11-17 2018-05-24 Technische Universität Berlin Verfahren zur Herstellung von Haarfollikeln und de novo Papillen sowie deren Verwendung für in vitro Tests und in vivo Implantate

Also Published As

Publication number Publication date
BR112020008348A2 (pt) 2020-11-03
WO2019086485A1 (fr) 2019-05-09
KR102390235B1 (ko) 2022-04-22
JP7005754B2 (ja) 2022-01-24
KR20200073281A (ko) 2020-06-23
EP3704226A1 (fr) 2020-09-09
CN111417717A (zh) 2020-07-14
JP2021500897A (ja) 2021-01-14
FR3072972A1 (fr) 2019-05-03
US20200255801A1 (en) 2020-08-13

Similar Documents

Publication Publication Date Title
CL2016000158A1 (es) Métodos para la fijación del pelo y piel
ES2933249R1 (es) Composiciones para la liberación controlada de ingredientes activos y métodos de preparación de las mismas
AR100215A1 (es) Conjugados de anticuerpo-fármaco anti-ptk7
BR112018005110A2 (pt) Composição emoliente e sua utilização cosmética, composição cosmética, dermatológica ou farmacêutica e sua utilização cosmética e processo de tratamento cosmético da pele
DK3377637T3 (da) Sammensætninger til anvendelse i fremgangsmåder til behandling af sår, lidelser og sygdomme i huden
DK3142637T3 (da) Keratin treatment formulations and methods
IL259862B (en) Inhibitors of proton tyrosine kinase and methods of using them
HK1250629A1 (zh) 用於治療人乳頭狀瘤病毒皮膚感染的含乙酰水楊酸的組合物和醫療裝置
HK1246177A1 (zh) 局部用紅細胞生成素製劑和用其提高傷口愈合的方法及其美容用途
EP3432778C0 (fr) Appareil et procédé pour localiser, mesurer et surveiller une inflammation des couches de tissu mou de la peau
PL2953539T3 (pl) System i sposób nieinwazyjnego pomiaru miękkiej tkanki biologicznej
GB201519200D0 (en) Skin care composition and method thereof
EP2986244A4 (fr) Dispositif et méthode de traitement rf fractionné de la peau
EP3468530A4 (fr) Formulations non comédogènes de soin des cheveux et du cuir chevelu et méthode d'utilisation
HK1259451A1 (zh) 護膚組合物及其方法
FR3072972B1 (fr) Procede de preparation in vitro d’equivalents de papille dermique et de follicule pileux
GB201611406D0 (en) Skin care composition and method thereof
EP3397238A4 (fr) Composition de lipides de plante pour stimuler la croissance des cheveux, procédé de stimulation de la croissance des cheveux et utilisations desdits lipides de plante
ZA202102676B (en) System for recognition of biological alteration in human tissues
GB201611362D0 (en) Skin care composition and method thereof
EP3386516A4 (fr) Formulations pharmaceutiques pour traiter les troubles cutanés et procédés de fabrication et d'utilisation associés
FI20175950A (fi) Hyönteisproteiinia sisältävä valmiste ja menetelmä androgeenipuutoksen hoitamiseksi naisilla
FR3019039B1 (fr) Composition cosmetique et/ou dermatologique pour la coloration de la peau
PL3344259T3 (pl) Kompozycja i wyrób medyczny zawierające kwas acetylosalicylowy do leczenia zakażeń skóry wywołanych wirusem brodawczaka ludzkiego
SI3344259T1 (sl) Sestavek in medicinska naprava, ki obsega acetilsalicilno kislino za zdravljenje kožnih okužb s humanim papilomavirusom

Legal Events

Date Code Title Description
PLSC Publication of the preliminary search report

Effective date: 20190503

PLFP Fee payment

Year of fee payment: 3

PLFP Fee payment

Year of fee payment: 4

PLFP Fee payment

Year of fee payment: 5

PLFP Fee payment

Year of fee payment: 6

PLFP Fee payment

Year of fee payment: 7