MX374458B - Compuestos de triaminopirimidina útiles para evitar o tratar la malaria. - Google Patents
Compuestos de triaminopirimidina útiles para evitar o tratar la malaria.Info
- Publication number
- MX374458B MX374458B MX2016014166A MX2016014166A MX374458B MX 374458 B MX374458 B MX 374458B MX 2016014166 A MX2016014166 A MX 2016014166A MX 2016014166 A MX2016014166 A MX 2016014166A MX 374458 B MX374458 B MX 374458B
- Authority
- MX
- Mexico
- Prior art keywords
- preventing
- compounds useful
- treating malaria
- triaminopyrimidine
- triaminopyrimidine compounds
- Prior art date
Links
- 201000004792 malaria Diseases 0.000 title abstract 2
- CSNFMBGHUOSBFU-UHFFFAOYSA-N pyrimidine-2,4,5-triamine Chemical class NC1=NC=C(N)C(N)=N1 CSNFMBGHUOSBFU-UHFFFAOYSA-N 0.000 title 1
- 241000224016 Plasmodium Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención se relaciona con triaminopirimidinas y con sales farmacéuticamente aceptables de las mismas, con su uso en el tratamiento o prevención de la malaria causada por especies de Plasmodium y con sus métodos de preparación.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2142CH2014 | 2014-04-28 | ||
| PCT/EP2015/056496 WO2015165660A1 (en) | 2014-04-28 | 2015-03-26 | Triaminopyrimidine compounds useful for preventing or treating malaria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016014166A MX2016014166A (es) | 2017-02-14 |
| MX374458B true MX374458B (es) | 2025-03-06 |
Family
ID=52779638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014166A MX374458B (es) | 2014-04-28 | 2015-03-26 | Compuestos de triaminopirimidina útiles para evitar o tratar la malaria. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9957253B2 (es) |
| EP (1) | EP3137455B1 (es) |
| JP (1) | JP6529983B2 (es) |
| CN (1) | CN106255685B (es) |
| AP (1) | AP2016009570A0 (es) |
| BR (1) | BR112016024467B1 (es) |
| CA (1) | CA2946654C (es) |
| CY (1) | CY1120700T1 (es) |
| DK (1) | DK3137455T3 (es) |
| ES (1) | ES2696350T3 (es) |
| HR (1) | HRP20181816T1 (es) |
| HU (1) | HUE042043T2 (es) |
| LT (1) | LT3137455T (es) |
| MX (1) | MX374458B (es) |
| MY (1) | MY178971A (es) |
| PH (1) | PH12016502322B1 (es) |
| PL (1) | PL3137455T3 (es) |
| PT (1) | PT3137455T (es) |
| RS (1) | RS58124B1 (es) |
| SI (1) | SI3137455T1 (es) |
| SM (1) | SMT201800588T1 (es) |
| WO (1) | WO2015165660A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105699584B (zh) * | 2016-02-03 | 2018-02-09 | 昆药集团股份有限公司 | 一种蒿甲醚相关物质的检测方法 |
| US10538521B2 (en) | 2016-10-26 | 2020-01-21 | Carna Biosciences, Inc. | Pyrimidine derivative having antimalarial activity |
| CN106727584A (zh) * | 2017-02-08 | 2017-05-31 | 于贵庆 | 一种治疗骨病的药物组合物 |
| EP3679030B1 (en) * | 2017-09-05 | 2024-03-27 | Zydus Lifesciences Limited | A process for preparation of triaminopyrimidine compound and intermediates thereof |
| CN117327007B (zh) * | 2023-09-26 | 2024-09-13 | 上海陶术生物科技有限公司 | 一种vt107的制备方法 |
| WO2025115034A1 (en) * | 2023-11-30 | 2025-06-05 | Zydus Lifesciences Limited | A process for the preparation of a triaminopyrimidine compound and novel intermediates thereof |
