CA2953079C - Intermittent dosing of mdm2 inhibitor - Google Patents
Intermittent dosing of mdm2 inhibitor Download PDFInfo
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- CA2953079C CA2953079C CA2953079A CA2953079A CA2953079C CA 2953079 C CA2953079 C CA 2953079C CA 2953079 A CA2953079 A CA 2953079A CA 2953079 A CA2953079 A CA 2953079A CA 2953079 C CA2953079 C CA 2953079C
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- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| EP3159352B1 (en) | 2007-03-28 | 2023-08-02 | President and Fellows of Harvard College | Stitched polypeptides |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| TW201613576A (en) | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
| KR20170058424A (ko) | 2014-09-24 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
| MX389354B (es) | 2014-09-24 | 2025-03-20 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y formulaciones de los mismos. |
| SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| AU2017362040C1 (en) * | 2016-11-15 | 2020-09-10 | Novartis Ag | Dose and regimen for HDM2-p53 interaction inhibitors |
| US20200281925A1 (en) * | 2017-03-31 | 2020-09-10 | Novartis Ag | Dose and regimen for an hdm2-p53 interaction inhibitor in hematological tumors |
| CN111971285B (zh) * | 2018-03-12 | 2023-08-15 | 罗欣药业(上海)有限公司 | 咪唑并吡咯酮化合物及其应用 |
| BR112020018755A2 (pt) | 2018-03-20 | 2021-01-05 | Novartis Ag | Combinações farmacêuticas |
| IL319432A (en) * | 2018-04-30 | 2025-05-01 | Kartos Therapeutics Inc | Methods of treating cancer |
| KR20210043499A (ko) | 2018-05-25 | 2021-04-21 | 카토스 테라퓨틱스, 인크. | 골수증식성 신생물 치료 방법 |
| JP2022513255A (ja) | 2018-12-20 | 2022-02-07 | ノバルティス アーゲー | ＨＤＭ２－ｐ５３相互作用阻害剤とＢＣＬ２阻害剤との組み合わせ及び癌を処置するためのその使用 |
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| KR100944301B1 (ko) | 2005-02-22 | 2010-02-24 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | Ｍｄｍ２의 소분자 억제제 및 이의 용도 |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
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| EP2948453B1 (en) | 2013-01-22 | 2017-08-02 | Novartis AG | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction |
| WO2015082384A1 (en) | 2013-12-05 | 2015-06-11 | F. Hoffmann-La Roche Ag | Novel combination treatment for acute myeloid leukemia (aml) |
| EP3086787B1 (en) | 2013-12-23 | 2021-01-20 | Novartis AG | Pharmaceutical combinations |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| TW201613576A (en) | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
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| KR20170134462A (ko) | 2015-04-13 | 2017-12-06 | 다이이찌 산쿄 가부시키가이샤 | Mdm2 저해제와 btk 저해제의 병용 치료법 |
| TWI804010B (zh) | 2015-08-03 | 2023-06-01 | 瑞士商諾華公司 | 作為血液學毒性生物標記之gdf-15 |
| AU2016314082B2 (en) | 2015-08-28 | 2019-07-25 | Novartis Ag | Mdm2 inhibitors and combinations thereof |
| AU2017362040C1 (en) | 2016-11-15 | 2020-09-10 | Novartis Ag | Dose and regimen for HDM2-p53 interaction inhibitors |
| PL3544982T3 (pl) | 2016-11-22 | 2022-02-14 | Novartis Ag | Chemiczny sposób otrzymywania pochodnych imidazopirolidynonu i ich produktów pośrednich |
| WO2018158225A1 (en) | 2017-02-28 | 2018-09-07 | Les Laboratoires Servier | Combination of a bcl-2 inhibitor and a mdm2 inhibitor, uses and pharmaceutical compositions thereof |
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| BR112020018755A2 (pt) | 2018-03-20 | 2021-01-05 | Novartis Ag | Combinações farmacêuticas |
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| CN113631558A (zh) | 2019-04-04 | 2021-11-09 | 诺华股份有限公司 | Siremadlin琥珀酸酯 |
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- 2015-06-25 CN CN201580034558.4A patent/CN106456635A/zh not_active Withdrawn
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