CA2943240C - Method for obtaining microbial secondary metabolites or derivatives thereof by heterologous expression of at least one synthetase of said secondary metabolites in filamentous fungi - Google Patents
Method for obtaining microbial secondary metabolites or derivatives thereof by heterologous expression of at least one synthetase of said secondary metabolites in filamentous fungi Download PDFInfo
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- CA2943240C CA2943240C CA2943240A CA2943240A CA2943240C CA 2943240 C CA2943240 C CA 2943240C CA 2943240 A CA2943240 A CA 2943240A CA 2943240 A CA2943240 A CA 2943240A CA 2943240 C CA2943240 C CA 2943240C
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
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- 239000011686 zinc sulphate Substances 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14160821.6 | 2014-03-20 | ||
| EP14160821 | 2014-03-20 | ||
| PCT/EP2015/055978 WO2015140315A2 (en) | 2014-03-20 | 2015-03-20 | Method for obtaining microbial secondary metabolites or derivatives thereof by heterologous expression of at least one synthetase of said secondary metabolites in filamentous fungi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2943240A1 CA2943240A1 (en) | 2015-09-24 |
| CA2943240C true CA2943240C (en) | 2021-06-29 |
Family
ID=50342210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2943240A Active CA2943240C (en) | 2014-03-20 | 2015-03-20 | Method for obtaining microbial secondary metabolites or derivatives thereof by heterologous expression of at least one synthetase of said secondary metabolites in filamentous fungi |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10738316B2 (es) |
| EP (1) | EP3119900B1 (es) |
| JP (1) | JP6524600B2 (es) |
| CN (1) | CN106414481A (es) |
| CA (1) | CA2943240C (es) |
| DK (1) | DK3119900T3 (es) |
| ES (1) | ES2682743T3 (es) |
| IL (1) | IL247880B (es) |
| WO (1) | WO2015140315A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112176004B (zh) * | 2019-07-05 | 2022-08-09 | 中粮生物科技股份有限公司 | 柠檬酸的生产方法 |
| CN114657155B (zh) * | 2021-12-23 | 2024-01-19 | 中国农业科学院生物技术研究所 | 一种新型的非核糖体多肽合成酶拆分表达方法 |
| CN117384924B (zh) * | 2023-12-11 | 2024-06-25 | 中国农业科学院生物技术研究所 | 一种基于酶结构域拆分的多肽生物合成方法 |
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| WO1994019334A1 (en) | 1993-02-19 | 1994-09-01 | Meiji Seika Kaisha, Ltd. | Pf1022 derivative, cyclic depsipeptide |
| DE60037181T2 (de) * | 1999-01-13 | 2008-10-09 | Novozymes, Inc., Davis | Verfahren zur herstellung von polypeptiden in cyclohexadepsipeptid-defizienten zellen |
| EP1215281B1 (en) * | 1999-09-07 | 2006-05-24 | Meiji Seika Kaisha Ltd. | Cyclic depsipeptide synthases, genes thereof and mass production system of cyclic depsipeptide |
| DE102009034359A1 (de) | 2009-07-17 | 2011-02-17 | Forschungsverbund Berlin E.V. | P-Kontakt und Leuchtdiode für den ultravioletten Spektralbereich |
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| JP2017508481A (ja) | 2017-03-30 |
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| US10738316B2 (en) | 2020-08-11 |
| JP6524600B2 (ja) | 2019-06-12 |
| IL247880B (en) | 2021-04-29 |
| IL247880A0 (en) | 2016-11-30 |
| EP3119900B1 (en) | 2018-05-09 |
| EP3119900A2 (en) | 2017-01-25 |
| DK3119900T3 (en) | 2018-08-13 |
| CN106414481A (zh) | 2017-02-15 |
| ES2682743T3 (es) | 2018-09-21 |
| US20170137832A1 (en) | 2017-05-18 |
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