| EP4574143A1 (en) | 2023-12-21 | 2025-06-25 | Universität Regensburg | Inhibitors of plasmodia remodeling enzymes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004037814A1 (en) * | 2002-10-25 | 2004-05-06 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
| CA2577467C (en) * | 2004-09-30 | 2013-05-28 | Tibotec Pharmaceuticals Ltd. | Hiv inhibiting 5-heterocyclyl pyrimidines |
| EP2903617B1 (en) * | 2012-10-08 | 2019-01-30 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
-
2015
- 2015-03-26 RS RS20181368A patent/RS58124B1/sr unknown
- 2015-03-26 HU HUE15713170A patent/HUE042043T2/hu unknown
- 2015-03-26 AP AP2016009570A patent/AP2016009570A0/en unknown
- 2015-03-26 SI SI201530475T patent/SI3137455T1/sl unknown
- 2015-03-26 PT PT15713170T patent/PT3137455T/pt unknown
- 2015-03-26 CA CA2946654A patent/CA2946654C/en active Active
- 2015-03-26 MX MX2016014166A patent/MX374458B/es active IP Right Grant
- 2015-03-26 PL PL15713170T patent/PL3137455T3/pl unknown
- 2015-03-26 CN CN201580022719.8A patent/CN106255685B/zh active Active
- 2015-03-26 DK DK15713170.7T patent/DK3137455T3/en active
- 2015-03-26 BR BR112016024467-2A patent/BR112016024467B1/pt active IP Right Grant
- 2015-03-26 US US15/307,382 patent/US9957253B2/en active Active
- 2015-03-26 SM SM20180588T patent/SMT201800588T1/it unknown
- 2015-03-26 ES ES15713170T patent/ES2696350T3/es active Active
- 2015-03-26 WO PCT/EP2015/056496 patent/WO2015165660A1/en not_active Ceased
- 2015-03-26 HR HRP20181816TT patent/HRP20181816T1/hr unknown
- 2015-03-26 EP EP15713170.7A patent/EP3137455B1/en active Active
- 2015-03-26 MY MYPI2016703966A patent/MY178971A/en unknown
- 2015-03-26 JP JP2016562579A patent/JP6529983B2/ja active Active
- 2015-03-26 LT LTEP15713170.7T patent/LT3137455T/lt unknown
-
2016
- 2016-11-22 PH PH12016502322A patent/PH12016502322B1/en unknown
-
2018
- 2018-09-27 CY CY181100997T patent/CY1120700T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6529983B2 (ja) | 2019-06-12 |
| ES2696350T3 (es) | 2019-01-15 |
| CN106255685B (zh) | 2019-08-20 |
| SMT201800588T1 (it) | 2019-01-11 |
| WO2015165660A1 (en) | 2015-11-05 |
| EP3137455B1 (en) | 2018-08-15 |
| JP2017514804A (ja) | 2017-06-08 |
| CA2946654A1 (en) | 2015-11-05 |
| PH12016502322B1 (en) | 2022-03-23 |
| US9957253B2 (en) | 2018-05-01 |
| PL3137455T3 (pl) | 2019-01-31 |
| BR112016024467B1 (pt) | 2022-11-29 |
| AP2016009570A0 (en) | 2016-11-30 |
| HRP20181816T1 (hr) | 2018-12-28 |
| BR112016024467A2 (pt) | 2017-08-15 |
| CY1120700T1 (el) | 2019-12-11 |
| CA2946654C (en) | 2022-08-23 |
| CN106255685A (zh) | 2016-12-21 |
| HUE042043T2 (hu) | 2019-06-28 |
| DK3137455T3 (en) | 2018-12-10 |
| HK1231478A1 (en) | 2017-12-22 |
| SI3137455T1 (sl) | 2019-01-31 |
| LT3137455T (lt) | 2018-10-25 |
| PH12016502322A1 (en) | 2017-01-30 |
| US20170050951A1 (en) | 2017-02-23 |
| MX2016014166A (es) | 2017-02-14 |
| EP3137455A1 (en) | 2017-03-08 |
| PT3137455T (pt) | 2018-11-21 |
| MY178971A (en) | 2020-10-26 |
| RS58124B1 (sr) | 2019-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |