CA2948823C - Quantitation of tamoxifen and metabolites thereof by mass spectrometry - Google Patents
Quantitation of tamoxifen and metabolites thereof by mass spectrometry Download PDFInfo
- Publication number
- CA2948823C CA2948823C CA2948823A CA2948823A CA2948823C CA 2948823 C CA2948823 C CA 2948823C CA 2948823 A CA2948823 A CA 2948823A CA 2948823 A CA2948823 A CA 2948823A CA 2948823 C CA2948823 C CA 2948823C
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- tamoxifen
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- detection
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- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 title claims abstract description 310
- 229960001603 tamoxifen Drugs 0.000 title claims abstract description 165
- 239000002207 metabolite Substances 0.000 title claims abstract description 47
- 238000004949 mass spectrometry Methods 0.000 title claims abstract description 39
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- YCQBLTPGQSYLHD-VHXPQNKSSA-N Norendoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN)=CC=1)/C1=CC=C(O)C=C1 YCQBLTPGQSYLHD-VHXPQNKSSA-N 0.000 claims abstract description 75
- DODQJNMQWMSYGS-QPLCGJKRSA-N 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 DODQJNMQWMSYGS-QPLCGJKRSA-N 0.000 claims description 108
- 150000002500 ions Chemical class 0.000 claims description 102
- MHJBZVSGOZTKRH-IZHYLOQSSA-N 4-Hydroxy-N-desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=C(O)C=C1 MHJBZVSGOZTKRH-IZHYLOQSSA-N 0.000 claims description 77
- NYDCDZSEEAUOHN-IZHYLOQSSA-N N-Desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=CC=C1 NYDCDZSEEAUOHN-IZHYLOQSSA-N 0.000 claims description 44
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Classifications
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- Y10T436/25125—Digestion or removing interfering materials
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
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| US201461992214P | 2014-05-12 | 2014-05-12 | |
| US61/992,214 | 2014-05-12 | ||
| PCT/US2015/030419 WO2015175561A1 (en) | 2014-05-12 | 2015-05-12 | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
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| CA2948823A1 CA2948823A1 (en) | 2015-11-19 |
| CA2948823C true CA2948823C (en) | 2020-09-22 |
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| CA2948823C (en) * | 2014-05-12 | 2020-09-22 | Quest Diagnostics Investments Incorporated | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
| CN105159539B (zh) * | 2015-09-10 | 2018-06-01 | 京东方科技集团股份有限公司 | 可穿戴设备的触控响应方法、装置及可穿戴设备 |
| CN114585915B (zh) | 2019-10-10 | 2024-02-23 | 瑞泽恩制药公司 | 用于分析两性电解质批次变化的液相色谱法-质谱法(lc-ms)方法 |
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| US12105102B2 (en) | 2022-03-30 | 2024-10-01 | University Of Utah Research Foundation | Methods for quantifying insulin-like growth factor-1 and insulin-like growth factor-2 |
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| CN104203961B (zh) * | 2012-03-05 | 2017-05-17 | 泽维尔大学 | 作为用于治疗乳腺癌的基于硼的4‑羟基他莫昔芬和因多昔芬前药 |
| WO2014014279A1 (ko) * | 2012-07-17 | 2014-01-23 | 서울대학교 산학협력단 | 질량 스펙트럼의 재현성 향상 방법 및 이를 이용한 정량 분석 방법 |
| CN103494787B (zh) * | 2013-07-22 | 2014-10-29 | 南通广泰生化制品有限公司 | 枸橼酸他莫昔芬滴丸 |
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