CA2949912C - Polymorphs of acyl sulfonamides - Google Patents

Polymorphs of acyl sulfonamides Download PDF

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Publication number
CA2949912C
CA2949912C CA2949912A CA2949912A CA2949912C CA 2949912 C CA2949912 C CA 2949912C CA 2949912 A CA2949912 A CA 2949912A CA 2949912 A CA2949912 A CA 2949912A CA 2949912 C CA2949912 C CA 2949912C
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CA
Canada
Prior art keywords
compound
acid
hiv
polymorphic
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2949912A
Other languages
English (en)
French (fr)
Other versions
CA2949912A1 (en
Inventor
James Prentice Davidson
Michael Martin
Fei Pang
Margaret Wong
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to CA3059552A priority Critical patent/CA3059552C/en
Priority to CA3003213A priority patent/CA3003213C/en
Publication of CA2949912A1 publication Critical patent/CA2949912A1/en
Application granted granted Critical
Publication of CA2949912C publication Critical patent/CA2949912C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CA2949912A 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides Active CA2949912C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA3059552A CA3059552C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3003213A CA3003213C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9536408P 2008-09-09 2008-09-09
US61/095,364 2008-09-09
CA2735192A CA2735192C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2735192A Division CA2735192C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA3059552A Division CA3059552C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3003213A Division CA3003213C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides

Publications (2)

Publication Number Publication Date
CA2949912A1 CA2949912A1 (en) 2010-03-18
CA2949912C true CA2949912C (en) 2019-12-03

Family

ID=41664548

Family Applications (5)

Application Number Title Priority Date Filing Date
CA2949912A Active CA2949912C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3003213A Active CA3003213C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3059552A Active CA3059552C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA2735192A Active CA2735192C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3086566A Active CA3086566C (en) 2008-09-09 2009-08-31 ACYLATE SULFONAMIDE POLYMORPHS

Family Applications After (4)

Application Number Title Priority Date Filing Date
CA3003213A Active CA3003213C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3059552A Active CA3059552C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA2735192A Active CA2735192C (en) 2008-09-09 2009-08-31 Polymorphs of acyl sulfonamides
CA3086566A Active CA3086566C (en) 2008-09-09 2009-08-31 ACYLATE SULFONAMIDE POLYMORPHS

Country Status (16)

Country Link
US (1) US8063103B2 (https=)
EP (1) EP2334638B1 (https=)
JP (6) JP5989339B2 (https=)
KR (7) KR101822319B1 (https=)
CN (1) CN102143943B (https=)
AU (1) AU2009290988B2 (https=)
BR (3) BRPI0918526B1 (https=)
CA (5) CA2949912C (https=)
EA (1) EA019340B1 (https=)
ES (1) ES2706875T3 (https=)
IL (4) IL299322B2 (https=)
MX (1) MX2011002319A (https=)
PL (1) PL2334638T3 (https=)
TR (1) TR201818979T4 (https=)
UA (1) UA107561C2 (https=)
WO (1) WO2010028968A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2644156C1 (ru) 2017-02-28 2018-02-08 Александр Васильевич Иващенко Пролекарство ингибитора NS5B HCV полимеразы, способ его получения и применения
RU2665383C9 (ru) * 2017-06-22 2019-07-23 Общество с ограниченной ответственностью "Вириом" Фармацевтическая наносуспензия для терапии ВИЧ-инфекции
RU2662160C9 (ru) 2017-07-03 2018-10-22 Александрович Иващенко Андрей Комбинированный лекарственный препарат для терапии вирусных инфекций
RU2716257C1 (ru) 2019-04-30 2020-03-11 Андрей Александрович Иващенко Активный компонент, фармацевтическая композиция и лекарственный препарат для терапии ВИЧ и СПИДа
RU2717101C1 (ru) 2019-06-03 2020-03-18 Андрей Александрович Иващенко Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2191922T3 (es) * 1997-01-23 2003-09-16 Yamanouchi Pharma Co Ltd Nuevos derivados de amida y sus composiciones medicinales.
US7166738B2 (en) * 2004-04-23 2007-01-23 Roche Palo Alto Llc Non-nucleoside reverse transcriptase inhibitors
BRPI0510059B8 (pt) * 2004-04-23 2021-05-25 Hoffmann La Roche inibidores da transcriptase reversa não-nucleosídica e seus usos
US7625949B2 (en) * 2004-04-23 2009-12-01 Roche Palo Alto Llc Methods for treating retroviral infections
US7618981B2 (en) * 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
BRPI0609879A2 (pt) * 2005-04-28 2010-05-11 Pfizer Ltd derivados de aminoácidos
CN101291905A (zh) * 2005-10-19 2008-10-22 弗·哈夫曼-拉罗切有限公司 苯乙酰胺nnrt抑制剂
EA032294B1 (ru) * 2007-07-30 2019-05-31 Арди Байосайенсиз, Инк. Способ получения полиморфной формы производного n-(ариламино)сульфонамида, фармацевтическая композиция, содержащая указанное производное, и способ лечения с помощью указанного производного
EP2262477A1 (en) * 2008-03-04 2010-12-22 F. Hoffmann-La Roche AG Process for preparing concentrated aqueous micellar solutions

