CA2956385A1 - Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule - Google Patents
Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule Download PDFInfo
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- A61K40/41—Vertebrate antigens
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- A61K2239/23—On/off switch
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
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- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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| EP15306036 | 2015-06-29 | ||
| EP15306036.3 | 2015-06-29 | ||
| PCT/EP2015/067090 WO2016012623A1 (en) | 2014-07-25 | 2015-07-24 | Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule |
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| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
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| WO2017180587A2 (en) * | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CN108276493B (zh) * | 2016-12-30 | 2023-11-14 | 南京传奇生物科技有限公司 | 一种嵌合抗原受体及其应用 |
| SG11201909931PA (en) | 2017-04-27 | 2019-11-28 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| EP3618870A4 (en) | 2017-05-01 | 2021-04-21 | The Trustees of The University of Pennsylvania | MONOCLONAL ANTIBODIES AGAINST ALPHA-SYNUCLEIN FIBRILLES |
| WO2019077165A1 (en) | 2017-10-20 | 2019-04-25 | Institut Curie | DAP10 / 12-BASED CHIMERIC ANTIGENIC RECEPTORS (CAR) ADAPTED FOR RUSH |
| WO2019077164A1 (en) | 2017-10-20 | 2019-04-25 | Institut Curie | CROCHET FUSION PROTEIN FOR REGULATING THE CELLULAR TRAFFIC OF A TARGET PROTEIN |
| US11760806B2 (en) | 2017-11-03 | 2023-09-19 | Sorrento Therapeutics, Inc. | CD-38 directed chimeric antigen receptor constructs |
| EP3740199B1 (en) | 2018-01-17 | 2024-08-14 | Ixaka France | Polymer-encapsulated viral vectors for genetic therapy |
| EP3549597A1 (en) * | 2018-04-06 | 2019-10-09 | Heinrich-Heine-Universität Düsseldorf | Synthetic signalling constructs and its use |
| EP3781176A4 (en) * | 2018-04-09 | 2022-05-25 | The Trustees of the University of Pennsylvania | METHODS AND COMPOSITIONS USING A VIRAL VECTOR FOR THE EXPRESSION OF A TRANSGENE AND AN EFFECTOR |
| US12215337B2 (en) * | 2018-04-12 | 2025-02-04 | Umoja Biopharma, Inc. | Viral vectors and packaging cell lines |
| IL280659B2 (en) | 2018-08-09 | 2024-11-01 | Juno Therapeutics Inc | Processes for generating engineered cells and compositions thereof |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| CN114258401B (zh) * | 2019-07-16 | 2025-08-12 | Inserm(法国国家健康医学研究院) | 对cd38具有特异性的抗体及其用途 |
| AU2020345943B2 (en) | 2019-09-10 | 2026-02-12 | Obsidian Therapeutics, Inc. | CA2-IL15 fusion proteins for tunable regulation |
| GB201914611D0 (en) * | 2019-10-09 | 2019-11-20 | Autolus Ltd | Engineered immune cell |
| CA3170369A1 (en) | 2020-03-05 | 2022-04-14 | Michal Shahar | Methods and compositions for treating cancer with immune cells |
| US20230323394A1 (en) * | 2020-09-01 | 2023-10-12 | The Trustees Of The University Of Pennsylvania | Improved generation of lentiviral vectors for t cell transduction using cocal envelope |
| WO2022101482A1 (en) | 2020-11-13 | 2022-05-19 | Honing Biosciences | Means and methods for regulating intracellular trafficking of secretory or cell membrane-anchored proteins of interest |
| AU2022267891A1 (en) * | 2021-04-27 | 2023-11-09 | Novartis Ag | Viral vector production system |
| IT202100011576A1 (it) * | 2021-05-06 | 2022-11-06 | Univ Degli Studi Padova | Nuova sequenza promotore per terapia genica |
| JP2024544566A (ja) | 2021-11-15 | 2024-12-03 | セラベクティス | ヒトパピローマウイルス（ｈｐｖ）抗原の発現の為のレンチウイルスベクター、並びにｈｐｖ誘発癌の処置におけるその実施 |
| CA3256704A1 (en) * | 2022-05-23 | 2023-11-30 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR CRISPR SCREENING OF IMMUNE CELLS |
| CA3263030A1 (en) | 2022-07-27 | 2024-02-01 | Institut Pasteur | Lentiviral vectors for the expression of human papillomavirus (HPV) antigens and their use in the treatment of HPV-induced cancers |
| US12484900B2 (en) | 2023-07-21 | 2025-12-02 | Cilag Gmbh International | Systems and subsystems for rolling a surgical instrument including articulation cables |
| EP4624494A1 (en) | 2024-03-29 | 2025-10-01 | Institut Curie | Her2 single domain antibody and uses thereof |
| WO2026020171A2 (en) | 2024-07-19 | 2026-01-22 | Aera Therapeutics, Inc. | Chimeric antigen receptor constructs |
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| US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
| EA201491574A1 (ru) * | 2012-02-22 | 2014-12-30 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Применение car, основанных на icos, для усиления противоопухолевой активности и длительного сохранения car |
| SI2884999T2 (sl) * | 2012-08-20 | 2026-01-30 | Fred Hutchinson Cancer Center | Metoda in sestavki za celično imunoterapijo |
| CA2886684C (en) * | 2012-10-10 | 2023-09-19 | Sangamo Biosciences, Inc. | T cell modifying compounds and uses thereof |
| JP6942467B2 (ja) * | 2013-12-20 | 2021-10-06 | フレッド ハッチンソン キャンサー リサーチ センター | タグ化キメラエフェクター分子およびそのレセプター |
| IL295616A (en) * | 2015-07-31 | 2022-10-01 | Us Health | Adapted cells and treatment methods |
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| US20210009653A1 (en) | 2021-01-14 |
| CN107531800B (zh) | 2021-08-10 |
| HK1248720A1 (zh) | 2018-10-19 |
| JP2017528158A (ja) | 2017-09-28 |
| WO2016012623A1 (en) | 2016-01-28 |
| EP3172228B1 (en) | 2019-02-27 |
| JP6940406B2 (ja) | 2021-09-29 |
| CN113846062B (zh) | 2025-02-21 |
| CN113846062A (zh) | 2021-12-28 |
| JP2023113656A (ja) | 2023-08-16 |
| EP3511413B1 (en) | 2022-09-07 |
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Effective date: 20200519 |
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| EEER | Examination request |
Effective date: 20200519 |
|
| EEER | Examination request |
Effective date: 20200519 |