CA2946654C - Triaminopyrimidine compounds useful for preventing or treating malaria - Google Patents

Triaminopyrimidine compounds useful for preventing or treating malaria Download PDF

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Publication number
CA2946654C
CA2946654C CA2946654A CA2946654A CA2946654C CA 2946654 C CA2946654 C CA 2946654C CA 2946654 A CA2946654 A CA 2946654A CA 2946654 A CA2946654 A CA 2946654A CA 2946654 C CA2946654 C CA 2946654C
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CA
Canada
Prior art keywords
compound
fluoro
diamine
formula
pyridy1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2946654A
Other languages
English (en)
French (fr)
Other versions
CA2946654A1 (en
Inventor
Shahul HAMEED PEER MOHAMED
Vikas PATIL
Kannan MURUGAN
Eknath VITHALRAO BELLALE
Anandkumar RAICHURKAR
Sudhir LANDGE
Jayashree PUTTUR
Nilanjana ROY CHOUDHURY
Gajanan SHANBHAG
Krishna KOUSHIK
Pravin Iyer
Vasan KIRTHIKA SAMBANDAMURTHY
Suresh Solapure
Shridhar Narayanan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MMV Medicines for Malaria Venture
Original Assignee
MMV Medicines for Malaria Venture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MMV Medicines for Malaria Venture filed Critical MMV Medicines for Malaria Venture
Publication of CA2946654A1 publication Critical patent/CA2946654A1/en
Application granted granted Critical
Publication of CA2946654C publication Critical patent/CA2946654C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2946654A 2014-04-28 2015-03-26 Triaminopyrimidine compounds useful for preventing or treating malaria Active CA2946654C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2142CH2014 2014-04-28
IN2142/CHE/2014 2014-04-28
PCT/EP2015/056496 WO2015165660A1 (en) 2014-04-28 2015-03-26 Triaminopyrimidine compounds useful for preventing or treating malaria

Publications (2)

Publication Number Publication Date
CA2946654A1 CA2946654A1 (en) 2015-11-05
CA2946654C true CA2946654C (en) 2022-08-23

Family

ID=52779638

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2946654A Active CA2946654C (en) 2014-04-28 2015-03-26 Triaminopyrimidine compounds useful for preventing or treating malaria

Country Status (22)

Country Link
US (1) US9957253B2 (https=)
EP (1) EP3137455B1 (https=)
JP (1) JP6529983B2 (https=)
CN (1) CN106255685B (https=)
AP (1) AP2016009570A0 (https=)
BR (1) BR112016024467B1 (https=)
CA (1) CA2946654C (https=)
CY (1) CY1120700T1 (https=)
DK (1) DK3137455T3 (https=)
ES (1) ES2696350T3 (https=)
HR (1) HRP20181816T1 (https=)
HU (1) HUE042043T2 (https=)
LT (1) LT3137455T (https=)
MX (1) MX374458B (https=)
MY (1) MY178971A (https=)
PH (1) PH12016502322B1 (https=)
PL (1) PL3137455T3 (https=)
PT (1) PT3137455T (https=)
RS (1) RS58124B1 (https=)
SI (1) SI3137455T1 (https=)
SM (1) SMT201800588T1 (https=)
WO (1) WO2015165660A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105699584B (zh) * 2016-02-03 2018-02-09 昆药集团股份有限公司 一种蒿甲醚相关物质的检测方法
WO2018079629A1 (ja) 2016-10-26 2018-05-03 カルナバイオサイエンス株式会社 抗マラリア活性を有する新規ピリミジン誘導体
CN106727584A (zh) * 2017-02-08 2017-05-31 于贵庆 一种治疗骨病的药物组合物
JP2020532513A (ja) * 2017-09-05 2020-11-12 カディラ ヘルスケア リミティド トリアミノピリミジン化合物およびその中間体の調製方法
CN117327007B (zh) * 2023-09-26 2024-09-13 上海陶术生物科技有限公司 一种vt107的制备方法
WO2025115034A1 (en) * 2023-11-30 2025-06-05 Zydus Lifesciences Limited A process for the preparation of a triaminopyrimidine compound and novel intermediates thereof
EP4574143A1 (en) 2023-12-21 2025-06-25 Universität Regensburg Inhibitors of plasmodia remodeling enzymes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003286711A1 (en) * 2002-10-25 2004-05-13 Vertex Pharmaceuticals Incorporated Indazolinone compositions useful as kinase inhibitors
RU2405778C2 (ru) * 2004-09-30 2010-12-10 Тиботек Фармасьютикалз Лтд. 5-гетероциклилпиримидины, ингибирующие вич
WO2014058685A1 (en) * 2012-10-08 2014-04-17 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity

Also Published As

Publication number Publication date
AP2016009570A0 (en) 2016-11-30
CA2946654A1 (en) 2015-11-05
MY178971A (en) 2020-10-26
CN106255685B (zh) 2019-08-20
EP3137455A1 (en) 2017-03-08
CN106255685A (zh) 2016-12-21
US20170050951A1 (en) 2017-02-23
RS58124B1 (sr) 2019-02-28
MX374458B (es) 2025-03-06
JP2017514804A (ja) 2017-06-08
PH12016502322B1 (en) 2022-03-23
PL3137455T3 (pl) 2019-01-31
MX2016014166A (es) 2017-02-14
PH12016502322A1 (en) 2017-01-30
BR112016024467B1 (pt) 2022-11-29
LT3137455T (lt) 2018-10-25
EP3137455B1 (en) 2018-08-15
BR112016024467A2 (pt) 2017-08-15
WO2015165660A1 (en) 2015-11-05
HK1231478A1 (en) 2017-12-22
CY1120700T1 (el) 2019-12-11
SI3137455T1 (sl) 2019-01-31
US9957253B2 (en) 2018-05-01
HRP20181816T1 (hr) 2018-12-28
PT3137455T (pt) 2018-11-21
DK3137455T3 (en) 2018-12-10
SMT201800588T1 (it) 2019-01-11
JP6529983B2 (ja) 2019-06-12
ES2696350T3 (es) 2019-01-15
HUE042043T2 (hu) 2019-06-28

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