CA2954082A1 - Methods and compositions for treatment of conditions associated with elevated triglycerides - Google Patents
Methods and compositions for treatment of conditions associated with elevated triglycerides Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
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- Emergency Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462059682P | 2014-10-03 | 2014-10-03 | |
| US62/059,682 | 2014-10-03 | ||
| PCT/US2015/053700 WO2016054494A1 (en) | 2014-10-03 | 2015-10-02 | Methods and compositions for treatment of conditions associated with elevated triglycerides |
Publications (1)
| Publication Number | Publication Date |
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| CA2954082A1 true CA2954082A1 (en) | 2016-04-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2954082A Pending CA2954082A1 (en) | 2014-10-03 | 2015-10-02 | Methods and compositions for treatment of conditions associated with elevated triglycerides |
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| Country | Link |
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| US (3) | US10071139B2 (enExample) |
| EP (2) | EP3822287A1 (enExample) |
| JP (1) | JP6680758B2 (enExample) |
| AU (1) | AU2015327900B2 (enExample) |
| CA (1) | CA2954082A1 (enExample) |
| ES (1) | ES2819866T3 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3822287A1 (en) | 2014-10-03 | 2021-05-19 | NGM Biopharmaceuticals, Inc. | Angptl8 polypeptide and its use for treatment of conditions associated with elevated triglycerides |
| TW201713690A (zh) * | 2015-08-07 | 2017-04-16 | 再生元醫藥公司 | 抗ａｎｇｐｔｌ８抗體及其用途 |
| JP6843872B2 (ja) * | 2016-02-04 | 2021-03-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 操作されたａｎｇｐｔｌ８遺伝子を有する非ヒト動物 |
| EA201891979A1 (ru) | 2016-03-03 | 2019-01-31 | Ридженерон Фармасьютикалз, Инк. | Способы лечения пациентов с гиперлипидемией введением ингибитора pcsk9 в комбинации с ингибитором angptl3 |
| US20190177391A1 (en) * | 2016-03-31 | 2019-06-13 | Baylor Research Institute | Angiopoietin-like protein 8 (angptl8) |
| PL3439689T3 (pl) * | 2016-04-08 | 2022-01-31 | Regeneron Pharmaceuticals, Inc. | Sposoby leczenia hiperlipidemii inhibitorem angptl8 i inhibitorem angptl3 |
| WO2018094112A1 (en) | 2016-11-17 | 2018-05-24 | Regeneron Pharmaceuticals, Inc. | Methods of treating obesity with anti-angptl8 antibodies |
| CN111315775A (zh) | 2017-11-10 | 2020-06-19 | 恩格姆生物制药公司 | Angptl8-结合剂及其使用方法 |
| US11977081B2 (en) | 2017-12-18 | 2024-05-07 | Regeneron Pharmaceuticals, Inc. | ANGPTL8 assay and uses thereof |
| TWI747098B (zh) * | 2018-12-21 | 2021-11-21 | 美商美國禮來大藥廠 | 抗angptl3/8複合物抗體及其使用方法 |
| CN110694068A (zh) * | 2019-11-06 | 2020-01-17 | 北京市心肺血管疾病研究所 | 一种抑制血管生成素样蛋白8的物质的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| ES2545090T3 (es) * | 2001-12-21 | 2015-09-08 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina y GCSF |
| WO2011084714A2 (en) | 2009-12-17 | 2011-07-14 | Biogen Idec Ma Inc. | STABILIZED ANTI-TNF-ALPHA scFv MOLECULES OR ANTI-TWEAK scFv MOLECULES AND USES THEREOF |
| CN104039357A (zh) | 2011-06-10 | 2014-09-10 | 哈佛学院校长同事会 | 胰腺β-细胞增殖的调节 |
| US10259863B2 (en) * | 2013-01-11 | 2019-04-16 | The California Institute For Biomedical Research | Bovine fusion antibodies |
| WO2015054691A2 (en) | 2013-10-11 | 2015-04-16 | The United States Of America, As Pepresented By The Secretary, Department Of Health And Human Services | Tem8 antibodies and their use |
| EP3822287A1 (en) | 2014-10-03 | 2021-05-19 | NGM Biopharmaceuticals, Inc. | Angptl8 polypeptide and its use for treatment of conditions associated with elevated triglycerides |
| TW201713690A (zh) | 2015-08-07 | 2017-04-16 | 再生元醫藥公司 | 抗ａｎｇｐｔｌ８抗體及其用途 |
| WO2018094112A1 (en) | 2016-11-17 | 2018-05-24 | Regeneron Pharmaceuticals, Inc. | Methods of treating obesity with anti-angptl8 antibodies |
| CN111315775A (zh) | 2017-11-10 | 2020-06-19 | 恩格姆生物制药公司 | Angptl8-结合剂及其使用方法 |
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2015
- 2015-10-02 EP EP20185093.0A patent/EP3822287A1/en not_active Withdrawn
- 2015-10-02 EP EP15848061.6A patent/EP3201225B1/en active Active
- 2015-10-02 AU AU2015327900A patent/AU2015327900B2/en not_active Ceased
- 2015-10-02 JP JP2017500335A patent/JP6680758B2/ja not_active Expired - Fee Related
- 2015-10-02 CA CA2954082A patent/CA2954082A1/en active Pending
- 2015-10-02 US US15/318,937 patent/US10071139B2/en active Active
- 2015-10-02 ES ES15848061T patent/ES2819866T3/es active Active
- 2015-10-02 WO PCT/US2015/053700 patent/WO2016054494A1/en not_active Ceased
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2018
- 2018-08-06 US US16/056,068 patent/US10702587B2/en not_active Expired - Fee Related
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2020
- 2020-05-29 US US16/888,249 patent/US20210015902A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP6680758B2 (ja) | 2020-04-15 |
| JP2017531613A (ja) | 2017-10-26 |
| US10071139B2 (en) | 2018-09-11 |
| EP3201225A4 (en) | 2018-05-23 |
| EP3822287A1 (en) | 2021-05-19 |
| US20170143799A1 (en) | 2017-05-25 |
| AU2015327900A1 (en) | 2017-02-02 |
| US20210015902A1 (en) | 2021-01-21 |
| EP3201225A1 (en) | 2017-08-09 |
| WO2016054494A1 (en) | 2016-04-07 |
| AU2015327900B2 (en) | 2020-04-30 |
| US10702587B2 (en) | 2020-07-07 |
| EP3201225B1 (en) | 2020-08-19 |
| US20190060408A1 (en) | 2019-02-28 |
| ES2819866T3 (es) | 2021-04-19 |
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