CA2944074C - Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators - Google Patents

Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators Download PDF

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CA2944074C
CA2944074C CA2944074A CA2944074A CA2944074C CA 2944074 C CA2944074 C CA 2944074C CA 2944074 A CA2944074 A CA 2944074A CA 2944074 A CA2944074 A CA 2944074A CA 2944074 C CA2944074 C CA 2944074C
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carbazol
difluoro
hydroxypropyl
hydroxy
alkyl
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French (fr)
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CA2944074A1 (en
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Ross BERSOT
Paul Humphries
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Synchronicity Pharma Inc
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Synchronicity Pharma Inc
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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    • C07D209/82—Carbazoles; Hydrogenated carbazoles
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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
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CA2944074A 2014-04-07 2015-04-06 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators Active CA2944074C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461976350P 2014-04-07 2014-04-07
US61/976,350 2014-04-07
PCT/US2015/024537 WO2015157182A1 (en) 2014-04-07 2015-04-06 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators

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CA2944074A1 CA2944074A1 (en) 2015-10-15
CA2944074C true CA2944074C (en) 2023-04-04

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EP (2) EP3939971A1 (enExample)
JP (4) JP6601916B2 (enExample)
KR (1) KR102224423B1 (enExample)
CN (2) CN110003172B (enExample)
AR (1) AR099970A1 (enExample)
AU (1) AU2015244060B2 (enExample)
CA (1) CA2944074C (enExample)
DK (1) DK3129366T3 (enExample)
ES (1) ES2886469T3 (enExample)
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HU (1) HUE055547T2 (enExample)
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SI (1) SI3129366T1 (enExample)
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NZ728724A (en) 2012-05-11 2018-03-23 Reset Therapeutics Inc Carbazole-containing sulfonamides as cryptochrome modulators
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
WO2018013546A1 (en) * 2016-07-11 2018-01-18 The Regents Of The University Of California Bic inhibitor of cry-cry and cry-cib oligomerization/clustering
CN108779115B (zh) 2016-10-14 2021-02-26 江苏恒瑞医药股份有限公司 五元杂芳环并桥环类衍生物、其制备方法及其在医药上的应用
JP6835308B2 (ja) * 2016-10-19 2021-02-24 国立研究開発法人理化学研究所 クリプトクロムの機能を抑制するための組成物
US12385914B2 (en) * 2017-01-10 2025-08-12 The Regents Of The University Of California CRY1-clock-BMAL1 complex-disrupting agents and methods of identifying and using same
US11713470B2 (en) * 2017-03-20 2023-08-01 University of Pittsburgh—of the Commonwealth System of Higher Education Targeted gene therapies for pain and other neuro-related disorders
US11542275B2 (en) * 2018-03-22 2023-01-03 Aurigene Discovery Technologies Limited Substituted imidazolidin-2-one derivatives as PRMT5 inhibitors
US20210267939A1 (en) * 2018-06-18 2021-09-02 Duke University Compositions and methods for treating nafld/nash and related disease phenotypes
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
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