Also Published As

Publication number Publication date
CA3059552C (en) 2021-03-16
EP2334638B1 (en) 2018-11-21
CN102143943B (zh) 2014-03-12
JP2016172741A (ja) 2016-09-29
PL2334638T3 (pl) 2019-04-30
JP2023082131A (ja) 2023-06-13
CA2735192C (en) 2017-02-28
JP2021176894A (ja) 2021-11-11
JP5989339B2 (ja) 2016-09-07
KR101678700B1 (ko) 2016-11-22
EA201100451A1 (ru) 2011-10-31
US20100063154A1 (en) 2010-03-11
CA3003213C (en) 2021-07-20
IL299322B1 (en) 2024-06-01
JP2012502075A (ja) 2012-01-26
UA107561C2 (xx) 2015-01-26
BRPI0918526B1 (pt) 2022-02-15
CA3003213A1 (en) 2010-03-18
KR20110053234A (ko) 2011-05-19
BR122021020475B1 (pt) 2022-06-07
CA2949912A1 (en) 2010-03-18
CA3059552A1 (en) 2010-03-18
CN102143943A (zh) 2011-08-03
KR20180110237A (ko) 2018-10-08
AU2009290988B2 (en) 2016-01-28
WO2010028968A3 (en) 2010-06-10
CA3086566A1 (en) 2010-03-18
IL264118A (en) 2019-02-28
KR101822319B1 (ko) 2018-01-25
JP2019194229A (ja) 2019-11-07
MX2011002319A (es) 2011-04-05
JP2018058862A (ja) 2018-04-12
IL299322A (en) 2023-02-01
US8063103B2 (en) 2011-11-22
KR102560207B1 (ko) 2023-07-27
TR201818979T4 (tr) 2019-01-21
BR122021020474B1 (pt) 2022-06-07
KR20230113420A (ko) 2023-07-28
BRPI0918526A2 (pt) 2015-12-01
CA2735192A1 (en) 2010-03-18
IL211353A0 (en) 2011-05-31
JP6450340B2 (ja) 2019-01-09
KR20160092049A (ko) 2016-08-03
KR20210108499A (ko) 2021-09-02
AU2009290988A1 (en) 2010-03-18
KR20220120723A (ko) 2022-08-30
IL299322B2 (en) 2024-10-01
KR102437499B1 (ko) 2022-08-29
WO2010028968A2 (en) 2010-03-18
EP2334638A2 (en) 2011-06-22
EA019340B1 (ru) 2014-02-28
KR20180001582A (ko) 2018-01-04
CA3086566C (en) 2025-09-02
IL244350A0 (en) 2016-05-01
IL211353A (en) 2016-04-21
ES2706875T3 (es) 2019-04-01

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